Assessment and treatment of right ventricular failure

Nature Reviews Cardiology

Volumn 10, Issue 4, 2013, Pages 204-218

  Simon, Marc A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; AUTOANTIBODY; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; INOTROPIC AGENT; MILRINONE; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; TROPONIN; VASODILATOR AGENT;

ANAMNESIS; ANGIOGRAPHY; CARDIOMYOPATHY; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR SYSTEM EXAMINATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL HEART DISEASE; DEVICE THERAPY; DISEASE CLASSIFICATION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EXTRACORPOREAL OXYGENATION; FUNCTIONAL ASSESSMENT; HEART HEMODYNAMICS; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE FUNCTION; HEART SURGERY; HEART TRANSPLANTATION; HUMAN; LABORATORY TEST; LIVER FUNCTION TEST; LUNG EMBOLISM; LUNG FUNCTION TEST; LUNG VENTILATION PERFUSION RATIO; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; RIGHT VENTRICULAR ASSIST DEVICE; SEPSIS; SEROLOGY; SLEEP; SYSTOLIC HEART FAILURE; THORAX RADIOGRAPHY; THYROID FUNCTION TEST; TRANSTHORACIC ECHOCARDIOGRAPHY; VALVULAR HEART DISEASE;

CARDIOVASCULAR AGENTS; DIAGNOSTIC IMAGING; HEART FAILURE; HEART TRANSPLANTATION; HEART-ASSIST DEVICES; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; PREDICTIVE VALUE OF TESTS; RISK FACTORS; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 84875497366     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2013.12     Document Type: Review

References (193)

1. Palevsky, H. I. & Fishman, A. P. Chronic cor pulmonale. Etiology and management. JAMA 263, 2347-2353 (1990
2. Andersen, H. R., Falk, E. & Nielsen, D. Right ventricular infarction: Frequency, size and topography in coronary heart disease: A prospective study comprising 107 consecutive autopsies from a coronary care unit. J. Am. Coll. Cardiol. 10, 1223-1232 (1987
3. Marelli, A. J., Mackie A. S., Ionescu-Ittu, R., Rahme, E. & Pilote, L. Congenital heart disease in the general population: Changing prevalence and age distribution. Circulation 115, 163-172 (2007
4. Warnes, C. A. et al. ACC/AHA 2008 Guidelines for the management of adults with congenital heart disease. Circulation 118, 2395-2451 (2008
5. Davlouros, P. A., Niwa, K., Webb, G. & Gatzoulis, M. A. The right ventricle in congenital heart disease. Heart 92 (Suppl. 1), i27-i38 (2006
6. Fogel, M. A. et al. Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: Clinical implications. J. Thorac. Cardiovasc. Surg. 143, 1279-1285 (2012
7. Galiè, N. et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur. Heart J. 30, 2493-2537 (2009
8. Murray, B. Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C): A review of molecular and clinical literature. J. Genet. Couns. 21, 494-504 (2012
9. Hunt, S. A. et al. Accaha 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation 112, e154-e235 (2005
10. Luk, A., Ahn, E., Soor, G. S. & Butany, J. Dilated cardiomyopathy: A review. J. Clin. Pathol. 62, 219-225 (2009
11. Simon, M. A. et al. Phenotyping the right ventricle in patients with pulmonary hypertension. Clin. Transl. Sci. 2, 294-249 (2009
12. Bogaard, H. J., Abe, K., Vonk Noordegraaf, A. & Voelkel, N. F. The right ventricle under pressure: Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest 135, 794-804 (2009
13. Modesti, P. A. et al. Different growth factor activation in the right and left ventricles in experimental volume overload. Hypertension 43, 101-108 (2004
14. Lowes, B. D. et al. Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J. Clin. Invest. 100, 2315-2324 (1997
15. Herron, T. J. & McDonald, K. S. Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments. Circ. Res. 90, 1150-1152 (2002
16. Gómez, A. et al. Right ventricular ischemia in patients with primary pulmonary hypertension. J. Am. Coll. Cardiol. 38, 1137-1142 (2001
17. Zaobornyj, T. et al. Mitochondrial nitric oxide metabolism during rat heart adaptation to high altitude: Effect of sildenafil, L NAME, and L arginine treatments. Am. J. Physiol. Heart Circ. Physiol. 296, H1741-H1747 (2009
18. Nagendran, J. et al. A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted. J. Thorac. Cardiovasc. Surg. 136, 168-178 (2008
19. Nagendran, J. et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116, 238-248 (2007
