Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats

Reproductive Toxicology

Volumn 15, Issue 6, 2001, Pages 647-663

  Delclos, K Barry ^a   Bucci, Thomas J ^b   Lomax, Larry G ^b   Latendresse, John R ^b   Warbritton, Alan ^b   Weis, Constance C ^a   Newbold, Retha R ^c  

^a Division of Biochemical Toxicology   (United States)

^b Pathology Associates International   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Endocrine disruptors; Genistein; Isoflavones; Reproductive toxicity; Soy

Indexed keywords

GENISTEIN; ISOFLAVONE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL MILK; BIOASSAY; BODY WEIGHT; BREAST HYPERPLASIA; CHILDBIRTH; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DOSE RESPONSE; EPIDIDYMIS; ESTROGEN ACTIVITY; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; HYPOPHYSIS; MALE; MAMMARY GLAND; NONHUMAN; ORGAN WEIGHT; OVARY FOLLICLE; PERINATAL PERIOD; PREGNANCY; SEMINIFEROUS TUBULE; SOYBEAN; SPERMATOGENESIS; SPERMATOZOON COUNT; WEANING; ANIMAL; CHEMICALLY INDUCED DISORDER; DIET; DRUG EFFECT; EATING; KIDNEY CALCIFICATION; KIDNEY TUBULE; ORGAN SIZE; PATHOLOGY; PROSTATE; RAT; REPRODUCTION; SPRAGUE DAWLEY RAT; TOXICITY TESTING; UDDER;

ANIMALS; BODY WEIGHT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ESTROGEN RECEPTOR MODULATORS; FEMALE; GENISTEIN; KIDNEY TUBULES; MALE; MAMMARY GLANDS, ANIMAL; NEPHROCALCINOSIS; ORGAN SIZE; PREGNANCY; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; TOXICITY TESTS;

EID: 0035655267     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(01)00177-0     Document Type: Article

References (91)

1. Phyto-oestrogens and Western diseases
2. Effect of genistein on in vitro and in vivo models of cancer
3. Rationale for the use of genistein containing soy matrices in chemoprevention trials for breast and prostate cancer
4. Physiological effects of phytoestrogens in relation to cancer and other human health risks
5. Soy and experimental cancer: Animal studies
6. Dietary phytoestrogens
7. Soy intake and cancer risk: A review of the in vitro and in vivo data
8. Dietary isoflavones: Biological effects and relevance to human health
9. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: A randomized controlled trial in humans
10. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women
11. Exposure of infants to phyto-oestrogens from soy-based infant formula
12. The fragile fetus
13. Cellular and molecular effects of developmental exposure to diethylstilbestrol: Implications for other environmental estrogens
14. Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo
15. Stimulatory influence of soy protein isolate on breast secretion in pre- and post-menopausal women
16. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats
17. The effect of genistein on the fertility of mice
18. Potential endocrine-modulating effects of various phytoestrogens in the diet
19. Naturally occurring estrogens in foods-a review
20. Naturally occurring food toxicants: Estrogens
21. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women
22. Biological effects of isoflavones in young women: Importance of the chemical composition of soyabean products
23. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women
24. Soy isoflavones exert modest hormonal effects in premenopausal women
25. Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women
26. Effect of soymilk consumption on serum estrogen concentrations in premenopausal Japanese women
27. Oestrogenic effects of plant foods in postmenopausal women
28. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women
29. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys
30. Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
31. Dietary genistein: Perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat
32. Genistein studies in rats: Potential for breast cancer prevention and reproductive and developmental toxicity
33. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats
34. Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS
35. On-line sample preparation using restricted-access media in the LC-ESI/MS analysis of the soy isoflavones, genistein and daidzein, in rat serum
36. The mouse bioassay for the detection of estrogenic activity in rodent diets: I. A standardized method for conducting the mouse bioassay
37. Daily sperm production and epididymal sperm reserves of pubertal and adult rats
38. Note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control
39. Tissue distribution of genistein in Sprague Dawley rats from dietary exposure
40. Transplacental transfer of genistein following dietary and gavage administration to Sprague Dawley rats
41. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro
42. Effects of genistein on sexually dimorphic behaviors in rats
43. The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats
44. Comparison of estrogen effects on uterine, and pituitary growth, and prolactin synthesis in F344, and Holtzman rats
45. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood
46. Sensitivity of a tier I screening battery compared to an in utero exposure for detecting the estrogen receptor agonist 17 β-estradiol
47. Developmental estrogenization and prostatic neoplasia
48. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses
49. The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma
50. Genistein exerts estrogen-like effects in male mouse reproductive tract
51. Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero
52. Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water
53. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A
54. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals
55. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol
56. Low-dose bioactivity of xenoestrogens in animals: Fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice
57. Comparison of the ligand binding specificity, and transcript tissue distribution of estrogen receptors α, and β
58. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
59. Genistein suppresses mammary cancer in rats
60. Reproductive sequelae in female rats after in utero and neonatal exposure to the phytoestrogen genistein
61. Nephrocalcinosis in the rat: A literature review
62. 90-Day feeding, and one-generation reproduction study in Crl;CD BR rats with 17 β-estradiol
63. Studies of the components of an oral contraceptive agent in albino rats, I. Estrogenic component
64. Effects of dietary ethinyl estradiol (EE2) exposure during development on male and female CD rats
65. 1 Sprague-Dawley rats fed para-nonylphenol in a soy-free casein-containing diet
66. Hormonal control of pubertal spermatogenesis
67. Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: Evidence for stimulatory effects of low estrogen levels
68. Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood
69. Influence of genistein (4′,5,7-trihydroxy-isoflavone) on the growth and proliferation of testicular cell lines
70. Cytotoxic potential of the phytochemical genistein isoflavone (4′, 5′, 7-trihydroxyisoflavone) and certain environmental chemical compounds on testicular cells
71. Regulation of Sertoli cell differentiation by the testicular paracrine factor PmodS: Analysis of common signal transduction pathways
72. Prepubertal genistein treatment modulates TGF-α, EGF and EGFreceptor mRNAs and proteins in the rat mammary gland
73. Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat
74. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis
75. Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring
76. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring
77. Progesterone signaling and mammary gland morphogenesis
78. Sexual dimorphism of the normal rat mammary gland
79. Phytoestrogens act as estrogen agonists in an estrogen-responsive pituitary cell line
80. Development of the mammary gland of the rat, A study of normal, experimental and pathologic changes and their endocrine relationships
81. Studies on the mammary gland III. A comparison of the developing mammary glands in male and female albino rats from the late fetal stages to ten weeks of age
82. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect
83. The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes
84. p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells
85. Induction of micronucleus formation in mouse splenocytes by the soy isoflavone genistein in vitro but not in vivo
86. Uterine adenocarcinoma in mice treated neonatally with genistein
87. Enhancement of experimental colon cancer by genistein
88. Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats