An insight on genistein as potential pharmacological and therapeutic agent

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 3 SUPPL., 2012, Pages

  Rahman, Shahedur ^a   Islam, Rezuanul ^b   Swaraz, A M ^a   Ansari, Anesa ^a   Parvez, Anowar Khasru ^c   Paul, Depak Kumar ^b  

^a JASHORE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Bangladesh)

^b ISLAMIC UNIVERSITY   (Bangladesh)

^c JAHANGIRNAGAR UNIVERSITY   (Bangladesh)

Author keywords

Genistein; Osteoclast; Phytoestrogens; Reproductive system

Indexed keywords

BIOFLAVONOID; CARMUSTINE; CASEIN PHOSPHOPEPTIDE; CATECHIN; CISPLATIN; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; ESTRADIOL; FLUOROURACIL; GEMCITABINE; GENISTEIN; GLUCOSE; LIPOPROTEIN LIPASE; OSTEOPROTEGERIN; PERIFOSINE; PHOSPHOPEPTIDE; PROGESTERONE; QUERCETIN; TAMOXIFEN; THEARUBIGIN; TIAZOFURIN; UNCLASSIFIED DRUG; ZINC;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTHMA; BONE METABOLISM; BREAST CARCINOMA; CANCER INHIBITION; CARDIAC GRAFT REJECTION; CELL ADHESION; CHEMOPROPHYLAXIS; CYSTIC FIBROSIS; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; DERMATITIS; DIET THERAPY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; GLUCOSE TRANSPORT; HORMONAL REGULATION; HORMONE SYNTHESIS; HOST RESISTANCE; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFERTILITY; LIPOGENESIS; LOW DRUG DOSE; LYMPHOCYTE PROLIFERATION; NATURAL KILLER T CELL; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPENIA; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROSTATE CARCINOMA; SANFILIPPO SYNDROME;

RATTUS;

EID: 84875394994     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(12)60522-X     Document Type: Article

References (141)