20. Shan, X. et al. Differential expression of PDE5 in failing and nonfailing human myocardium. Circ. Heart Fail. 5, 79-86 (2012
21. Haddad, F. et al. Pulmonary hypertension associated with left heart disease: Characteristics, emerging concepts, and treatment strategies. Prog. Cardiovasc. Dis. 54, 154-167 (2011
22. Matthews J. C. & McLaughlin, V. Acute right ventricular failure in the setting of acute pulmonary embolism or chronic pulmonary hypertension: A detailed review of the pathophysiology, diagnosis, and management. Curr. Cardiol. Rev. 4, 49-59 (2008
23. Watts, J. A., Marchick, M. R. & Kline J. A. Right ventricular heart failure from pulmonary embolism: Key distinctions from chronic pulmonary hypertension. J. Card. Fail. 16, 250-259 (2010
24. Simonneau, G. et al. Clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 43 (Suppl. S), 5S-12S (2004
25. Santamore, W. P. & Dell'Italia, L. J. Ventricular interdependence: Significant left ventricular contributions to right ventricular systolic function. Prog. Cardiovasc. Dis. 40, 289-308 (1998
26. Weber, K. T., Janicki, J. S., Shroff, S. & Fishman, A. P. Contractile mechanisms and interaction of the right and left ventricles. Am. J. Cardiol. 47, 686-695 (1981
27. Hoffman, D., Sisto, D., Frater, R. W. & Nikolic, S. D. Left to right ventricular interaction with a noncontracting right ventricle. J. Thorac. Cardiovasc. Surg. 107, 1496-1502 (1994
28. Van Tassell, B. W. et al. Right ventricular systolic dysfunction in patients with reperfused ST segment elevation acute myocardial infarction. Int. J. Cardiol. 155, 314-316 (2012
29. Hirose, K., Shu, N. H., Reed, J. E. & Rumberger, J. A. Right ventricular dilatation and remodeling the first year after an initial transmural wall left ventricular myocardial infarction. Am. J. Cardiol. 72, 1126-1130 (1993
30. Bussani, R. et al. Right ventricular dilatation after left ventricular acute myocardial infarction is predictive of extremely high peri-infarctual apoptosis at postmortem examination in humans. J. Clin. Pathol. 56, 672-676 (2003
31. Toldo, S. et al. Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse. PLoS ONE 6, e18102 (2011
32. Miszalski-Jamka, T. et al. Extent of RV dysfunction and myocardial infarction assessed by CMR are independent outcome predictors early after STEMI treated with primary angioplasty. JACC Cardiovasc. Imaging 3, 1237-1246 (2010
33. Antoni, M. L. et al. Prognostic value of right ventricular function in patients after acute myocardial infarction treated with primary percutaneous coronary intervention. Circ. Cardiovasc. Imaging 3, 264-271 (2010
34. Anavekar, N. S. et al. Usefulness of right ventricular fractional area change to predict death, heart failure, and stroke following myocardial infarction (from the VALIANT ECHO Study). Am. J. Cardiol. 101, 607-612 (2008
35. Zornoff, L. A. et al. Right ventricular dysfunction and risk of heart failure and mortality after myocardial infarction. J. Am. Coll. Cardiol. 39, 1450-1455 (2002
36. Mehta, S. R. et al. Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction. J. Am. Coll. Cardiol. 37, 37-43 (2001
37. Haddad, F., Hunt, S. A., Rosenthal, D. N. & Murphy, D. J. Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation 117, 1436-1448 (2008
38. Gan, C. T. et al. Impaired left ventricular filling due to right to left ventricular interaction in patients with pulmonary arterial hypertension. Am. J. Physiol. Heart Circ. Physiol. 290, H1528-H1533 (2006
39. Hopkins, W. E. & Waggoner, A. D. Severe pulmonary hypertension without right ventricular failure: The unique hearts of patients with Eisenmenger syndrome. Am. J. Cardiol. 89, 34-38 (2002
40. Hopkins, W. E. Right ventricular performance in congenital heart disease: A physiologic and pathophysiologic perspective. Cardiol. Clin. 30, 205-218 (2012
41. Warnes, C. A. Adult congenital heart disease importance of the right ventricle. J. Am. Coll. Cardiol. 54, 1903-1910 (2009
42. Mitsuo, T., Shimazaki, S. & Matsuda, H. Right ventricular dysfunction in septic patients. Crit. Care Med. 20, 630-634 (1992
43. Chan, C. M. & Klinger, J. R. The right ventricle in sepsis. Clin. Chest Med. 20, 661-676 (2008
44. Dhainaut, J. F. et al. Right ventricular dysfunction in patients with septic shock. Intensive Care Med. 14, 488-491 (1988
