Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 cells

Journal of Microbiology and Biotechnology

Volumn 18, Issue 12, 2008, Pages 1997-2003

  Jin, Cheng Yun ^a   Kim, Gi Young ^b   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Jeju National University   (South Korea)

Author keywords

Akt; Apoptosis; Caspase 3; Cordyceps militaris

Indexed keywords

CASPASE 3; CORDYCEPS MILITARIS EXTRACT; HERBACEOUS AGENT; PROTEIN KINASE B; UNCLASSIFIED DRUG; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; BENZOYLCARBONYL ASPARTYL GLUTAMYL VALYL ASPARTYL FLUOROMETHYL KETONE; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; CASPASE; CHROMONE DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; MORPHOLINE DERIVATIVE; OLIGOPEPTIDE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; CORDYCEPS; CORDYCEPS MILITARIS; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; PROTEIN FUNCTION; BREAST TUMOR; CELL PROLIFERATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; METABOLISM; TUMOR CELL LINE;

BASIDIOMYCOTA; CORDYCEPS MILITARIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; CORDYCEPS; CYSTEINE PROTEINASE INHIBITORS; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 67651011983     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0800.272     Document Type: Article

References (34)

1. Alkhalaf, M., A. El-Mowafy, W. Renno, O. Rachid, A. Ali, and R. Al-Attyiah. 2008. Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway. Arch. Med. Res. 39: 162-168.
2. Chung, H., Y. M. Jung, D. H. Shin, J. Y. Lee, M. Y. Oh, H. J. Kim, et al. 2008. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int. J. Cancer 122: 816-822.
3. Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: A play in three Akts. Genes Dev. 13: 2905-2927.
4. Dizin, E., H. Ray, F. Suau, T. Voeltzel, and N. Dalla Venezia. 2008. Caspase-dependent BRCA1 cleavage facilitates chemotherapy-induced apoptosis. Apoptosis 13: 237-246.
5. Dlugosz, P. J., L. P. Billen, M. G. Annis, W. Zhu, Z. Zhang, J. Lin, B. Leber, and D. W. Andrews. 2006 Bcl-2 changes conformation to inhibit Bax oligomerization EMBO J. 25: 2287-2296.
6. Emi, M., R. Kim, K. Tanabe, Y. Uchida, and T. Toge. 2005. Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res. 7: R940-R952.
7. Hseu, Y. C., S. C. Chen, P. C. Tsai, C. S. Chen, F. J. Lu, N. W. Chang, and H. L. Yang. 2007. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata. Food Chem. Toxicol. 45: 1107-1115.
8. Jin, C. Y., Y. H. Choi, D. O. Moon, C. Park, Y. M. Park, S. C. Jeong, et al. 2006. Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei. Oncol. Rep. 16: 1349-1355.
9. Jin, C. Y., D. O. Moon, J. D. Lee, M. S. Heo, Y. H. Choi, C. M. Lee, Y. M. Park, and G. Y. Kim. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis 28: 1058-1066.
10. Kim, K. C., J. S. Kim, J. K. Son, and I. G. Kim. 2007. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett. 246: 210-217.
11. Kim, G. Y., W. S. Ko, J. Y. Lee, J. O. Lee, C. H. Ryu, B. T. Choi, et al. 2006. Water extract of Cordyceps militaris enhances maturation of murine bone marrow-derived dendritic cells in vitro. Biol. Pharm. Bull. 29: 354-360.
12. Kim, T. H., J. W. Park, J. Y. Lee, Y. J. Surh, and T. K. Kwon. 2003. Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation. Biochem. Pharmacol. 66: 1779-1786.
13. Kuo, M. C., C. Y. Chang, T. L. Cheng, and M. J. Wu. 2007. Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: Enhancement of cytokine synthesis, CD11b expression, and phagocytosis. Appl. Microbiol. Biotechnol. 75: 769-775.
