Acute right ventricular failure in the setting of acute pulmonary embolism or chronic pulmonary hypertension: A detailed review of the pathophysiology, diagnosis, and management

Current Cardiology Reviews

Volumn 4, Issue 1, 2008, Pages 49-59

  Matthews, Jennifer Cowger ^a,b   McLaughlin, Vallerie ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Pulmonary embolism; Pulmonary hypertension; Right ventricular failure; Shock

Indexed keywords

AMBRISENTAN; AMIODARONE; ANTICOAGULANT AGENT; ANTITHROMBIN; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BOSENTAN; BRAIN NATRIURETIC PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN; DOBUTAMINE; DOPAMINE; ENDOTHELIN RECEPTOR ANTAGONIST; FIBRINOLYTIC AGENT; HYPERTENSIVE AGENT; MILRINONE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; ORAL CONTRACEPTIVE AGENT; OXYGEN; PHENYLEPHRINE; PLACEBO; PROSTACYCLIN; SEDATIVE AGENT; STREPTOKINASE; TISSUE PLASMINOGEN ACTIVATOR; TROPONIN; UNINDEXED DRUG; UROKINASE;

ARTIFICIAL VENTILATION; CARDIOVASCULAR RISK; CARDIOVERSION; CLINICAL TRIAL; CONTINUOUS INFUSION; DEFIBRILLATION; DIAGNOSTIC VALUE; DIARRHEA; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG FATALITY; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG SELECTIVITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ECG ABNORMALITY; ELECTROCARDIOGRAM; EMBOLECTOMY; FIBRINOLYTIC THERAPY; FLUID RESUSCITATION; HEART AFTERLOAD; HEART ARRHYTHMIA; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART PRELOAD; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE VOLUME; HEART SURGERY; HIGH RISK PATIENT; HORMONE SUBSTITUTION; HUMAN; HYPOXEMIA; IATROGENIC DISEASE; LUNG EMBOLISM; MORTALITY; MYALGIA; NAUSEA; PATHOPHYSIOLOGY; PERCUTANEOUS CORONARY INTERVENTION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROGNOSIS; PULMONARY HYPERTENSION; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEPSIS; SURVIVAL RATE; SWAN GANZ CATHETER; TACHYCARDIA; TRANSTHORACIC ECHOCARDIOGRAPHY;

EID: 48249149196     PISSN: 1573403X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340308783565384     Document Type: Review

References (60)

