메뉴 건너뛰기




Volumn 33, Issue 2, 2013, Pages 118-129

Renal and Extrarenal Actions of Klotho

Author keywords

Acute kidney injury; Cardiac hypertrophy; Chronic kidney disease; Hyperparathyroidism; Klotho

Indexed keywords

CALCITRIOL; CARRIER PROTEIN; FIBROBLAST GROWTH FACTOR 23; ION CHANNEL; KLOTHO PROTEIN; PARATHYROID HORMONE; PROTEIN ROMK1; SODIUM PHOSPHATE COTRANSPORTER 2A; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5;

EID: 84875262394     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2012.12.013     Document Type: Article
Times cited : (134)

References (89)
  • 1
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3    Kawaguchi, H.4    Suga, T.5    Utsugi, T.6
  • 3
    • 0034685014 scopus 로고    scopus 로고
    • Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys
    • Kato Y., Arakawa E., Kinoshita S., Shirai A., Furuya A., Yamano K., et al. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Biochem Biophys Res Commun 2000, 267:597-602.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 597-602
    • Kato, Y.1    Arakawa, E.2    Kinoshita, S.3    Shirai, A.4    Furuya, A.5    Yamano, K.6
  • 4
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu M.C., Shi M., Zhang J., Pastor J., Nakatani T., Lanske B., et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 2010, 24:3438-3450.
    • (2010) FASEB J , vol.24 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3    Pastor, J.4    Nakatani, T.5    Lanske, B.6
  • 7
    • 38049144010 scopus 로고    scopus 로고
    • Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
    • Chen C.D., Podvin S., Gillespie E., Leeman S.E., Abraham C.R. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A 2007, 104:19796-19801.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19796-19801
    • Chen, C.D.1    Podvin, S.2    Gillespie, E.3    Leeman, S.E.4    Abraham, C.R.5
  • 8
    • 2342610541 scopus 로고    scopus 로고
    • Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
    • Imura A., Iwano A., Tohyama O., Tsuji Y., Nozaki K., Hashimoto N., et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 2004, 565:143-147.
    • (2004) FEBS Lett , vol.565 , pp. 143-147
    • Imura, A.1    Iwano, A.2    Tohyama, O.3    Tsuji, Y.4    Nozaki, K.5    Hashimoto, N.6
  • 9
    • 78651408919 scopus 로고    scopus 로고
    • Klotho deficiency causes vascular calcification in chronic kidney disease
    • Hu M.C., Shi M., Zhang J., Quinones H., Griffith C., Kuro-o M., et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 2011, 22:124-136.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 124-136
    • Hu, M.C.1    Shi, M.2    Zhang, J.3    Quinones, H.4    Griffith, C.5    Kuro-o, M.6
  • 10
    • 76249084836 scopus 로고    scopus 로고
    • Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    • Goetz R., Nakada Y., Hu M.C., Kurosu H., Wang L., Nakatani T., et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci U S A 2010, 107:407-412.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 407-412
    • Goetz, R.1    Nakada, Y.2    Hu, M.C.3    Kurosu, H.4    Wang, L.5    Nakatani, T.6
  • 11
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006, 444:770-774.
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5    Okawa, K.6
  • 14
    • 79952281150 scopus 로고    scopus 로고
    • Klotho suppresses RIG-I-mediated senescence-associated inflammation
    • Liu F., Wu S., Ren H., Gu J. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 2011, 13:254-262.
    • (2011) Nat Cell Biol , vol.13 , pp. 254-262
    • Liu, F.1    Wu, S.2    Ren, H.3    Gu, J.4
  • 15
    • 0036150953 scopus 로고    scopus 로고
    • Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene
    • Yoshida T., Fujimori T., Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 2002, 143:683-689.
    • (2002) Endocrinology , vol.143 , pp. 683-689
    • Yoshida, T.1    Fujimori, T.2    Nabeshima, Y.3
  • 16
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003, 17:2393-2403.
    • (2003) Mol Endocrinol , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.5
  • 17
    • 67349229781 scopus 로고    scopus 로고
    • Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase
    • Ohnishi M., Nakatani T., Lanske B., Razzaque M.S. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 2009, 75:1166-1172.