45. Haddad, F., Doyle, R., Murphy, D. J. & Hunt, S. A. Right ventricular function in cardiovascular disease, part II: Pathophysiology, clinical importance, and management of right ventricular failure. Circulation 117, 1717-1731 (2008
46. Guazzi, M. & Arena, R. Pulmonary hypertension with left-sided heart disease. Nat. Rev. Cardiol. 7, 648-659 (2010
47. Mullens, W. et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J. Am. Coll. Cardiol. 53, 589-596 (2009
48. Damman, K. et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J. Am. Coll. Cardiol. 53, 582-588 (2009
49. Schrier, R. W. & Bansal, S. Pulmonary hypertension, right ventricular failure, and kidney: Different from left ventricular failure? Clin. J. Am. Soc. Nephrol. 3, 1232-1237 (2008
50. Feldt, R. H. et al. Protein-losing enteropathy after the Fontan operation. J. Thorac. Cardiovasc. Surg. 112, 672-680 (1996
51. McGoon, M. D. & Kane, G. C. Pulmonary hypertension: Diagnosis and management. Mayo Clin. Proc. 84, 191-207 (2009
52. Sanz, J., Conroy, J. & Narula, J. Imaging of the right ventricle. Cardiol. Clin. 30, 189-203 (2012
53. Forfia, P. R. et al. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 174, 1034-1041 (2006
54. van Wolferen, S. A. et al. Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur. Heart J. 28, 1250-1257 (2007
55. McLaughlin, V. V. et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J. Am. Coll. Cardiol. 53, 1573-1619 (2009
56. Horton, K. D., Meece, R. W. & Hill, J. C. Assessment of the right ventricle by echocardiography: A primer for cardiac sonographers. J. Am. Soc. Echocardiogr. 22, 776-792 (2009
57. Woodard, P. K. et al. ACR practice guideline for the performance and interpretation of cardiac magnetic resonance imaging (MRI). J. Am. Coll. Radiol. 3, 665-676 (2006
58. Ma, N. et al. Cardiac magnetic resonance imaging in arrhythmogenic right ventricular cardiomyopathy: Correlation to the QRS dispersion. Magn. Reson. 30, 1454-1460 (2012
59. Tei, C. et al. Doppler echocardiographic index for assessment of global right ventricular function. J. Am. Soc. Echocardiogr. 9, 838-847 (1996
60. Dujardin, K. S. et al. Prognostic value of a Doppler index combining systolic and diastolic performance in idiopathic-dilated cardiomyopathy. Am. J. Cardiol. 82, 1071-1076 (1998
61. Eidem, B. W., Tei, C., O'Leary, P. W., Cetta, F. & Seward, J. B. Nongeometric quantitative assessment of right and left ventricular function: Myocardial performance index in normal children and patients with Ebstein anomaly. J. Am. Soc. Echocardiogr. 11, 849-856 (1998
62. Ishii, M. et al. Quantitation of the global right ventricular function in children with normal heart and congenital heart disease: A right ventricular myocardial performance index. Pediatr. Cardiol. 21, 416-421 (2000
63. Eidem, B. W., O'Leary, P. W., Tei, C. & Seward, J. B. Usefulness of the myocardial performance index for assessing right ventricular function in congenital heart disease. Am. J. Cardiol. 86, 654-658 (2000
64. Damy, T. et al. Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. J. Card. Fail. 18, 216-225 (2012
65. Rajagopalan, N., Simon, M. A., Mathier, M. A. & López- Candales, A. Identifying right ventricular dysfunction with tissue Doppler imaging in pulmonary hypertension. Int. J. Cardiol. 128, 359-363 (2008
66. Simon, M. A. et al. Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. Congest. Heart Fail. 15, 271-276 (2009
67. Sade, L. E. et al. Tissue Doppler study of the right ventricle with a multisegmental approach: Comparison with cardiac magnetic resonance imaging. J. Am. Soc. Echocardiogr. 22, 361-368 (2009
68. Matias, C. et al. Speckle tracking derived strain and strain-rate analysis: A technique for the evaluation of early alterations in right ventricle systolic function in patients with systemic sclerosis and normal pulmonary artery pressure. J. Cardiovasc. Med. (Hagerstown) 10, 129-134 (2009
69. Jategaonkar, S. R. et al. Two-dimensional strain and strain rate imaging of the right ventricle in adult patients before and after percutaneous closure of atrial septal defects. Eur. J. Echocardiogr. 10, 499-502 (2009
70. Meris, A. et al. Timing and magnitude of regional right ventricular function: A speckle tracking-derived strain study of normal subjects and patients with right ventricular dysfunction. J. Am. Soc. Echocardiogr. 23, 823-831 (2010
71. Schindera, S. T., Mehwald, P. S., Sahn, D. J. & Kececioglu, D. Accuracy of real-Time three-dimensional echocardiography for quantifying right ventricular volume: Static and pulsatile flow studies in an anatomic in vitro model. J. Ultrasound Med. 21, 1069-1075 (2002
72. Hubka, M. et al. Three-dimensional echocardiographic measurement of left and right ventricular mass and volume: In vitro validation. Int. J. Cardiovasc. Imaging 18, 111-118 (2002
73. Menzel, T. et al. Quantitative assessment of right ventricular volumes in severe chronic thromboembolic pulmonary hypertension using transthoracic three-dimensional echocardiography: Changes due to pulmonary thromboendarterectomy. Eur. J. Echocardiogr. 3, 67-72 (2002
74. Caiani, E. G. et al. Improved semiautomated quantification of left ventricular volumes and ejection fraction using 3 dimensional echocardiography with a full matrix-Array transducer: Comparison with magnetic resonance imaging. J. Am. Soc. Echocardiogr. 18, 779-788 (2005
75. Benza, R., Biederman, R., Murali, S. & Gupta, H. Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension. J. Am. Coll. Cardiol. 52, 1683-1692 (2008
76. McLure, L. E. & Peacock, A. J. Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension. Eur. Respir. J. 33, 1454-1466 (2009
77. Sanz, J. et al. Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance. JACC Cardiovasc. Imaging 2, 286-295 (2009
78. Reiter, G. et al. Magnetic resonance-derived 3 dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure. Circ. Cardiovasc. Imaging 1, 23-30 (2008
79. Swift, A. J. et al. Diagnostic accuracy of cardiovascular magnetic resonance imaging of right ventricular morphology and function in the assessment of suspected pulmonary hypertension results from the ASPIRE registry. J. Cardiovasc. Magn. Reson. 14, 40 (2012
80. Chen, S. S. et al. Cardiovascular magnetic resonance tagging of the right ventricular free wall for the assessment of long axis myocardial function in congenital heart disease. J. Cardiovasc. Magn. Reson. 13, 80 (2011
81. Kim, R. J. et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N. Engl. J. Med. 343, 1445-1453 (2000
82. Tandri, H. et al. Noninvasive detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement magnetic resonance imaging. J. Am. Coll. Cardiol. 45, 98-103 (2005
83. Shehata, M. L. et al. Myocardial delayed enhancement in pulmonary hypertension: Pulmonary hemodynamics, right ventricular function, and remodeling. Am. J. Roentgenol. 196, 87-94 (2011
84. Wong T. C. et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short term mortality. Circulation 126, 1206-1216 (2012
85. Plumhans, C. et al. Assessment of global right ventricular function on 64-MDCT compared with MRI. Am. J. Roentgenol. 190, 1358-1361 (2008
86. Koch, K. et al. Assessment of right ventricular function by 16 detector row CT: Comparison with magnetic resonance imaging. Eur. Radiol. 15, 312-318 (2005
87. Raman, S. V., Shah, M., McCarthy, B., Garcia, A. & Ferketich, A. K. Multi-detector row cardiac computed tomography accurately quantifies right and left ventricular size and function compared with cardiac magnetic resonance. Am. Heart J. 151, 736-744 (2006
88. Wu, J., Wang, Y., Simon, M. A. & Brigham, J. C. A new approach to kinematic feature extraction from the human right ventricle for classification of hypertension: A feasibility study. Phys. Med. Biol. 57, 7905-7922 (2012
89. Steele, P., Kirch, D., LeFree, M. & Battock, D. Measurement of right and left ventricular ejection fractions by radionuclide angiocardiography in coronary artery disease. Chest 70, 51-56 (1976
90. van der Maas, N. et al. Right ventricular ejection fraction measured by multigated planar equilibrium radionuclide ventriculography is an independent prognostic factor in patients with ischemic heart disease. J. Nucl. Cardiol. 19, 1162-1169 (2012
91. de Groote, P. et al. Right ventricular systolic function for risk stratification in patients with stable left ventricular systolic dysfunction: Comparison of radionuclide angiography to echoDoppler parameters. Eur. Heart J. 33, 2672-2679 (2012
92. Brent, B. N., Mahler, D., Matthay, R. A., Berger, H. J. & Zaret, B. L. Noninvasive diagnosis of pulmonary arterial hypertension in chronic obstructive pulmonary disease: Right ventricular ejection fraction at rest. Am. J. Cardiol. 53, 1349-1353 (1984
