메뉴 건너뛰기




Volumn 159, Issue 3, 2012, Pages 312-323

Polymeric micelles drug delivery system in oncology

Author keywords

Clinical translation; Clinical trial; Drug delivery system; Oncology; Polymeric micelles; Preclinical study

Indexed keywords

CLINICAL TRANSLATION; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; POLYMERIC MICELLE; PRECLINICAL STUDIES;

EID: 84862804633     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.012     Document Type: Review
Times cited : (501)

References (120)
  • 1
    • 84862796495 scopus 로고    scopus 로고
    • http://www.fda.gov/Drugs/DevelopmentApprovalProcess/ HowDrugsareDevelopedandApproved/DrugandBiologicApprovalReports/ucm081690.htm
  • 2
    • 0036742053 scopus 로고    scopus 로고
    • Poor aqueous solubility - An industry wide problem in drug discovery
    • C. Lipinski Poor aqueous solubility - an industry wide problem in drug discovery Am. Pharm. Rev. 5 2002 82 85
    • (2002) Am. Pharm. Rev. , vol.5 , pp. 82-85
    • Lipinski, C.1
  • 3
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284
    • (2000) J. Control. Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 4
    • 79953048071 scopus 로고    scopus 로고
    • Tumor delivery of macromolecular drugs based on the EPR effect
    • V. Torchilin Tumor delivery of macromolecular drugs based on the EPR effect Adv. Drug Deliv. Rev. 63 2011 131 135
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 5
    • 68549126855 scopus 로고    scopus 로고
    • Block copolymer micelles for delivery of cancer therapy: Transport at the whole body, tissue and cellular levels
    • A.S. Mikhail, and C. Allen Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels J. Control. Release 138 2009 214 223
    • (2009) J. Control. Release , vol.138 , pp. 214-223
    • Mikhail, A.S.1    Allen, C.2
  • 8
    • 2542559832 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
    • T.Y. Kim, D.W. Kim, J.Y. Chung, S.G. Shin, S.C. Kim, D.S. Heo, N.K. Kim, and Y.J. Bang Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies Clin. Cancer Res. 10 2004 3708 3716
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3708-3716
    • Kim, T.Y.1    Kim, D.W.2    Chung, J.Y.3    Shin, S.G.4    Kim, S.C.5    Heo, D.S.6    Kim, N.K.7    Bang, Y.J.8
  • 9
    • 77949526367 scopus 로고    scopus 로고
    • Phase i pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol-PM) in patients with solid tumors
    • W.T. Lim, E.H. Tan, C.K. Toh, S.W. Hee, S.S. Leong, P.C. Ang, N.S. Wong, and B. Chowbay Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol-PM) in patients with solid tumors Ann. Oncol. 21 2010 382 388
    • (2010) Ann. Oncol. , vol.21 , pp. 382-388
    • Lim, W.T.1    Tan, E.H.2    Toh, C.K.3    Hee, S.W.4    Leong, S.S.5    Ang, P.C.6    Wong, N.S.7    Chowbay, B.8
  • 10
    • 39749178252 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer
    • K.S. Lee, H.C. Chung, S.A. Im, Y.H. Park, C.S. Kim, S.B. Kim, S.Y. Rha, M.Y. Lee, and J. Ro Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer Breast Cancer Res. Treat. 108 2008 241 250
    • (2008) Breast Cancer Res. Treat. , vol.108 , pp. 241-250
    • Lee, K.S.1    Chung, H.C.2    Im, S.A.3    Park, Y.H.4    Kim, C.S.5    Kim, S.B.6    Rha, S.Y.7    Lee, M.Y.8    Ro, J.9
  • 11
    • 37349080672 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer
    • D.W. Kim, S.Y. Kim, H.K. Kim, S.W. Kim, S.W. Shin, J.S. Kim, K. Park, M.Y. Lee, and D.S. Heo Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer Ann. Oncol. 18 2007 2009 2014
    • (2007) Ann. Oncol. , vol.18 , pp. 2009-2014
    • Kim, D.W.1    Kim, S.Y.2    Kim, H.K.3    Kim, S.W.4    Shin, S.W.5    Kim, J.S.6    Park, K.7    Lee, M.Y.8    Heo, D.S.9
  • 12
    • 42949162981 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM (GPM), a novel Cremophor-free, polymeric micelle formulation of paclitaxel in patients with advanced pancreatic cancer (APC): Final results
    • Abstr
    • M.W. Saif, M.S. Rubin, J.A. Figueroa, and R.O. Kerr Multicenter phase II trial of Genexol-PM (GPM), a novel Cremophor-free, polymeric micelle formulation of paclitaxel in patients with advanced pancreatic cancer (APC): Final results Gastrointestinal Cancers Symposium 2008 269 Abstr
