Structural basis for the activity of the RSK-specific inhibitor, SL0101

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 14, 2007, Pages 5018-5034

  Smith, Jeffrey A ^a   Maloney, David J ^b   Hecht, Sidney M ^b   Lannigan, Deborah A ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Kaempferol 3 O (3 ,4 di O acetyl l rhamnopyranoside); Kinase inhibitor; RSK; SL0101; Structure activity relationship

Indexed keywords

4',5',7 TRI O ACETYLKAEMPFEROL 3 O (2'',3'',4'' TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); 4',5,7 TRI O METHYLKAEMPFEROL 3 O (3'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); 4',7 DIDEOXYKAEMPFEROL 3 O (3'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); 5 DEOXYKAEMPFEROL 3 O (3'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); 7 DIDEOXYKAEMPFEROL 3 O (3'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; HYDROXYL GROUP; KAEMPFEROL 3 O (2'',3'',4'' TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (2'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (3'',4 '' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (3'',4'' DI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (3'',4'' DI O BUTYRYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (3'',4'' DI O ETHYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (4'' MONO O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); RHAMNOSE; RIBOSOMAL S6 PROTEIN KINASE INHIBITOR; SL 0101; UNCLASSIFIED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROLYSIS; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ALKYLATION; BENZOPYRANS; CELL LINE, TUMOR; HUMANS; HYDROPHOBICITY; HYDROXYLATION; KAEMPFEROLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOSACCHARIDES; PROTEIN KINASE INHIBITORS; RHAMNOSE; RIBOSOMAL PROTEIN S6 KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249661589     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.087     Document Type: Article

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