    • (2009) Kidney Int , vol.75 , pp. 1166-1172
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 18
    • 77956637592 scopus 로고    scopus 로고
    • Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
    • Ohnishi M., Razzaque M.S. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 2010, 24:3562-3571.
    • (2010) FASEB J , vol.24 , pp. 3562-3571
    • Ohnishi, M.1    Razzaque, M.S.2
  • 21
    • 47749148805 scopus 로고    scopus 로고
    • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    • Cha S.K., Ortega B., Kurosu H., Rosenblatt K.P., Kuro O.M., Huang C.L. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A 2008, 105:9805-9810.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9805-9810
    • Cha, S.K.1    Ortega, B.2    Kurosu, H.3    Rosenblatt, K.P.4    Kuro, O.M.5    Huang, C.L.6
  • 23
    • 67649834455 scopus 로고    scopus 로고
    • Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho
    • Cha S.K., Hu M.C., Kurosu H., Kuro-o M., Moe O., Huang C.L. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol 2009, 76:38-46.
    • (2009) Mol Pharmacol , vol.76 , pp. 38-46
    • Cha, S.K.1    Hu, M.C.2    Kurosu, H.3    Kuro-o, M.4    Moe, O.5    Huang, C.L.6
  • 24
    • 1642352496 scopus 로고    scopus 로고
    • Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides
    • Tohyama O., Imura A., Iwano A., Freund J.N., Henrissat B., Fujimori T., et al. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem 2004, 279:9777-9784.
    • (2004) J Biol Chem , vol.279 , pp. 9777-9784
    • Tohyama, O.1    Imura, A.2    Iwano, A.3    Freund, J.N.4    Henrissat, B.5    Fujimori, T.6
  • 25
    • 65949111729 scopus 로고    scopus 로고
    • PiT-2 coming out of the pits
    • Moe O.W. PiT-2 coming out of the pits. Am J Physiol Renal Physiol 2009, 296:F689-F690.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Moe, O.W.1
  • 26
    • 0035208924 scopus 로고    scopus 로고
    • The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc
    • Morishita K., Shirai A., Kubota M., Katakura Y., Nabeshima Y., Takeshige K., et al. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr 2001, 131:3182-3188.
    • (2001) J Nutr , vol.131 , pp. 3182-3188
    • Morishita, K.1    Shirai, A.2    Kubota, M.3    Katakura, Y.4    Nabeshima, Y.5    Takeshige, K.6
  • 29
    • 2342599742 scopus 로고    scopus 로고
    • Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression
    • Takeshita K., Fujimori T., Kurotaki Y., Honjo H., Tsujikawa H., Yasui K., et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation 2004, 109:1776-1782.
    • (2004) Circulation , vol.109 , pp. 1776-1782
    • Takeshita, K.1    Fujimori, T.2    Kurotaki, Y.3    Honjo, H.4    Tsujikawa, H.5    Yasui, K.6
  • 31
    • 7844250506 scopus 로고    scopus 로고
    • Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands
    • Tatsumi S., Segawa H., Morita K., Haga H., Kouda T., Yamamoto H., et al. Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. Endocrinology 1998, 139:1692-1699.
    • (1998) Endocrinology , vol.139 , pp. 1692-1699
    • Tatsumi, S.1    Segawa, H.2    Morita, K.3    Haga, H.4    Kouda, T.5    Yamamoto, H.6
  • 32
  • 34
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • Liu H., Fergusson M.M., Castilho R.M., Liu J., Cao L., Chen J., et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007, 317:803-806.
    • (2007) Science , vol.317 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3    Liu, J.4    Cao, L.5    Chen, J.6
  • 35
    • 80053274845 scopus 로고    scopus 로고
    • Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway
    • Maekawa Y., Ohishi M., Ikushima M., Yamamoto K., Yasuda O., Oguro R., et al. Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway. Geriatr Gerontol Int 2011, 11:510-516.
    • (2011) Geriatr Gerontol Int , vol.11 , pp. 510-516
    • Maekawa, Y.1    Ohishi, M.2    Ikushima, M.3    Yamamoto, K.4    Yasuda, O.5    Oguro, R.6
  • 36
    • 33749342012 scopus 로고    scopus 로고
    • Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
    • de Oliveira R.M. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett 2006, 580:5753-5758.
