메뉴 건너뛰기




Volumn 58, Issue 8, 2010, Pages 4786-4793

Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway

Author keywords

Apoptosis; Cytotoxicity; Fatty acid synthase; Osthole

Indexed keywords

COUMARIN DERIVATIVE; FATTY ACID SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN; OSTHOLE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 77951279924     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf100352c     Document Type: Article
Times cited : (76)

References (30)
  • 1
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda, F. P. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology Nutrition 2000, 16, 202-208
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 2
    • 0024315871 scopus 로고
    • Fatty acid synthase, a proficient multifunctional enzyme
    • Wakil, S. J. Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 1989, 28, 4523-4530
    • (1989) Biochemistry , vol.28 , pp. 4523-4530
    • Wakil, S.J.1
  • 3
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • Kuhajda, F. P. Fatty acid synthase and cancer: new application of an old pathway Cancer Res. 2006, 66, 5977-5980
    • (2006) Cancer Res. , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 4
    • 70349649506 scopus 로고    scopus 로고
    • EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
    • Huang, C. H.; Tsai, S. J.; Wang, Y. J.; Pan, M. H.; Kao, J. Y.; Way, T. D. EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells Mol. Nutr. Food Res. 2009, 53, 1156-1165
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 1156-1165
    • Huang, C.H.1    Tsai, S.J.2    Wang, Y.J.3    Pan, M.H.4    Kao, J.Y.5    Way, T.D.6
  • 5
    • 33750287996 scopus 로고    scopus 로고
    • Breast cancer treatment and ovarian failure: Risk factors and emerging genetic determinants
    • Stearns, V.; Schneider, B.; Henry, N. L.; Hayes, D. F.; Flockhart, D. A. Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants Nat. Rev. Cancer 2006, 6, 886-893
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 886-893
    • Stearns, V.1    Schneider, B.2    Henry, N.L.3    Hayes, D.F.4    Flockhart, D.A.5
  • 6
    • 66949136442 scopus 로고    scopus 로고
    • Level of HER2/neu gene amplification as a predictive factor of response to trastuzumab-based therapy in patients with HER2-positive metastatic breast cancer
    • Gullo, G.; Bettio, D.; Torri, V.; Masci, G.; Salvini, P.; Santoro, A. Level of HER2/neu gene amplification as a predictive factor of response to trastuzumab-based therapy in patients with HER2-positive metastatic breast cancer Invest. New Drugs 2009, 27, 179-183
    • (2009) Invest. New Drugs , vol.27 , pp. 179-183
    • Gullo, G.1    Bettio, D.2    Torri, V.3    Masci, G.4    Salvini, P.5    Santoro, A.6
  • 7
    • 0034638917 scopus 로고    scopus 로고
    • Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
    • Yu, D.; Hung, M. C. Overexpression of ErbB2 in cancer and ErbB2-targeting strategies Oncogene 2000, 19, 6115-6121
    • (2000) Oncogene , vol.19 , pp. 6115-6121
    • Yu, D.1    Hung, M.C.2
  • 8
    • 0037226462 scopus 로고    scopus 로고
    • Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
    • Kumar-Sinha, C.; Ignatoski, K. W.; Lippman, M. E.; Ethier, S. P.; Chinnaiyan, A. M. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis Cancer Res. 2003, 63, 132-139
    • (2003) Cancer Res. , vol.63 , pp. 132-139
    • Kumar-Sinha, C.1    Ignatoski, K.W.2    Lippman, M.E.3    Ethier, S.P.4    Chinnaiyan, A.M.5
  • 9
    • 7244252915 scopus 로고    scopus 로고
    • Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation
    • Menendez, J. A.; Mehmi, I.; Verma, V. A.; Teng, P. K.; Lupu, R. Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation Mol. Carcinog. 2004, 41, 164-178