1. Rusin A, Krawczyk Z, Grynkiewicz G, Gogler A, Zawisza-Puchałka J, Szeja W Synthetic derivatives of genistein, their properties and possible applications. Acta Biochimica Polonica 2010, 57:23-34.
2. Veitch NC Isoflavonoids of the leguminosae. Nat Prod Rep 2007, 24:417-464.
3. Eustache F, Mondon F, Canivenc-Lavier MC, Lesaffre C, Fulla Y, Berges R, Cravedi JP, Vaiman D, Auger J, Chan WH Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility. Environ Health Perspect 2009, 117:1272-1279.
4. Banerjee S, LI Y, Wang Z, Sarkar FH Multi-targeted therapy of cancer by genistein. Cancer Lett 2008, 269(2):226-242.
5. Pavese JM, Farmer RL, Bergan RC Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev 2010, 29:465-482.
6. Yamaguchi M Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis. Yakugaku Zasshi 2006, 126(11):1117-1137.
7. Setchell KDR, Lydeking-Olsen E Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 2003, 78:593S-609S.
8. Sugimoto E, Yamaguchi M Anabolic effect of genistein in osteoblastic MC3T3-E1 cells. Int J Mol Med 2000, 5:515-520.
9. Onyia JE, Galvin RJS, Ma YL, Halladay DL, Miles RR, Yang X, Fuson T, Cain RL, Zeng QQ, Chandrasekhar S, Emkey R, Xu Y, Thirunavukkarasu K, Bryant HU, Martin TJ Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption. The Journal of Pharmacology and Experimental Therapeutics 2004, 309:369-379.
10. Pei J, Gao Y, Li B, Zhou L, Zhang Z, Suna D Effect of fluoride on osteoclast formation at various levels of receptor activator of nuclear factor kappa-b ligand (RANKL). Research report Fluoride 2012, 45(2):86-93.
11. Viereck V, Grundker C, Blaschke S, Siggelkow S, Emons G, Hofbauer L Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts. J Cell Biochem 2002, 84:725-735.
12. Yamaguchi M β-Cryptoxanthin and bone metabolism: The preventive role in osteoporosis. Journal of Health Science 2008, 54(4):356-369.
13. Garimella R, Tague SE, Zhang J, Belibi F, Nahar N, Sun BH, Insogna K, Wang J, Anderson HC Expression and synthesis of bone morphogenetic proteins by osteoclasts: A possible path to anabolic bone remodeling. Journal of Histochemistry & Cytochemistry 2008, 56(6):569-577.
14. Yamaguchi M Isoflavone and bone metabolism: its cellular mechanism and preventive role in bone loss. Journal of Health Science 2002, 48(3):209-222.
15. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D'anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Uadrito F Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study. Journal of Bone and Mineral Research 2002, 17(10):1904-1912.
16. Okamoto F, Okabe K, Kajiya H Genistein, a soybean isoflavone, inhibits inward rectifier K+ channels in rat osteoclasts. Jpn J Physiol 2001, 51:501-509.
17. Gao YH, Yamaguchi M Suppressive effect of genistein on rat bone osteoclasts: involvement of protein kinase inhibition and protein tyrosine phosphatase activation. Int J Mol Med 2000, 5:261-267.
18. Blair HC, Jordan SE, Peterson TG, Barnes S Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. J Cell Biochem 1996, 61:629-637.
19. Yamaguchi M, Gao YH, Ma ZJ Synergistic effect of genistein and zinc on bone components in the femoral-metaphyseal tissues of female rats. J Bone Miner Metab 2000, 18(2):77-83.
20. Ma ZJ, Yamaguchi M Synergistic effect of genistein and casein phosphopeptides on bone components in young and elderly female rats. J. Health Sci 2000, 46:474-479.
21. Sakai T, Kogiso M Soy isoflavones and immunity. J Med Invest 2008, 55(3-4):167-173.
22. Cooke PS, Selvaraj V, Yellayi S Genistein, estrogen receptors, and the acquired immune response. The Journal of Nutrition 2006, 136(3):704-708.
23. Yellayi S, Naaz A, Szewczykowski MA, Sato T, Woods JA, Chang J, Segre M, Allred CD, Helferich WG, Cooke PS The phytoestrogen genistein induces thymic and immune changes: a human health concern. Proc Natl Acad Sci USA 2002, 99:7616-7621.
24. Yellayi S, Szewczykowski MA, Selvaraj V, Valli VE, Ghanta V, Helferich WG, Cooke PS The phytoestrogen genistein suppresses cell - mediated immunity in mice. J Endocrinol 2003, 176:267-274.