93. Le Guludec, D. et al. Prognostic value of radionuclide angiography in patients with right ventricular arrhythmias. Circulation 103, 1972-1976 (2001
94. Morise, A. P. & Goodwin, C. Exercise radionuclide angiography in patients with mitral stenosis: Value of right ventricular response. Am. Heart J. 112, 509-517 (1986
95. Aepfelbacher, F. C., Yeon, S. B., Ho, K. K., Parker, J. A. & Danias, P. G. ECG-gated 99mTc single-photon emission CT for assessment of right ventricular structure and function: Is the information provided similar to echocardiography? Chest 124, 227-232 (2003
96. Caresia-Aroztegui, A. P. et al. Gated-SPECT equilibrium radionuclide angiography in right ventricular assessment of patients with repaired tetralogy of Fallot. Nucl. Med. Commun. 28, 159-164 (2007
97. Le Guludec, D. et al. Evaluation of radionuclide angiography in diagnosis of arrhythmogenic right ventricular cardiomyopathy. J. Am. Coll. Cardiol. 26, 1476-1483 (1995
98. Arora, R., Zhao, Q. H., Guguchev, P. A., Wexler, J. P. & Travin, M. I. Identification of severe right ventricular dysfunction and pressure overload by stress radionuclide myocardial perfusion SPECT imaging with gating. J. Nucl. Cardiol. 6, 375-376 (1999
99. Daou, D., Coaguila, C. & Vilain, D. Electrocardiograph-gated single photon emission computed tomography radionuclide angiography presents good interstudy reproducibility for the quantification of global systolic right ventricular function. Nucl. Med. Commun. 28, 391-399 (2007
100. Mazraeshahi, R. M., Striet, J., Oeltgen, R. C. & Gerson, M. C. Myocardial SPECT images for diagnosis of pulmonary hypertension and right ventricular hypertrophy. J. Nucl. Med. Technol. 38, 175-180 (2010
101. Nishijima, K., Miyahara, Y., Furukawa, K., Matsushita, T. & Kohno, S. Simultaneous assessment of right ventricular function and hypertrophy by Tc 99m MIBI. Clin. Nucl. Med. 24, 151-155 (1999
102. Ukkonen, H. et al. Is ventilatory efficiency (VE/VCO2 slope) associated with right ventricular oxidative metabolism in patients with congestive heart failure? Eur. J. Heart Fail. 10, 1117-1122 (2008
103. Mielniczuk, L. M. et al. Relation between right ventricular function and increased right ventricular [18F]fluorodeoxyglucose accumulation in patients with heart failure. Circ. Cardiovasc. Imaging 4, 59-66 (2011
104. Oikawa, M. et al. Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J. Am. Coll. Cardiol. 45, 1849-1855 (2005
105. Champion, H. C., Michelakis, E. D. & Hassoun, P. M. Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: State of the art and clinical and research implications. Circulation 120, 992-1007 (2009
106. Rich, S., Kaufmann, E. & Levy, P. S. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N. Engl. J Med. 327, 76-81 (1992
107. Lankhaar, J. W. et al. Quantification of right ventricular afterload in patients with and without pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 291, H1731-H1737 (2006
108. Lankhaar, J. et al. Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension. Eur. Heart J. 29, 1688-1695 (2008
109. Tedford, R. J. et al. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation 125, 289-297 (2012
110. Mahapatra, S., Nishimura, R. A., Sorajja, P., Cha, S. & McGoon, M. D. Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J. Am. Coll. Cardiol. 47, 799-803 (2006
111. Kerbaul, F. et al. How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension. Am. J. Respir. Crit. Care Med. 175, 846-850 (2007
112. Hunter, K. S. et al. Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension. Am. Heart J. 155, 166-174 (2008
113. Ghofrani, H. A. et al. Future perspectives for the treatment of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54, S108-S117 (2009
114. Badesch, D. B. et al. Diagnosis and assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54 (Suppl. S), S55-S66 (2009
115. Bistola, V. et al. Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B type natriuretic peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am. J. Cardiol. 105, 249-254 (2010
116. Fijalkowska, A. et al. Serum N terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension. Chest 129, 1313-1321 (2006
117. Nagaya, N. et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 102, 865-870 (2000
