Luteolin is a novel p90 ribosomal s6 kinase (RSK) inhibitor that suppresses notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)

Oncotarget

Volumn 4, Issue 2, 2013, Pages 329-345

  Reipas, Kristen M ^a   Law, Jennifer H ^a   Couto, Nicole ^a   Islam, Sumaiya ^a   Li, Yvonne ^b   Li, Huifang ^c   Cherkasov, Artem ^c   Jung, Karen ^d   Cheema, Amarpal S ^a   Jones, Steven J M ^b   Hassell, John A ^e   Dunn, Sandra E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

Drug repositioning; p90 ribosomal S6 kinase; Triple negative breast cancer; Tumor initiating cells; Y box binding protein 1

Indexed keywords

APIGENIN; CD24 ANTIGEN; HERMES ANTIGEN; KAEMPFEROL; LUTEOLIN; LUTIMAX; MESSENGER RNA; NOTCH4 RECEPTOR; PACLITAXEL; S6 KINASE; S6 KINASE 1; S6 KINASE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; ENZYMATIC ASSAY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DOCKING; MONOTHERAPY; NUCLEOTIDE SEQUENCE; PHARMACOLOGICAL BLOCKING; PROMOTER REGION; PROTEIN DNA BINDING; STRUCTURE ACTIVITY RELATION; TRIPLE NEGATIVE BREAST CANCER;

EID: 84875791033     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.834     Document Type: Article

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