HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride

Cellular Signalling

Volumn 20, Issue 10, 2008, Pages 1839-1847

  Tsoyi, Konstantin ^a   Kim, Hye Jung ^a   Shin, Jae Soo ^b   Kim, Dal Hyun ^b   Cho, Hee Jeong ^b   Lee, Sung Sook ^b   Ahn, Sun Kil ^b   Yun Choi, Hye Sook ^c   Lee, Jae Heun ^a   Seo, Han Geuk ^a   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Chong Kun Dang Institute   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Cyclooxtgenase; Heme oxygeanse; Inducible nitric oxide synthase; Lipopolysaccharide; Tetrahydroisoquinoline

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CKD 712; CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 2; LIPOPOLYSACCHARIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NITRIC OXIDE; PROSTAGLANDIN E2; SMALL INTERFERING RNA; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TETRAHYDROISOQUINOLINE DERIVATIVE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ALKALOIDS; ANIMALS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HEME OXYGENASE-1; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TETRAHYDROISOQUINOLINES;

MUS;

EID: 49649119361     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.06.012     Document Type: Article

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