Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis

Gastroenterology

Volumn 144, Issue 4, 2013, Pages

  Peters, Ulrike ^a,b   Jiao, Shuo ^a   Schumacher, Fredrick R ^c   Hutter, Carolyn M ^a,b   Aragaki, Aaron K ^a   Baron, John A ^d   Berndt, Sonja I ^e   Bézieau, Stéphane ^f   Brenner, Hermann ^g   Butterbach, Katja ^g   Caan, Bette J ^h   Campbell, Peter T ⁱ   Carlson, Christopher S ^a,b   Casey, Graham ^c   Chan, Andrew T ^j,k   Chang Claude, Jenny ^g   Chanock, Stephen J ^e   Chen, Lin S ^l   Coetzee, Gerhard A ^c   Coetzee, Simon G ^c   Conti, David V ^c   Curtis, Keith R ^a   Duggan, David ^m   Edwards, Todd ⁿ   Fuchs, Charles S ^k,o   Gallinger, Steven ^p   Giovannucci, Edward L ^k,q   Gogarten, Stephanie M ^b   Gruber, Stephen B ^c   Haile, Robert W ^c   Harrison, Tabitha A ^a   Hayes, Richard B ^r   Henderson, Brian E ^c   Hoffmeister, Michael ^g   Hopper, John L ^s   Hudson, Thomas J ^t,u   Hunter, David J ^q   Jackson, Rebecca D ^v   Jee, Sun Ha ^w   Jenkins, Mark A ^s   Jia, Wei Hua ^x   Kolonel, Laurence N ^y   Kooperberg, Charles ^a   Küry, Sébastien ^f   Lacroix, Andrea Z ^a   Laurie, Cathy C ^b   Laurie, Cecelia A ^b   Le Marchand, Loic ^y   Lemire, Mathieu ^t   Levine, David ^b   Lindor, Noralane M ^z   Liu, Yan ^aa   Ma, Jing ^k   Makar, Karen W ^a   Matsuo, Keitaro ^ab   Newcomb, Polly A ^a,b   Potter, John D ^a,ac   Prentice, Ross L ^a   Qu, Conghui ^a   Rohan, Thomas ^ad   Rosse, Stephanie A ^a,b   Schoen, Robert E ^ae   Seminara, Daniela ^e   Shrubsole, Martha ⁿ   Shu, Xiao Ou ⁿ   Slattery, Martha L ^af   Taverna, Darin ^m   Thibodeau, Stephen N ^ag   Ulrich, Cornelia M ^a,b,g   White, Emily ^a,b   Xiang, Yongbing ^ah   Zanke, Brent W ^ai   Zeng, Yi Xin ^x   Zhang, Ben ⁿ   Zheng, Wei ^aj   Hsu, Li ^a   more..

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f NANTES UNIVERSITY HOSPITAL   (France)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h DIVISION OF RESEARCH   (United States)

ⁱ AMERICAN CANCER SOCIETY   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k BRIGHAM AND WOMEN S HOSPITAL   (United States)

^l UNIVERSITY OF CHICAGO   (United States)

^m TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

ⁿ VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o DANA FARBER CANCER INSTITUTE   (United States)

^p TORONTO GENERAL HOSPITAL   (Canada)

^q HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^r NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s UNIVERSITY OF MELBOURNE   (Australia)

^t ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^u UNIVERSITY OF TORONTO   (Canada)

^v OHIO STATE UNIVERSITY   (United States)

^w Yonsei University   (South Korea)

^x SUN YAT SEN UNIVERSITY   (China)

^y UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^z MAYO CLINIC   (United States)

^aa Stephens and Associates   (United States)

^ab AICHI CANCER CENTER HOSPITAL   (Japan)

^ac MASSEY UNIVERSITY   (New Zealand)

^ad ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^ae UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^af UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^ag MAYO CLINIC   (United States)

^ah SHANGHAI CANCER INSTITUTE   (China)

^ai UNIVERSITY OF OTTAWA   (Canada)