25. Kogiso M, Sakai T, Mitsuya K, Komatsu T, Yamamoto S Genistein suppresses antigen -specific immue responses through competition with 17β - estradiol for estrogen receptors in ovalbumin- immunized BALB/c mice. Nutrition 2006, 22:802-809.
26. Sakai T, Kogiso M, Mitsuya K, Komatsu T, Yamamoto S Genistein enhances antigen - specific cytokine production in female DO11.10 transgenic mice. J Nutr Sci Vitaminol 2006, 52:327-332.
27. Guo TL, McCay JN, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6CF1 mice. J Nutr 2001, 131:3251-3258.
28. Santell RC, Kieu N, Helferich WG Genistein inhibits growth of estrogen - independent human breast cancer cells in culture but not in athymic mice. J Nutr 2000, 1665-1669.
29. Sakai T, Ire AV, Matoba T, Yamamoto S Dietary trans fatty acids suppress the development of spontaneous atopic-like dermatitis in NC/Nga mice. J Nutr Sci Vitaminol 2009, 55(5):412-416.
30. Duan W, Kuo IC, Selvarajan S, Chua KY, Bay BH, Wong WSF Anti - inflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma. Am J Respir Crit Care Med 2003, 167:185-192.
31. Salem ML, Matsuzaki G, Kishihara K, Madkour GA, Nomoto K β-Estradiol suppresses T cell -mediated delayed - type hypersensitivity through suppression of antigen - presenting cell function and Th1 induction. Int Arch Allergy Immunol 2000, 121:161-169.
32. Jansson L, Holmdahl R Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage. Arth Rheum 2001, 44:2168-2175.
33. Ito A, Bebo BF, Matejuk A, Zamora A, Silverman M, Fyfe - Johnson A, Offner H Estrogen treatment down- regulates TNF- α production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice. J Immunol 2001, 167:542-552.
34. Wong WSF, Leong KP Tyrosine kinase inhibitors: a new approach for asthma. Biochem Biophys Acta 2004, 1697(1-2):53-69.
35. Curran EM, Judy BM, Newton LG, Lubahn DB, Rottinghaus GE, Macdonald RS, Franklin C, Estes DM Dietary soy phytoestrogens and ERalpha signalling modulate interferon gamma production in response to bacterial infection. Clin Exp Immunol 2004, 135:219-225.
36. Calemine J, Zalenka J, Karpuzoglu-Sahin E, Ward DL, Lengi A, Ahmed SA The immune system of geriatric mice is modulated by estrogenic endocrine disruptors (diethylstilbestrol, alpha-zearalanol, and genistein): effects on interferongamma. Toxicology 2003, 194:115-1128.
37. O'Connor TP, Liesen DA, Mann PC, Rolando L, Banz WJ A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts. J Nutr 2002, 132:2283-2287.
38. Harp JB New insights into inhibitors of adipogenesis. Curr Opin Lipidol 2004, 15:303-307.
39. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ The biology of white adipocyte proliferation. Obes Rev 2001, 2:239-254.
40. Anderson LA, Philip GM The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site. J Clin Endocrinol Metab 2001, 86:5045-5051.
41. Misso ML, Murata Y, Boon WC, Jones ME, Britt KL, Simpson ER Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse. Endocrinology 2003, 144:1474-1480.
42. Naaz A, Yellayi S, Zakroczymski MA, Bunick D, Doerge DR, Lubahn DB, Helferich WG, Cooke PS The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 2003, 144:3315-3320.
43. Heim M, Frank O, Kampmann G, Sochocky N, Pennimpede T, Fuchs P, Hunziker W, Weber P, Martin I, Bendik I The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004, 145:848-859.
44. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003, 113:159-170.
45. Rosen ED The transcriptional basis of adipocyte development. Prostaglandins Leukot Essent Fatty Acids 2005, 73:31-34.
46. Nuttall ME, Gimble JM Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?. Bone 2000, 27:177-184.
47. Kim S, Shin HJ, Kim SY, Kim JH, Lee YS, Kim DH, Lee MO Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol 2004, 220:51-58.
48. Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Lowik CW Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein. J Biol Chem 2003, 278:962-967.
49. Shen P, Liu MH, Ng TY, Chan YH, Yong EL Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 2006, 136:899-905.