118. Lowenthal, A. et al. Usefulness of B type natriuretic peptide and N terminal pro B type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am. J. Cardiol. 109, 866-872 (2012
119. Kucher, N., Printzen, G. & Goldhaber, S. Z. Prognostic role of brain natriuretic peptide in acute pulmonary embolism. Circulation 107, 2545-2547 (2003
120. Andresen, M. et al. Natriuretic peptide type B can be a marker of reperfusion in patients with pulmonary thromboembolism subjected to invasive treatment. Int. J. Cardiovasc. Imaging 28, 659-666 (2012
121. Kaya, M. G. et al. Plasma B type natriuretic peptide in diagnosing inferior myocardial infarction with right ventricular involvement. Coron. Artery Dis. 19, 609-613 (2008
122. Kostrubiec, M. et al. Signs of myocardial ischemia on electrocardiogram correlate with elevated plasma cardiac troponin and right ventricular systolic dysfunction in acute pulmonary embolism. Cardiol. J. 17, 157-162 (2010
123. Torbicki, A. et al. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension. Circulation 108, 844-848 (2003
124. Mullens, W. et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J. Am. Coll. Cardiol. 53, 589-596 (2009
125. Damman, K. et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J. Am. Coll. Cardiol. 53, 582-588 (2009
126. Cook, J. A. et al. Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with congestive heart failure. Clin. Pharmacol. Ther. 44, 487-500 (1988
127. Brater, D. C., Day, B., Burdette, A. & Anderson, S. Bumetanide and furosemide in heart failure. Kidney Int. 26, 183-189 (1984
128. Binanay, C. et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: The ESCAPE trial. JAMA 294, 1625-1633 (2005
129. Lowes, B. D., Simon, M. A., Tsvetkova, T. O. & Bristow, M. R. Inotropes in the beta-blocker era. Clin. Cardiol. 23 (Suppl.), III11-III16 (2000
130. Chen, E. P., Bittner, H. B., Davis, R. D. Jr & Van Trigt, P. 3rd Milrinone improves pulmonary hemodynamics and right ventricular function in chronic pulmonary hypertension. Ann. Thorac. Surg. 63, 814-821 (1997
131. Pepke-Zaba, J., Higenbottam, T. W., Dinh Xuan, A. T., Stone, D. & Wallwork, J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 338, 1173-1174 (1991
132. Rossaint, R. et al. Effects of inhaled nitric oxide on right ventricular function in severe acute respiratory distress syndrome. Intensive Care Med. 21, 197-203 (1995
133. Szold, O. et al. Inhaled nitric oxide improves pulmonary functions following massive pulmonary embolism: A report of four patients and review of the literature. Lung 184, 1-5 (2006
134. Summerfield, D. T., Desai, H., Levitov, A., Grooms, D. A. & Marik, P. E. Inhaled nitric oxide as salvage therapy in massive pulmonary embolism: A case series. Respir. Care 57, 444-448 (2012
135. Solina, A. et al. A comparison of inhaled nitric oxide and milrinone for the treatment of pulmonary hypertension in adult cardiac surgery patients. J. Cardiothorac. Vasc. Anesth. 14, 12-17 (2000
136. Solina, A. R. et al. Dose response to nitric oxide in adult cardiac surgery patients. J. Clin. Anesth. 13, 281-286 (2001
137. Stobierska-Dzierzek, B., Awad, H. & Michler, R. E. The evolving management of acute right-sided heart failure in cardiac transplant recipients. J. Am. Coll. Cardiol. 38, 923-931 (2001
138. Semigran, M. J. et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J. Am. Coll. Cardiol. 24, 982-988 (1994
139. Jolliet, P., Bulpa, P., Thorens, J. B., Ritz, M. & Chevrolet, J. C. Nitric oxide and prostacyclin as test agents of vasoreactivity in severe precapillary pulmonary hypertension: Predictive ability and consequences on haemodynamics and gas exchange. Thorax 52, 369-372 (1997
140. Taylor, R. W. et al. Low-dose inhaled nitric oxide in patients with acute lung injury: A randomized controlled trial. JAMA 291, 1603-1609 (2004
141. Griffiths, M. J. & Evans, T. W. Inhaled nitric oxide therapy in adults. N. Engl. J. Med. 353, 2683-2695 (2005
142. Kushner, F. G. et al. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 54, 2205-2241 (2009
143. Jacobs, A. K. et al. Cardiogenic shock caused by right ventricular infarction: A report from the SHOCK registry. J. Am. Coll. Cardiol. 41, 1273-1279 (2003
144. Kucher, N. & Goldhaber, S. Z. Management of massive pulmonary embolism. Circulation 112, e28-e32 (2005
145. Konstantinides, S. & Goldhaber, S. Z. Pulmonary embolism: Risk assessment and management. Eur. Heart J. 33, 3014-3022 (2012
146. Bogaard, H. J. et al. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am. J. Respir. Crit. Care Med. 182, 652-660 (2010
147. Quaife, R. A. et al. Effects of carvedilol on right ventricular function in chronic heart failure. Am. J. Cardiol. 81, 247-250 (1998
148. Henein, M. Y., O'Sullivan, C. A., Coats, A. J. & Gibson, D. G. Angiotensin-converting enzyme (ACE) inhibitors revert abnormal right ventricular filling in patients with restrictive left ventricular disease. J. Am. Coll. Cardiol. 32, 1187-1193 (1998
149. Nguyen, Q. T. et al. AT1 receptor antagonist therapy preferentially ameliorated right ventricular function and phenotype during the early phase of remodeling post-MI. Br. J. Pharmacol. 138, 1485-1494 (2003
150. de Man, F. S. et al. Dysregulated renin angiotensin aldosterone system contributes to pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 186, 780-789 (2012
151. Rich, S. & Brundage, B. H. High-dose calcium channel-blocking therapy for primary pulmonary hypertension: Evidence for long-Term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation 76, 135-141 (1987
152. Hinderliter, A. L. et al. Effects of long-Term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension. Primary Pulmonary Hypertension Study Group. Circulation 95, 1479-1486 (1997
153. Roeleveld, R. J. et al. Effects of epoprostenol on right ventricular hypertrophy and dilatation in pulmonary hypertension. Chest 125, 572-579 (2004
154. Lewis, G. D. et al. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation 116, 1555-1562 (2007
155. Hoeper, M. M. et al. Riociguat for interstitial lung disease and pulmonary hypertension: A pilot trial. Eur. Respir. J. http://dx.doi.org/10. 1183/09031936.00213911
156. Ghio, S. et al. Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): Rationale and design. Eur. J. Heart Fail. 14, 946-953 (2012
157. Sidharta, P. N., van Giersbergen, P. L., Halabi, A. & Dingemanse, J. Macitentan: Entry into humans study with a new endothelin receptor antagonist. Eur. J. Clin. Pharmacol. 67, 977-984 (2011
158. Bogaard, H. J. et al. Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation 120, 1951-1960 (2009
159. Garjani, A. et al. Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats. BMC Complement. Altern. Med. 9, 28 (2009
160. Rich, S. & Lam, W. Atrial septostomy as palliative therapy for refractory primary pulmonary hypertension. Am. J. Cardiol. 51, 1560-1561 (1983
161. Papaioannou, T. G. & Stefanadis, C. Basic principles of the intraaortic balloon pump and mechanisms affecting its performance. ASAIO J. 51, 296-300 (2005
162. Goldstein, J. A. & Kern, M. J. Percutaneous mechanical support for the failing right heart. Cardiol. Clin. 30, 303-310 (2012
163. Berman, M., Tsui, S., Vuylsteke, A., Klein, A. & Jenkins, D. P. Life-Threatening right ventricular failure in pulmonary hypertension: RVAD or ECMO? J. Heart Lung Transplant. 27, 1188-1189 (2008
164. Berman, M. et al. Successful extracorporeal membrane oxygenation support after pulmonary thromboendarterectomy. Ann. Thorac. Surg. 86, 1261-1267 (2008
165. Scherer, M., Sirat, A. S., Moritz, A. & Martens, S. Extracorporeal membrane oxygenation as perioperative right ventricular support in patients with biventricular failure undergoing left ventricular assist device implantation. Eur. J. Cardiothorac. Surg. 39, 939-944 (2011
166. Scherer, M., Moritz, A. & Martens, S. The use of extracorporeal membrane oxygenation in patients with therapy refractory cardiogenic shock as a bridge to implantable left ventricular assist device and perioperative right heart support. J. Artif. Organs 12, 160-165 (2009
167. Taghavi, S. et al. Extracorporeal membrane oxygenation is superior to
168. Moazami, N. et al. Mechanical support for isolated right ventricular failure in patients after cardiotomy. J. Heart Lung Transplant. 23, 1371-1375 (2004
169. Kaul, T. K. & Kahn, D. R. Postinfarct refractory right ventricle: Right ventricular exclusion. A possible option to mechanical cardiac support, in patients unsuitable for heart transplant. J. Cardiovasc. Surg. (Torino) 41, 349-355 (2000
