Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: A candidate gene study of the Framingham Offspring Cohort

Nephrology Dialysis Transplantation

Volumn 26, Issue 12, 2011, Pages 3998-4002

  Tangri, Navdeep ^a   Alam, Ahsan ^b   Wooten, Eric C ^a   Huggins, Gordon S ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

calcification; Klotho; mitral annulus; valvular; vascular

Indexed keywords

FIBROBLAST GROWTH FACTOR 23;

ADULT; ARTICLE; BLOOD VESSEL CALCIFICATION; CAUCASIAN; CHRONIC KIDNEY DISEASE; DISEASE COURSE; DNA POLYMORPHISM; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; KLOTHO GENE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AORTIC VALVE; CALCINOSIS; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCURONIDASE; HEART VALVE DISEASES; HUMANS; MALE; MIDDLE AGED; MITRAL VALVE; VASCULAR CALCIFICATION;

EID: 82255194301     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr188     Document Type: Article

References (27)

1. Benjamin EJ, Plehn JF, D'Agostino RB et al. Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med 1992; 327: 374-379
2. Fox CS, Parise H, Vasan RS et al. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004; 173: 291-294 (Pubitemid 38469798)
3. Fox CS, Vasan RS, Parise H et al. Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study. Circulation 2003; 107: 1492-1496 (Pubitemid 36378486)
4. Arking DE, Krebsova A, Macek M Sr et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 2002; 99: 856-861 (Pubitemid 34106600)
5. Bella JN, Tang W, Kraja A et al. Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study. Hypertension 2007; 49: 453-460
6. Boon A, Cheriex E, Lodder J et al. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 1997; 78: 472-474 (Pubitemid 27515107)
7. Horne BD, Camp NJ, Muhlestein JB et al. Evidence for a heritable component in death resulting from aortic and mitral valve diseases. Circulation 2004; 110: 3143-3148 (Pubitemid 39492011)
8. Novaro GM, Sachar R, Pearce GL et al. Association between apolipoprotein E alleles and calcific valvular heart disease. Circulation 2003; 108: 1804-1808 (Pubitemid 37296088)
9. Maher ER, Young G, Smyth-Walsh B et al. Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet 1987; 2: 875-877 (Pubitemid 17154752)
10. Mazzaferro S, Coen G, Bandini S et al. Role of ageing, chronic renal failure and dialysis in the calcification of mitral annulus. Nephrol Dial Transplant 1993; 8: 335-340 (Pubitemid 23129901)
11. Kuro-o M. Overview of the FGF23-Klotho axis. Pediatr Nephrol 2010; 25: 583-590
12. Kuro-o M, Matsumura Y, Aizawa H et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51 (Pubitemid 27494749)
13. Kurosu H, Kuro OM. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 2009; 299: 72-78
14. Arking DE, Atzmon G, Arking A et al. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 2005; 96: 412-418 (Pubitemid 40354534)
15. Arking DE, Becker DM, Yanek LR et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 2003; 72: 1154-1161 (Pubitemid 36530003)
16. Rhee EJ, Oh KW, Lee WY et al. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Metabolism 2006; 55: 1344-1351
17. Memon F, El-Abbadi M, Nakatani T et al. Does Fgf 23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int 2008; 74: 566-570
18. Ohnishi M, Nakatani T, Lanske B et al. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 2009; 75: 1166-1172
19. Kannel WB, Feinleib M, McNamara PM et al. An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol 1979; 110: 281-290 (Pubitemid 10204328)
20. Vasan RS, Larson MG, Levy D et al. Distribution and categorization of echocardiographic measurements in relation to reference limits: the Framingham Heart Study: formulation of a height-and sex-specific classification and its prospective validation. Circulation 1997; 96: 1863-1873 (Pubitemid 27400746)
21. Agatston AS, Janowitz WR, Hildner FJ et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15: 827-832 (Pubitemid 20101575)
22. Stevens LA, Coresh J, Schmid CH et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406 (Pubitemid 351273480)
23. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575 (Pubitemid 47330214)
24. Bostrom MA, Hicks PJ, Lu L et al. Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans. Nephrol Dial Transplant 2010; 10: 3348-3355
25. Friedman DJ, Afkarian M, Tamez H et al. Klotho variants and chronic hemodialysis mortality. J Bone Miner Res 2009; 24: 1847-1855
26. Oguro R, Kamide K, Kokubo Y et al. Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension. Geriatr Gerontol Int 2010; 4: 311-318
27. Stranger BE, Nica AC, Forrest MS et al. Population genomics of human gene expression. Nat Genet 2007; 39: 1217-1224 (Pubitemid 47482691)