Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL

Toxicology and Applied Pharmacology

Volumn 241, Issue 2, 2009, Pages 210-220

  Kim, Sun Mi ^a   Park, Hae Sun ^a   Jun, Do Youn ^a   Woo, Hyun Ju ^a   Woo, Mi Hee ^b   Yang, Chae Ha ^c   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

^b Catholic University of Daegu   (South Korea)

^c Daegu Haany University   (South Korea)

Author keywords

Apoptosis; Bcl xL; Caspase cascade; Cytotoxicity; ER stress; Leukemia Jurkat T cells; Mitochondrial cytochrome c; Mollugin; Rubia cordifolia L.

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; FLICE INHIBITORY PROTEIN; MOLLUGIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROTEIN BCL XL; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PLANT ROOT; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RUBIA; RUBIA CORDIFOLIA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CASPASE 12; CYTOCHROMES C; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; G2 PHASE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MITOCHONDRIA; PLANT ROOTS; PYRANS; RUBIA;

RUBIA CORDIFOLIA;

EID: 70350221910     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.08.024     Document Type: Article

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