Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: A light and electron microscopic immunocytochemical study

Neuroscience

Volumn 97, Issue 1, 2000, Pages 143-153

  Ong, W Y ^a   Hu, C Y ^a   Soh, Y P ^a   Lim, T M ^a   Pentchev, P G ^b   Patel, S C ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Pain Neurosensory Mechanisms Br N   (United States)

^c VA Connecticut Hlthcare S   (United States)

Author keywords

Cholesterol; Fatty acids; Gene expression; Neurons; Niemann Pick type C disease; SREBP 1

Indexed keywords

CHOLESTEROL; EPITOPE; POLYCLONAL ANTIBODY; PROTEIN ANTIBODY; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN NERVE CELL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; FATTY ACID SYNTHESIS; FEMALE; GENE EXPRESSION; GENE MUTATION; GLIA CELL; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD STAINING; MACACA; MALE; MICROSCOPY; MOLECULAR WEIGHT; MOUSE; MUTANT; NEOCORTEX; NERVE DEGENERATION; NIEMANN PICK DISEASE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; NEURONS; NIEMANN-PICK DISEASES; NUCLEAR PROTEINS; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TEMPORAL LOBE; TRANSCRIPTION FACTORS;

EID: 0034086227     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00031-2     Document Type: Article

References (28)

1. Bjorkhem I., Lutjohann D., Breuer O., Sakinis A., Wennmalm A. Importance of a novel oxidative mechanism for elimination of brain cholesterol. J. biol. Chem. 272:1997;30,178-30,184.
2. Briggs M.R., Yokoyama C., Wang X., Brown M.S., Goldstein J.L. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter I. Identification of the protein and delineation of its target nucleotide sequence. J. biol. Chem. 268:1993;14,490-14,496.
3. Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:1997;331-340.
4. Carstea E.D., Morris J.A., Coleman K.G., Loftus S.K., Zhang D., Cummings C., Gu J., Rosefield M.A., Pavan W.J., Krizman D.B., Nagle J., Polymeropoulos M.H., Sturley S.L., Ioannou Y.A., Higgins M.E., Comly M., Cooney A., Brown A., Kaneski C.R., Blanchette-Mackie E.J., Dyer N.K., Neufeld E.B., Chang T., Liscum L., Strauss J.F. III, Ohno K., Zeigler M., Carmi R., Sokol J., Markie D., O'Neill R.R., van Diggelen O.P. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science. 277:1997;228-231.
5. Fairen N A., DeFelipe J. and Regidor J. (1984) Nonpyramidal neurons. In Cerebral Cortex: Cellular Components of the Cerebral Cortex (eds Peters A. and Jones E. J.), Vol. 1, pp. 201-253. Plenum, New York.
6. Feldman M. L. (1984) Morphology of the neocortical pyramidal neuron. In Cerebral Cortex: Cellular Components of the Cerebral Cortex (eds Peters A. and Jones E. J.), Vol. 1, pp. 123-200. Plenum, New York.
7. Horton J.D., Shimomura I. Sterol regulatory element binding proteins: activators of cholesterol and fatty acid synthesis. Curr. Opin. Lipidol. 10:1999;143-150.
8. Hua X., Yokoyama C., Wu J., Briggs M.R., Brown M.S., Goldstein J.L., Wang X. SREBP-2, a second basic helix-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. natn. Acad. Sci. U.S.A. 90:1993;11,603-11,607.
9. Hua X., Sakai J., Ho Y.K., Goldstein J.L., Brown M.S. Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection. J. biol. Chem. 270:1995;29,422-29,427.
10. Kim J.B., Spiegelman B.M. ADD1/SREBP-1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10:1996;1096-1097.
11. Ledesma M.D., Simons K., Dotti C.G. Neuronal polarity: essential role of protein-lipid complexes in axonal sorting. Proc. natn. Acad. Sci. U.S.A. 95:(7):1998;3966-3971.
12. Loftus S.K., Morris J.A., Carstea E.D., Gu J.Z., Cummings C., Brown A., Ellison J., Ohno K., Rosenfield D.A., Tagle D.A., Pentchev P.G., Pavan W.J. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science. 277:1997;232-235.
13. Neufeld E.B., Wastney M., Patel S., Suresh S., Cooney A.M., Dwyer N.K., Roff C.F., Ohno K., Morris J.A., Carstea E.D., Incardonna J.P., Strauss III J.F., Vanier M.T., Patterson M.C., Brady R.O., Pentchev P.G., Blanchette-Mackie E.J. The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J. biol. Chem. 274:(14):1999;9627-9635.
14. Ong W.Y., Garey L.J. Ultrastructural characteristics of human adult and infant cerebral cortical neurons. J. Anat. 175:1991;79-104.
15. Osborne T.F. Transcriptional control mechanisms in the regulation of cholesterol balance. Crit. Rev. Eukar. Gene Expr. 5:1995;317-335.
16. Patel S.C., Suresh S., Kumar U., Hu C.Y., Cooney A., Blanchette-Mackie E.J., Neufeld E.B., Patel R.C., Brady R.O., Patel Y.C., Pentchev P., Ong W.Y. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann-Pick type C disease. Proc. natn. Acad. Sci. U.S.A. 96:1999;1657-1662.
17. Pentchev P. G., Vanier M. T., Suzuki K. and Patterson M. C. (1995). Niemann-Pick disease, type C: a cellular cholesterol lipidosis. In The Metabolic and Molecular Bases of Inherited Disease (eds Scriver C. R., Beaudet A. L., Sly W. S. and Valle D.), pp. 2625-2640. McGraw-Hill, New York.
18. Peters A. and Jones E. G. (1984) Classification of cortical neurons. In Cerebral Cortex: Cellular Components of the Cerebral Cortex (eds Peters A. and Jones E. J.), Vol. 1, pp. 107-121. Plenum, New York.
19. Peters A., Kaiserman-Abramof I.R. The small pyramidal neuron of the rat cortex: the perikaryon, dendrites and spines. Am. J. Anat. 127:1970;321-356.
20. Sakai J., Duncan E.A., Rawson R.B., Hua X., Brown M.S., Goldstein J.L. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85:1996;1037-1046.
21. Sato R., Yang J., Wang X., Evans M.J., Ho Y.K., Goldstein J.L., Brown M.S. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J. biol. Chem. 269:1994;17267-17273.
22. Shee W.L., Ong W.Y., Lim T.M. Distribution of perlecan in mouse hippocampus following intracerebroventricular kainate injections. Brain Res. 799:1998;292-300.
23. Simons M., Keller B., DeStrooper B., Beyreuther K., Dottii C.G., Simons K. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc. natn. Acad. Sci. U.S.A. 95:1998;6460-6464.
24. Tint G.S., Irons M., Elias E.R., Batta A.K., Frieden R., Chen T.S., Salen G. Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome. New Engl. J. Med. 330:(2):1994;107-113.
25. Vance J.E., De Chaves E.P., Campenot R.B., Vance D.E. Role of axons in membrane phospholipid synthesis in rat sympathetic neurons. Neurobiol. Aging. 16:(3):1995;493-498.
26. Wang X., Briggs M.R., Hua X., Yokoyama C., Goldstein J.L., Brown M.S. Nuclear protein that binds sterol regulatory element of low density lipoprotein (LDL) receptor promoter: II Purification and characterization. J. biol. Chem. 268:1993;14,497-14,504.
27. Wang X., Sato R., Brown M.S., Hua X., Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:1994;53-62.
28. Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S. SREBP-1, a basic helix-loop-helix leucine zipper protein that controls transcription of the low density lipoprotein (LDL) receptor gene. Cell. 75:1993;187-197.