^aj VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

Colon Cancer; Genetics; Risk Factors; SNP

Indexed keywords

CYCLIN D2; LAMININ GAMMA1; NUCLEIC ACID BINDING PROTEIN; SPACER DNA; T BOX TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; ASIA; CANCER RISK; CHROMOSOME 12P; CHROMOSOME 1Q; CHROMOSOME 2Q; COLORECTAL ADENOMA; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; EUROPE; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MALE; META ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

EID: 84875253066     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.12.020     Document Type: Article

References (111)

1. P. Lichtenstein, N.V. Holm, P.K. Verkasalo Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland N Engl J Med 343 2000 78 85
2. I. Tomlinson, E. Webb, L. Carvajal-Carmona A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 Nat Genet 39 2007 984 988
3. B.W. Zanke, C.M. Greenwood, J. Rangrej Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 Nat Genet 39 2007 989 994
4. P. Broderick, L. Carvajal-Carmona, A.M. Pittman A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk Nat Genet 39 2007 1315 1317
5. A. Tenesa, S.M. Farrington, J.G. Prendergast Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 Nat Genet 40 2008 631 637
6. E. Jaeger, E. Webb, K. Howarth Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk Nat Genet 40 2008 26 28
7. I.P. Tomlinson, E. Webb, L. Carvajal-Carmona A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 Nat Genet 40 2008 623 630
8. R.S. Houlston, E. Webb, P. Broderick Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer Nat Genet 40 2008 1426 1435
9. R.S. Houlston, J. Cheadle, S.E. Dobbins Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 Nat Genet 42 2010 973 977
10. I.P. Tomlinson, L.G. Carvajal-Carmona, S.E. Dobbins Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer PLoS Genet 7 2011 e1002105
11. U. Peters, C.M. Hutter, L. Hsu Meta-analysis of new genomewide association studies of colorectal cancer risk Hum Genet 131 2012 217 234
12. M.G. Dunlop, S.E. Dobbins, S.M. Farrington Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk Nat Genet 44 2012 770 776
13. H. Brenner, M. Hoffmeister, C. Stegmaier Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies Gut 56 2007 1585 1589
14. K.W. Kinzler, B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
15. T.J. Eide Risk of colorectal cancer in adenoma-bearing individuals within a defined population Int J Cancer 38 1986 173 176
16. S.J. Stryker, B.G. Wolff, C.E. Culp Natural history of untreated colonic polyps Gastroenterology 93 1987 1009 1013
17. J.D. Potter Colorectal cancer: molecules and populations J Natl Cancer Inst 91 1999 916 932
18. S. Jiao, L. Hsu, C.M. Hutter The use of imputed values in the meta-analysis of genome-wide association studies Genet Epidemiol 35 2011 597 605
19. D. Clayton Testing for association on the X chromosome Biostatistics 9 2008 593 600
20. P.F. Hickey, M. Bahlo X chromosome association testing in genome wide association studies Genet Epidemiol 35 2011 664 670
21. J.P. Ioannidis, N.A. Patsopoulos, E. Evangelou Heterogeneity in meta-analyses of genome-wide association investigations PLoS ONE 2 2007 e841
22. S. Purcell, B. Neale, K. Todd-Brown PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575
23. R Development Core Team R: a language and environment for statistical computing 2011 R Foundation for Statistical Computing Vienna, Austria
24. R.J. Pruim, R.P. Welch, S. Sanna LocusZoom: regional visualization of genome-wide association scan results Bioinformatics 26 2010 2336 2337
25. Y. Li, C.J. Willer, J. Ding MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes Genet Epidemiol 34 2010 816 834
26. C.J. Willer, Y. Li, G.R. Abecasis METAL: fast and efficient meta-analysis of genomewide association scans Bioinformatics 26 2010 2190 2191
