Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 1, 2011, Pages 157-175

  Loccisano, Anne E ^a   Campbell, Jerry L ^a   Andersen, Melvin E ^a   Clewell, Harvey J ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

PBPK; Perfluoroalkyls; PFOA; PFOS; Pharmacokinetics; Physiologically based pharmacokinetic modeling; Toxicokinetic modeling

Indexed keywords

DRINKING WATER; PERFLUOROOCTANE; PERFLUOROOCTANESULFONIC ACID; ALKANESULFONIC ACID; CARBOXYLIC ACID; FLUORIDE; FLUOROCARBON; OCTANOIC ACID DERIVATIVE; PERFLUOROOCTANE SULFONIC ACID; PERFLUOROOCTANOIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HALF LIFE TIME; HAPLORHINI; MALE; NONHUMAN; OCCUPATIONAL EXPOSURE; PREDICTION; PRIORITY JOURNAL; SIMULATION; TOXICOKINETICS; ADOLESCENT; ADULT; AGED; ALKYLATION; ANIMAL; BLOOD; CHEMICAL MODEL; COMPARATIVE STUDY; DRINKING; EVALUATION; FLUORIDATION; GERMANY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MACACA FASCICULARIS; MIDDLE AGED; NUTRITION; ORAL DRUG ADMINISTRATION; PREDICTIVE VALUE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; STANDARD; STATISTICAL MODEL; TIME; UNITED STATES; WATER SUPPLY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ALKANESULFONATES; ALKANESULFONIC ACIDS; ALKYLATION; ANIMALS; CARBOXYLIC ACIDS; DRINKING; FEMALE; FLUORIDATION; FLUORIDES; FLUOROCARBONS; GERMANY; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, STATISTICAL; NUTRITION SURVEYS; OCTANOIC ACIDS; OHIO; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TIME FACTORS; UNITED STATES; WATER SUPPLY;

EID: 79960094221     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.12.004     Document Type: Article

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