Flavopiridol Potentiates the Cytotoxic Effects of Radiation in Radioresistant Tumor Cells in Which p53 is Mutated or Bcl-2 is Overexpressed

International Journal of Radiation Oncology Biology Physics

Volumn 71, Issue 5, 2008, Pages 1485-1495

  Hara, Takamitsu ^a   Omura Minamisawa, Motoko ^a   Kang, Yun ^a   Cheng, Chao ^a   Inoue, Tomio ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bcl 2; DNA double strand break; Flavopiridol; p53

Indexed keywords

ACTIVATION ANALYSIS; ANIMAL CELL CULTURE; CELL CULTURE; DNA; GENES; HEALTH; MAINTENANCE; NUCLEIC ACIDS; ONCOLOGY; ORGANIC ACIDS; RADIATION; RADIATION EFFECTS; REPAIR; TUMORS;

ANTI-APOPTOTIC PROTEINS; BCL-2 EXPRESSION; CANCER CELLS; CELL CYCLING; CELL LINES; CELL-VIABILITY; CERVICAL CANCERS; COLONY FORMATION; CYTOTOXIC EFFECTS; DAMAGE REPAIRS; DOUBLE STRAND BREAK (DSB); IN-VITRO; IN-VIVO; MALIGNANT TUMORS; OVER-EXPRESSION; PHOSPHORYLATED HISTONE; POST TREATMENTS; RADIORESISTANCE; RADIORESISTANT TUMOR CELLS; REGULATORY PROTEINS; SENSITIVE INDICATOR; TUMOR CELLS; WILD-TYPE (WT); WILD-TYPE (WT) CELLS;

CELLS;

DOUBLE STRANDED DNA; FLAVOPIRIDOL; HISTONE H2AX; PROTEIN BCL 2; PROTEIN P53;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DNA REPAIR; FEMALE; FLAVONOIDS; GENES, BCL-2; GENES, P53; GLIOMA; HELA CELLS; HUMANS; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TRANSFECTION; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 47149114984     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.03.039     Document Type: Article

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