    • (2006) FEBS Lett , vol.580 , pp. 5753-5758
    • de Oliveira, R.M.1
  • 37
    • 38149103006 scopus 로고    scopus 로고
    • High NaCl promotes cellular senescence
    • Dmitrieva N.I., Burg M.B. High NaCl promotes cellular senescence. Cell Cycle 2007, 6:3108-3113.
    • (2007) Cell Cycle , vol.6 , pp. 3108-3113
    • Dmitrieva, N.I.1    Burg, M.B.2
  • 38
    • 70350438009 scopus 로고    scopus 로고
    • Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition
    • Nakano-Kurimoto R., Ikeda K., Uraoka M., Nakagawa Y., Yutaka K., Koide M., et al. Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition. Am J Physiol Heart Circ Physiol 2009, 297:H1673-H1684.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Nakano-Kurimoto, R.1    Ikeda, K.2    Uraoka, M.3    Nakagawa, Y.4    Yutaka, K.5    Koide, M.6
  • 42
    • 0034130405 scopus 로고    scopus 로고
    • Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
    • Nagai R., Saito Y., Ohyama Y., Aizawa H., Suga T., Nakamura T., et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 2000, 57:738-746.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 738-746
    • Nagai, R.1    Saito, Y.2    Ohyama, Y.3    Aizawa, H.4    Suga, T.5    Nakamura, T.6
  • 43
    • 4944242707 scopus 로고    scopus 로고
    • Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse
    • Shimada T., Takeshita Y., Murohara T., Sasaki K., Egami K., Shintani S., et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004, 110:1148-1155.
    • (2004) Circulation , vol.110 , pp. 1148-1155
    • Shimada, T.1    Takeshita, Y.2    Murohara, T.3    Sasaki, K.4    Egami, K.5    Shintani, S.6
  • 45
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003, 112:1486-1494.
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 46
    • 12244263052 scopus 로고    scopus 로고
    • Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse
    • Takeshita K., Yamamoto K., Ito M., Kondo T., Matsushita T., Hirai M., et al. Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse. Semin Thromb Hemost 2002, 28:545-554.
    • (2002) Semin Thromb Hemost , vol.28 , pp. 545-554
    • Takeshita, K.1    Yamamoto, K.2    Ito, M.3    Kondo, T.4    Matsushita, T.5    Hirai, M.6
  • 48
    • 79953138206 scopus 로고    scopus 로고
    • Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    • Doi S., Zou Y., Togao O., Pastor J.V., John G.B., Wang L., et al. Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 2011, 286:8655-8665.
    • (2011) J Biol Chem , vol.286 , pp. 8655-8665
    • Doi, S.1    Zou, Y.2    Togao, O.3    Pastor, J.V.4    John, G.B.5    Wang, L.6
  • 49
    • 84864286004 scopus 로고    scopus 로고
    • Cardiovascular risk in double diabetes mellitus-when two worlds collide
    • Cleland S.J. Cardiovascular risk in double diabetes mellitus-when two worlds collide. Nat Rev Endocrinol 2012, 8:476-485.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 476-485
    • Cleland, S.J.1
  • 50
    • 84860208900 scopus 로고    scopus 로고
    • Epidemiological evidence of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease in Japan
    • Saito I. Epidemiological evidence of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease in Japan. Circ J 2012, 76:1066-1073.
    • (2012) Circ J , vol.76 , pp. 1066-1073
    • Saito, I.1
  • 51
    • 27444433127 scopus 로고    scopus 로고
    • Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults
    • Kurella M., Lo J.C., Chertow G.M. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol 2005, 16:2134-2140.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2134-2140
    • Kurella, M.1    Lo, J.C.2    Chertow, G.M.3
  • 52
    • 79955015611 scopus 로고    scopus 로고
    • Association of exonic variants of Klotho with metabolic syndrome in Asian Indians
    • Majumdar V., Christopher R. Association of exonic variants of Klotho with metabolic syndrome in Asian Indians. Clin Chim Acta 2011, 412:1116-1121.