    • (2008) Gastrointestinal Cancers Symposium , pp. 269
    • Saif, M.W.1    Rubin, M.S.2    Figueroa, J.A.3    Kerr, R.O.4
  • 13
    • 20944450473 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
    • T. Hamaguchi, Y. Matsumura, M. Suzuki, K. Shimizu, R. Goda, I. Nakamura, I. Nakatomi, M. Yokoyama, K. Kataoka, and T. Kakizoe NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel Br. J. Cancer 92 2005 1240 1246
    • (2005) Br. J. Cancer , vol.92 , pp. 1240-1246
    • Hamaguchi, T.1    Matsumura, Y.2    Suzuki, M.3    Shimizu, K.4    Goda, R.5    Nakamura, I.6    Nakatomi, I.7    Yokoyama, M.8    Kataoka, K.9    Kakizoe, T.10
  • 14
    • 33748289523 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel
    • T. Negishi, F. Koizumi, H. Uchino, J. Kuroda, T. Kawaguchi, S. Naito, and Y. Matsumura NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel Br. J. Cancer 95 2006 601 606
    • (2006) Br. J. Cancer , vol.95 , pp. 601-606
    • Negishi, T.1    Koizumi, F.2    Uchino, H.3    Kuroda, J.4    Kawaguchi, T.5    Naito, S.6    Matsumura, Y.7
  • 19
    • 84862825627 scopus 로고    scopus 로고
    • http://www.nanocarrier.co.jp/en/research/pipeline/03.html
  • 20
    • 33750549679 scopus 로고    scopus 로고
    • Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors
    • F. Koizumi, M. Kitagawa, T. Negishi, T. Onda, S. Matsumoto, T. Hamaguchi, and Y. Matsumura Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors Cancer Res. 66 2006 10048 10056
    • (2006) Cancer Res. , vol.66 , pp. 10048-10056
    • Koizumi, F.1    Kitagawa, M.2    Negishi, T.3    Onda, T.4    Matsumoto, S.5    Hamaguchi, T.6    Matsumura, Y.7
  • 25
    • 1942470679 scopus 로고    scopus 로고
    • Phase i dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer
    • S. Danson, D. Ferry, V. Alakhov, J. Margison, D. Kerr, D. Jowle, M. Brampton, G. Halbert, and M. Ranson Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer Br. J. Cancer 90 2004 2085 2091
    • (2004) Br. J. Cancer , vol.90 , pp. 2085-2091
    • Danson, S.1    Ferry, D.2    Alakhov, V.3    Margison, J.4    Kerr, D.5    Jowle, D.6    Brampton, M.7    Halbert, G.8    Ranson, M.9
  • 26
    • 84855921796 scopus 로고    scopus 로고
    • A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction
    • J. Valle, A. Armstrong, C. Newman, V. Alakhov, G. Pietrzynski, J. Brewer, S. Campbell, P. Corrie, E. Rowinsky, and M. Ranson A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction Invest. New Drugs 29 2010 1029 1037
    • (2010) Invest. New Drugs , vol.29 , pp. 1029-1037
    • Valle, J.1    Armstrong, A.2    Newman, C.3    Alakhov, V.4    Pietrzynski, G.5    Brewer, J.6    Campbell, S.7    Corrie, P.8    Rowinsky, E.9    Ranson, M.10
  • 27
    • 0027968083 scopus 로고
    • A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer
    • C.M. Spencer, D. Faulds, and Paclitaxel A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer Drugs 48 1994 794 847
    • (1994) Drugs , vol.48 , pp. 794-847
    • Spencer, C.M.1    Faulds, D.2    Paclitaxel3
  • 28
    • 0034880214 scopus 로고    scopus 로고
    • Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation
    • H. Gelderblom, J. Verweij, K. Nooter, and A. Sparreboom Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation Eur. J. Cancer 37 2001 1590 1598
    • (2001) Eur. J. Cancer , vol.37 , pp. 1590-1598
    • Gelderblom, H.1    Verweij, J.2    Nooter, K.3    Sparreboom, A.4
  • 29
    • 0037413394 scopus 로고    scopus 로고
    • An alternative paclitaxel microemulsion formulation: Hypersensitivity evaluation and pharmacokinetic profile
    • L. He, G.L. Wang, and Q. Zhang An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile Int. J. Pharm. 250 2003 45 50
    • (2003) Int. J. Pharm. , vol.250 , pp. 45-50
    • He, L.1    Wang, G.L.2    Zhang, Q.3
  • 30
    • 77954534436 scopus 로고    scopus 로고
    • Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery
    • R.R. Sawant, O.S. Vaze, K. Rockwell, and V.P. Torchilin Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery Eur. J. Pharm. Biopharm. 75 2010 321 326
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , pp. 321-326