27. J. Marchini, B. Howie, S. Myers A new multipoint method for genome-wide association studies by imputation of genotypes Nat Genet 39 2007 906 913
28. N. Risch, K. Merikangas The future of genetic studies of complex human diseases Science 273 1996 1516 1517
29. International HapMap Consortium A haplotype map of the human genome Nature 437 2005 1299 1320
30. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
31. C.J. Hoggart, T.G. Clark, I.M. De Genome-wide significance for dense SNP and resequencing data Genet Epidemiol 32 2008 179 185
32. I. Pe'er, R. Yelensk, D. Altshuler Estimation of the multiple testing burden for genomewide association studies of nearly all common variants Genet Epidemiol 32 2008 381 385
33. F. Dudbridge, A. Gusnanto Estimation of significance thresholds for genomewide association scans Genet Epidemiol 32 2008 227 234
34. J. Yang, B. Benyamin, B.P. McEvoy Common SNPs explain a large proportion of the heritability for human height Nat Genet 42 2010 565 569
35. J. Yang, S.H. Lee, M.E. Goddard GCTA: a tool for genome-wide complex trait analysis Am J Hum Genet 88 2011 76 82
36. N. Howlader, A.M. Noone, M. Krapcho SEER cancer statistics review, 1975-2009 2012 National Cancer Institute Bethesda, MD
37. H.C. So, A.H. Gui, S.S. Cherny Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases Genet Epidemiol 35 2011 310 317
38. J.H. Park, S. Wacholder, M.H. Gail Estimation of effect size distribution from genome-wide association studies and implications for future discoveries Nat Genet 42 2010 570 575
39. D.J. Richard, E. Bolderson, L. Cubeddu Single-stranded DNA-binding protein hSSB1 is critical for genomic stability Nature 453 2008 677 681
40. A. Bochkarev, E. Bochkareva, L. Frappier The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding EMBO J 18 1999 4498 4504
41. M.S. Wold Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism Annu Rev Biochem 66 1997 61 92
42. H. Yang, P.D. Jeffrey, J. Miller BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure Science 297 2002 1837 1848
43. Y. Li, E. Bolderson, R. Kumar HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response J Biol Chem 284 2009 23525 23531
44. S. Broderick, K. Rehmet, C. Concannon Eukaryotic single-stranded DNA binding proteins: central factors in genome stability Subcell Biochem 50 2010 143 163
45. O.A. Panagiotou, J.P. Ioannidis What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations Int J Epidemiol 41 2012 273 286
46. R. Kalluri Basement membranes: structure, assembly and role in tumour angiogenesis Nat Rev Cancer 3 2003 422 433
47. N. Turck, I. Gross, P. Gendry Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells Exp Cell Res 303 2005 494 503
48. N. Pouliot, N.A. Saunders, P. Kaur Laminin 10/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration Exp Dermatol 11 2002 387 397
49. T. Gudjonsson, L. Ronnov-Jessen, R. Villadsen Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition J Cell Sci 115 2002 39 50
50. M. Patarroyo, K. Tryggvason, I. Virtanen Laminin isoforms in tumor invasion, angiogenesis and metastasis Semin Cancer Biol 12 2002 197 207
51. A. Akhavan, O.L. Griffith, L. Soroceanu Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes Cancer Res 72 2012 2578 2588
52. J. Lukas, H. Muller, J. Bartkova DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1 J Cell Biol 125 1994 625 638
53. H. Matsushime, D.E. Quelle, S.A. Shurtleff D-type cyclin-dependent kinase activity in mammalian cells Mol Cell Biol 14 1994 2066 2076
54. M. Ragusa, L. Statello, M. Maugeri Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors J Mol Med (Berl) 90 2012 1421 1438
55. P. Zhang, Y. Ma, F. Wang Comprehensive gene and microRNA expression profiling reveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis Mol Biol Rep 39 2012 1471 1478
56. Y. Yang, F. Wang, C. Shi Cyclin D1 G870A polymorphism contributes to colorectal cancer susceptibility: evidence from a systematic review of 22 case-control studies PLoS One 7 2012 e36813
