Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 2, 2009, Pages 188-199

  Knight, Andrew W ^a   Little, Stephen ^b   Houck, Keith ^b   Dix, David ^b   Judson, Richard ^b   Richard, Ann ^b   McCarroll, Nancy ^b   Akerman, Gregory ^b   Yang, Chihae ^c   Birrell, Louise ^a   Walmsley, Richard M ^a  

^a Gentronix Ltd   (United Kingdom)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

CellCiphr; CellSensor; GADD45 alpha; Genotoxicity; GreenScreen HC; Hazard assessment; High throughput screening; In vitro; p53; Pesticides; ToxCast

Indexed keywords

CARCINOGEN; CHLORSULFURON; DNA; GREEN FLUORESCENT PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PESTICIDE; PHTHALIC ACID DIBUTYL ESTER; PROTEIN P53;

ACCURACY; AMES TEST; ARTICLE; CARCINOGENICITY; CONCENTRATION (PARAMETERS); DNA DAMAGE; ENVIRONMENTAL PROTECTION; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; INTERMETHOD COMPARISON; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING; TOXICOGENETICS; UNITED STATES;

ANIMALS; BIOLOGICAL ASSAY; CELL LINE; CELL SURVIVAL; DNA; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION REGULATION; GENES, REGULATOR; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HCT116 CELLS; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MALE; MICE; MUTAGENICITY TESTS; MUTAGENS; PESTICIDES; RATS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ANIMALIA; RODENTIA;

EID: 70349512691     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.07.004     Document Type: Article

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