    • Sawant, R.R.1    Vaze, O.S.2    Rockwell, K.3    Torchilin, V.P.4
  • 33
    • 67349143352 scopus 로고    scopus 로고
    • Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles
    • J. Gong, M. Huo, J. Zhou, Y. Zhang, X. Peng, D. Yu, H. Zhang, and J. Li Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles Int. J. Pharm. 376 2009 161 168
    • (2009) Int. J. Pharm. , vol.376 , pp. 161-168
    • Gong, J.1    Huo, M.2    Zhou, J.3    Zhang, Y.4    Peng, X.5    Yu, D.6    Zhang, H.7    Li, J.8
  • 34
    • 20344370984 scopus 로고    scopus 로고
    • Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in Cremophor (Taxol)
    • A. Sparreboom, C.D. Scripture, V. Trieu, P.J. Williams, T. De, A. Yang, B. Beals, W.D. Figg, M. Hawkins, and N. Desai Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in Cremophor (Taxol) Clin. Cancer Res. 11 2005 4136 4143
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4136-4143
    • Sparreboom, A.1    Scripture, C.D.2    Trieu, V.3    Williams, P.J.4    De, T.5    Yang, A.6    Beals, B.7    Figg, W.D.8    Hawkins, M.9    Desai, N.10
  • 35
    • 0029980834 scopus 로고    scopus 로고
    • Development of amphiphilic diblock copolymers as micellar carriers of taxol
    • X. Zhang, J.K. Jackson, and H.M. Burt Development of amphiphilic diblock copolymers as micellar carriers of taxol Int. J. Pharm. 132 1996 195 206
    • (1996) Int. J. Pharm. , vol.132 , pp. 195-206
    • Zhang, X.1    Jackson, J.K.2    Burt, H.M.3
  • 36
    • 0032828963 scopus 로고    scopus 로고
    • Development of copolymers of poly(D, L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
    • H.M. Burt, X. Zhang, P. Toleikis, L. Embree, and W.L. Hunter Development of copolymers of poly(D, L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel Colloids Surf., B 16 1999 161 171
    • (1999) Colloids Surf., B , vol.16 , pp. 161-171
    • Burt, H.M.1    Zhang, X.2    Toleikis, P.3    Embree, L.4    Hunter, W.L.5
  • 38
    • 44649136172 scopus 로고    scopus 로고
    • Fast Release of Lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo förster resonance energy transfer imaging
    • H. Chen, S. Kim, W. He, H. Wang, P.S. Low, K. Park, and J.-X. Cheng Fast Release of Lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo förster resonance energy transfer imaging Langmuir 24 2008 5213 5217
    • (2008) Langmuir , vol.24 , pp. 5213-5217
    • Chen, H.1    Kim, S.2    He, W.3    Wang, H.4    Low, P.S.5    Park, K.6    Cheng, J.-X.7
  • 43
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • W.J. Gradishar, S. Tjulandin, N. Davidson, H. Shaw, N. Desai, P. Bhar, M. Hawkins, and J. O'Shaughnessy Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer J. Clin. Oncol. 23 2005 7794 7803
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3    Shaw, H.4    Desai, N.5    Bhar, P.6    Hawkins, M.7    O'Shaughnessy, J.8
  • 44
    • 33747887418 scopus 로고    scopus 로고
    • Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer
    • M.R. Green, G.M. Manikhas, S. Orlov, B. Afanasyev, A.M. Makhson, P. Bhar, and M.J. Hawkins Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer Ann. Oncol. 17 2006 1263 1268
    • (2006) Ann. Oncol. , vol.17 , pp. 1263-1268
    • Green, M.R.1    Manikhas, G.M.2    Orlov, S.3    Afanasyev, B.4    Makhson, A.M.5    Bhar, P.6    Hawkins, M.J.7
  • 46
    • 0036167369 scopus 로고    scopus 로고
    • Biological basis for chemo-radiotherapy interactions
    • C. Hennequin, and V. Favaudon Biological basis for chemo-radiotherapy interactions Eur. J. Cancer 38 2002 223 230
    • (2002) Eur. J. Cancer , vol.38 , pp. 223-230
    • Hennequin, C.1    Favaudon, V.2
  • 47
    • 84864053366 scopus 로고    scopus 로고
    • Concomitant chemoradiotherapy using low-dose weekly gemcitabine versus low-dose weekly paclitaxel in locally advanced head and neck squamous cell carcinoma: A phase III study
    • doi:10.1007/s12032-010-9811-x doi
    • A.A. Halim, H.A. Wahba, H.A. El-Hadaad, and A. Abo-Elyazeed Concomitant chemoradiotherapy using low-dose weekly gemcitabine versus low-dose weekly paclitaxel in locally advanced head and neck squamous cell carcinoma: a phase III study Med. Oncol. 2011 doi: 10.1007/s12032-010-9811-x
    • (2011) Med. Oncol.
