Uncoupling Protein 3 (UCP3) Stimulates Glucose Uptake in Muscle Cells through a Phosphoinositide 3-Kinase-dependent Mechanism

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12520-12529

  Huppertz, Christine ^a   Fischer, Britta M ^a   Kim, Young Bum ^a   Kotani, Ko ^a   Vidal Puig, Antonio ^a   Slieker, Lawrence J ^b   Sloop, Kyle W ^b   Lowell, Bradford B ^a   Kahn, Barbara B ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CARDIOLOGY; CELL MEMBRANES; METABOLISM; MUSCLE;

BIOCHEMICAL PATHWAYS;

BIOCHEMISTRY;

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOVIRUS VECTOR; DEOXYGLUCOSE; DOXYCYCLINE; GENISTEIN; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN P85; PROTEIN TYROSINE KINASE INHIBITOR; TETRACYCLINE; UNCOUPLING PROTEIN 3; WORTMANNIN; ANDROSTANE DERIVATIVE; CARRIER PROTEIN; ENZYME INHIBITOR; ION CHANNEL; LACTIC ACID DERIVATIVE; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; RECOMBINANT PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BLAST CELL; CELL SURFACE; CELL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; GENE CONSTRUCT; GENE OVEREXPRESSION; GENE REPRESSION; GENE TRANSFER; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; MITOCHONDRIAL MEMBRANE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SKELETAL MUSCLE; ANIMAL; CELL LINE; CELL MEMBRANE; CELL STRAIN 3T3; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; HEART MUSCLE; HUMAN; METABOLISM; MITOCHONDRION; TRANSPORT AT THE CELLULAR LEVEL;

ADENOVIRIDAE; ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; DEOXYGLUCOSE; DOXYCYCLINE; ENZYME INHIBITORS; GENISTEIN; GLUCOSE; HUMANS; INSULIN; ION CHANNELS; LACTATES; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; MYOCARDIUM; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0035918162     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011708200     Document Type: Article

References (51)

