Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis

Cancer Research

Volumn 56, Issue 8, 1996, Pages 1775-1785

  Gallahan, Daniel ^a   Jhappan, Chamelli ^a   Robinson, Gertraud ^b   Hennighausen, Lothar ^b   Sharp, Richard ^a   Kordon, Edith ^a   Callahan, Robert ^a   Merlino, Glenn ^a   Smith, Gilbert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST DUCT; BREAST EPITHELIUM; CONTROLLED STUDY; FEMALE; GENE INSERTION; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; DNA PRIMERS; EPITHELIAL CELLS; EPITHELIUM; FEMALE; GENE EXPRESSION; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MILK PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; PREGNANCY; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; RECOMBINANT PROTEINS; TRANSCRIPTION, GENETIC;

EID: 0029871104     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Callahan, R., and Salomon, D. S. Oncogenes, Tumor Suppressor Genes and Growth Factors in Breast Cancer Novel Targets for Diagnosis, Prognosis, and Therapy. Cancer Surv., 18 35-56, 1993.
2. Nusse, R. The int genes in mammary tumorigenesis and in normal development. Trends Genet., 4: 291-295, 1988.
3. Callahan, R MMTV induced mutations in mouse mammary tumors: their potential relevance to human breast cancer. In: R. Clarke (ed.), Breast Cancer Research and Treatment Boston Kluwer Academic Publishers, in press, 1995.
4. Gallahan, D., and Callahan, R. Mammary tumorigenesis in feral mice. Identification of a new int locus in mouse mammary tumor virus(CzechII)-induced mammary tumors. J. Virol , 61: 66-74, 1987.
5. Robbins, J., Blondel, B. J , Gallahan, D , and Callahan, R Mouse mammary tumor gene Int-3 A member of the notch gene family transforms mammary epithelial cells J. Virol., 66: 2594-2599, 1992
6. Artavanis-Tsakonas, S , Matsuno, K., and Fortini, M. E Notch signaling. Science (Washington DC), 268: 225-232, 1995.
7. Nye, J. S , Kopan, R. and Axel, R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development (Camb), 120: 2421-2430, 1994.
8. Medina, D., and Smith, G H In search of mammary gland stem cells. Protoplasma, 159: 77-84, 1990.
9. Smith, G. H , and Medina, D. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J. Cell Sci., 89: 173-183, 1988.
10. Jhappan, C., Gallahan, D., Stahle, C., Chu, E., Smith, G. H., Merlino, G. T., and Callahan, R Expression of an Activated Notch-Related Int-3 Transgene Interferes with Cell Differentiation and Induces Neoplastic Transformation in Mammary and Salivary Glands. Genes & Dev., 6: 345-355, 1992
11. Smith, G. H., Gallahan, D. L., Diella, F., Jhappan, C., Merlino, G., and Callahan, R. Constitutive expression of a truncated Int3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth & Differ., 6: 563-577, 1995.
12. Pittius, C., Hennighausen, L., Lee, E., Westphal, H., Nicols, E , Vitale, J., and Gordon, K. A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc. Natl. Acad. Sci. USA, 85: 5874-5878, 1988.
13. Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., and Merlino, G T TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61. 1137-1146, 1990.
14. Hogan, D. L., and Smith, G. H. Unconventional application of standard light and electron immunocytochemical analysis to aldehyde-fixed, Araldite-embedded tissues J. Histochem. Cytochem., 30: 1301-1306, 1982
15. Hennighausen, L., McKnight, R., Burton, T., Baik, M., Wall, R. J., and Smith, G. H. Whey acid protein extrinsically expressed from the mouse mammary tumor virus long terminal repeat results in hyperplasia of the coagulation gland epithelium and impaired mammary development. Cell Growth & Differ., 5: 607-613, 1994.
16. Smith, G. H., Mehrel, T , and Roop, D. Differential keratin gene expression in developing, differentiating, preneoplastic and neoplastic mouse mammary epithelium. Cell Growth & Differ., 1 161-170, 1990.
17. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
18. Burdon, T , Sankaran, L., Wall, R., Spencer, M , and Hennighausen, L Expression of a whey acidic protein transgene during mammary development: evidence for different mechanisms of regulation during pregnancy and lactation. J. Biol Chem., 266: 6909-6914, 1991.
19. Liu, X., Robinson, G. W., Gouilleux, F., Groner, B., and Hennighausen, L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue Proc. Natl. Acad. Sci. USA, 92: 8831-8835, 1995.
20. Robinson, G. W., McKnight, R. A., Smith, G. H , and Hennighausen, L. Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development (Camb.), 121: 2079-2090, 1995
21. Kordon, E C , McKnight, R , Jhappan, C., Hennighausen, L., Merlino, G., and Smith, G. H. Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population Dev. Biol , 168: 47-61, 1995.
22. Li, M., Hu, J., Heermeier, K., Hennighausen, L , and Furth, P. Disruption of cell cycle control by a viral oncogene during development of the mammary gland alters cell fate: induction of p53-independent apoptosis is followed by impairment of milk protein synthesis in surviving cells Cell Growth & Differ., 7: 3-11, 1996
23. Sandgren, E. R., Lutteke, N. C , Palmiter, R D., Brinster, R. L., and Lee, D. C Overexpression of TGFα in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61: 1121-1135, 1990
24. Daniel, C. W , and Silberstein, G B. Postnatal development of the rodent mammary gland. In: M. C. Neville and C W Daniel (eds.), The Mammary Gland: Development, Regulation, and Function, pp. 3-36 New York Plenum Press, 1987.
25. Smith, G. H. Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and tabular phenotype Breast Cancer Res. Treat., in press, 1996.
26. Struhl, G., Fitzgerald, K., and Greenwald, I. Intrinsic activity of the lin-12 and Notch intracellular domains in vivo Cell, 74: 331-345, 1993.