Exploring polymeric micelles for improved delivery of anticancer agents: Recent developments in preclinical studies

Pharmaceutics

Volumn 5, Issue 1, 2013, Pages 201-219

  Tan, Chalet ^a   Wang, Yingzhe ^a   Fan, Wei ^a  

^a MERCER UNIVERSITY   (United States)

Author keywords

Block polymer; EPR effect; Pharmacokinetics; Targeted cancer therapy; Tumor targeting ligand

Indexed keywords

ANGIOPEPTIN; ANTINEOPLASTIC AGENT; AP PEPTIDE; BETA LAPACHONE; CAMPTOTHECIN; COPOLYMER; CRGD; DISTEAROYLPHOSPHATIDYLETHANOLAMINE; DOCETAXEL; DOXORUBICIN; DRUG CARRIER; FENRETINIDE; FIRTECAN; FOLIC ACID; IRINOTECAN; LEVO SP5; LYP 1; MACROGOL; OA02 PEPTIDE; PACLITAXEL; PLASMID DNA; POLY(BENZYL ASPARTATE); POLY(PROPYL OXIDE); POLYCAPROLACTONE; POLYLACTIDE; POLYMER; SMALL INTERFERING RNA; TANESPIMYCIN; TRANSFERRIN; UNCLASSIFIED DRUG;

BREAST CANCER; CERVICAL ADENOCARCINOMA; COLON CANCER; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; GENE TARGETING; GLIOBLASTOMA; GLIOMA; HYDROPHOBICITY; LUNG METASTASIS; MELANOMA; MICELLE; NONHUMAN; OVARY CANCER; REVIEW; STOMACH CANCER; UTERINE CERVIX CARCINOMA;

EID: 84875450519     PISSN: None     EISSN: 19994923     Source Type: Journal    
DOI: 10.3390/pharmaceutics5010201     Document Type: Review

References (63)