    • Halim, A.A.1    Wahba, H.A.2    El-Hadaad, H.A.3    Abo-Elyazeed, A.4
  • 49
    • 84862825628 scopus 로고    scopus 로고
    • http://www.nanocarrier.co.jp/en/company/history.html
  • 52
    • 0032803387 scopus 로고    scopus 로고
    • Preparation and Characterization of self-assembled polymer-metal complex micelle from cis-Dichlorodiammineplatinum(II) and Poly(ethylene glycol)-Poly(α, β-aspartic acid) block copolymer in an aqueous medium
    • N. Nishiyama, M. Yokoyama, T. Aoyagi, T. Okano, Y. Sakurai, and K. Kataoka Preparation and Characterization of self-assembled polymer-metal complex micelle from cis-Dichlorodiammineplatinum(II) and Poly(ethylene glycol)-Poly(α, β-aspartic acid) block copolymer in an aqueous medium Langmuir 15 1998 377 383
    • (1998) Langmuir , vol.15 , pp. 377-383
    • Nishiyama, N.1    Yokoyama, M.2    Aoyagi, T.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 53
    • 0037344002 scopus 로고    scopus 로고
    • Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles
    • N. Nishiyama, F. Koizumi, S. Okazaki, Y. Matsumura, K. Nishio, and K. Kataoka Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles Bioconjug. Chem. 14 2003 449 457
    • (2003) Bioconjug. Chem. , vol.14 , pp. 449-457
    • Nishiyama, N.1    Koizumi, F.2    Okazaki, S.3    Matsumura, Y.4    Nishio, K.5    Kataoka, K.6
  • 54
    • 0034867065 scopus 로고    scopus 로고
    • Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system
    • N. Nishiyama, Y. Kato, Y. Sugiyama, and K. Kataoka Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system Pharm. Res. 18 2001 1035 1041
    • (2001) Pharm. Res. , vol.18 , pp. 1035-1041
    • Nishiyama, N.1    Kato, Y.2    Sugiyama, Y.3    Kataoka, K.4
  • 56
    • 84862796491 scopus 로고    scopus 로고
    • http://www.nanocarrier.co.jp/en/news/topics/pdf/e20101013.pdf
  • 57
    • 10044271109 scopus 로고    scopus 로고
    • Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II) (DACHPt)-loaded polymeric micelles
    • H. Cabral, N. Nishiyama, S. Okazaki, H. Koyama, and K. Kataoka Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II) (DACHPt)-loaded polymeric micelles J. Control. Release 101 2005 223 232
    • (2005) J. Control. Release , vol.101 , pp. 223-232
    • Cabral, H.1    Nishiyama, N.2    Okazaki, S.3    Koyama, H.4    Kataoka, K.5
  • 58
    • 34547673162 scopus 로고    scopus 로고
    • Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity
    • H. Cabral, N. Nishiyama, and K. Kataoka Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity J. Control. Release 121 2007 146 155
    • (2007) J. Control. Release , vol.121 , pp. 146-155
    • Cabral, H.1    Nishiyama, N.2    Kataoka, K.3
  • 60
    • 43549107330 scopus 로고    scopus 로고
    • Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor
    • Y. Saito, M. Yasunaga, J. Kuroda, Y. Koga, and Y. Matsumura Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor Cancer Sci. 99 2008 1258 1264
    • (2008) Cancer Sci. , vol.99 , pp. 1258-1264
    • Saito, Y.1    Yasunaga, M.2    Kuroda, J.3    Koga, Y.4    Matsumura, Y.5
  • 61
    • 64249091937 scopus 로고    scopus 로고
    • Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma
    • J. Kuroda, J. Kuratsu, M. Yasunaga, Y. Koga, Y. Saito, and Y. Matsumura Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma Int. J. Cancer 124 2009 2505 2511
    • (2009) Int. J. Cancer , vol.124 , pp. 2505-2511
    • Kuroda, J.1    Kuratsu, J.2    Yasunaga, M.3    Koga, Y.4    Saito, Y.5    Matsumura, Y.6