1. Fineberg MH, Wiggers CJ. Compensation and failure of the right ventricle. Am Heart J 1936; 11: 255-63.
2. Bristow MR, Zisman LS, Lowes BD, et al. The pressure-overloaded right ventricle in pulmonary hypertension. Chest 1998; 14: 101S-06S.
3. Mebazaa A, Karpati P, Renaud E, Algotsson L. Acute right ventricular failure- from pathophysiology to new treatments. Intensive Care Med 2004; 30: 185-96.
4. Chin KM, Kim N, Rubin LJ. The right ventricle in pulmonary hypertension. Coron Artery Dis 2005; 16: 13-18.
5. Stephanazzi J, Guidon-Attali C, Escarment J. Right ventricular function: physiological and pathophysiological features. Ann Fr Anesth Reanim 1997; 16: 165-86.
6. Vlahakes GJ, Turley K, Hoffman JI. The pathophysiology of failure in acute right ventricular hypertension: hemodynamic and biochemical correlations. Circulation 1981; 63: 87-95.
7. Redington AN, Gray JJ, Hodson ME, Rigby ML, Oldershaw PJ. Characterization of the normal right ventricular pressure-volume relation by biplane angiography and simultaneous micromanometer pressure measurements. Br Heart J 1988; 59: 23-30.
8. Redington AN, Rigby ML, Shinebourne EA, Oldershaw PJ. Changes in the pressurc-volume relation of the right ventricle when its loading conditions are modified. Br Heart J 1990; 63: 45-9.
9. Brooks H, Kirk ES, Vokonas PS, Urschel CW, Sonnenblick E. Performance of the right ventricle under stress: relation to right coronary flow. J Clin Invest 1971; 50: 2176-83.
10. Zehender M, Kasper W, Kauder E, et al. Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. N Engl J Med 1993; 328: 981-8.
11. Ignarro LJ. Haem-dep6endant activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signaling. Pharmacol Toxicol 1990; 67: 1-7.
12. Higenbottam TW, Laude EA. Endothelial dysfunction providing the basis for the treatment of pulmonary hypertension, Chest 1998; 114: 72S-9S.
13. Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 1975; 72: 2994-8.
14. Barst RJ, Rubin LJ, Long WA, et al. A comparison of continuous intravenous epoprostenol (Prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med 1996; 334: 296-301.
15. Stewart DJ, Levy RD, Cernacek P, Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease. Ann Intern Med 1991; 114: 464-9.
16. Cacoub P, Dorent T, Maistre G, et al. Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome. Am J Cardiol 1993; 71: 448-50.
17. Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomized placebo controlled study. Lancet 2001; 358: 1119-23.
18. Rubin LJ, Badesch DB, Barst RJ, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346: 896-903.
19. Rozkovec A, Mantanes P, Oakley CM. Factors that influence the outcome of primary pulmonary hypertension. Br Heart J 1986; 55: 449-58.
20. Rothman A, Sklansky MS, Lucas VW, et al. Atrial septostomy as a bridge to lung transplantation in patients with severe pulmonary hypertension. Am J Cardiol 1999; 84: 682-86.
21. Rich S, Dodin E, McLaughlin VV. Usefulness of atrial septostomy as a treatment for primary pulmonary hypertension and guidelines for its application. Am J Cardiol 1997; 80: 369-71.
22. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998; 158: 585-93.
23. Stein, PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital at autopsy. Chest 1995; 108: 978-81.
24. Rubinstein I, Murray D, Hoffstein V. Fatal pulmonary embolism in hospitalized patients. Arch Intern Med 1988; 148: 1425-6.
25. McIntyre KM, Sasahara AA. The hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. Am J Cardiol 1971-128: 288-94.
26. McIntyre KM, Sasahara AA. The ratio of pulmonary arterial pressure to pulmonary vascular obstruction: index of preembolic cardiopulmonary status. Chest 1977; 71: 692-7.
27. Douketis JD. Prognosis in pulmonary embolism. Curr Opin Pulm Med 2001; 7: 354-9.
28. Urokinase Pulmonary Embolism Trail. Phase 1 results: a cooperative study. JAMA 1970; 214: 2163-72.
29. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 1999; 353: 1386-9.
30. Alpert JS, Smith R, Carlson J, Ockene IS, Dexter L, Dalen JE. Mortality in patients treated for pulmonary embolism. JAMA 1976; 236: 1477-80.
31. Kasper W, Konstantinides S, Geibel A, et al. Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J Am Coll Cardiol 1997; 30: 1165-71.
32. Comess KA, DeRook FA, Russell ML, Tognazzi-Evans TA, Beach KW. The incidence of pulmonary embolism in unexplained sudden cardiac arrest with pulseless electrical activity. Am J Med 2000; 109: 351-6.