14. Lee, H., Y. J. Kim, H. W. Kim, D. H. Lee, M. K. Sung, and T. Park. 2006. Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells. Biol. Pharm. Bull. 29: 670-674.
15. Lin, P. H., C. H. Lin, C. C. Huang, M. C. Chuang, and P. Lin. 2007. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines. Toxicol. Lett. 172: 146-158.
16. McDonald, P. C., A. Oloumi, J. Mills, I. Dobreva, M. Maidan, V. Gray, et al. 2008. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 68: 1618-1624.
17. Nicholson, K. M. and N. G. Anderson. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14: 381-395.
18. Nigam, M., V. Ranjan, S. Srivastava, R. Sharma, and A. K. Balapure. 2008. Centchroman induces G(0)/G(1) arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells. Life Sci. 82: 577-590.
19. Oh, J. Y., Y. M. Baek, S. W. Kim, H. J. Hwang, H. S. Hwang, S. H. Lee, and J. W. Yun. 2008. Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala. J. Microbiol. Biotechnol. 18: 512-519.
20. Oliveras-Ferraros, C., A. Vazquez-Martin, R. Colomer, R. De Llorens, J. Brunet, and J. A. Menendez. 2008. Sequence-dependent synergism and antagonism between paclitaxel and gemcitabine in breast cancer cells: The importance of scheduling. Int. J. Oncol. 32: 113-120.
21. Parihar, A., M. S. Parihar, and P. Ghafourifar. 2008. Significance of mitochondrial calcium and nitric oxide for apoptosis of human breast cancer cells induced by tamoxifen and etoposide. Int. J. Mol. Med. 21: 317-324.
22. Park, C., S. H. Hong, J. Y. Lee, G. Y. Kim, B. T. Choi, Y. T. Lee, et al. 2005. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. Oncol. Rep. 13: 1211-1246.
23. Park, J. W., Y. J. Choi, S. I. Suh, W. K. Baek, M. H. Suh, I. N. Jin, et al. 2001. Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis 22: 1633-1639.
24. Qiao, X., X. Chen, D. Wu, R. Ding, J. Wang, Q. Hong, et al. 2005. Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury. J. Gerontol. A Biol. Sci. Med. Sci. 60: 830-839.
25. Rahmani, M., E. Reese, Y. Dai, C. Bauer, S. G. Payne, P. Dent, S. Spiegel, and S. Grant. 2005. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res. 65: 2422-2432.
26. Thees, S., G. B. Hubbard, J. Winckler, C. Schultz, and A. Rami. 2005. Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor. Neurol. Neurosci. 23: 1-9.
27. Wu, C. C., M. L. Chan, W. Y. Chen, C. Y. Tsai, F. R. Chang, and Y. C. Wu. 2005. Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. Mol. Cancer Ther. 4: 1277-1285.
28. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
29. Xiao, D., V. Vogel, and S. V. Singh. 2006. Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol. Cancer Ther. 5: 2931-2945.
30. Yang, H. L., C. S. Chen, W. H. Chang, F. J. Lu, Y. C. Lai, C. C. Chen, T. H. Hseu, C. T. Kuo, and Y. C. Hseu. 2006. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett. 231: 215-227.
31. Yang, H. Y., S. F. Leu, Y. K. Wang, C. S. Wu, and B. M. Huang. 2006. Cordyceps sinensis mycelium induces MA-10 mouse Leydig tumor cell apoptosis by activating the caspase-8 pathway and suppressing the NF-κB pathway. Arch. Androl. 52: 103-110.
32. Yu, C., X. Mao, and W. X. Li. 2005. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochem. Biophys. Res. Commun. 331: 391-397.
33. Zhang, M., R. Guo, Y. Zhai, and D. Yang. 2003. LIGHT sensitizes IFNγ-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. Cancer Lett. 195: 201-210.
34. Zhu, J. S., G. M. Halpern, and K. Jones. 1998. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis. J. Altern. Complem. Med. 4: 289-303.