Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs

International Journal for Parasitology

Volumn 41, Issue 2, 2011, Pages 165-171

  Martinelli, Axel ^a   Henriques, Gisela ^a   Cravo, Pedro ^a   Hunt, Paul ^b  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Folate; Mdr2; Mutation; Plasmodium; Sulphadoxine

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; MULTIDRUG RESISTANCE PROTEIN 2; PYRIMETHAMINE; SULFADOXINE;

DRUG; GENETIC MARKER; GENOME; MALARIA; MUTATION;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 2; CONTROLLED STUDY; DRUG SENSITIVITY; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENETIC MARKER; GENOMICS; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; PLASMODIUM CHABAUDI; POINT MUTATION; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIPROTOZOAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DNA, PROTOZOAN; DRUG COMBINATIONS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; GENES, MDR; MICE; MICE, INBRED CBA; MUTATION, MISSENSE; PLASMODIUM CHABAUDI; PROTOZOAN PROTEINS; PYRIMETHAMINE; SEQUENCE ANALYSIS, DNA; SULFADOXINE;

PLASMODIUM CHABAUDI; RODENTIA;

EID: 79151484995     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2010.08.008     Document Type: Article

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