1. Jacobsson, A., Stadler, U., Glotzer, M. A., and Kozak, L. P. (1985) J. Biol. Chem. 260, 16250-16254
2. Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., and Warden, C. H. (1997) Nat. Genet. 15, 269-272
3. Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J. S., and Lowell, B. B. (1997) Biochem. Biophys. Res. Commun. 235, 79-82
4. Boss, O., Samec, S., Paoloni-Giacobino, A., Rossier, C., Dulloo, A., Seydoux, J., Muzzin, P., and Giacobino, J. P. (1997) FEBS Lett. 408, 39-42
5. Solanes, G., Vidal-Puig, A., Grujic, D., Flier, J. S., and Lowell, B. B. (1997) J. Biol. Chem. 272, 25433-25436
6. Zhang, C.-Y., Hagen, T., Mootha, V. K., Slieker, L. J., and Lowell, B. B. (1999) FEBS Lett., in press
7. Hinz, W., Faller, B., Gruninger, S., Gazzotti, P., and Chiesi, M. (1999) FEBS Lett. 448, 57-61
8. Jaburek, M., Varecha, M., Gimeno, R. E., Dembski, M., Jezek, P., Zhang, M., Burn, P., Tartaglia, L. A., and Garlid, K. D. (1999) J. Biol. Chem. 274, 26003-26007
9. Boss, O., Samec, S., Kuhne, F., Bijlenga, P., Assimacopoulos-Jeannet, F., Seydoux, J., Giacobino, J. P., and Muzzin, P. (1998) J. Biol. Chem. 273, 5-8
10. Zurlo, F., Larson, K., Bogardus, C., and Ravussin, E. (1990) J. Clin. Invest. 86, 1423-1427
11. Schrauwen, P., Xia, J., Bogardus, C., Pratley, R. E., and Ravussin, E. (1999) Diabetes 48, 146-149
12. Argyropoulos, G., Brown, A. M., Willi, S. M., Zhu, J., He, Y., Reitman, M., Gevao, S. M., Spruill, I., and Garvey, W. T. (1998) J. Clin. Invest. 102, 1345-1351
13. Clapham, J. C., Arch, J. R., Chapman, H., Haynes, A., Lister, C., Moore, G. B., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., Beeley, L. J., Godden, R. J., Herrity, N., Skehel, M., Changani, K. K., Hockings, P. D., Reid, D. G., Squires, S. M., Hatcher, J., Trail, B., Latcham, J., Rastan, S., Harper, A. J., Cadenas, S., Buckingham, J. A., Brand, M. D., and Abuin, A. (2000) Nature 406, 415-418
14. Li, B., Nolte, L. A., Ju, J. S., Ho Han, D., Coleman, T., Holloszy, J. O., and Semenkovich, C. F. (2000) Nat. Med. 6, 1115-1120
15. Vidal-Puig, A. J., Grujic, D., Zhang, C. Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., Muoio, D. M., and Lowell, B. B. (2000) J. Biol. Chem. 275, 16258-16266
16. Gong, D. W., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus-Samuels, B., Chou, C. J., Everett, C., Kozak, L. P., Li, C., Deng, C., Harper, M. E., and Reitman, M. L. (2000) J. Biol. Chem. 275, 16251-16257
17. Krook, A., Digby, J., O'Rahilly, S., Zierath, J. R., and Wallberg-Henriksson, H. (1998) Diabetes 47, 1528-1531
18. Bashan, N., Burdett, E., Guma, A., Sargeant, R., Tumiati, L., Liu, Z., and Klip, A. (1993) Am. J. Physiol. 264, C430-C440
19. Khayat, Z. A., Tsakiridis, T., Ueyama, A., Somwar, R., Ebina, Y., and Klip, A. (1998) Am. J. Physiol. 275, C1487-C1497
20. Khayat, Z. A., McCall, A. L., and Klip, A. (1998) Biochem. J. 333, 713-718
21. Nagase, I., Yoshida, S., Canas, X., Irie, Y., Kimura, K., Yoshida, T., and Saito, M. (1999) FEBS Lett. 461, 319-322
22. Tsakiridis, T., Vranic, M., and Klip, A. (1995) Biochem. J. 309, 1-5
23. Khayat, Z. A., Tong, P., Yaworsky, K., Bloch, R. J., and Klip, A. (2000) J. Cell Sci. 113, 279-290
24. Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C. R. (1994) Mol. Cell. Biol. 14, 4902-4911
25. Kotani, K., Carozzi, A. J., Sakaue, H., Hara, K., Robinson, L. J., Clark, S. F., Yonezawa, K., James, D. E., and Kasuga, M. (1995) Biochem. Biophys. Res. Commun. 209, 343-348
26. Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., and Ui, M. (1994) J. Biol. Chem. 269, 3568-3573
27. Frevert, E. U., and Kahn, B. B. (1997) Mol. Cell. Biol. 17, 190-198
28. Yeh, J. I., Gulve, E. A., Rameh, L., and Birnbaum, M. J. (1995) J. Biol. Chem. 270, 2107-2111
29. Azevedo, J., Jr., Carey, J. O., Pories, W. J., Morris, P. G., and Dohm, G. L. (1995) Diabetes 44, 695-698
30. Chen, D., Elmendorf, J. S., Olson, A. L., Li, X., Earp, H. S., and Pessin, J. E. (1997) J. Biol. Chem. 272, 27401-27410
31. Le Marchand-Brustel, Y., Gautier, N., Cormont, M., and Van Obberghen, E. (1995) Endocrinology 136, 3564-3570
32. Mitsumoto, Y., and Klip, A. (1992) J. Biol. Chem. 267, 4957-4962
33. Becker, T. C., Noel, R. J., Coats, W. S., Gomez-Foix, A. M., Alam, T., Gerard, R. D., and Newgard, C. B. (1994) Methods Cell Biol. 43, 161-189
34. Quon, M. J., Guerre-Millo, M., Zarnowski, M. J., Butte, A. J., Era, M., Cushman, S. W., and Taylor, S. I. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5587-5591
35. O'Brien, K., Otto, K., and Rao, R. N. (1997) Gene 184, 115-120
36. Maher, F., Vannucci, S., Takeda, J., and Simpson, I. A. (1992) Biochem. Biophys. Res. Commun. 182, 703-711
37. Kim, Y.-B., Zhu, J.-S., Zierath, J. R., Shen, H.-Q., Baron, A. D., and Kahn, B. B. (1999) Diabetes 48, 310-320
38. Goodyear, L. J., Giorgino, F., Sherman, L. A., Carey, J., Smith, R. J., and Dohm, G. L. (1995) J. Clin. Invest. 95, 2195-2204
39. Wang, Q., Khayat, Z., Kishi, K., Ebina, Y., and Klip, A. (1998) FEBS Lett. 427, 193-197
40. Schrauwen, P., Walder, K., and Ravussin, E. (1999) Obes. Res. 7, 97-105
41. Vallerand, A. L., Perusse, F., and Bukowiecki, L. J. (1990)Am. J. Physiol. 259, R1043-R1049
42. Negre-Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Penicaud, L., and Casteilla, L. (1997) FASEB J. 11, 809-815
43. Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves-Guerra, M. C., Goubern, M., Surwit, R., Bouillaud, F., Richard, D., Collins, S., and Ricquier, D. (2000) Nat. Genet. 26, 435-439
44. Finkel, T. (1999) J. Leukoc. Biol. 65, 337-340
45. Nemoto, S., Takeda, K., Yu, Z. X., Ferrans, V. J., and Finkel, T. (2000) Mol. Cell. Biol. 20, 7311-7318
46. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K., and Finkel, T. (1995) Science 270, 296-299
47. Kozlovsky, N., Rudich, A., Potashnik, R., and Bashan, N. (1997) Free Radic. Biol. Med. 23, 859-869
48. Kono, T., Robinson, F. W., Blevins, T. L., and Ezaki, O. (1982) J. Biol. Chem. 257, 10942-10947
49. Tirosh, A., Potashnik, R., Bashan, N., and Rudich, A. (1999) J. Biol. Chem. 274, 10595-10602
50. Marchisio, M., Bertagnolo, V., Colamussi, M. L., Capitani, S., and Neri, L. M. (1998) Biochem. Biophys. Res. Commun. 253, 346-351
51. Tanaka, K., Horiguchi, K., Yoshida, T., Takeda, M., Fujisawa, H., Takeuchi, K., Umeda, M., Kato, S., Ihara, S., Nagata, S., and Fukui, Y. (1999) J. Biol. Chem. 274, 3919-3922