The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatment (Review)

Oncology Letters

Volumn 5, Issue 5, 2013, Pages 1439-1447

  Jia, Lili ^a   Ma, Shumei ^a   Hou, Xue ^a   Wang, Xin ^b   Qased, Abu Baker Layth ^c   Sun, Xuefei ^b   Liang, Nan ^a   Li, Huicheng ^d   Yi, Heqing ^a   Kong, Dejuan ^a   Liu, Xiaodong ^a,b   Fan, Feiyue ^e  

^a Center for Radiological Research   (China)

^b CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^c THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^d PR China   (China)

^e INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Apoptosis; Autophagy; Cancer treatment; Radiosensitization; Traditional Chinese medicine

Indexed keywords

ARSENIC TRIOXIDE; BAICALIN; BCG VACCINE; BERBAMINE; BERBERINE; BROXURIDINE; CANTHARIDIN; CELASTROL; CHINESE DRUG; DIALLYL TRISULFIDE; DIHYDROARTEMISININ; GANODERMA LUCIDUM EXTRACT; GECKO EXTRACT; GEKKO EXTRACT; GENISTEIN; HEMOPOIETIC GROWTH FACTOR; ICARIIN; INTERSTITIAL COLLAGENASE; KANG LAI TE EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; OSTHOLE; PAEONIFLORIN; PLUMBAGIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TANSHINONE IIA; TOONA SINENSIS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; YANHUSUO EXTRACT;

APOPTOSIS; AUTOPHAGY; BREAST CANCER; CANCER CHEMOTHERAPY; CHINESE HERB; CHINESE MEDICINE; CHRONIC DISEASE; COLONY FORMING UNIT S; COLORECTAL CANCER; CORDYCEPS; CYTOTOXICITY; DNA DAMAGE; ESOPHAGUS CANCER; GANODERMA; GECKO PLANT; GEKKO PLANT; HUMAN; IMMUNOCOMPETENCE; LIVER CELL CARCINOMA; LUNG CANCER; NEOPLASM; NEUROBLASTOMA; NONHUMAN; OSTEOSARCOMA; PANCREAS CANCER; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STOMACH CANCER; UTERINE CERVIX CANCER; YANHUSUO PLANT;

EID: 84875759308     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1245     Document Type: Review

References (88)

