A novel lanreotide-encoded micelle system targets paclitaxel to the tumors with overexpression of somatostatin receptors

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1175-1188

  Zheng, Nan ^a   Dai, Wenbing ^a   Du, Wenwen ^a   Zhang, Haoran ^a   Lei, Liandi ^a   Zhang, Hua ^a   Wang, Xueqing ^a   Wang, Jiancheng ^a   Zhang, Xuan ^a   Gao, Jinming ^b   Zhang, Qiang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

active targeting micelles; antitumor efficacy; distribution in tumor; lanreotide; paclitaxel; receptor mediated cellular uptake; somatostatin receptors; toxicity

Indexed keywords

ANGIOPEPTIN; MACROGOL; PACLITAXEL; POLYCAPROLACTONE; SOMATOSTATIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; ENCAPSULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; LUNG CANCER; MALE; MICELLE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED BALB C; MICELLES; MICROSCOPY, CONFOCAL; PACLITAXEL; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84860783713     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200464x     Document Type: Article

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