1. Gong, J.; Chen, M.; Zheng, Y.; Wang, S.; Wang, Y. Polymeric micelles drug delivery system in oncology. J. Control. Release 2012, 159, 312-323.
2. Maeda, H.; Nakamura, H.; Fang, J. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv. Drug Deliv. Rev. 2013, 65, 71-79.
3. Xu, S.; Olenyuk, B.Z.; Okamoto, C.T.; Hamm-Alvarez, S.F. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv. Drug Deliv. Rev. 2013, 65, 121-138.
4. Blanco, E.; Kessinger, C.W.; Sumer, B.D.; Gao, J. Multifunctional micellar nanomedicine for cancer therapy. Exp. Biol. Med. 2009, 234, 123-131.
5. Kwon, G.S.; Kataoka, K. Block copolymer micelles as long-circulating drug vehicles. Adv. Drug Deliv. Rev. 2012, 64, 237-245.
6. Torchilin, V.P. Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 2012, 64, 302-315.
7. Blanco, E.; Bey, E.A.; Khemtong, C.; Yang, S.G.; Setti-Guthi, J.; Chen, H.; Kessinger, C.W.; Carnevale, K.A.; Bornmann, W.G.; Boothman, D.A.; et al. β-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. Cancer Res. 2010, 70, 3896-3904.
8. Mu, C.F.; Balakrishnan, P.; Cui, F.D.; Yin, Y.M.; Lee, Y.B.; Choi, H.G.; Yong, C.S.; Chung, S.J.; Shim, C.K.; Kim, D.D. The effects of mixed MPEG-PLA/Pluronic® copolymer micelles on the bioavailability and multidrug resistance of docetaxel. Biomaterials 2010, 31, 2371-2379.
9. Tang, N.; Du, G.; Wang, N.; Liu, C.; Hang, H.; Liang, W. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. J. Natl. Cancer Inst. 2007, 99, 1004-1015.
10. Tong, S.W.; Xiang, B.; Dong, D.W.; Qi, X.R. Enhanced antitumor efficacy and decreased toxicity by self-associated docetaxel in phospholipid-based micelles. Int. J. Pharm. 2012, 434, 413-419.
11. Katragadda, U.; Fan, W.; Wang, Y.; Teng, Q.; Tan, C. Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: pharmacokinetics, efficacy and metabolomic analysis. PLoS One 2013, 8, e58619.
12. Kawano, K.; Watanabe, M.; Yamamoto, T.; Yokoyama, M.; Opanasopit, P.; Okano, T.; Maitani, Y. Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles. J. Control. Release 2006, 112, 329-332.
13. Okuda, T.; Kawakami, S.; Higuchi, Y.; Satoh, T.; Oka, Y.; Yokoyama, M.; Yamashita, F.; Hashida, M. Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles. Int. J. Pharm. 2009, 373, 100-106.
14. Zhang, L.; He, Y.; Ma, G.; Song, C.; Sun, H. Paclitaxel-loaded polymeric micelles based on poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) triblock copolymers: In vitro and in vivo evaluation. Nanomedicine 2012, 8, 925-934.
15. Peng, C.L.; Lai, P.S.; Lin, F.H.; Wu, S.Y.-H.; Shieh, M.J. Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles. Biomaterials 2009, 30, 3614-3625.
16. Zhang, W.; Shi, Y.; Chen, Y.; Hao, J.; Sha, X.; Fang, X. The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models. Biomaterials 2011, 32, 5934-5944.
17. Wang, Y.; Hao, J.; Li, Y.; Zhang, Z.; Sha, X.; Han, L.; Fang, X. Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors. Biomaterials 2012, 33, 4741-4751.
18. Jadhav, V.B.; Jun, Y.J.; Song, J.H.; Park, M.K.; Oh, J.H.; Chae, S.W.; Kim, I.S.; Choi, S.J.; Lee, H.J.; Sohn, Y.S. A novel micelle-encapsulated platinum (II) anticancer agent. J. Control. Release 2010, 147, 144-150.
19. Jun, Y.J.; Jadhav, V.B.; Min, J.H.; Cui, J.X.; Chae, S.W.; Choi, J.M.; Kim, I.S.; Choi, S.J.; Lee, H.J.; Sohn, Y.S. Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphile. Int. J. Pharm. 2012, 31, 374-380.
20. Ko, J.; Park, K.; Kim, Y.-S.; Kim, M.S.; Han, J.K.; Kim, K.; Park, R.-W.; Kim, I.-S.; Song, H.Y.; Lee, D.S.; et al. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy. J. Control. Release 2007, 123, 109-115.
21. Min, K.H.; Kim, J.-H.; Bae, S.M.; Shin, H.; Kim, M.S.; Park, S.; Lee, H.; Park, R.-W.; Kim, I.-S.; Kim, K.; et al. Tumoral acidic pH-responsive MPEG-poly(β-amino ester) polymeric micelles for cancer targeting therapy. J. Control. Release 2010, 144, 259-266.
