Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells

Clinical and Experimental Metastasis

Volumn 24, Issue 3, 2007, Pages 157-167

  Hiscox, Stephen ^a   Jordan, Nicola J ^a   Morgan, Liam ^a   Green, Tim P ^b   Nicholson, Robert I ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

FAK; Matrix adhesion; Migration; Src; Tamoxifen resistance

Indexed keywords

AZD 0530; COLLAGEN; FIBRONECTIN; FOCAL ADHESION KINASE; LAMININ; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG; VITRONECTIN;

ARTICLE; BREAST CANCER; CANCER CELL; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; DRUG RESISTANCE, NEOPLASM; FEMALE; FOCAL ADHESION KINASE 1; HUMANS; PHOSPHORYLATION; SRC-FAMILY KINASES; TAMOXIFEN;

EID: 34249776956     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10585-007-9065-y     Document Type: Article

References (39)

1. Hiscox S, Morgan L, Green TP et al (2005) Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res Treat 97:263-274
2. Guo W, Giancotti FG (2004) Integrin signalling during tumour progression. Natl Rev Mol Cell Biol 5:816-826
3. Plow EF, Haas TA, Zhang L et al (2000) Ligand binding to integrins. J Biol Chem 275:21785-21788
4. Schaller MD (2001) Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 1540:1-21
5. Schaller MD, Hildebrand JD, Shannon JD et al (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14:1680-1688
6. Playford MP, Schaller MD (2004) The interplay between Src and integrins in normal and tumor biology. Oncogene 23:7928-7946
7. Vadlamudi RK, Sahin AA, Adam L et al (2003) Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. FEBS Lett 543:76-80
8. Brunton VG, Avizienyte E, Fincham VJ et al (2005) Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res 65:1335-1342
9. Schlaepfer DD, Mitra SK, Ilic D (2004) Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 1692:77-102
10. Owens LV, Xu L, Marston WA et al (2001) Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia. J Vasc Surg 34:344-349
11. Owens LV, Xu L, Craven RJ et al (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55:2752-2755
12. Rovin JD, Frierson HF Jr, Ledinh W et al (2002) Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Prostate 53:124-132
13. Agochiya M, Brunton VG, Owens DW et al (1999) Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 18:5646-5653
14. Gabarra-Niecko V, Schaller MD, Dunty JM (2003) FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev 22:359-374
15. Verbeek BS, Vroom TM, Rijksen G (1999) Overexpression of c-Src enhances cell-matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts. Exp Cell Res 248:531-537
16. Russello SV, Shore SK (2004) SRC in human carcinogenesis. Front Biosci 9:139-144
17. Wiener JR, Nakano K, Kruzelock RP et al (1999) Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model. Clin Cancer Res 5:2164-2170
18. Irby RB, Yeatman TJ (2002) Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells. Cancer Res 62:2669-2674
19. Summy JM, Gallick GE (2003) Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22:337-358
20. Masaki T, Igarashi K, Tokuda M et al (2003) pp60c-src activation in lung adenocarcinoma. Eur J Cancer 39:1447-1455
21. Avizienyte E, Frame MC (2005) Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol 17:542-547
22. Frame MC (2002) Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602:114-130
23. Knowlden JM, Hutcheson IR, Jones HE et al (2003) Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144:1032-1044
24. Hennequin L, Allen J, Breed J et al (2006) N-(5-Chloro-1,3-benzodioxol-4- yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy) quinazolin-4-amine, a novel, highly selective, orally a, dual-specific c-Src/Abl kinase inhibitor. J Med Chem 49:6465-6488
25. Calalb MB, Zhang X, Polte TR et al (1996) Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem Biophys Res Commun 228:662-668
26. Slack JK, Adams RB, Rovin JD et al (2001) Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells. Oncogene 20:1152-1163
27. Choma DP, Milano V, Pumiglia KM et al (2007) Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5. J Invest Dermatol 127:31-40
28. Park HB, Golubovskaya V, Xu L et al (2004) Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells. Biochem J 378:559-567
29. Jones RJ, Avizienyte E, Wyke AW et al (2002) Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer 87:1128-1135
30. Matsumoto T, Jiang J, Kiguchi K et al (2003) Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis. Cancer Res 63:4819-4828
31. Kaplan KB, Swedlow JR, Morgan DO et al (1995) c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev 9:1505-1517
32. Schwartzberg PL, Xing L, Hoffmann O et al (1997) Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev 11:2835-2844
33. Reynolds AB, Roesel DJ, Kanner SB et al (1989) Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol 9:629-638
34. Sieg DJ, Hauck CR, Schlaepfer DD (1999) Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci 112(Pt 16):2677-2691
35. Cobb BS, Schaller MD, Leu TH et al (1994) Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol 14:147-155
36. Xing Z, Chen HC, Nowlen JK et al (1994) Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell 5:413-421
37. Calalb MB, Polte TR, Hanks SK (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 15:954-963
38. Schlaepfer DD, Hunter T (1996) Signal transduction from the extracellular matrix-a role for the focal adhesion protein-tyrosine kinase FAK. Cell Struct Funct 21:445-450
39. Planas-Silva MD, Bruggeman RD, Grenko RT et al (2006) Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. Biochem Biophys Res Commun 341:73-81