Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model

Reproductive Toxicology

Volumn 33, Issue 4, 2012, Pages 452-467

  Loccisano, Anne E ^a   Campbell Jr , Jerry L ^a   Butenhoff, John L ^b   Andersen, Melvin E ^a   Clewell III, Harvey J ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b 3M COMPANY   (United States)

Author keywords

PBPK; Perfluoroalkyls; PFOA; PFOS; Pharmacokinetics; Physiologically based pharmacokinetic modeling; Toxicokinetic modeling

Indexed keywords

PERFLUOROOCTANE; PERFLUOROOCTANESULFONIC ACID;

ADULT ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; BINDING AFFINITY; BLOOD LEVEL; BODY WEIGHT; CHEMICAL BINDING; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL RAT; FECES; FEMALE; FETUS RISK; HEALTH HAZARD; HEART OUTPUT; HEMATOCRIT; KIDNEY TUBULE ABSORPTION; LACTATION; LIVER LEVEL; MALE; NONHUMAN; PLASMA HALF LIFE; PREGNANCY; RAT; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SEX DIFFERENCE; TISSUE DISTRIBUTION; TOXICITY TESTING; TOXICOKINETICS; URINARY EXCRETION;

ALKANESULFONIC ACIDS; ANIMALS; BODY WEIGHT; CARDIAC OUTPUT; COMPUTER SIMULATION; FEMALE; FLUOROCARBONS; INTESTINES; KIDNEY; LIVER; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; OCTANOIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SEX FACTORS; TIME FACTORS; TISSUE DISTRIBUTION;

RATTUS;

EID: 84861531610     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.04.006     Document Type: Article

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