22. Xiao, K.; Luo, J.; Fowler, W.L.; Li, Y.; Lee, J.S.; Xing, L.; Cheng, R.H.; Wang, L.; Lam, K.S. A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer. Biomaterials 2009, 30, 6006-6016.
23. Xiao, K.; Li, Y.; Luo, J.; Lee, J.S.; Xiao, W.; Gonik, A.M.; Agarwal, R.G.; Lam, K.S. PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma. J. Control. Release 2011, 155, 272-281.
24. Gao, Z.G.; Tian, L.; Hu, J.; Park, I.S.; Bae, Y.H. Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J. Control. Release 2011, 1521, 84-89.
25. Kim, D.; Gao, Z.G.; Lee, E.S.; Bae, Y.H. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Mol. Pharm. 2009, 6, 1353-1362.
26. Tsai, H.C.; Chang, W.H.; Lo, C.L.; Tsai, C.H.; Chang, C.H.; Ou, T.W.; Yen, T.C.; Hsiue, G.H. Graft and diblock copolymer multifunctional micelles for cancer chemotherapy and imaging. Biomaterials 2010, 31, 2293-2301.
27. Zhang, W.; Shi, Y.; Chen, Y.; Ye, J.; Sha, X.; Fang, X. Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors. Biomaterials 2011, 32, 2894-2906.
28. Syu, W.J.; Yu, H.P.; Hsu, C.Y.; Rajan, Y.C.; Hsu, Y.H.; Chang, Y.C.; Hsieh, W.Y.; Wang, C.H.; Lai, P.S. Improved photodynamic cancer treatment by folate-conjugated polymeric micelles in a KB xenografted animal model. Small 2012, 8, 2060-2069.
29. Zhang, P.; Hu, L.; Yin, Q.; Zhang, Z.; Feng, L.; Li, Y. Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation. J. Control. Release 2012, 159, 429-434.
30. Zhan, C.; Gu, B.; Xie, C.; Li, J.; Liu, Y.; Lu, W. Cyclic RGD conjugated poly (ethylene glycol)-co-poly (lactic acid) micelle enhances paclitaxel anti-glioblastoma effect. J. Control. Release 2010, 143, 136-142.
31. Zhao, B.J.; Ke, X.Y.; Huang, Y.; Chen, X.M.; Zhao, X.; Zhao, B.X.; Lu, W.L.; Lou, J.N.; Zhang, X.; Zhang, Q. The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats. J. Drug Target. 2011, 19, 382-390.
32. Ying, L.; Lei, Y.; Wagner, E.; Xie, C.; Lu, W.; Zhu, J.; Shen, J.; Wang, J.; Liu, M. Potent retro-inverso D-peptide for simultaneous targeting of angiogenic blood vasculature and tumor cells. Bioconjug. Chem. 2013, 24, 133-143.
33. Xiao, K.; Li, Y.; Lee, J.S.; Gonik, A.M.; Dong, T.; Fung, G.; Sanchez, E.; Xing, L.; Cheng, H.R.; Luo, J.; et al. "OA02" peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo. Cancer Res. 2012, 72, 2100-2110.
34. Sawant, R.R.; Torchilin, V.P. Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo. Int. J. Pharm. 2009, 31, 114-118.
35. Zheng, N.; Dai, W.; Du, W.; Zhang, H.; Lei, L.; Zhang, H.; Wang, X.; Wang, J.; Zhang, X.; Gao, J.; et al. A novel lanreotide-encoded micelle system targets paclitaxel to the tumors with overexpression of somatostatin receptors. Mol. Pharm. 2012, 9, 1175-1188.
36. Wang, Z.; Yu, Y.; Ma, J.; Zhang, H.; Zhang, H.; Wang, X.; Wang, J.; Zhang, X.; Zhang, Q. LyP-1 modification to enhance delivery of artemisinin or fluorescent probe loaded polymeric micelles to highly metastatic tumor and its lymphatics. Mol. Pharm. 2012, 9, 2646-2657.
37. Wu, X.L.; Kim, J.H.; Koo, H.; Bae, S.M.; Shin, H.; Kim, M.S.; Lee, B.H.; Park, R.W.; Kim, I.S.; Choi, K.; et al. Tumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy. Bioconjug. Chem. 2010, 21, 208-213.
38. Lu, Y.; Low, P.S. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv. Drug Deliv. Rev. 2012, 64, 342-352.
39. Daniels, T.R.; Bernabeu, E.; Rodríguez, J.A.; Patel, S.; Kozman, M.; Chiappetta, D.A.; Holler, E.; Ljubimova, J.Y.; Helguera, G.; Penichet, M.L. The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochim. Biophys. Acta 2012, 1820, 291-317.
40. Desgrosellier, J.S.; Cheresh, D.A. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 2010, 10, 9-22.
41. Curnis, F.; Arrigoni, G.; Sacchi, A.; Fischetti, L.; Arap, W.; Pasqualini, R.; Corti, A. Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells. Cancer Res. 2002, 62, 867-874.
