Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

Cancer Science

Volumn 101, Issue 5, 2010, Pages 1226-1233

  Li, Wei ^a,b   Xie, Li ^a   Chen, Zheng ^a   Zhu, Yi ^a   Sun, Yujie ^b   Miao, Yi ^b   Xu, Zekuan ^a   Han, Xiao ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANTHARIDIN; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 1; DEATH RECEPTOR 4; DEATH RECEPTOR 5; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BID; PROTEIN P21; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

APOPTOSIS; CANTHARIDIN; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; G2 PHASE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; PROTEIN PHOSPHATASE 2;

EID: 77953204596     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01523.x     Document Type: Article

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