    • (2004) Mol. Carcinog. , vol.41 , pp. 164-178
    • Menendez, J.A.1    Mehmi, I.2    Verma, V.A.3    Teng, P.K.4    Lupu, R.5
  • 10
    • 12444252156 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
    • Alli, P. M.; Pinn, M. L.; Jaffee, E. M.; McFadden, J. M.; Kuhajda, F. P. Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice Oncogene 2005, 24, 39-46
    • (2005) Oncogene , vol.24 , pp. 39-46
    • Alli, P.M.1    Pinn, M.L.2    Jaffee, E.M.3    McFadden, J.M.4    Kuhajda, F.P.5
  • 11
    • 67149146566 scopus 로고    scopus 로고
    • Modulation of inflammatory genes by natural dietary bioactive compounds
    • Pan, M. H.; Lai, C. S.; Dushenkov, S.; Ho, C. T. Modulation of inflammatory genes by natural dietary bioactive compounds J. Agric. Food Chem. 2009, 57, 4467-4477
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 4467-4477
    • Pan, M.H.1    Lai, C.S.2    Dushenkov, S.3    Ho, C.T.4
  • 13
    • 0037441385 scopus 로고    scopus 로고
    • Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway
    • Okamoto, T.; Kawasaki, T.; Hino, O. Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway Biochem. Pharmacol. 2003, 65, 677-681
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 677-681
    • Okamoto, T.1    Kawasaki, T.2    Hino, O.3
  • 14
    • 0036595830 scopus 로고    scopus 로고
    • Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol
    • Matsuda, H.; Tomohiro, N.; Ido, Y.; Kubo, M. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol Biol. Pharm. Bull. 2002, 25, 809-812
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 809-812
    • Matsuda, H.1    Tomohiro, N.2    Ido, Y.3    Kubo, M.4
  • 16
    • 33947581715 scopus 로고    scopus 로고
    • Antitumor effects of Osthol from Cnidium monnieri: An in vitro and in vivo study
    • Chou, S. Y.; Hsu, C. S.; Wang, K. T.; Wang, M. C.; Wang, C. C. Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study Phytother. Res. 2007, 21, 226-230
    • (2007) Phytother. Res. , vol.21 , pp. 226-230
    • Chou, S.Y.1    Hsu, C.S.2    Wang, K.T.3    Wang, M.C.4    Wang, C.C.5
  • 17
    • 58149161248 scopus 로고    scopus 로고
    • Inhibitory effect of osthole on alcohol induced fatty liver in mice
    • Sun, F.; Xie, M. L.; Zhu, L. J.; Xue, J.; Gu, Z. L. Inhibitory effect of osthole on alcohol induced fatty liver in mice Dig. Liver Dis. 2009, 41, 127-133
    • (2009) Dig. Liver Dis. , vol.41 , pp. 127-133
    • Sun, F.1    Xie, M.L.2    Zhu, L.J.3    Xue, J.4    Gu, Z.L.5
  • 18
    • 0032214980 scopus 로고    scopus 로고
    • Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
    • Yu, D.; Jing, T.; Liu, B.; Yao, J.; Tan, M.; McDonnell, T. J.; Hung, M. C. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase Mol. Cell 1998, 2, 581-591
    • (1998) Mol. Cell , vol.2 , pp. 581-591
    • Yu, D.1    Jing, T.2    Liu, B.3    Yao, J.4    Tan, M.5    McDonnell, T.J.6    Hung, M.C.7
  • 19
    • 67649173298 scopus 로고    scopus 로고
    • Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells
    • Way, T. D.; Lin, H. Y.; Kuo, D. H.; Tsai, S. J.; Shieh, J. C.; Wu, J. C.; Lee, M. R.; Lin, J. K. Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells J. Agric. Food Chem. 2009, 57, 5257-5264
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 5257-5264
    • Way, T.D.1    Lin, H.Y.2    Kuo, D.H.3    Tsai, S.J.4    Shieh, J.C.5    Wu, J.C.6    Lee, M.R.7    Lin, J.K.8
  • 20
    • 65349163593 scopus 로고    scopus 로고
    • Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression
    • Kuo, P. T.; Lin, T. P.; Liu, L. C.; Huang, C. H.; Lin, J. K.; Kao, J. Y.; Way, T. D. Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression J. Agric. Food Chem. 2009, 57, 3331-3339
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 3331-3339
