Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension

Circulation

Volumn 95, Issue 6, 1997, Pages 1479-1486

  Hinderliter, Alan L ^a   Willis IV, Park W ^a   Barst, Robyn J ^c   Rich, Stuart ^d   Rubin, Lewis J ^e   Badesch, David B ^f   Groves, Bertron M ^f   McGoon, Michael D ^g   Tapson, Victor F ^h   Bourge, Robert C ⁱ   Brundage, Bruce H ^j   Koerner, Spencer K ^k   Langleben, David ^l   Keller, Cesar A ^m   Murali, Srinivas ⁿ   Uretsky, Barry F ⁿ   Koch, Gary ^b   Li, Shu ^b   Clayton, Linda M ^o   Jöbsis, Maria M ^o   Blackburn Jr , Shelmer D ^o   Crow, James W ^p   Long, Walker A ^a   more..

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b IL   (United States)

^c University of Illinois at Chicago ^*  (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g MAYO CLINIC   (United States)

^h DUKE UNIVERSITY   (United States)

ⁱ UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^j HARBOR UCLA MEDICAL CENTER   (United States)

^k CEDARS SINAI MEDICAL CENTER   (United States)

^l MCGILL UNIVERSITY   (Canada)

^m BAYLOR COLLEGE OF MEDICINE   (United States)

ⁿ PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^o GLAXOSMITHKLINE   (United States)

^p CATO RESEARCH LTD   (United States)

more..

Author keywords

heart failure; hypertension; prostacyclin; pulmonary

Indexed keywords

PROSTACYCLIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; EXERCISE; FEMALE; HEART RIGHT VENTRICLE FAILURE; HEMODYNAMICS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERICARDIAL EFFUSION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE;

EID: 8244225826     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.6.1479     Document Type: Article

References (11)

1. Rich S, Dantzker DR, Ayres SM, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Koerner SK, Levy PC, Reid LM, Vreim CE, Williams GW. Primary pulmonary hypertension: a national prospective study. Ann Intern Med. 1987;107:216-223.
2. Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation. 1984;70:580-587.
3. Eysmann SB, Palevsky HI, Reichek N, Hackney K, Douglas PS. Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension. Circulation. 1989;80:353-360.
4. Louie EK, Rich S, Levitsky S, Brundage BH. Doppler echocardiographic assessment of impaired left ventricular filling in patients with right ventricular pressure overload due to primary pulmonary hypertension. J Am Coll Cardiol. 1986;8:1298-1306.
5. Rich S, Brundage BH. High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation. 1987;76:135-141.
6. Goodman DJ, Harrison DC, Popp RL. Echocardiographic features of primary pulmonary hypertension. Am J Cardiol. 1974;33:438-443.
7. D'Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT, Levy PS, Pietra GG, Reid LM, Reeves JT, Rich S, Vreim CE, Williams GW, Wu M. Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med. 1991;115:343-349.
8. Higenbottam T, Wells F, Wheeldon D, Wallwork J. Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet. 1984;1:1046-1047.
9. Rubin LJ, Mendoza J, Hood M, McGoon M, Barst R, Williams WB, Diehl JH, Crow J, Long W. Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol): results of a randomized trial. Ann Intern Med. 1990;112:485-491.
10. Barst RJ, Rubin LJ, McGoon MD, Caldwell EJ, Long WA, Levy PS. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med. 1994;121:409-415.
11. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, Koerner SK, Langleben D, Keller CA, Murali S, Uretsky BF, Clayton LM, Jöbsis MM, Blackburn SD, Shortino D, Crow JW, for the Primary Pulmonary Hypertension Study Group. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996;334:296-301.