Dextran-spermine-based polyplexes - Evaluation of transgene expression and of local and systemic toxicity in mice

Biomaterials

Volumn 27, Issue 8, 2006, Pages 1636-1645

  Eliyahu, Hagit ^a,b   Joseph, Aviva ^a   Azzam, Tony ^b   Barenholz, Yechezkel ^a   Domb, Abraham J ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Gene delivery; Polycation; Toxicity; Transgene expression

Indexed keywords

BIOLOGICAL ORGANS; CATIONIC POLYMERIZATION; DEXTROSE; LIVING SYSTEMS STUDIES; MUSCLE; NUCLEIC ACIDS; POLYMERS; SELF ASSEMBLY; TOXICITY;

GENE DELIVERY; POLYCATION; POLYPLEXES; TRANSGENE EXPRESSION;

GENE TRANSFER;

5 BROMO 4 CHLORO 3 INDOLYL BETA DEXTRO GALACTOPYRANOSIDE; BETA GALACTOSIDASE; DEXTRAN; POLYMER; PYRANOSIDE; SPERMINE; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TOLERABILITY; FEMALE; GENE EXPRESSION; GENE TARGETING; HISTOPATHOLOGY; LEUKOCYTE COUNT; LIVER; LIVER CELL; LOCAL TOXICITY; LUNG; LUNG ALVEOLUS CELL; MOUSE; MUSCLE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; STAINING; SYSTEMIC TOXICITY; THROMBOCYTE COUNT; TOXICITY; TOXICITY TESTING; TRANSGENE;

ANIMALS; BIOCOMPATIBLE MATERIALS; DEXTRANS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; LIVER; LUNG; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MUSCLE, SKELETAL; ORGAN SPECIFICITY; SPERMINE; TRANSFECTION; TRANSGENES;

ANIMALIA;

EID: 28444453367     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.08.024     Document Type: Article

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