Mollugin inhibits the inflammatory response in lipopolysaccharide- stimulated RAW264.7 macrophages by blocking the janus kinase-signal transducers and activators of transcription signaling pathway

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 3, 2013, Pages 399-406

  Zhu, Zheng Guang ^a   Jin, Hong ^a   Yu, Peng Jiu ^a   Tian, Yuan Xin ^a   Zhang, Jia Jie ^a   Wu, Shu Guang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Inflammatory mediator; Janus kinase signal transducer and activator of transcription; Macrophage; Mollugin; Nuclear factor kappa

Indexed keywords

HYDROQUINONE DERIVATIVE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; MOLLUGIN; NITRIC OXIDE; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; MACROPHAGE; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RUBIA CORDIFOLIA; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DRUGS, CHINESE HERBAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; PYRANS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 84875552260     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00804     Document Type: Article

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