33. Kürkciyan I, Meron G, Sterz F, et al. Pulmonary embolism as cause of cardiac arrest. Arch Intern Med 2000; 160: 1529-35.
34. Kasper W, Konstantinidcs S, Geibel A, Tiede N, Krause T, Just H. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart 1997; 77: 346-9.
35. Wolde M, Söhne M, Quak E, Mac Gillavry M, Büller HR. Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism. Arch Intern Med 2004; 164: 1685-9.
36. Grifoni A, Olivotto I, Cecchini P, et al. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation 2000; 101: 2817-22.
37. Stein PD, Terrin ML, Hales CA, et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest 1991; 100: 598-603.
38. Tapson VF. Acute pulmonary embolism. Cardiol Clin 2004; 22: 353-65.
39. Yoshinaga T, Ikeda S, Nishimura E, et al. Serial changes in negative T wave on electrocardiogram in acute pulmonary thromboembolism. Int J Cardiol 1999; 72: 65-72.
40. Ferrari E, Imbert A, Chevalier T, Mihoubi A, Morand P, Baudouy M. The ECG in pulmonary embolism: predictive value of negative T waves in precordial leads. Chest 1997; 111: 537-43.
41. Kucher N, Walpoth N, Wustmann K, Noveanu M, Gertsch M. QR in V1- an ECG sign associated with right ventricular strain and adverse clinical outcome in pulmonary embolism. Eur Heart J 2003; 24: 1113-19.
42. Sallach JA, Sallach SM, Thomas JD, Garcia MJ, Hudson MP, McCord JK. Prognostic value of electrocardiographic abnormalities in patients with acute pulmonary embolism. Chest 2003; 124: 239S.
43. Giannitsis E, Müller-Bardorff M, Kurowski V, et al. Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism. Circulation 2000; 102: 211-17.
44. Douketis JD, Crowther MA, Stanton EB, Ginsberg JS. Elevated cardiac troponin levels in patients with submassive pulmonary embolism. Arch Intern Med 2002; 162: 79-81.
45. Punukollu G, Khan IA, Gowda RM, Lakhanpal G, Vasavada BC, Sacchi TJ. Cardiac troponin I release in acute pulmonary embolism in relation to duration of symptoms. Int J Cardiol 2005; 99: 207-11.
46. Pruszczyk P, Bochowicz A, Torbicki A, et al. Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism. Chest 2003; 123: 1947-52.
47. Wolde MT, Tulevski II, Mulder JW, et al. Brain natriuretic peptide as a predictor of adverse outcome in patients with pulmonary embolism. Circulation 2003; 107: 2082-84.
48. Kucher N, Printzen G, Goldhaber SZ. Prognostic role of brain natriuretic peptide in acute pulmonary embolism. Circulation 2003; 107: 2545-7.
49. Miller RL, Das S, Anandarangam T, et al. Association between right ventricular function and perfusion abnormalities in hemodynamically stable patients with acute pulmonary embolism. Chest 1998; 113: 665-70.
50. Wolfe MW, Lee RT, Feldstein ML, Parker JA, Come PC, Goldhaber SZ. Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J 1994; 127: 1371-5.
51. McConnell MV, Solomon SD, Rayan ME, et al. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol 1996; 78: 469-73.
52. Wood KE. Major pulmonary embolism: Review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002; 121: 877-905.
53. Vieillard-baron A, Qanadli SD, Antakly Y, et al. Transesophageal echocardiography for the diagnosis of pulmonary embolism with acute cor pulmonale: a comparison with radiologic procedures. Intensive Care Med 1998; 24: 429-33.
54. Pruszczyk P, Torbicki A, Pacho R, et al. Noninvasive diagnosis of suspected severe pulmonary embolism: transesophageal echocardiography vs. spiral CT. Chest 1997; 112: 722-8.
55. Arcasoy SM, Kreit JW. Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence. Chest 1999; 115: 1695-1707.
56. Diehl JL, Meyer G, Igual J, et al. Effectiveness and safety of bolus administration of alteplase in massive pulmonary embolism. Am J Cardiol 1992; 70: 1477-80.
57. Hamel E, Pacouret G, Vincentelli D. Thrombolysis or heparin therapy in massive pulmonary embolism with right ventricular dilation: results from 128 patient monocenter registry. Chest 2001; 120: 120-5.
58. Konstantinides S, Geibel A, Olschewski M, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation 1997; 96: 882-8.
59. Schmid CH, Zietlow ST, Wagner TO, Laas J, Borst HG. Fulminate pulmonary embolism: symptoms, diagnostics, operative techniques, and results. Ann Thorac Surg 1991; 52: 1102-7.
60. Stulz P, Schläpfer R, Feer R, Habicht J, Grädel E. Decision making in the surgical treatment of massive pulmonary embolism. Eur J Cardiothorac Surg 1994; 8: 188-93.