    • Kuo, P.T.1    Lin, T.P.2    Liu, L.C.3    Huang, C.H.4    Lin, J.K.5    Kao, J.Y.6    Way, T.D.7
  • 21
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang, Y. A.; Han, W. F.; Morin, P. J.; Chrest, F. J.; Pizer, E. S. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase Exp. Cell Res. 2002, 279, 80-90
    • (2002) Exp. Cell Res. , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 22
    • 0029830451 scopus 로고    scopus 로고
    • Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms
    • Yu, D.; Liu, B.; Tan, M.; Li, J.; Wang, S. S.; Hung, M. C. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms Oncogene 1996, 13, 1359-1365
    • (1996) Oncogene , vol.13 , pp. 1359-1365
    • Yu, D.1    Liu, B.2    Tan, M.3    Li, J.4    Wang, S.S.5    Hung, M.C.6
  • 23
    • 17644394237 scopus 로고    scopus 로고
    • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity
    • Menendez, J. A.; Vellon, L.; Colomer, R.; Lupu, R. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity Int. J. Cancer 2005, 115, 19-35
    • (2005) Int. J. Cancer , vol.115 , pp. 19-35
    • Menendez, J.A.1    Vellon, L.2    Colomer, R.3    Lupu, R.4
  • 24
    • 3242685815 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
    • Menendez, J. A.; Vellon, L.; Mehmi, I.; Oza, B. P.; Ropero, S.; Colomer, R.; Lupu, R. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 10715-10720
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10715-10720
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3    Oza, B.P.4    Ropero, S.5    Colomer, R.6    Lupu, R.7
  • 25
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes - The Achilles heal of cancer
    • Weinstein, I. B. Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 2002, 297, 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 26
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • Wang, H. Q.; Altomare, D. A.; Skele, K. L.; Poulikakos, P. I.; Kuhajda, F. P.; Di, C. A.; Testa, J. R. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells Oncogene 2005, 24, 3574-3582
    • (2005) Oncogene , vol.24 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di, C.A.6    Testa, J.R.7
  • 27
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of Acetyl-CoA Carboxylase {alpha} and Fatty Acid Synthase by Human Epidermal Growth Factor Receptor 2 at the Translational Level in Breast Cancer Cells
    • Yoon, S.; Lee, M. Y.; Park, S. W.; Moon, J. S.; Koh, Y. K.; Ahn, Y. H.; Park, B. W.; Kim, K. S. Up-regulation of Acetyl-CoA Carboxylase {alpha} and Fatty Acid Synthase by Human Epidermal Growth Factor Receptor 2 at the Translational Level in Breast Cancer Cells J. Biol. Chem. 2007, 282, 26122-26131
    • (2007) J. Biol. Chem. , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3    Moon, J.S.4    Koh, Y.K.5    Ahn, Y.H.6    Park, B.W.7    Kim, K.S.8
  • 28
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou, X.; Tan, M.; Stone Hawthorne, V.; Klos, K. S.; Lan, K. H.; Yang, Y.; Yang, W.; Smith, T. L.; Shi, D.; Yu, D. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers Clin. Cancer Res. 2004, 10, 6779-6788
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone Hawthorne, V.3    Klos, K.S.4    Lan, K.H.5    Yang, Y.6    Yang, W.7    Smith, T.L.8    Shi, D.9    Yu, D.10
  • 29
    • 6044259204 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
    • Mondesire, W. H.; Jian, W.; Zhang, H.; Ensor, J.; Hung, M. C.; Mills, G. B.; Meric-Bernstam, F. Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells Clin. Cancer Res. 2004, 10, 7031-7042
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7031-7042
    • Mondesire, W.H.1    Jian, W.2    Zhang, H.3    Ensor, J.4    Hung, M.C.5    Mills, G.B.6    Meric-Bernstam, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.