1. Gao JL, Shi JM, He K, et al: Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep 20: 819-824, 2008.
2. Pang X, Yi Z, Zhang J, et al: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res 70: 1951-1959, 2010.
3. Wang Y, Dong H, Zhu M, et al: Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway. Eur J Pharmacol635: 40-48, 2010.
4. Pan TL, Hung YC, Wang PW, et al: Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics10: 914-929, 2010.
5. Yuxian X, Feng T, Ren L and Zhengcai L: Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells invitro and invivo. Tumori 95: 789-795, 2009.
6. Duan H, Luan J, Liu Q, Yagasaki K and Zhang G: Suppression of human lung cancer cell growth and migration by berbamine. Cytotechnology 62: 341-348, 2010.
7. Chen D, Yao WJ, Zhang XL, et al: Effects of Gekko sulfated polysaccharide-protein complex on human hepatoma SMMC-7721 cells: inhibition of proliferation and migration. JEthnopharmacol 127: 702-708, 2010.
8. Liu F, Wang JG, Wang SY, Li Y, Wu YP and Xi SM: Antitumor effect and mechanism of Gecko on human esophageal carcinoma cell lines invitro and xenografted sarcoma 180 in Kunming mice. World J Gastroenterol 14: 3990-3996, 2008.
9. Hsu SC, Ou CC, Li JW, et al: Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest. JEthnopharmacol 120: 394-401, 2008.
10. Zhang YK, Zhang XH, Li JM, Sun de S, Yang Q and Diao DM: A proteomic study on a human osteosarcoma cell line Saos-2 treated with diallyl trisulfide. Anticancer Drugs 20: 702-712, 2009.
11. Hsu HY, Hau DM and Lin CC: Effects of kuei-pi-tang on cellular immunocompetence of gamma-irradiated mice. Am J Chin Med21: 151-158, 1993.
12. Yang MW, He MD and Li MZ: Effects of zaizhang-I, a traditional Chinese herbal medicine, on hematopoietic recovery from radiation injury in mice. J Tongji Med Univ 14: 224-226, 1994.
13. Ohnishi Y, Yasumizu R, Fan HX, et al: Effects of juzen-taiho-toh (TJ-48), a traditional Oriental medicine, on hematopoietic recovery from radiation injury in mice. Exp Hematol 18: 18-22, 1990.
14. Fujii Y, Imamura M, Han M, et al: Recipient-mediated effect of a traditional Chinese herbal medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantation. Int J Immunopharmacol 16: 615-622, 1994.
15. Chen WC, Hau DM, Chen KT, Wang MI and Lin IH: Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice. Am J Chin Med 24: 83-92, 1996.
16. Hsu HY and Lin CC: A preliminary study on the radioprotection of mouse hematopoiesis by dang-gui-shao-yao-san. JEthnopharmacol 55: 43-48, 1996.
17. Chen WC, Hau DM and Lee SS: Effects of Ganoderma lucidum and krestin on cellular immunocompetence in gamma-ray-irradiated mice. Am J Chin Med 23: 71-80, 1995.
18. Lee SE, Oh H, Yang JA, et al: Radioprotective effects of two traditional Chinese medicine prescriptions: si-wu-tang and si-jun-zi-tang. Am J Chin Med 27: 387-396, 1999.
19. Lawenda BD: Response to "Radiation therapeutic gain and Asian botanicals, " by Stephen Sagar. Integr Cancer Ther 9: 14-15, 2010.
20. Reeve VE, Allanson M, Arun SJ, Domanski D and Painter N: Mice drinking goji berry juice (Lycium barbarum) are protected from UV radiation-induced skin damage via antioxidant pathways. Photochem Photobiol Sci 9: 601-607, 2010.
21. Liu FY, Wang JN, Yu SD, Wang B and Zhang JD: Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi MedJ28: 1791-1795, 2007.
22. Kim SH, Lee SE, Oh H, et al: The radioprotective effects of bu-zhong-yi-qi-tang: a prescription of traditional Chinese medicine. Am J Chin Med 30: 127-137, 2002.
23. Li CR, Zhou Z, Zhu D, Sun YN, Dai JM and Wang SQ: Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. Int J Biochem Cell Biol39: 426-438, 2007.
24. Kim S and Chung JH: Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts. Phytomedicine 15: 749-753, 2008.
25. Chiu TM, Huang CC, Lin TJ, Fang JY, Wu NL and Hung CF: Invitro and invivo anti-photoaging effects of an isoflavone extract from soybean cake. J Ethnopharmacol 126: 108-113, 2009.
26. Dai AW, Li ZY, Wang LH, Li SY and Yang H: Effect of Yangyin Humo Decoction on oral mucomembranous reaction to radiotherapy. Chin J Integr Med 15: 303-306, 2009.
27. Wang ZW, Zhou JM, Huang ZS, et al: Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis. J Radiat Res 45: 447-454, 2004.
28. Lu Y, Wu LQ, Dong Q and Li CS: Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2. Hepatobiliary Pancreat Dis Int 8: 267-272, 2009.
