Low-Dose Inhaled Nitric Oxide in Patients with Acute Lung Injury: A Randomized Controlled Trial

JAMA

Volumn 291, Issue 13, 2004, Pages 1603-1609

  Taylor, Robert W ^b   Zimmerman, Janice L ^c   Dellinger, R Phillip ^a   Straube, Richard C ^d   Criner, Gerard J ^e   Davis, Kenneth ^f   Kelly, Kathleen M ^g   Smith, Thomas C ^h   Small, Robert J ^d  

^a Department of Anesthesiology   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BEN TAUB GENERAL HOSPITAL   (United States)

^d INO Therapeutics Inc   (United States)

^e TEMPLE UNIVERSITY HOSPITAL   (United States)

^f UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^g Ortho Biotech ^*  (United States)

^h ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PLACEBO;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; ARTIFICIAL VENTILATION; BLOOD OXYGENATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EXTUBATION; FEMALE; HUMAN; LOW DRUG DOSE; LUNG INJURY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; POSITIVE END EXPIRATORY PRESSURE;

ADMINISTRATION, INHALATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; POSITIVE-PRESSURE RESPIRATION; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 1842433745     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.291.13.1603     Document Type: Article

References (31)

1. Frostell C, Fratacci MD, Wain JC, et al. Inhaled nitric oxide: a selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 1991;83:2038-2047.
2. Frostell CG, Blomqvist H, Hedenstiema G, et al. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology. 1993;78:427-435.
3. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med. 1997;336:597-604.
4. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med. 2000;342:469-474.
5. Rovfra I, Chen TY, Winkler M, et al. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol. 1994;76:345-355.
6. Putensen C, Räsänen J, Downs JB. Effect of endogenous and inhaled nitric oxide on ventilation-perfusion relationships in oleic-acid lung injury. Am J Respir Crit Care Med. 1994;150:330-336.
7. Zhu GF, Sun B, Niu SF, et al. Combined surfactant therapy and inhaled nitric oxide in rabbits with oleic acid-induced acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998;158:437-443.
8. Gust R, McCarthy TJ, Kozlowski J, et al. Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmonary blood flow prior to its administration. Am J Respir Crit Care Med. 1999;159:563-570.
9. Puybasset L, Stewart T, Rouby JJ, et al. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology. 1994;80:1254-1267.
10. Rossaint R, Gerlach H, Schmidt-Ruhnke H, et al. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest. 1995;107:1107-1115.
11. Krafft P, Fridrich P, Fitzgerald RD, et al. Effectiveness of nitric oxide inhalation in septic ARDS. Chest. 1996;109:486-493.
12. Papazian L, Bregeon F, Gaillat F, et al. Respective and combined effects of prone position and inhaled nitric oxide in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998;157:580-585.
13. Gallart L, Lu Q, Puybasset L, et al, for the NO Almitrine Study Group. Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998;158:1770-1777.
14. Gerlach H, Keh D, Semmerow A, et al. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 2003;167:1008-1015.
15. Lundin S, Westfelt UN, Stenqvist O, et al. Response to nitric oxide inhalation in early acute lung injury. Intensive Care Med. 1996;22:728-734.
16. Rossaint R, Falke KJ, Lopez F. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993;328:399-405.
17. Michael JR, Barton RG, Saffle JR, et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med. 1998;157:1372-1380.
18. Troncy E, Collet JP, Shapiro S, et al. Inhaled nitric oxide in acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998;157:1483-1488.
19. Dellinger RP, Zimmerrnan JL, Taylor RW, et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Crit Care Med. 1998;26:15-23.
20. Lundin S, Mang H, Smithies M, et al, for the European Study Group of Inhaled Nitric Oxide. Inhalation of nitric oxide in acute lung injury. Intensive Care Med. 1999;25:911-919.
21. Payen D, Vallet B, and Groupe d'Etude sur le NO inhale au cours de l'ARDS (GENOA). Results of the French prospective multicentric randomized double-blind placebo-controlled trial on inhaled nitric oxide (NO) in ARDS [abstract 645]. Intensive Care Med. 1999;25(suppl 1):S166.
22. Bernard GR, Artigas A, Brigham KL, et al. Report of the American-European Consensus Conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. J Crit Care. 1994;9:72-81.
23. Esteban A, Frutos F, Tobin MJ, et al, for the Spanish Lung Failure Collaborative Group. A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med. 1995;332:345-350.
24. Puybasset L, Rouby JJ, Mourgeon E, et al. Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure. Am J Respir Crit Care Med. 1995;152:318-328.
25. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.
26. Sokol J, Jacobs SE, Bohn D. Inhaled nitric oxide for acute hypoxic respiratory failure in children and adults: a meta-analysis. Anesth Analg. 2003;97:989-998.
27. Cornfield DN, Milla CE, Haddad IY, et al. Safety of inhaled nitric oxide after lung transplantation. J Heart Lung Transplant. 2003;22:903-907.
28. Meade MO, Granton IT, Matte-Martyn A, et al. A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med. 2003;167:1483-1489.
29. Gerlach H, Keh D, Semmerow A, et al. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome. Am J Respir Crit Care Med. 2003;167:1008-1015.
30. Kroncke KD, Fehsel K, Kolb-Bachofen V. Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where? Nitric Oxide. 1997;1:107-120.
31. Jean D, Maitre B, Tankovic J, et al. Beneficial effects of nitric oxide inhalation on pulmonary bacterial clearance. Crit Care Med. 2002;30:442-447.