Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphile

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 374-380

  Jun, Yong Joo ^a   Jadhav, Vithal B ^a   Min, Jee Hyon ^a   Cui, Jin Xin ^a   Chae, Song Wha ^a   Choi, Jong Min ^a   Kim, In Sun ^b   Choi, Soo Jin ^b   Lee, Hwa Jeong ^a   Sohn, Youn Soo ^a  

^a Ewha Womans University   (South Korea)

^b Seoul Women University   (South Korea)

Author keywords

Anticancer drug; Cyclotriphosphazene; Docetaxel; Micelle; Taxane

Indexed keywords

AMPHOPHILE; COPOLYMER; CP 750; DOCETAXEL; POLYMER; SODIUM CHLORIDE; SOLVENT; TRIPODAL CYCLOTRIPHOSPHAZENE AMPHIPHILE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LD 50; LIGHT; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; MOUSE; NANOENCAPSULATION; NONHUMAN; OPTIMAL DRUG DOSE; PHARMACODYNAMICS; PHOTODEGRADATION; POLYMERIZATION; POWDER; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE; STOMACH CANCER; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; MICE, NUDE; MICELLES; PEPTIDES; PHOTOLYSIS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH NEOPLASMS; TAXOIDS; TECHNOLOGY, PHARMACEUTICAL; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84655164349     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.052     Document Type: Article

References (31)