42. Lee, T.Y.; Lin, C.T.; Kuo, S.Y.; Chang, D.K.; Wu, H.C. Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery. Cancer Res. 2007, 67, 10958-10965.
43. Bolhassani, A. Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer. Biochim. Biophys. Acta 2011, 1816, 232-246.
44. Sun, L.C.; Coy, D.H. Somatostatin receptor-targeted anti-cancer therapy. Curr. Drug Deliv. 2011, 8, 2-10.
45. Laakkonen, P.; Porkka, K.; Hoffman, J.A.; Ruoslahti, E. A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat. Med. 2002, 8, 751-755.
46. Leland, P.; Taguchi, J.; Husain, S.R.; Kreitman, R.J.; Pastan, I.; Puri, R.K. Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo. Mol. Med. 2000, 6, 165-178.
47. Van Nostrum, C.F. Covalently cross-linked amphiphilic block copolymer micelles. Soft Matter 2011, 7, 3246-3259.
48. Cheng, R.; Feng, F.; Meng, F.; Deng, C.; Feijen, J.; Zhong, Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J. Control. Release 2011, 152, 2-12.
49. Lee, S.Y.; Kim, S.; Tyler, J.Y.; Park, K.; Cheng, J.X. Blood-stable, tumor-adaptable disulfide bonded mPEG-(Cys)4-PDLLA micelles for chemotherapy. Biomaterials 2013, 34, 552-561.
50. Li, Y.; Xiao, K.; Luo, J.; Xiao, W.; Lee, J.S.; Gonik, A.M.; Kato, J.; Dong, T.A.; Lam, K.S. Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery. Biomaterials 2011, 32, 6633-6645.
51. Koo, A.N.; Min, K.H.; Lee, H.J.; Lee, S.U.; Kim, K.; Kwon, I.C.; Cho, S.H.; Jeong, S.Y.; Lee, S.C. Tumor accumulation and antitumor efficacy of docetaxel-loaded core-shell-corona micelles with shell-specific redox-responsive cross-links. Biomaterials 2012, 33, 1489-1499.
52. Talelli, M.; Iman, M.; Varkouhi, A.K.; Rijcken, C.J.; Schiffelers, R.M.; Etrych, T.; Ulbrich, K.; van Nostrum, C.F.; Lammers, T.; Storm, G.; et al. Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials 2010, 31, 7797-7804.
53. Fernandez, C.A.; Rice, K.G. Engineered nanoscaled polyplex gene delivery systems. Mol. Pharm. 2009, 6, 1277-1289.
54. Osada, K.; Christie, R.J.; Kataoka, K. Polymeric micelles from poly (ethylene glycol)-poly (amino acid) block copolymer for drug and gene delivery. J. R. Soc. Interface 2009, 6, S325-S339.
55. Lee, S.H.; Chung, B.H.; Park, T.G.; Nam, Y.S.; Mok, H. Small-interfering RNA (siRNA)-based functional micro-and nanostructures for efficient and selective gene silencing. Acc. Chem. Res. 2012, 45, 1014-1025.
56. Davidson, B.L.; McCray, P.B., Jr. Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 2011, 329-340.
57. Oba, M.; Vachutinsky, Y.; Miyata, K.; Kano, M.R.; Ikeda, S.; Nishiyama, N.; Itaka, K.; Miyazono, K.; Koyama, H.; Kataoka, K. Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharm. 2010, 7, 501-509.
58. Vachutinsky, Y.; Oba, M.; Miyata, K.; Hiki, S.; Kano, M.R.; Nishiyama, N.; Koyama, H.; Miyazono, K.; Kataoka, K. Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 2011, 149, 51-57.
59. Kumagai, M.; Shimoda, S.; Wakabayashi, R.; Kunisawa, Y.; Ishii, T.; Osada, K.; Itaka, K.; Nishiyama, N.; Kataoka, K.; Nakano, K. Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. J. Control. Release 2012, 2012, 542-551.
60. Christie, R.J.; Matsumoto, Y.; Miyata, K.; Nomoto, T.; Fukushima, S.; Osada, K.; Halnaut, J.; Pittella, F.; Kim, H.J.; Nishiyama, N.; et al. Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 2012, 6, 5174-5189.
61. Kim, S.H.; Jeong, J.H.; Lee, S.H.; Kim, S.W.; Park, T.G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 2008, 129, 107-116.
62. Mao, C.Q.; Du, J.Z.; Sun, T.M.; Yao, Y.D.; Zhang, P.Z.; Song, E.W.; Wang, J. A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy. Biomaterials 2011, 32, 3124-3133.
63. Sun, T.M.; Du, J.Z.; Yao, Y.D.; Mao, C.Q.; Dou, S.; Huang, S.Y.; Zhang, P.Z.; Leong, K.W.; Song, E.W.; Wang, J. Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression. ACS Nano 2011, 5, 1483-1494.