Pyranocoumarins isolated from Peucedanum praeruptorum Dunn suppress lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-κB and STAT3 activation

Inflammation

Volumn 35, Issue 3, 2012, Pages 967-977

  Yu, Peng Jiu ^a   Jin, Hong ^a   Zhang, Jun Yan ^a   Wang, Guang Fa ^a   Li, Jing Rong ^a   Zhu, Zheng Guang ^a   Tian, Yuan Xin ^a   Wu, Shao Yu ^a   Xu, Wei ^a   Zhang, Jia Jie ^a   Wu, Shu Guang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Interleukin 6; Lipopolysaccharide; Macrophage; Nitric oxide; Nuclear factor B; Pyranocoumarin; Signal transducer and activator of transcription 3; Tumor necrosis factor

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NITRIC OXIDE; PRAERUPTORIN C; PRAERUPTORIN D; PRAERUPTORIN E; PYRANOCOUMARIN DERIVATIVE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; IC 50; INFLAMMATION; MACROPHAGE; MEDICINAL PLANT; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOTIDE SEQUENCE; PEUCEDANUM PRAERUPTORUM; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APIACEAE; CELL LINE; COUMARINS; I-KAPPA B KINASE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PLANT EXTRACTS; PYRANOCOUMARINS; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

APIACEAE; MURINAE; PEUCEDANUM PRAERUPTORUM;

EID: 84863787867     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9400-y     Document Type: Article

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