57. J. Yang, G. Zhang, J. Chen CCND1 G870A polymorphism is associated with increased risk of colorectal cancer, especially for sporadic colorectal cancer and in Caucasians: a meta-analysis Clin Res Hepatol Gastroenterol 36 2012 169 177
58. C. Turnbull, E.A. Rapley, S. Seal Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer Nat Genet 42 2010 604 607
59. J. Smith, S. Mowla, S. Prince Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites Gene 486 2011 41 46
60. A.J. Washkowitz, S. Gavrilov, S. Begum Diverse functional networks of Tbx3 in development and disease Wiley Interdiscip Rev Syst Biol Med 4 2012 273 283
61. C.A. Renard, C. Labalette, C. Armengol Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer Cancer Res 67 2007 901 910
62. P.J. Morin, A.B. Sparks, V. Korinek Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 1997 1787 1790
63. J. Yu, X. Ma, K.F. Cheung Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer Oncogene 29 2010 6464 6474
64. C. Garner Upward bias in odds ratio estimates from genome-wide association studies Genet Epidemiol 31 2007 288 295
65. V.W. Setiawan, J. Haessler, F. Schumacher HNF1B and endometrial cancer risk: results from the PAGE study PLoS One 7 2012 e30390
66. S. Lindstrom, F.R. Schumacher, D. Campa Replication of five prostate cancer loci identified in an Asian population-results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3) Cancer Epidemiol Biomarkers Prev 21 2012 212 216
67. L. Dumitrescu, C.L. Carty, K. Taylor Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study PLoS Genet 7 2011 e1002138
68. S. Buyske, Y. Wu, C.L. Carty Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study PLoS One 7 2012 e35651
69. J.K. Pritchard, M. Przeworski Linkage disequilibrium in humans: models and data Am J Hum Genet 69 2001 1 14
70. C.N. Newton-Cheh, M. Eijgelsheim, K.M. Rice Common variants at ten loci infuence QT interval duration in the QTGEN Study Nat Genet 41 2009 399 406
71. M. Cotterchio, M. Manno, N. Klar Colorectal screening is associated with reduced colorectal cancer risk: a case-control study within the population-based Ontario Familial Colorectal Cancer Registry Cancer Causes Control 16 2005 865 875
72. M. Cotterchio, G. Keown-Eyssen, H. Sutherland Ontario familial colon cancer registry: methods and first-year response rates Chronic Dis Can 21 2000 81 86
73. B.W. Zanke, C.M. Greenwood, J. Rangrej Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 Nat Genet 39 2007 989 994
74. S. Küry, B. Buecher, S. Robiou-du-Pont Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption Cancer Epidemiol Biomarkers Prev 16 2007 1460 1467
75. P.A. Newcomb, J. Baron, M. Cotterchio Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer Cancer Epidemiol Biomarkers Prev 16 2007 2331 2343
76. J.C. Figueiredo, J.P. Lewinger, C. Song Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study Cancer Epidemiol Biomarkers Prev 20 2011 758 766
77. H. Brenner, J. Chang-Claude, C.M. Seiler Protection from colorectal cancer after colonoscopy: population-based case-control study Ann Intern Med 154 2011 22 30
78. C. Lilla, E. Verla-Tebit, A. Risch Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption Cancer Epidemiol Biomarkers Prev 15 2006 99 107
79. M.L. Slattery, J. Potter, B. Caan Energy balance and colon cancer-beyond physical activity Cancer Res 57 1997 75 80
80. L. Le Marchand, J.H. Hankin, L.R. Wilkens Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk Cancer Epidemiol Biomarkers Prev 10 2001 1259 1266
81. E.B. Rimm, M.J. Stampfer, G.A. Colditz Validity of self-reported waist and hip circumferences in men and women Epidemiology 1 1990 466 473
82. L.N. Kolonel, B.E. Henderson, J.H. Hankin A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics Am J Epidemiol 151 2000 346 357
83. C.F. Belanger, C.H. Hennekens, B. Rosner The Nurses' Health Study Am J Nurs 78 1978 1039 1040