50. Harmon AW, Patel YM, Harp JB Genistein inhibits CCAAT/enhancer- binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression. Biochem J 2002, 367:203-208.
51. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM Transcriptional regulation of adipogenesis. Genes Dev 2000, 14:1293-1307.
52. Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 2003, 133:1238-1243.
53. Khan E, Bu-Amer Y Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. J Lab Clin Med 2003, 142:29-34.
54. Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, Brandi ML, Onso-Magdalena P, Nadal A, Ottobrini L, Parolini O, Bignotti E, Calza S, Maggi A, Grigolato PG, Di LD Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner. Endocrinology 2006, 147:5740-5751.
55. Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, Ha J, Park OJ Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 2005, 338:694-699.
56. Szkudelska K, Nogowski L, Szkudelski T Genistein affects lipogenesis and lipolysis in isolated rat adipocytes. J Steroid Biochem Mol Biol 2000, 75:265-271.
57. Bazuine M, van den Broek PJ, Maassen JA Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2005, 326:511-514.
58. Kim HK, Nelson-Dooley C, La-Fera MA, Yang JY, Zhang W, Duan J, Hartzell DL, Hamrick MW, Baile CA Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr 2006, 136:409-414.
59. Chodon D, Ramamurty N, Sakthisekaran D Preliminary studies on induction of apoptosis by genistein on HepG2 cell line. Toxicol In Vitro 2007, 21:887-891.
60. Po LS, Wang TT, Chen ZY, Leung LK Genistein-induced apoptosis in MCF-7 cells involves changes in Bak and Bcl-x without evidence of anti-oestrogenic effects. Br J Nutr 2002, 88:463-469.
61. Gullicksen PS, Hausman DB, Dean RG, Hartzell DL, Baile CA Adipose tissue cellularity and apoptosis after intracerebroventricular injections of leptin and 21 days of recovery in rats. Int J Obes Relat Metab Disord 2003, 27:302-312.
62. Kim S, Sohn I, Lee YS, Lee YS Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity. J Nutr 2005, 135:33-41.
63. Lee YM, Choi JS, Kim MH, Jung MH, Lee YS, Song J Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition 2006, 22:956-964.
64. Yang JY, Lee SJ, Park HW, Cha YS Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food 2006, 9:459-467.
65. Borradaile NM, de Dreu LE, Wilcox LJ, Edwards JY, Huff MW Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochem J 2002, 366:531-539.
66. Owen AJ, Roach PD, Abbey M Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model. Ann Nutr Metab 2004, 48:269-275.
67. Mullen E, Brown RM, Osborne TF, Shay NF Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBPregulated genes in HepG2 cells. J Nutr 2004, 134:2942-2947.
68. Slikker W, Scallet AC, Doerge DR, Ferguson SA Gender-based differences in rats after chronic dietary exposure to genistein. Int J Toxicol 2001, 20:175-179.
69. Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001, 131:2957-2962.
70. Davis J, Higginbotham A, O'Connor T, Moustaid-Moussa N, Tebbe A, Kim YC, Cho KW, Shay N, Adler S, Peterson R, Banz W Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat. Ann Nutr Metab 2007, 51:42-52.
71. Michael MR, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J Acute, subchronic and chronic safety studies with genistein in rats. Food Chem Toxicol 2006, 44:56-80.
72. Orgaard A, Jensen L The effects of soy isoflavones on obesity. Exp Biol Med 2008, 233:1066-1080.
73. Bhathena SJ, Velasquez MT Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr December 2002, 76(6):1191-1201.
74. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem 2001, 276:2520-2529.
75. Bhathena SJ, Velasquez MT Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 2002, 76:1191-1201.
76. Dusza L, Ciereszko R, Skarzyński DJ, Nogowski L, Opałka M, Kamińska B, Nynca A, Kraszewska O, Słomczyńska M, Woclawek-Potocka I, Korzekwa A, Pruszyńska-Oszmałek E, Szkudelska K Mechanism of phytoestrogen action in reproductive processes of mammals and birds. Reproductive Biology 2006, 1:151-174.