1. M.-C. Bissery, D. Guenard, F. Gueritte-Voegelein, and F. Lavelle Experimental antitumor activity of Taxotere® (RP 56976, NSC 628503), a taxol analogue Cancer Res. 51 1991 4845 4852
2. M.C. Bissery, G. Nohynek, G.J. Sanderink, and F. Lavelle Docetaxel (Taxotere®): a review of preclinical and clinical experience. Part I: preclinical experience Anticancer Drugs 6 1995 339 355
3. M.G. Carstens, P.H.J.L.F. De Jong, C.F. Van Nostrum, J. Kemmink, R. Verrijk, L.G.J. deLeede, D.J.A. Crommelin, and W.E. Hennink The effect of core composition in biodegradable oligomeric micelles as taxane formulations Eur. J. Pharm. Biopharm. 68 2008 596 606 (Pubitemid 351318214)
4. S.J. Clarke, and L.P. Rivory Clinical pharmacokinetics of docetaxel Clin. Pharmacokinet. 36 1999 99 114 (Pubitemid 29121684)
5. R.V. Dev, J.M. Babu, K. Vyas, P.S. Ram, P. Ramachandra, N.M. Sekhar, D.N.M. Reddy, and N.S. Rao Isolation and characterization of impurities in docetaxel J. Pharmaceut. Biomed. 40 2006 614 622 (Pubitemid 43227385)
6. G. Gaucher, R.H. Marchessault, and J.-C. Leroux Polyester-based micelles for the parenteral delivery of taxanes J. Control. Release 143 2010 2 12
7. K. Gelmon The taxoids: paclitaxel and docetaxel Lancet 344 1994 1267 1272 (Pubitemid 24334685)
8. R. Haag, and F. Kratz Polymer therapeutics: concepts and applications Angew. Chem. Int. Ed. 45 2006 1198 1215 (Pubitemid 44097641)
9. K.L. Hennenfent, and R. Govindan Novel formulations of taxanes: a review. Oldwine in a new bottle? Ann. Oncol. 17 2006 735 749
10. T. Inoue, G. Chen, K. Nakamae, and A.S. Hoffman An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs J. Control. Release 51 1998 221 229 (Pubitemid 28252874)
11. V.B. Jadhav, Y.J. Jun, J.H. Song, M.K. Park, J.H. Oh, S.H. Chae, I.-S. Kim, S.-J. Choi, H.J. Lee, and Y.S. Sohn A novel micelle-encapsulated platinum anticancer agent J. Control. Release 147 2010 144 150
12. Y.J. Jun, U.S. Toti, H.Y. Kim, J.Y. Yu, B. Jeong, M.J. Jun, and Y.S. Sohn Thermoresponsive micelles from oligopeptide grafted cyclotriphosphazenes Angew. Chem. Int. Ed. 45 2006 6173 6176 (Pubitemid 44453067)
13. A.V. Kabanov, and T. Okano Challenges in polymer therapeutics H. Maeda, Polymer Drugs in the Clinical Stage 2003 Kluwer Academic/Plenum Publishers New York 1 27
14. L.A. Kraus, S.K. Samuel, S.M. Schmid, D.J. Dykes, W.R. Waud, and M.C. Bissery The mechanism of action of docetaxel (Taxotere®) in xenograft models is not limited to bcl-2 phosphorylation Invest. New Drugs 21 2003 259 268 (Pubitemid 37486328)
15. D. Kumar, R.S. Tomar, S.K. Deolia, M. Mitra, R. Mukherjee, and A.C. Burman Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation J. Pharmaceut. Biomed. 43 2007 1228 1235
16. D. Le Garrec, S. Gori, D. Karkan, L. Luo, D.G. Lessard, D. Smith, M. Ranger, M.-A. Yessine, and J.-C. Leroux Preparation, characterization, cytotoxicity and biodistribution of docetaxel loaded polymeric micelle formulations J. Drug Del. Sci. Technol. 15 2005 115 120 (Pubitemid 40477974)
17. S.B. Lee, S.-C. Song, J.-I. Jin, and Y.S. Sohn Thermosensitive cyclotriphosphazenes J. Am. Chem. Soc. 122 2000 8315 8316
18. E. Mahmoud, P. Marie-Eve, B. Nicolas, Y. Ga-Er, and L. Jean-Christophe Solubilization of docetaxel in poly(ethylene oxide)-block-poly(butylene/styrene oxide) micelles Biomacromolecules 8 2007 2250 2257
19. C.-F. Mu, P. Balakrishnan, F.-D. Cui, Y.-M. Yin, Y.-B. Lee, H.-G. Choi, C.S. Yong, S.-J. Chung, C.-K. Shim, and D.-D. Kim The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel Biomaterials 31 2010 2371 2379
20. B. Nuijen, M. Bouma, J.H. Schellens, and J.H. Beijnen Progress in the development of altenative pharmaceutical formulations of taxanes Invest. New Drugs 19 2001 143 153 (Pubitemid 32423719)
21. E. Persohn, A. Canta, S. Schoepfer, M. Traebert, L. Mueller, A. Gilardini, S. Galbiati, G. Nicolini, A. Scuteri, F. Lanzani, G. Giussani, and G. Cavaletti Morphological and morphometric analysis of paclitaxel and docetaxel-induced peripheral neuropathy in rats Eur. J. Cancer 41 2005 1460 1466 (Pubitemid 40826471)
22. N. Rapoport Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery Prog. Polym. Sci. 32 2007 962 990 (Pubitemid 47198285)
23. H.-C. Shin, A.W.G. Alani, D.A. Rao, N.C. Rockich, and G.S. Kwon Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs J. Control. Release 140 2009 294 300
24. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd New colorimetric cytotoxicity assay for anticancer-drug screening J. Natl. Cancer Inst. 82 1990 1107 1112 (Pubitemid 20213250)
25. Y.S. Sohn, and Y.J. Jun Polyphosphazenes for biomedical applications A.K. Andrianov, Poly- and Cyclotriphosphazenes as Drug Carriers for Anticancer Therapy 2009 A John Wiley & Sons New Jersey 249 275
26. R. Song, Y.J. Jun, J.I. Kim, C. Jin, and Y.S. Sohn Synthesis, characterization, and tumor selectivity of a polyphosphazene-platinum(II) conjugate J. Control. Release 105 2005 142 150 (Pubitemid 40805482)
27. V.P. Torchilin Structure and design of polymeric surfactant-based drug delivery systems J. Control. Release 73 2001 137 172 (Pubitemid 32544594)
28. U.S. Toti, S.H. Moon, H.Y. Kim, Y.J. Jun, B.M. Kim, Y.M. Park, B. Jeong, and Y.S. Sohn Thermosensitive and biocompatible cyclotriphosphazene micelles J. Control. Release 119 2007 34 40 (Pubitemid 46561538)
29. A.T. Van Oosterom, and D. Schrijvers Docetaxel (Taxotere®): a review of preclinical and clinical experience. Part II: clinical experience Anticancer Drugs 6 1995 356 368
30. L. Van Zuylen, J. Verweij, and A. Sparreboom Role of formulation vehicles in taxane pharmacology Invest. New Drugs 19 2001 125 141 (Pubitemid 32423718)
31. J.Z. Xu, S.H. Moon, B. Jeong, and Y.S. Sohn Thermosensitive micelles from PEGylated oligopeptides Polymer 48 2007 3673 3678 (Pubitemid 46856548)