29. Wang GY, Lv QH, Dong Q, Xu RZ and Dong QH: Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. J Asian Nat Prod Res 11: 219-228, 2009.
30. Zhang Z, Wang S, Qiu H, Duan C, Ding K and Wang Z: Waltonitone induces human hepatocellular carcinoma cells apoptosis invitro and invivo. Cancer Lett 286: 223-231, 2009.
31. Sung B, Park B, Yadav VR and Aggarwal BB: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. J Biol Chem 285: 11498-11507, 2010.
32. Li W, Xie L, Chen Z, et al: Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. Cancer Sci 101: 1226-1233, 2010.
33. Fang SC, Hsu CL, Lin HT and Yen GC: Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells. J Agric Food Chem 58: 814-820, 2010.
34. Lin VC, Chou CH, Lin YC, et al: Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway. J Agric Food Chem 58: 4786-4793, 2010.
35. Deng R, Tang J, Xie BF, et al: SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway. Int J Cancer 127: 220-229, 2010.
36. Shen JK, Du HP, Yang M, Wang YG and Jin J: Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann Hematol 88: 743-752, 2009.
37. Jin CY, Kim GY and Choi YH: Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 cells. J Microbiol Biotechnol 18: 1997-2003, 2008.
38. Chiang PC, Lin SC, Pan SL, et al: Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol79: 162-171, 2010.
39. Yang CJ, Huang YJ, Wang CY, et al: Antiproliferative and antitumorigenic activity of Toona sinensis leaf extracts in lung adenocarcinoma. J Med Food 13: 54-61, 2010.
40. Mi JX, Wang GF, Wang HB, et al: Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. Acta Pharmacol Sin 29: 1467-1477, 2008.
41. Wang N, Tang LJ, Zhu GQ, et al: Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells. J Asian Nat Prod Res 10: 1129-1135, 2008.
42. 3)-mediated apoptosis using berberine in human neuroblastoma SH-SY5Y cells. J Korean Neurosurg Soc 42: 392-399, 2007.
43. Su CL, Lin TY, Lin CN and Won SJ: Involvement of caspases and apoptosis-inducing factor in bufotalin-induced apoptosis of Hep 3B cells. J Agric Food Chem 57: 55-61, 2009.
44. Xie H, Qin YX, Zhou YL, et al: GA3, a new gambogic acid derivative, exhibits potent antitumor activities invitro via apoptosis-involved mechanisms. Acta Pharmacol Sin 30: 346-354, 2009.
45. Xu X, Liu Y, Wang L, et al: Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells. IntJ Dermatol 48: 186-192, 2009.
46. Li DD, Wu XQ, Tang J, Wei XY and Zhu XF: ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biol Ther 8: 739-743, 2009.
47. Lai WW, Yang JS, Lai KC, et al: Rhein induced apoptosis through the endoplasmic reticulum stress, caspase-and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells. In Vivo 23: 309-316, 2009.
48. Xiao X, Bai P, Bui Nguyen TM, et al: The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway. Mol Cancer Ther 8: 1179-1188, 2009.
49. Xu Y, Ge R, Du J, et al: Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. Cancer Lett 284: 229-237, 2009.
50. Yang HL, Chen SC, Chen CS, Wang SY and Hseu YC: Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway. Food Chem Toxicol 46: 3318-3324, 2008.
51. Qi F, Li A, Zhao L, et al: Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol 128: 654-661, 2010.
52. Tang YJ, Yang JS, Lin CF, et al: Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncol Rep 22: 1051-1056, 2009.
53. Lu YY, Chen TS, Qu JL, Pan WL, Sun L and Wei XB: Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. JBiomed Sci 16: 16, 2009.
54. Chen CA, Chang HH, Kao CY, Tsai TH and Chen YJ: Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells. Pancreatology 9: 797-809, 2009.
55. Kim HG, Song H, Yoon DH, et al: Cordyceps pruinosa extracts induce apoptosis of HeLa cells by a caspase dependent pathway. J Ethnopharmacol 128: 342-351, 2010.
56. Efferth T, Giaisi M, Merling A, Krammer PH and Li-Weber M: Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One 2: e693, 2007.
57. Wu F, Hu Y, Long J, et al: Cytotoxicity and radiosensitization effect of TRA-8 on radioresistant human larynx squamous carcinoma cells. Oncol Rep 21: 461-465, 2009.
58. Ortiz T, Burguillos MA, Lopez-Lluch G, et al: Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin. Radiat Environ Biophys 47: 445-452, 2008.
59. Du XL, Jiang T, Wen ZQ, Gao R, Cui M and Wang F: Silencing of heat shock protein 70 expression enhances radiotherapy efficacy and inhibits cell invasion in endometrial cancer cell line. Croat Med J 50: 143-150, 2009.