    • (2011) Clin Chim Acta , vol.412 , pp. 1116-1121
    • Majumdar, V.1    Christopher, R.2
  • 53
    • 84857784178 scopus 로고    scopus 로고
    • Decreased renal alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
    • Asai O., Nakatani K., Tanaka T., Sakan H., Imura A., Yoshimoto S., et al. Decreased renal alpha-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int 2012, 81:539-547.
    • (2012) Kidney Int , vol.81 , pp. 539-547
    • Asai, O.1    Nakatani, K.2    Tanaka, T.3    Sakan, H.4    Imura, A.5    Yoshimoto, S.6
  • 54
    • 80052101334 scopus 로고    scopus 로고
    • Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
    • Zhao Y., Banerjee S., Dey N., LeJeune W.S., Sarkar P.S., Brobey R., et al. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 2011, 60:1907-1916.
    • (2011) Diabetes , vol.60 , pp. 1907-1916
    • Zhao, Y.1    Banerjee, S.2    Dey, N.3    LeJeune, W.S.4    Sarkar, P.S.5    Brobey, R.6
  • 55
    • 0032575483 scopus 로고    scopus 로고
    • Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats
    • Aizawa H., Saito Y., Nakamura T., Inoue M., Imanari T., Ohyama Y., et al. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem Biophys Res Commun 1998, 249:865-871.
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 865-871
    • Aizawa, H.1    Saito, Y.2    Nakamura, T.3    Inoue, M.4    Imanari, T.5    Ohyama, Y.6
  • 56
    • 0035207072 scopus 로고    scopus 로고
    • Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors
    • Yamagishi T., Saito Y., Nakamura T., Takeda S., Kanai H., Sumino H., et al. Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors. Hypertens Res 2001, 24:705-709.
    • (2001) Hypertens Res , vol.24 , pp. 705-709
    • Yamagishi, T.1    Saito, Y.2    Nakamura, T.3    Takeda, S.4    Kanai, H.5    Sumino, H.6
  • 57
    • 70349659193 scopus 로고    scopus 로고
    • Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage
    • Wang Y., Sun Z. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension 2009, 54:810-817.
    • (2009) Hypertension , vol.54 , pp. 810-817
    • Wang, Y.1    Sun, Z.2
  • 58
    • 0034710838 scopus 로고    scopus 로고
    • In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
    • Saito Y., Nakamura T., Ohyama Y., Suzuki T., Iida A., Shiraki-Iida T., et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 2000, 276:767-772.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 767-772
    • Saito, Y.1    Nakamura, T.2    Ohyama, Y.3    Suzuki, T.4    Iida, A.5    Shiraki-Iida, T.6
  • 59
    • 77955362051 scopus 로고    scopus 로고
    • Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats
    • Cheng M.F., Chen L.J., Cheng J.T. Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats. J Biomed Biotechnol 2010, 2010:513853.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 513853
    • Cheng, M.F.1    Chen, L.J.2    Cheng, J.T.3
  • 60
    • 30044451280 scopus 로고    scopus 로고
    • Klotho-induced insulin resistance: a blessing in disguise?
    • Unger R.H. Klotho-induced insulin resistance: a blessing in disguise?. Nat Med 2006, 12:56-57.
    • (2006) Nat Med , vol.12 , pp. 56-57
    • Unger, R.H.1
  • 61
    • 77956251466 scopus 로고    scopus 로고
    • Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation
    • Wang X., Liu X., Zhan Y., Lavallie E.R., Diblasio-Smith L., Collins-Racie L., et al. Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation. J Pharmacol Exp Ther 2010, 334:820-829.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 820-829
    • Wang, X.1    Liu, X.2    Zhan, Y.3    Lavallie, E.R.4    Diblasio-Smith, L.5    Collins-Racie, L.6
  • 62
    • 67649873051 scopus 로고    scopus 로고
    • Association of secondary hyperparathyroidism with CKD progression, health care costs and survival in diabetic predialysis CKD patients
    • Schumock G.T., Andress D.L., Marx S.E., Sterz R., Joyce A.T., Kalantar-Zadeh K. Association of secondary hyperparathyroidism with CKD progression, health care costs and survival in diabetic predialysis CKD patients. Nephron Clin Pract 2009, 113:c54-c61.