  • 62
    • 77957599889 scopus 로고    scopus 로고
    • The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts
    • H. Kenmotsu, M. Yasunaga, K. Goto, T. Nagano, J. Kuroda, Y. Koga, A. Takahashi, Y. Nishiwaki, and Y. Matsumura The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts Cancer 116 2010 4597 4604
    • (2010) Cancer , vol.116 , pp. 4597-4604
    • Kenmotsu, H.1    Yasunaga, M.2    Goto, K.3    Nagano, T.4    Kuroda, J.5    Koga, Y.6    Takahashi, A.7    Nishiwaki, Y.8    Matsumura, Y.9
  • 63
    • 75149138953 scopus 로고    scopus 로고
    • Antitumour activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour
    • Y. Saito, M. Yasunaga, J. Kuroda, Y. Koga, and Y. Matsumura Antitumour activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour Eur. J. Cancer 46 2010 650 658
    • (2010) Eur. J. Cancer , vol.46 , pp. 650-658
    • Saito, Y.1    Yasunaga, M.2    Kuroda, J.3    Koga, Y.4    Matsumura, Y.5
  • 65
    • 67650360798 scopus 로고    scopus 로고
    • Antitumor activity of NK012 combined with cisplatin against small cell lung cancer and intestinal mucosal changes in tumor-bearing mouse after treatment
    • T. Nagano, M. Yasunaga, K. Goto, H. Kenmotsu, Y. Koga, J. Kuroda, Y. Nishimura, T. Sugino, Y. Nishiwaki, and Y. Matsumura Antitumor activity of NK012 combined with cisplatin against small cell lung cancer and intestinal mucosal changes in tumor-bearing mouse after treatment Clin. Cancer Res. 15 2009 4348 4355
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4348-4355
    • Nagano, T.1    Yasunaga, M.2    Goto, K.3    Kenmotsu, H.4    Koga, Y.5    Kuroda, J.6    Nishimura, Y.7    Sugino, T.8    Nishiwaki, Y.9    Matsumura, Y.10
  • 66
    • 77957592476 scopus 로고    scopus 로고
    • Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases
    • A. Takahashi, N. Ohkohchi, M. Yasunaga, J. Kuroda, Y. Koga, H. Kenmotsu, T. Kinoshita, and Y. Matsumura Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases Clin. Cancer Res. 16 2010 4822 4831
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4822-4831
    • Takahashi, A.1    Ohkohchi, N.2    Yasunaga, M.3    Kuroda, J.4    Koga, Y.5    Kenmotsu, H.6    Kinoshita, T.7    Matsumura, Y.8
  • 67
    • 40749107087 scopus 로고    scopus 로고
    • Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil
    • T.E. Nakajima, M. Yasunaga, Y. Kano, F. Koizumi, K. Kato, T. Hamaguchi, Y. Yamada, K. Shirao, Y. Shimada, and Y. Matsumura Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil Int. J. Cancer 122 2008 2148 2153
    • (2008) Int. J. Cancer , vol.122 , pp. 2148-2153
    • Nakajima, T.E.1    Yasunaga, M.2    Kano, Y.3    Koizumi, F.4    Kato, K.5    Hamaguchi, T.6    Yamada, Y.7    Shirao, K.8    Shimada, Y.9    Matsumura, Y.10
  • 72
    • 84862831872 scopus 로고    scopus 로고
    • http://clinicaltrialsfeeds.org/clinical-trials/results/term=nk012
  • 73
    • 0000428523 scopus 로고
    • Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. A new type of polymeric anticancer agent
    • M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, and Y. Sakurai Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. A new type of polymeric anticancer agent Die Makromol. Chem., Rapid Commun. 8 1987 431 435
    • (1987) Die Makromol. Chem., Rapid Commun. , vol.8 , pp. 431-435
    • Yokoyama, M.1    Inoue, S.2    Kataoka, K.3    Yui, N.4    Sakurai, Y.5
  • 74
    • 0025874282 scopus 로고
    • Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood
    • M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Shibazaki, and K. Kataoka Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood Cancer Res. 51 1991 3229 3236
    • (1991) Cancer Res. , vol.51 , pp. 3229-3236
    • Yokoyama, M.1    Okano, T.2    Sakurai, Y.3    Ekimoto, H.4    Shibazaki, C.5    Kataoka, K.6
  • 75
    • 0028346185 scopus 로고
    • Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates
    • G. Kwon, S. Suwa, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates J. Control. Release 29 1994 17 23
    • (1994) J. Control. Release , vol.29 , pp. 17-23
    • Kwon, G.1    Suwa, S.2    Yokoyama, M.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 76
    • 0028135121 scopus 로고
    • Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin
    • M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin J. Control. Release 32 1994 269 277
    • (1994) J. Control. Release , vol.32 , pp. 269-277
    • Yokoyama, M.1    Okano, T.2    Sakurai, Y.3    Kataoka, K.4
  • 77
    • 0032472352 scopus 로고    scopus 로고
    • Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor
    • M. Yokoyama, S. Fukushima, R. Uehara, K. Okamoto, K. Kataoka, Y. Sakurai, and T. Okano Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor J. Control. Release 50 1998 79 92
    • (1998) J. Control. Release , vol.50 , pp. 79-92
    • Yokoyama, M.1    Fukushima, S.2    Uehara, R.3    Okamoto, K.4    Kataoka, K.5    Sakurai, Y.6    Okano, T.7
  • 79
    • 0036807955 scopus 로고    scopus 로고
    • Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil)
    • Y. Tsukioka, Y. Matsumura, T. Hamaguchi, H. Koike, F. Moriyasu, and T. Kakizoe Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil) Jpn. J. Cancer Res. 93 2002 1145 1153
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 1145-1153
    • Tsukioka, Y.1    Matsumura, Y.2    Hamaguchi, T.3    Koike, H.4    Moriyasu, F.5    Kakizoe, T.6
  • 80
    • 33847256149 scopus 로고    scopus 로고
    • Phase 1 clinical study of pegylated liposomal doxorubicin (JNS002) in Japanese patients with solid tumors
    • Y. Fujisaka, A. Horiike, T. Shimizu, N. Yamamoto, Y. Yamada, and T. Tamura Phase 1 clinical study of pegylated liposomal doxorubicin (JNS002) in Japanese patients with solid tumors Jpn. J. Clin. Oncol. 36 2006 768 774
    • (2006) Jpn. J. Clin. Oncol. , vol.36 , pp. 768-774
    • Fujisaka, Y.1    Horiike, A.2    Shimizu, T.3    Yamamoto, N.4    Yamada, Y.5    Tamura, T.6
  • 83
    • 33646473367 scopus 로고    scopus 로고
    • A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or esophagus
    • M.H. Kulke, B. Wu, J.W. Clark, P.C. Enzinger, T.J. Lynch, M. Vincitore, A. Michelini, and C.S. Fuchs A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or esophagus Cancer Invest. 24 2006 229 234
    • (2006) Cancer Invest. , vol.24 , pp. 229-234
    • Kulke, M.H.1    Wu, B.2    Clark, J.W.3    Enzinger, P.C.4    Lynch, T.J.5    Vincitore, M.6    Michelini, A.7    Fuchs, C.S.8
  • 84
    • 79955622641 scopus 로고    scopus 로고
    • Nanomedicine for oral chemotherapy
    • S.S. Feng, L. Zhao, and J. Tang Nanomedicine for oral chemotherapy Nanomedicine 6 2011 407 410
    • (2011) Nanomedicine , vol.6 , pp. 407-410
    • Feng, S.S.1    Zhao, L.2    Tang, J.3
  • 85
    • 33846671748 scopus 로고    scopus 로고
    • New-concept chemotherapy by nanoparticles of biodegradable polymers: Where are we now?
