Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest

Journal of Ethnopharmacology

Volumn 120, Issue 3, 2008, Pages 394-401

  Hsu, Shih Chung ^a,b   Ou, Chien Chih ^c,d   Li, Jhy Wei ^e,f   Chuang, Tzu Chao ^g   Kuo, Han Pon ^e   Liu, Jah Yao ^c   Chen, Chin Shiang ^h   Lin, Song Chow ^a   Su, Ching Hua ^a   Kao, Ming Ching ^e,i  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b Kang Ning Junior College of Medical Care and Management   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d KEELUNG HOSPITAL   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^f Da Chien General Hospital   (Taiwan)

^g TAMKANG UNIVERSITY   (Taiwan)

^h CHINESE CULTURE UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cancer therapy; Colo205; Colorectal cancer; Ganoderma tsugae; Lingzhi (Reishi)

Indexed keywords

GANODERMA TSUGAE EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; COLORECTAL CANCER; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG SAFETY; GANODERMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE;

ADENOCARCINOMA; ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; GANODERMA; HUMANS; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, NUDE; PHYTOTHERAPY; PLANT EXTRACTS; TAIWAN;

ANIMALIA; GANODERMA; GANODERMA TSUGAE; MUS MUSCULUS;

EID: 56349126537     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.09.025     Document Type: Article

References (27)

1. Akli S., and Keyomarsi K. Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy. Cancer Biology and Therapy 2 (2003) S38-S47
2. Bani M.R., Nicoletti M.I., Alkharouf N.W., Ghilardi C., Petersen D., Erba E., Sausville E.A., Liu E.T., and Giavazzi R. Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. Molecular Cancer Therapeutics 3 (2004) 111-121
3. Chen H.S., Tsai Y.F., Lin S., Lin C.C., Khoo K.H., Lin C.H., and Wong C.H. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorganic and Medicinal Chemistry 12 (2004) 5595-5601
4. Chen J.G., Yang C.P., Cammer M., and Horwitz S.B. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Research 63 (2003) 7891-7899
5. Chien C.M., Cheng J.L., Chang W.T., Tien M.H., Tsao C.M., Chang Y.H., Chang H.Y., Hsieh J.F., Wong C.H., and Chen S.T. Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorganic and Medicinal Chemistry 12 (2004) 5603-5609
6. Chuang T.C., Lee Y.J., Liu J.Y., Lin Y.S., Li J.W., Wang V., Law S.L., and Kao M.C. EBNA1 may prolong G(2)/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs. Biochemical and Biophysical Research Communications 307 (2003) 653-659
7. Gan K.H., Fann Y.F., Hsu S.H., Kuo K.W., and Lin C.N. Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle. Journal of Natural Products 61 (1998) 485-487
8. Hu H., Ahn N.S., Yang X., Lee Y.S., and Kang K.S. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. International Journal of Cancer 102 (2002) 250-253
9. Jiang J., Slivova V., Valachovicova T., Harvey K., and Sliva D. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. International Journal of Oncology 24 (2004) 1093-1099
10. Kimura Y., Taniguchi M., and Baba K. Antitumor and antimetastatic effects on liver triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of active substance. Anticancer Research 22 (2002) 3309-3318
11. Li J.W., Chuang T.C., Yang A.H., Hsu C.K., and Kao M.C. Clinicopathological relevance of HER2/neu and a related gene-protein cubic regression correlation in colorectal adenocarcinomas in Taiwan. International Journal of Oncology 26 (2005) 933-943
12. Lin S.B., Li C.H., Lee S.S., and Kan L.S. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sciences 72 (2003) 2381-2390
13. Lin Z.B., and Zhang H.N. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and it possible mechanisms. Acta Pharmacologica Sinica 25 (2004) 1387-1395
14. Min B.S., Gao J.J., Nakamura N., and Hattori M. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against Meth-A and LLC tumor cells. Chemical and Pharmaceutical Bulletin 48 (2000) 1026-1033
15. Miyazaki T., and Nishijima M. Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chemical and Pharmaceutical Bulletin 29 (1981) 3611-3616
16. Muraoka-Cook R.S., Sandahl M., Husted C., Hunter D., Miraglia L., Feng S.M., Elenius K., and Earp III H.S. The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Molecular Biology of the Cell 17 (2006) 4118-4129
17. Shiao M.S. Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. The Chemical Record 3 (2003) 172-180
18. Skladanowski A., Come M.G., Sabisz M., Escargueil A.E., and Larsen A.K. Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents. Molecular Pharmacology 68 (2005) 625-634
19. Sliva D., Labarrere C., Slivova V., Sedlak M., Lloyad Jr. F.P., and Ho N.W.Y. Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochemical and Biophysical Research Communications 298 (2002) 603-612
20. Stanley G., Harvey K., Slivova V., Jiang J., and Sliva D. Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells. Biochemical and Biophysical Research Communications 330 (2005) 46-52
21. Su C.H., Yang Y.Z., Ho H.O., Hu C.H., and Sheu M.T. High-performance liquid chromatographic analysis for the characterization of triterpenoids from Ganoderma. Journal of Chromatographic Science 39 (2001) 93-100
22. Tang W., Liu J.W., Zhao W.M., Wei D.Z., and Zhong J.J. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sciences 80 (2006) 205-211
23. Wang G., Zhang J., Mizuno T., Zhuang C., Ito H., Mayuzumi H., Okamoto H., and Li J. Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae. Bioscience, Biotechnology, and Biochemistry 57 (1993) 894-900
24. Wang S.S., Lee Y.J., Hsu S.C., Chang H.O., Yin W.K., Chang L.S., and Chou S.Y. Linker-modified triamine-linked acridine dimers: Synthesis and cytotoxicity properties in vitro and in vivo. Bioorganic & Medicinal Chemistry 15 (2007) 735-748
25. Wolpin B.M., Meyerhardt J.A., Mamon H.J., and Mayer R.J. Adjuvant treatment of colorectal cancer. CA A Cancer Journal for Clinicians 57 (2007) 168-185
26. Xing X., Liu V., Xia W., Stephens L.C., Huang L., Lopez-Berestein G., and Hung M.C. Safety studies of the intraperitoneal injection of E1A-liposome complex in mice. Gene Therapy 4 (1997) 238-243
27. Zhu H.S., Yang X.L., Wang L.B., Zhao D.X., and Chen L. Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells. Cell Biology and Toxicology 16 (2000) 201-206