A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 4, 2011, Pages 1033-1044

  Ahmed, Ahmed Ashour ^a,b,c   Goldsmith, Juliet ^b,c   Fokt, Izabela ^a   Le, Xiao Feng ^a   Krzysko, Krystiana A ^d   Lesyng, Bogdan ^d,e   Bast Jr , Robert C ^a   Priebe, Waldemar ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF WARSAW   (Poland)

^e MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Experimental therapeutics; ITB 301; Mitosis; Ovarian cancer; Tubulin

Indexed keywords

BUB1 RELATED PROTEIN; COLCHICINE; DOXORUBICIN; GENISTEIN; ITB 301; NOCODAZOLE; PACLITAXEL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERAPAMIL;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; MICROTUBULE DEPOLYMERIZATION; MITOSIS INHIBITION; MULTIDRUG RESISTANCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN MODIFICATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENISTEIN; GLYCOSIDES; HUMANS; INHIBITORY CONCENTRATION 50; MICROTUBULES; MITOSIS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; OVARIAN NEOPLASMS; PROTEIN BINDING; TUBULIN;

EID: 80054751066     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1575-2     Document Type: Article

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