60. Efimova EV, Liang H, Pitroda SP, et al: Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling. Int J Radiat Biol 85: 421-431, 2009.
61. Chiou SH, Kao CL, Chen YW, et al: Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One 3: e2090, 2008.
62. Guoan X, Hanning W, Kaiyun C and Hao L: Adenovirus-mediated siRNA targeting Mcl-1 gene increases radiosensitivity of pancreatic carcinoma cells invitro and invivo. Surgery 147: 553-561, 2010.
63. Hara T, Omura-Minamisawa M, Kang Y, Cheng C and InoueT: Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. Int J Radiat Oncol Biol Phys 71: 1485-1495, 2008.
64. Ezekwudo D, Shashidharamurthy R, Devineni D, BozemanE, Palaniappan R and Selvaraj P: Inhibition of expression of anti-apoptotic protein Bcl-2 and induction of cell death in radioresistant human prostate adenocarcinoma cell line (PC-3) by methyl jasmonate. Cancer Lett 270: 277-285, 2008.
65. Wang TJ, Liu ZS, Zeng ZC, et al: Caffeine enhances radiosensitization to orthotopic transplant LM3 hepatocellular carcinoma invivo. Cancer Sci 101: 1440-1446, 2010.
66. You ZY, Zhao Y, Liu F, Zhang YD and Wang JJ: The radiosensitization effects of Endostar on human lung squamous cancer cells H-520. Cancer Cell Int 10: 17, 2010.
67. Che SM, Zhang XZ, Hou L and Song TB: Cyclooxygenase-2 inhibitor NS398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting AKT activation and inducing apoptosis. Cancer Invest 28: 679-688, 2010.
68. Liu J, Zhang J, Wang X, et al: HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells. Exp Cell Res 316: 1985-1993, 2010.
69. Gao L, Li F, Dong B, et al: Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. Int J Radiat Oncol Biol Phys 77: 1223-1231, 2010.
70. Chen X, Wong P, Radany E and Wong JY: HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells. Cancer Biother Radiopharm 24: 689-699, 2009.
71. Yu J and Zhang L: PUMA, a potent killer with or without p53. Oncogene 27 (Suppl 1): S71-S83, 2008.
72. Mi J, Bolesta E, Brautigan DL and Larner JM: PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Mol Cancer Ther 8: 135-140, 2009.
73. Wang R, Lin F, Wang X, et al: Suppression of Bcl-xL expression by a novel tumor-specific RNA interference system inhibits proliferation and enhances radiosensitivity in prostatic carcinoma cells. Cancer Chemother Pharmacol 61: 943-952, 2008.
74. Ho SY, Chen WC, Chiu HW, Lai CS, Guo HR and Wang YJ: Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation. Chem Biol Interact 179: 304-313, 2009.
75. Lee TK, Johnke RM, Allison RR, O'Brien KF and Dobbs LJ, Jr.: Radioprotective potential of ginseng. Mutagenesis 20: 237-243, 2005.
76. Rubinsztein DC, DiFiglia M, Heintz N, et al: Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1: 11-22, 2005.
77. Adi-Harel S, Erlich S, Schmukler E, et al: Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment. J Cell Biochem 110: 1262-1271, 2010.
78. Maiuri MC, Criollo A and Kroemer G: Crosstalk between apoptosis and autophagy within the Beclin 1 interactome. EMBOJ 29: 515-516, 2010.
79. Pimkina J, Humbey O, Zilfou JT, Jarnik M and Murphy ME: ARF induces autophagy by virtue of interaction with Bcl-xl. JBiol Chem 284: 2803-2810, 2009.
80. Moretti L, Attia A, Kim KW and Lu B: Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy. Autophagy 3: 142-144, 2007.
81. Zalckvar E, Berissi H, Mizrachy L, et al: DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 10: 285-292, 2009.
82. Thyagarajan A, Jedinak A, Nguyen H, et al: Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr Cancer 62: 630-640, 2010.
83. Bui-Xuan NH, Tang PM, Wong CK and Fung KP: Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. J Ethnopharmacol 131: 95-103, 2010.
84. Kuo YF, Su YZ, Tseng YH, Wang SY, Wang HM and Chueh PJ: Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Free Radic Biol Med 49: 214-226, 2010.
85. Yo YT, Shieh GS, Hsu KF, Wu CL and Shiau AL: Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem 57: 8266-8273, 2009.
86. 2+ ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther 9: 718-730, 2010.
87. Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI and Lu B: Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4: 659-668, 2008.
88. Kim KW, Moretti L, Mitchell LR, Jung DK and Lu B: Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model. Clin Cancer Res 15: 6096-6105, 2009.