Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study

Journal of Bone and Mineral Research

Volumn 17, Issue 10, 2002, Pages 1904-1912

  Morabito, Nunziata ^a   Crisafulli, Alessandra ^a   Vergara, Caterina ^b   Gaudio, Agostino ^b   Lasco, Antonino ^b   Frisina, Nicola ^b   D'Anna, Rosario ^b   Corrado, Francesco ^b   Pizzoleo, Maria Antonia ^b   Cincotta, Maria ^b   Altavilla, Domenica ^b   Ientile, Riccardo ^b   Squadrito, Francesco ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Bone formation; Bone resorption; Estrogen receptors; Genistein; Osteoporosis; Tyrosine kinase

Indexed keywords

ALKALINE PHOSPHATASE; DEOXYPYRIDINOLINE; ESTRADIOL; ESTRADIOL PLUS NORETHISTERONE ACETATE; ESTROGEN RECEPTOR; GENISTEIN; ISOFLAVONE; NORETHISTERONE; OSTEOCALCIN; PHYTOESTROGEN; PLACEBO; PROTEIN TYROSINE KINASE; PYRIDINOLINE; AMINO ACID; DRUG DERIVATIVE; FOLLITROPIN; ISOENZYME; NORETHISTERONE ACETATE;

ADULT; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS LINKING; DISEASE MODEL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; ENDOMETRIUM HYPERPLASIA; EVALUATION; FAT INTAKE; FEMALE; FEMUR NECK; HORMONE SUBSTITUTION; HOT FLUSH; HUMAN; MAJOR CLINICAL STUDY; MASTALGIA; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; URINARY EXCRETION; VAGINA BLEEDING; BLOOD; DRUG EFFECT; ESTROGEN THERAPY; FEMUR; LOW FAT DIET; LUMBAR VERTEBRA; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; POSTMENOPAUSE OSTEOPOROSIS; RADIOGRAPHY; URINE;

ALKALINE PHOSPHATASE; AMINO ACIDS; BONE DENSITY; COMBINED MODALITY THERAPY; DIET, FAT-RESTRICTED; DOUBLE-BLIND METHOD; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; FEMUR; FOLLICLE STIMULATING HORMONE; GENISTEIN; HUMANS; ISOENZYMES; LUMBAR VERTEBRAE; MIDDLE AGED; NORETHINDRONE; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 0036785298     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.10.1904     Document Type: Article

References (41)

1. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
2. Recker RR 1993 Current therapy for osteoporosis. J Clin Endocrinol Metab 76:14-16.
3. Agnusdei D, Gennari C, Bufalino L 1995 Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone. Osteoporos Int 5:462-466.
4. Collaborative Group on Hormonal Factors in Breast Cancer 1997 Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350:1047-1059.
5. Finking G, Hess B, Hanke H 1999 The value of phytoestrogens as a possible therapeutic option in postmenopausal women with coronary heart disease. J Obstet Gynaecol 19: 455-459.
6. Anderson JJB, Anthony MS, Messina M, Garner SC 1999 Effects of phytoestrogens on tissues. Nutr Res Rev 12:75-116.
7. Draper CR, Edel MJ, Dick IM, Randall AG, Martin GB, Prince RL 1997 Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. J Nutr 127:1795-1799.
8. Harrison E, Adjei A, Ameho C, Yamamoto S, Kono S 1997 The effect of soybean protein on bone loss in a rat model of postmenopausal osteoporosis. J Nutr Sci Vitaminol 44:257-268.
9. Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz-Sapuntzakis M, Guo P, Kukreja SC 1996 Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 126:161-167.
10. Horiuchi T, Onouchi T, Takahashi M, Ito H, Orimo H 2000 Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporos Int 11:721-724.
11. Anderson JJ, Anthony MS, Cline JM, Washburn SA, Garner SC 1999 Health potential of soy isoflavones for menopausal women. Public Health Nutr 2:489-504.
12. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263.
13. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyana Y, Ito M, Wang X, Suda T, Ikegami S 1999 Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 140: 1893-1900.
14. Coward L, Barnes NC, Setchell KDR, Barnes S 1993 Genistein, daidzein, and their beta-glycoside conjugates-antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41:1961-1967.
15. Setchell KD 1998 Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68(Suppl 6):1333S-1346S.
16. Supko JG, Phillips LR 1995 High-performance liquid chromatography assay for genistein in biological fluids. J Chromatogr B Biomed Appl 666:157-167.
17. Hesley RP, Shepard KA, Jenkins DK, Riggs BL 1998 Monitoring estrogen replacement therapy and identifying rapid bone losers with an immunoassay for deoxypyridinoline. Osteoporos Int 8:159-164.
18. Gao YH, Yamaguchi M 1999 Suppressive effect of genistein on rat bone osteoclasts: Apoptosis is induced through Ca 2+ signalling. Biol Pharm Bull 22:805-809.
19. Gao YH, Yamaguchi M 2000 Suppressive effect of genistein on rat bone osteoclasts: Involvement of protein kinase inhibition and protein tyrosine phosphatase activation. Int J Mol Med 5:261-267.
20. Kajiya H, Okabe K, Okamoto F, Tsuzuki T, Soeda H 2000 Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts. J Cell Physiol 183:83-90.
21. Gao YH, Yamaguchi M 1999 Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures. Biochem Pharmacol 58:767-772.
22. Blair HC, Jordan SE, Peterson TG, Barnes S 1996 Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. J Cell Biochem 61:629-637.
23. Yamaguchi M, Gao YH 1997 Anabolic effect of genistein on bone metabolism in the femoral-metaphyseal tissues of elderly rats is inhibited by the antiestrogen tamoxifene. Res Exp Med 197:101-107.
24. Yamaguchi M, Gao YH 1998 Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: The genistein effect is enhanced by zinc. Mol Cell Biochem 178:377-382.
25. Gao YH, Yamaguchi M 1998 Zinc enhancement of genistein's anabolic effect on bone components in elderly female rats. Gen Pharmacol 31:199-202.
26. Yamaguchi M, Gao YH 1997 Inhibitory effect of genistein on bone resorption in tissue culture. Biochem Pharmacol 55:71-76.
27. Fanti P, Monier-Faugere MC, Geng Z, Schmidt J, Morris PE, Cohen D, Malluche HH 1998 The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int 8:274-281.
28. Yamaguchi M, Ying HG, Zhong JM 2000 Synergistic effect of genistein and zinc on bone components in the femoralmetaphyseal tissues of female rats. J Bone Miner Metab 18: 77-83.
29. Yamaguchi M, Sugimoto E 2000 Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase. Mol Cell Biochem 214:97-102.
30. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T 1997 Expression of estrogen receptor β in rat bone. Endocrinology 138: 4509-4512.
31. Kuiper GGJM, Carlson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-A 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor-α and -β. Endocrinology 138:863-870.
32. Liu Y, Bhalla K, Hill C, Priest DG 1994 Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line. Biochem Pharmacol 48: 1265-1272.
33. Spinozzi F, Pagliacci MC, Migliorati G, Moraca R, Grignami F, Riccardi C, Nicoletti I 1994 The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkatt T-leukemia cells. Leuk Res 18:431-439.
34. Yoon H-K, Chen K, Baylink DJ, Lau K-HW 1998 Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int 63:243-249.
35. Kassem M, Okazaki R, De Leon D, Harris SA, Robinson JA, Spelsberg TC, Conover CA, Riggs BL 1996 Potential mechanism of estrogen-mediated decrease in bone formation: Estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. Proc Assoc Am Physicians 108:155-164.
36. Choi Y-H, Han I-K, Yoon H-K 1997 Ipriflavone for the treatment of osteoporosis. Osteoporos Int 7:S174-S178.
37. Pouyssegur J, Seuwen K 1992 Transmembrane receptors and intracellular pathways that control cell proliferation. Annu Rev Physiol 54:195-210.
38. Koroma BM, de Juan E Jr 1994 Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein. Biochem Pharmacol 48:809-818.
39. Basson MD, Beidler DR, Turowski G, Zarif A, Modlin IM, Jena BP, Madri JA 1994 Effect of tyrosine kinase inhibition on basal and epidermal growth factor-stimulated human Caco-2 enterocyte sheet migration and proliferation. J Cell Physiol 160:491-501.
40. Cassidy A, Bingham S, Setchell K 1995 Biological effects of isoflavones in young women: Importance of the chemical composition of soybean products. Br J Nutr 74:587-601.
41. Xu X, Duncan AM, Merz BE, Kurzer MS 1998 Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomark Prev 7:1111-1118.