84. C.H. Hennekens, K. Eberlein A randomized trial of aspirin and beta-carotene among U.S. physicians Prev Med 14 1985 165 168
85. W.G. Christen, J.M. Gaziano, C.H. Hennekens Design of Physicians' Health Study II-a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials Ann Epidemiol 10 2000 125 134
86. P.C. Prorok, G.L. Andriole, R.S. Bresalier Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial Control Clin Trials 21 2000 273S 309S
87. J.K. Gohagan, P.C. Prorok, R.B. Hayes The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial of the National Cancer Institute: history, organization, and status Control Clin Trials 21 2000 251S 272S
88. National Cancer Institute Cancer Genetic Markers of Susceptibility (CGEMS) data website http://cgems.cancer.gov/data-access.html CGEMS Data Accessed October 5, 2009
89. M. Yeager, N. Chatterjee, J. Ciampa Identification of a new prostate cancer susceptibility locus on chromosome 8q24 Nat Genet 41 2009 1055 1057
90. M.T. Landi, N. Chatterjee, K. Yu A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma Am J Hum Genet 85 2009 679 691
91. P.A. Newcomb, Y. Zheng, V.M. Chia Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women Cancer Res 67 2007 7534 7539
92. E. White, R.E. Patterson, A.R. Kristal VITamins And Lifestyle cohort study: study design and characteristics of supplement users Am J Epidemiol 159 2004 83 93
93. J. Hays, J.R. Hunt, F.A. Hubbell The Women's Health Initiative recruitment methods and results Ann Epidemiol 13 2003 S18 S77
94. The Women's Health Initiative Study Group Design of the Women's Health Initiative clinical trial and observational study Control Clin Trials 19 1998 61 109
95. E.J. Bergstralh, J.L. Kosanke Computerized matching of cases to controls 56th ed. 1995 Department of Health Sciences Research, Mayo Clinic Rochester MN
96. W. Zheng, W.H. Chow, G. Yang The Shanghai Women's Health Study: rationale, study design, and baseline characteristics Am J Epidemiol 162 2005 1123 1131
97. H. Cai, W. Zheng, Y.B. Xiang Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study Br J Nutr 98 2007 1006 1013
98. W. Zheng, J. Long, Y.T. Gao Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1 Nat Genet 41 2009 324 328
99. J.X. Bei, Y. Li, W.H. Jia A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci Nat Genet 42 2010 599 603
100. K. Matsuo, T. Suzuki, H. Ito Association between an 8q24 locus and the risk of colorectal cancer in Japanese BMC Cancer 9 2009 379
101. I. Nakata, K. Yamashiro, R. Yamada Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese PLoS One 6 2011 e19108
102. S.H. Jee, J.W. Sull, J.E. Lee Adiponectin concentrations: a genome-wide association study Am J Hum Genet 87 2010 545 552
103. T.L. Edwards, M.J. Shrubsole, Q. Cai A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma Cancer Prev Res (Phila) 5 2012 855 863
104. U. Peters, C.M. Hutter, L. Hsu Meta-analysis of new genomewide association studies of colorectal cancer risk Hum Genet 131 2012 217 234
105. J. Marchini, B. Howie, S. Myers A new multipoint method for genome-wide association studies by imputation of genotypes Nat Genet 39 2007 906 913
106. S.R. Browning, B.L. Browning Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering Am J Hum Genet 81 2007 1084 1097
107. Y. Li, C.J. Willer, J. Ding MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes Genet Epidemiol 34 2010 816 834
108. M. Nothnagel, D. Ellinghaus, S. Schreiber A comprehensive evaluation of SNP genotype imputation Hum Genet 125 2009 163 171
109. M. Gogele, C. Minelli, A. Thakkinstian Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence Am J Epidemiol 175 2012 739 749
110. W.J. Kent, C.W. Sugnet, T.S. Furey The human genome browser at UCSC Genome Res 12 2002 996 1006
111. R.J. Pruim, R.P. Welch, S. Sanna LocusZoom: regional visualization of genome-wide association scan results Bioinformatics 26 2010 2336 2337