    • S.S. Feng New-concept chemotherapy by nanoparticles of biodegradable polymers: where are we now? Nanomedicine 1 2006 297 309
    • (2006) Nanomedicine , vol.1 , pp. 297-309
    • Feng, S.S.1
  • 86
    • 79951769859 scopus 로고    scopus 로고
    • The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery
    • H.J. Yao, R.J. Ju, X.X. Wang, Y. Zhang, R.J. Li, Y. Yu, L. Zhang, and W.L. Lu The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery Biomaterials 32 2011 3285 3302
    • (2011) Biomaterials , vol.32 , pp. 3285-3302
    • Yao, H.J.1    Ju, R.J.2    Wang, X.X.3    Zhang, Y.4    Li, R.J.5    Yu, Y.6    Zhang, L.7    Lu, W.L.8
  • 88
    • 33344463203 scopus 로고    scopus 로고
    • Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
    • F. Mathot, L. van Beijsterveldt, V. Préat, M. Brewster, and A. Ariën Intestinal uptake and biodistribution of novel polymeric micelles after oral administration J. Control. Release 111 2006 47 55
    • (2006) J. Control. Release , vol.111 , pp. 47-55
    • Mathot, F.1    Van Beijsterveldt, L.2    Préat, V.3    Brewster, M.4    Ariën, A.5
  • 89
  • 91
    • 46749107462 scopus 로고    scopus 로고
    • In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy
    • Z. Zhang, S.H. Lee, C.W. Gan, and S.S. Feng In vitro and in vivo investigation on PLA-TPGS nanoparticles for controlled and sustained small molecule chemotherapy Pharm. Res. 25 2008 1925 1935
    • (2008) Pharm. Res. , vol.25 , pp. 1925-1935
    • Zhang, Z.1    Lee, S.H.2    Gan, C.W.3    Feng, S.S.4
  • 92
    • 0032714228 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)
    • J.M. Dintaman, and J.A. Silverman Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) Pharm. Res. 16 1999 1550 1556
    • (1999) Pharm. Res. , vol.16 , pp. 1550-1556
    • Dintaman, J.M.1    Silverman, J.A.2
  • 93
    • 0036849724 scopus 로고    scopus 로고
    • Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers
    • J. Zastre, J. Jackson, M. Bajwa, R. Liggins, F. Iqbal, and H. Burt Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by caco-2 cells using low molecular weight methoxypolyethylene glycol-block- polycaprolactone diblock copolymers Eur. J. Pharm. Biopharm. 54 2002 299 309
    • (2002) Eur. J. Pharm. Biopharm. , vol.54 , pp. 299-309
    • Zastre, J.1    Jackson, J.2    Bajwa, M.3    Liggins, R.4    Iqbal, F.5    Burt, H.6
  • 94
    • 33646367645 scopus 로고    scopus 로고
    • Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: Some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux
    • R.D. Dabholkar, R.M. Sawant, D.A. Mongayt, P.V. Devarajan, and V.P. Torchilin Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: Some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux Int. J. Pharm. 315 2006 148 157
    • (2006) Int. J. Pharm. , vol.315 , pp. 148-157
    • Dabholkar, R.D.1    Sawant, R.M.2    Mongayt, D.A.3    Devarajan, P.V.4    Torchilin, V.P.5
  • 95
    • 79956094659 scopus 로고    scopus 로고
    • Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
    • L. Xiao, X. Xiong, X. Sun, Y. Zhu, H. Yang, H. Chen, L. Gan, H. Xu, and X. Yang Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles Biomaterials 32 2011 5148 5157
    • (2011) Biomaterials , vol.32 , pp. 5148-5157
    • Xiao, L.1    Xiong, X.2    Sun, X.3    Zhu, Y.4    Yang, H.5    Chen, H.6    Gan, L.7    Xu, H.8    Yang, X.9
  • 96
    • 79955522520 scopus 로고    scopus 로고
    • The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles
    • R. Mo, X. Jin, N. Li, C. Ju, M. Sun, C. Zhang, and Q. Ping The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles Biomaterials 32 2011 4609 4620
    • (2011) Biomaterials , vol.32 , pp. 4609-4620
    • Mo, R.1    Jin, X.2    Li, N.3    Ju, C.4    Sun, M.5    Zhang, C.6    Ping, Q.7
  • 97
    • 77951538902 scopus 로고    scopus 로고
    • Combining HME & solubilization: Soluplus - The solid solution
    • H. Hardung, D. Djuric, and S. Ali Combining HME & solubilization: Soluplus - the solid solution Drug Deliv. Technol. 10 2010 20 27
    • (2010) Drug Deliv. Technol. , vol.10 , pp. 20-27
    • Hardung, H.1    Djuric, D.2    Ali, S.3
  • 98
  • 99
    • 84945509838 scopus 로고    scopus 로고
    • Hard to swallow
    • Hard to swallow Nature 448 2007 105 106
    • (2007) Nature , vol.448 , pp. 105-106
  • 103
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    • H. Maeda, G.Y. Bharate, and J. Daruwalla Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect Eur. J. Pharm. Biopharm. 71 2009 409 419
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 409-419
    • Maeda, H.1    Bharate, G.Y.2    Daruwalla, J.3
  • 104
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