170. Furukawa, K., Motomura, T. & Nosé, Y. Right ventricular failure after left ventricular assist device implantation: The need for an implantable right ventricular assist device. Artif. Organs 29, 369-377 (2005
171. Klima, U. et al. Severe right heart failure after heart transplantation. A single-center experience. Transpl. Int. 18, 326-332 (2005
172. Kormos, R. L. et al. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: Incidence, risk factors, and effect on outcomes. J. Thorac. Cardiovasc. Surg. 139, 1316-1324 (2010
173. Matthews, J. C., Koelling, T. M., Pagani, F. D. & Aaronson, K. D. The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates. J. Am. Coll. Cardiol. 51, 2163-2172 (2008
174. Fitzpatrick, J. R. 3rd et al. Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support. J. Heart Lung Transplant. 27, 1286-1292 (2008
175. Drakos, S. G. et al. Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am. J. Cardiol. 105, 1030-1035 (2010
176. Potapov, E. V. et al. Tricuspid incompetence and geometry of the right ventricle as predictors of right ventricular function after implantation of a left ventricular assist device. J. Heart Lung Transplant. 27, 1275-1281 (2008
177. Kukucka, M. et al. Right to left ventricular end-diastolic diameter ratio and prediction of right ventricular failure with continuous-flow left ventricular assist devices. J. Heart Lung Transplant. 30, 64-69 (2011
178. Grant, A. D., Smedira, N. G., Starling, R. C. & Marwick, T. H. Independent and incremental role of quantitative right ventricular evaluation for the prediction of right ventricular failure after left ventricular assist device implantation. J. Am. Coll. Cardiol. 60, 521-528 (2012
179. Fitzpatrick, J. R. 3rd et al. Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device. J. Thorac. Cardiovasc. Surg. 137, 971-977 (2009
180. Palardy, M. et al. Right ventricular dysfunction during intensive pharmacologic unloading persists after mechanical unloading. J. Card. Fail. 16, 218-224 (2010
181. Bhama, J. K. et al. Clinical experience using the Levitronix CentriMag system for temporary right ventricular mechanical circulatory support. J. Heart Lung Transplant. 28, 971-976 (2009
182. Takayama, H. et al. A novel approach to percutaneous right-ventricular mechanical support. Eur. J. Cardiothorac. Surg. 41, 423-426 (2012
183. McGee, E. C. Jr et al. Biventricular continuous flow VADs demonstrate diurnal flow variation and lead to end-organ recovery. Ann. Thorac. Surg. 92, e1-e3 (2011
184. Loebe, M. et al. Initial clinical experience of total cardiac replacement with dual HeartMate-II axial flow pumps for severe biventricular heart failure. Methodist Debakey Cardiovasc. J. 7, 40-44 (2011
185. Takagaki, M. et al. Successful conversion of TandemHeart left ventricular assist device to right ventricular assist device after implantation of a HeartMate XVE. Ann. Thorac. Surg. 86, 1677-1679 (2008
186. Giesler, G. M., Gomez, J. S., Letsou, G., Vooletich, M. & Smalling, R. W. Initial report of percutaneous right ventricular assist for right ventricular shock secondary to right ventricular infarction. Catheter. Cardiovasc. Interv. 68, 263-266 (2006
187. Prutkin, J. M., Strote, J. A. & Stout, K. K. Percutaneous right ventricular assist device as support for cardiogenic shock due to right ventricular infarction. J. Invasive Cardiol. 20, E215-E216 (2008
188. Copeland, J. G. et al. Cardiac replacement with a total artificial heart as a bridge to transplantation. N. Engl. J. Med. 351, 859-867 (2004
189. Kirsch, M. et al. Survival after biventricular mechanical circulatory support: Does the type of device matter? J. Heart Lung Transplant. 31, 501-508 (2012
190. Meyns, B. P. et al. Clinical benefits of partial circulatory support in New York Heart Association class IIIB and early class IV patients. Eur. J. Cardiothorac. Surg. 39, 693-698 (2011
191. Schmitto, J. D. et al. Two axial-flow Synergy Micro-pumps as a biventricular assist device in an ovine animal model. J. Heart Lung Transplant. 31, 1223-1229 (2012
192. Stehlik, J. et al. The Registry of the International Society for Heart and Lung Transplantation: 29th official adult heart transplant report-2012. J. Heart Lung Transplant. 31, 1052-1064 (2012
193. Christie, J. D. et al. The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. J. Heart Lung Transplant. 31, 1073-1086 (2012