    • (2009) Nephron Clin Pract , vol.113
    • Schumock, G.T.1    Andress, D.L.2    Marx, S.E.3    Sterz, R.4    Joyce, A.T.5    Kalantar-Zadeh, K.6
  • 63
    • 79957870135 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    • Isakova T., Wahl P., Vargas G.S., Gutierrez O.M., Scialla J., Xie H., et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 2011, 79:1370-1378.
    • (2011) Kidney Int , vol.79 , pp. 1370-1378
    • Isakova, T.1    Wahl, P.2    Vargas, G.S.3    Gutierrez, O.M.4    Scialla, J.5    Xie, H.6
  • 64
    • 78049463249 scopus 로고    scopus 로고
    • Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    • Hasegawa H., Nagano N., Urakawa I., Yamazaki Y., Iijima K., Fujita T., et al. Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int 2010, 78:975-980.
    • (2010) Kidney Int , vol.78 , pp. 975-980
    • Hasegawa, H.1    Nagano, N.2    Urakawa, I.3    Yamazaki, Y.4    Iijima, K.5    Fujita, T.6
  • 65
    • 84868364558 scopus 로고    scopus 로고
    • Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
    • Shimamura Y., Hamada K., Inoue K., Ogata K., Ishihara M., Kagawa T., et al. Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol 2012, 16:722-729.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 722-729
    • Shimamura, Y.1    Hamada, K.2    Inoue, K.3    Ogata, K.4    Ishihara, M.5    Kagawa, T.6
  • 66
    • 76149101238 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active
    • Shimada T., Urakawa I., Isakova T., Yamazaki Y., Epstein M., Wesseling-Perry K., et al. Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J Clin Endocrinol Metab 2010, 95:578-585.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 578-585
    • Shimada, T.1    Urakawa, I.2    Isakova, T.3    Yamazaki, Y.4    Epstein, M.5    Wesseling-Perry, K.6
  • 67
    • 73649099139 scopus 로고    scopus 로고
    • Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism
    • Kumata C., Mizobuchi M., Ogata H., Koiwa F., Nakazawa A., Kondo F., et al. Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism. Am J Nephrol 2010, 31:230-238.
    • (2010) Am J Nephrol , vol.31 , pp. 230-238
    • Kumata, C.1    Mizobuchi, M.2    Ogata, H.3    Koiwa, F.4    Nakazawa, A.5    Kondo, F.6
  • 68
    • 74449086740 scopus 로고    scopus 로고
    • Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    • Komaba H., Goto S., Fujii H., Hamada Y., Kobayashi A., Shibuya K., et al. Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int 2010, 77:232-238.
    • (2010) Kidney Int , vol.77 , pp. 232-238
    • Komaba, H.1    Goto, S.2    Fujii, H.3    Hamada, Y.4    Kobayashi, A.5    Shibuya, K.6
  • 69
    • 78049481921 scopus 로고    scopus 로고
    • Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
    • Krajisnik T., Olauson H., Mirza M.A., Hellman P., Akerstrom G., Westin G., et al. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int 2010, 78:1024-1032.
    • (2010) Kidney Int , vol.78 , pp. 1024-1032
    • Krajisnik, T.1    Olauson, H.2    Mirza, M.A.3    Hellman, P.4    Akerstrom, G.5    Westin, G.6
  • 70
    • 74449094013 scopus 로고    scopus 로고
    • Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
    • Galitzer H., Ben-Dov I.Z., Silver J., Naveh-Many T. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int 2010, 77:211-218.
    • (2010) Kidney Int , vol.77 , pp. 211-218
    • Galitzer, H.1    Ben-Dov, I.Z.2    Silver, J.3    Naveh-Many, T.4
  • 72
  • 73
    • 59649091992 scopus 로고    scopus 로고
    • In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
    • Nakatani T., Sarraj B., Ohnishi M., Densmore M.J., Taguchi T., Goetz R., et al. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J 2009, 23:433-441.
