Hepatocyte-targeting gene transfer mediated by galactosylated poly(ethylene glycol)- graft-polyethylenimine derivative

Drug Design, Development and Therapy

Volumn 7, Issue , 2013, Pages 211-221

  Wang, Yuqiang ^a   Su, Jing ^b   Cai, Wenwei ^c   Lu, Ping ^c   Yuan, Lifen ^c   Jin, Tuo ^b   Chen, Shuyan ^a   Sheng, Jing ^c  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Cytotoxicity; Galactose; Gene delivery; Hepatocyte targeting; Transfection efficiency

Indexed keywords

GALACTOSYLATED POLY(ETHYLENE GLYCOL) GRAFT POLYETHYLENIMINE DERIVATIVE; LACTOBIONIC ACID; LUCIFERASE; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; ATOMIC FORCE MICROSCOPY; CELL SPECIFICITY; CELL TRANSPORT; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GEL PERMEATION CHROMATOGRAPHY; GEL RETARDATION ASSAY; GENETIC TRANSFECTION; HEPATOCYTE TARGETING GENE TRANSFER; HUMAN; HUMAN CELL; LIVER CELL; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TOXICITY TESTING; ZETA POTENTIAL;

CYTOTOXICITY; GALACTOSE; GENE DELIVERY; HEPATOCYTE TARGETING; TRANSFECTION EFFICIENCY;

ANIMALS; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GALACTOSE; GENE TRANSFER TECHNIQUES; HELA CELLS; HEPATOCYTES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ATOMIC FORCE; MOLECULAR WEIGHT; NANOPARTICLES; PARTICLE SIZE; PLASMIDS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; RATS; TRANSFECTION;

EID: 84875675290     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S42582     Document Type: Article

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