77. Nynca A, Ciereszko RE Effect of genistein on steroidogenic response of granulosa cell populations from porcine preovulatory follicles. Reproductive Biology 2006, 6:31-50.
78. Whitehead SA, Cross JE, Burden C, Lacey M Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells. Human Reproduction 2002, 17:589-594.
79. Ciereszko R, Opałka M, Kamińska B, Górska T, Dusza L Prolactin signaling in porcine theca cells: involvement of protein kinases and phosphatases. Reproduction. Fertility and Development 2003, 15:27-35.
80. Nynca A, Kraszewska O, Słomczynska M, Ciereszko R. Phytoestrogens action in granulosa cells derived from small ovarian follicles in pigs: steroidogenesis, proliferation and expression of estrogen receptors. The 4th Symposium of the Society for Biology of Reproduction and Joint Polish-Japanese Seminar 2005; 22-24 September, Kraków, Poland, p.129.
81. Harrison RM, Philippi PP, Kenneth FS, Henson MS Effect of genistein on steroid hormone production in the pregnant rhesus monkey. Proceedings of the Society for Experimental Biology and Medicine 1999, 222:78-84.
82. Hughes CL, Liu G, Beall S, Foster WG, Davis V Effects of genistein or soy milk during late gestation and lactation on adult uterine organization in the rat. Proceedings of the Society for Experimental Biology and Medicine 2004, 229:108-117.
83. Nogowski L, Szkudelska K, Szkudelski T, Pruszyńska-Oszmałek E The effect of phytoestrogen - genistein on hormonal and metabolic status of pregnant rats. Journal of Animal and Feed Sciences 2006, 15:275-286.
84. Ohno S, Nakajima Y, Inoue K, Nakazawa H, Nakajin S Genistein administration decreases serum corticosterone and testosterone levels in rats. Life Sciences 2003, 74:733-742.
85. Wisniewski AB, Klein SL, Lakshmanan Y, Gearhart JP Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats. Journal of Urology 2003, 169:1582-1586.
86. Delclos KB, Bucci TJ, Lomax LG, Latendresse JR, Warbritton A, Weis CC, Newbold RR Effect of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats. Reproductive Toxicology 2001, 15:647-663.
87. Nagao T, Yoshimura S, Saito Y, Nakagomi M, Usumi K, Ono H Reproductive effects in male and female rats of neonatal exposure to genistein. Reproductive Toxicology 2001, 15:399-411.
88. Opałka M, Kamińska B, Piskuła MK, Puchajda-Skowrońska H, Dusza L The effects of phytoestrogens on testosterone secretion by Leydig cells from Biłgoraj ganders (Anser anser). British Poultry Science 2006, 47:237-245.
89. Svechnikov K, Supornsilchai V, Strand M-L, Wahlgren A, Seidlova-Wuttke D, Wuttke W, Söder O Influenceoflong-termdietaryadministrationofprocymidone, afungicydewith anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. Journal of Endocrinology 2005, 187:117-124.
90. Jefferson W, Newbold R, Padilla-Banks E, Pepling M Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survival. Biology of Reproduction 2006, 74:161-168.
91. Jefferson WN, Couse JF, Padilla-Banks E, Korach KS, Newbold RR Neonatal exposure to genistein induces estrogen receptor (ER) alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions. Biol Reprod 2002, 67:1285-1296.
92. Chen Y, Jefferson WN, Newbold RR, Padilla-Banks E, Pepling ME Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in Vitro and in Vivo. Endocrinology 2007, 148(8):3580-3590.
93. Cimafranca MA, Davila J, Ekman GC, Andrews RN, Neese SL, Peretz J, Woodling KA, Helferich WG, Sarkar J, Flaws JA, Schantz SL, Doerge DR, Cooke PS Acute and chronic effects of oral genistein administration in neonatal mice. Biol Reprod 2010, 83(1):114-121.
94. Jefferson WN, Padilla-Banksa E, Newbold RR Disruption of the female reproductive system by the phytoestrogen genistein. Reproductive Toxicology 2007, 23:308-316.
95. Benetti R, García-Cao M, Blasco MA Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 2007, 39:243-250.
96. Ross AE, Marchionni L, Phillips TM, Miller RM, Hurley PJ, Simons BW, Salmasi AH, Schaeffer AJ, Gearhart JP, Schaeffer EM Molecular effects of genistein on male urethral development. J Urol 2011, 185(5):1894-1898.