    • (2009) FASEB J , vol.23 , pp. 433-441
    • Nakatani, T.1    Sarraj, B.2    Ohnishi, M.3    Densmore, M.J.4    Taguchi, T.5    Goetz, R.6
  • 74
    • 82255194301 scopus 로고    scopus 로고
    • Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort
    • Tangri N., Alam A., Wooten E.C., Huggins G.S. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant 2011, 26:3998-4002.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 3998-4002
    • Tangri, N.1    Alam, A.2    Wooten, E.C.3    Huggins, G.S.4
  • 77
    • 84860778116 scopus 로고    scopus 로고
    • Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF23
    • Lim K., Lu T.S., Molostvov G., Lee C., Lam F., Zehnder D., et al. Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF23. Circulation 2012, 125:2243-2255.
    • (2012) Circulation , vol.125 , pp. 2243-2255
    • Lim, K.1    Lu, T.S.2    Molostvov, G.3    Lee, C.4    Lam, F.5    Zehnder, D.6
  • 79
    • 84862781824 scopus 로고    scopus 로고
    • Stanniocalcin 2 is associated with ectopic calcification in alpha-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells
    • Takei Y., Yamamoto H., Sato T., Otani A., Kozai M., Masuda M., et al. Stanniocalcin 2 is associated with ectopic calcification in alpha-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone 2012, 50:998-1005.
    • (2012) Bone , vol.50 , pp. 998-1005
    • Takei, Y.1    Yamamoto, H.2    Sato, T.3    Otani, A.4    Kozai, M.5    Masuda, M.6
  • 80
    • 24944566874 scopus 로고    scopus 로고
    • The role of vitamin D in left ventricular hypertrophy and cardiac function
    • Achinger S.G., Ayus J.C. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int Suppl 2005, 95:S37-S42.
    • (2005) Kidney Int Suppl , vol.95
    • Achinger, S.G.1    Ayus, J.C.2
  • 82
    • 70450230670 scopus 로고    scopus 로고
    • Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    • Mirza M.A., Larsson A., Melhus H., Lind L., Larsson T.E. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 2009, 207:546-551.
    • (2009) Atherosclerosis , vol.207 , pp. 546-551
    • Mirza, M.A.1    Larsson, A.2    Melhus, H.3    Lind, L.4    Larsson, T.E.5
  • 84
    • 0036235099 scopus 로고    scopus 로고
    • In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
    • Mitani H., Ishizaka N., Aizawa T., Ohno M., Usui S., Suzuki T., et al. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002, 39:838-843.
    • (2002) Hypertension , vol.39 , pp. 838-843
    • Mitani, H.1    Ishizaka, N.2    Aizawa, T.3    Ohno, M.4    Usui, S.5    Suzuki, T.6
  • 85
    • 78649642147 scopus 로고    scopus 로고
    • Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    • Hu M.C., Shi M., Zhang J., Quinones H., Kuro-o M., Moe O.W. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int 2010, 78:1240-1251.
    • (2010) Kidney Int , vol.78 , pp. 1240-1251
    • Hu, M.C.1    Shi, M.2    Zhang, J.3    Quinones, H.4    Kuro-o, M.5    Moe, O.W.6
  • 87
    • 5444269240 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells
    • Narumiya H., Sasaki S., Kuwahara N., Irie H., Kusaba T., Kameyama H., et al. HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. Cardiovasc Res 2004, 64:331-336.
    • (2004) Cardiovasc Res , vol.64 , pp. 331-336
    • Narumiya, H.1    Sasaki, S.2    Kuwahara, N.3    Irie, H.4    Kusaba, T.5    Kameyama, H.6
  • 88
    • 79952167540 scopus 로고    scopus 로고
    • Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
    • Yoon H.E., Ghee J.Y., Piao S., Song J.H., Han D.H., Kim S., et al. Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant 2011, 26:800-813.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 800-813
    • Yoon, H.E.1    Ghee, J.Y.2    Piao, S.3    Song, J.H.4    Han, D.H.5    Kim, S.6
  • 89
    • 80755188093 scopus 로고    scopus 로고
    • Circulating levels of soluble alpha-Klotho in patients with chronic kidney disease
    • Sugiura H., Tsuchiya K., Nitta K. Circulating levels of soluble alpha-Klotho in patients with chronic kidney disease. Clin Exp Nephrol 2011, 15:795-796.
    • (2011) Clin Exp Nephrol , vol.15 , pp. 795-796
    • Sugiura, H.1    Tsuchiya, K.2    Nitta, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.