Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays

Toxicological Sciences

Volumn 132, Issue 2, 2013, Pages 327-346

  Wetmore, Barbara A ^a   Wambaugh, John F ^b   Ferguson, Stephen S ^c   Li, Lili ^d   Clewell, Harvey J ^a   Judson, Richard S ^b   Freeman, Kimberly ^c   Bao, Wenjun ^d   Sochaski, Mark A ^a   Chu, Tzu Ming ^d   Black, Michael B ^a   Healy, Eric ^a   Allen, Brittany ^a   Andersen, Melvin E ^a   Wolfinger, Russell D ^d   Thomas, Russell S ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c Life Technologies Corporation   (United States)

^d SAS INSTITUTE INC   (United States)

Author keywords

Alternatives to animal testing; Dose response; Metabolism; Pharmacokinetics; Predictive toxicology

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; 4,4' ISOPROPYLIDENEDIPHENOL; CARBARIL; LINDANE; PERFLUOROOCTANESULFONIC ACID; PERFLUOROOCTANOIC ACID; PERMETHRIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; TRICLOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; HAZARD; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PHARMACEUTICAL EQUIVALENCE; PLASMA PROTEIN BINDING; PREDICTION; RAT; STATISTICAL ANALYSIS; TOXICITY TESTING;

ANIMALS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, THEORETICAL; PHARMACOKINETICS; RATS; TOXICITY TESTS;

EID: 84875279062     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft012     Document Type: Article

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