    • H. Maeda Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjug. Chem. 21 2010 797 802
    • (2010) Bioconjug. Chem. , vol.21 , pp. 797-802
    • Maeda, H.1
  • 106
    • 0037732561 scopus 로고    scopus 로고
    • Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium
    • S. Tanaka, T. Akaike, J. Wu, J. Fang, T. Sawa, M. Ogawa, T. Beppu, and H. Maeda Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium J. Drug Target. 11 2003 45 52
    • (2003) J. Drug Target. , vol.11 , pp. 45-52
    • Tanaka, S.1    Akaike, T.2    Wu, J.3    Fang, J.4    Sawa, T.5    Ogawa, M.6    Beppu, T.7    Maeda, H.8
  • 107
    • 70649088695 scopus 로고    scopus 로고
    • Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
    • T. Seki, J. Fang, and H. Maeda Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application Cancer Sci. 100 2009 2426 2430
    • (2009) Cancer Sci. , vol.100 , pp. 2426-2430
    • Seki, T.1    Fang, J.2    Maeda, H.3
  • 108
    • 35348906219 scopus 로고    scopus 로고
    • MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin
    • G.Y. Lee, K. Park, S.Y. Kim, and Y. Byun MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin Eur. J. Pharm. Biopharm. 67 2007 646 654
    • (2007) Eur. J. Pharm. Biopharm. , vol.67 , pp. 646-654
    • Lee, G.Y.1    Park, K.2    Kim, S.Y.3    Byun, Y.4
  • 110
    • 77952468065 scopus 로고    scopus 로고
    • Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells
    • S.D. Funk, A. Yurdagul Jr., J.M. Green, K.A. Jhaveri, M.A. Schwartz, and A.W. Orr Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells Circ. Res. 106 2010 1394 1403
    • (2010) Circ. Res. , vol.106 , pp. 1394-1403
    • Funk, S.D.1    Yurdagul, Jr.A.2    Green, J.M.3    Jhaveri, K.A.4    Schwartz, M.A.5    Orr, A.W.6
  • 111
    • 33750324646 scopus 로고    scopus 로고
    • Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes
    • T. Ishida, M. Ichihara, X. Wang, and H. Kiwada Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes J. Control. Release 115 2006 243 250
    • (2006) J. Control. Release , vol.115 , pp. 243-250
    • Ishida, T.1    Ichihara, M.2    Wang, X.3    Kiwada, H.4
  • 112
    • 40849138014 scopus 로고    scopus 로고
    • Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
    • T. Ishida, and H. Kiwada Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes Int. J. Pharm. 354 2008 56 62
    • (2008) Int. J. Pharm. , vol.354 , pp. 56-62
    • Ishida, T.1    Kiwada, H.2
  • 113
    • 34248589255 scopus 로고    scopus 로고
    • Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes
    • X. Wang, T. Ishida, and H. Kiwada Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes J. Control. Release 119 2007 236 244
    • (2007) J. Control. Release , vol.119 , pp. 236-244
    • Wang, X.1    Ishida, T.2    Kiwada, H.3
  • 115
    • 77951086240 scopus 로고    scopus 로고
    • Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes
    • H. Xu, K.Q. Wang, Y.H. Deng, and W. Chen da Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes Biomaterials 31 2010 4757 4763
    • (2010) Biomaterials , vol.31 , pp. 4757-4763
    • Xu, H.1    Wang, K.Q.2    Deng, Y.H.3    Chen Da, W.4
  • 118
    • 18144423485 scopus 로고    scopus 로고
    • Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats
    • X.Y. Wang, T. Ishida, M. Ichihara, and H. Kiwada Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats J. Control. Release 104 2005 91 102
    • (2005) J. Control. Release , vol.104 , pp. 91-102
    • Wang, X.Y.1    Ishida, T.2    Ichihara, M.3    Kiwada, H.4
  • 119
    • 77949272712 scopus 로고    scopus 로고
    • Accelerated blood clearance was not induced for a gadolinium-containing PEG-poly(L-lysine)-based polymeric micelle in mice
    • H. Ma, K. Shiraishi, T. Minowa, K. Kawano, M. Yokoyama, Y. Hattori, and Y. Maitani Accelerated blood clearance was not induced for a gadolinium-containing PEG-poly(L-lysine)-based polymeric micelle in mice Pharm. Res. 27 2010 296 302
    • (2010) Pharm. Res. , vol.27 , pp. 296-302
    • Ma, H.1    Shiraishi, K.2    Minowa, T.3    Kawano, K.4    Yokoyama, M.5    Hattori, Y.6    Maitani, Y.7
  • 120
    • 38049019767 scopus 로고    scopus 로고
    • An open-label study to evaluate dose and cycle dependence of the pharmacokinetics of pegylated liposomal doxorubicin
    • A. Gabizon, R. Isacson, O. Rosengarten, D. Tzemach, H. Shmeeda, and R. Sapir An open-label study to evaluate dose and cycle dependence of the pharmacokinetics of pegylated liposomal doxorubicin Cancer Chemother. Pharmacol. 61 2008 695 702
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 695-702
    • Gabizon, A.1    Isacson, R.2    Rosengarten, O.3    Tzemach, D.4    Shmeeda, H.5    Sapir, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.