97. Ford JA, Clark SG, Walters EM, Wheeler MB, Hurley WL Estrogenic effects of genistein on reproductive tissues of ovariectomized gilts. J Anim Sci 2006, 84:834-842.
98. Burton JL, Wells M The effect of phytoestrogens on the female genital tract. J Clin Pathol 2002, 55:401-407.
99. Warri A, Saarinen NM, Makela S, Hilakivi-Clarke L The role of early life genistein exposures in modifying breast cancer risk. British Journal of Cancer 2008, 98:1485-1493.
100. Ramos S Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. The Journal of Nutritional Biochemistry 2007, 18(7):427-442.
101. Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, Pelling JC, Bergan RC Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Research 2008, 68(6):2024-2032.
102. Farina HG, Pomies M, Alonso DF, Gomez DE Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncology Reports 2006, 16(4):885-891.
103. Hiscox S, Jordan NJ, Morgan L, Green TP, Nicholson RI Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifenresistant breast cancer cells. Clinical & Experimental Metastasis 2007, 24(3):157-167.
104. Meng XN, Jin Y, Yu Y, Bai J, Liu GY, Zhu J, Zhao YZ, Wang Z, Chen F, Lee KY, Fu SB Characterisation of fibronectin-mediated FAK signaling pathways in lung cancer cell migration and invasion. British Journal of Cancer 2009, 101(2):327-334.
105. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF Fak-src signaling through paxillin, erk and mlck regulates adhesion disassembly. Nature Cell Biology 2004, 6(2):154-161.
106. Gu Y, Zhu CF, Dai YL, Zhong Q, Sun B Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma. World Journal of Gastroenterology 2009, 15(39):4952-4957.
107. Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H, Manabe T Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Molecular Cancer 2005, 4:37.
108. Miekus K, Madeja Z Genistein inhibits the contactstimulated migration of prostate cancer cells. Cellular and Molecular Biology Letters 2007, 12:348-361.
109. Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC, Bergan RC Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Research 2005, 65(8):3470-3478.
110. Kumi-Diaka JK, Hassanhi M, Merchant K, Horman V Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells. Journal of Medicinal Food 2006, 9(4):491-497.
111. Lee WY, Huang SC, Tzeng CC, Chang TL, Hsu KF Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated hcc1395 breast cancer cells. Nutrition and Cancer 2007, 58(2):239-246.
112. Kousidou OC, Mitropoulou TN, Roussidis AE, Kletsas D, Theocharis AD, Karamanos NK Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors. International Journal of Oncology 2005, 26(4):1101-1109.
113. Ravindranath MH, Muthugounder S, Presser N, Viswanathan S Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 2004, 546:121-165.
114. Casagrande F, Darbon JM p21CIP1 is dispensable for the G2 arrest caused by genistein in human melanoma cells. Exp Cell Res 2000, 258:101-108.
115. Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 2005, 65:9064-9072.
116. Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, Abbruzzese JL, Sarkar FH In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic ancer. Int J Cancer 2007, 120:906-917.
117. Saggioro D Anti-Apoptotic Effect of Tax: An NF-κB Path or a CREB Way?. Viruses 2011, 3(7):1001-1014.
118. Li Y, Sarkar FH Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 2002, 8:2369-2377.
119. Tophkhane C, Yang S, Bales W, Archer L, Osunkoya A, Thor AD, Yang X Bcl-2 overexpression sensitizes mcf-7 cells to genistein by multiple mechanisms. International Journal of Oncology 2007, 31(4):867-874.
120. Zhang B, Shi ZL, Liu B, Yan XB, Feng J, Tao HM Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: The role of akt and nuclear factor-kappab. Anti-Cancer Drugs 2010, 21(3):288-296.
121. Jagadeesh S, Kyo S, Banerjee PP Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res 2006, 66(4):2107-2115.
122. Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. J Nutr 2007, 137:205S-210S.
123. Tominaga Y, Wang A, Wang RH, Wang X, Cao L, Deng CX Genistein inhibits Brca1 mutant tumor growth through activation of DNA damage checkpoints, cell cycle arrest, and mitotic catastrophe. Cell Death Differ 2007, 14(3):472-479.
124. Privat M, Aubel C, Arnould S, Communal Y, Ferrara M, Bignon YJ Breast cancer cell response to genistein is conditioned by BRCA1 mutations. Biochem Biophys Res Commun 2009, 379(3):785-789.
125. Wegrzyn G, Jakó bkiewicz-Banecka J, Gabig-Cimiń ska M, Piotrowska E, Narajczyk M, Kloska A, Malinowska M, Dziedzic D, Gołebiewska I, Moskot M, Wegrzyn A Genistein: a natural isoflavone with a potential for treatment of genetic diseases. Biochemical Society Transactions 2010, 38(2):695-701.
126. Amaral MD, Kunzelmann K Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis. Trends Pharmacol Sci 2007, 28:334-341.
127. Schmidt A, Hughes LK, Cai Z, Mendes F, Li H, Sheppard DN, Amaral MD Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator. Br J Pharmacol 2008, 153:1311-1323.
128. Kloska A, Jakóbkiewicz-Banecka J, Narajczyk M, Banecka-Majkutewicz Z, Wegrzyn G Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. Metab Brain Dis 2011, 26:1-8.
129. Jakobkiewicz-Banecka J, Piotrowska E, Narajczyk M, Baranska S, Wegrzyn G Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway. J Biomed Sci 2009, 16:26.
130. Ahmed AA, Goldsmith J, Fokt I, Le X, Krzysko K, Lesyng B, Bast RC, Priebe W A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer. Cancer Chemother Pharmacol 2011, 68(4):1033-1044.
131. Rusin A, Zawisza-Puchałka J, Kujawa K, Gogler-Pigłowska A, Wietrzyk J, Świtalska M, Głowala-Kosińska M, Gruca A, Szeja W, Krawczyk Z, Grynkiewicz G Synthetic conjugates of genistein affecting proliferation and mitosis of cancer cells. Bioorganic & Medicinal Chemistry 2011, 19:295-305.
132. Rayalam S, Della-Fera MA, Ambati S, Yang J, Park HJ, Baile CA Enhanced effects of 1,25(OH)2D3 plus genistein on adipogenesis and apoptosis in 3T3-L1 adipocytes. Obesity 2008, 163:539-546.
133. Park HJ, Yang JY, Ambati S, Della-Fera MA, Hausman DB, Rayalam S, Baile CA Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food 2008, 11(4):773-783.
134. Kohen F, Gayer B, Kulik T, Frydman V, Nevo N, Katzburg S, Limor R, Sharon O, Stern N, Somjen D Synthesis and evaluation of the antiproliferative activities of derivatives of carboxyalkyl isoflavones linked to N-t-Bochexylenediamine. Journal of Medicinal Chemistry 2007, 50:6405-6410.
135. Gentile MS, Vasu C, Green A, Murillo G, Das Gupta TK, Constantinou AI, Prabhakar BS, Salti GI Targeting colon cancer cells with genistein-17.1A immunoconjugate;. International Journal of Oncology 2003, 22:955-959.
136. Vera R, Sánchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, Pérez-Vizcaíno F, Duarte J Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS; caveolin and calmodulin expression and NADPH oxidase activity. Clinical Science (London) 2007, 112(3):183-191.
137. Liu D, Zhen W, Yang Z, Carter JD, Si H, Reynolds KA Genistein acutely stimulates insulin secretion in pancreatic β -cells through a cAMP-dependent protein kinase pathway. Diabetes 2006, 55:1043-1050.
138. Babu PVA, Si H, Fu Z, Zhen W, Liu D Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice 1-3. The Journal of Nutrition 2012, 1-7.
139. Ulanowska K, Majchrzak A, Moskot M, Jakóbkiewicz-Banecka J, Wegrzyn G Assessment of antibacterial effects of flavonoids by estimation of generation times in liquid bacterial cultures. Biologia; Bratislava. Section Cellular and Molecular Biology 2007, 62(2):132-135.
140. Zhang Y, Li XL, Yao XS, Wong MS Osteogenic activities of genistein derivatives were influenced by the presence of prenyl group at ring A. Archives of Pharmacal Research 2008, 31(12):1534-1539.
141. Li HQ, Xue JY, Shi L, Gui SY, Zhu HL Synthesis; crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. European Journal of Medicinal Chemistry 2008, 43(3):662-667.