Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption

Cancer Epidemiology Biomarkers and Prevention

Volumn 15, Issue 1, 2006, Pages 99-107

  Lilla, Carmen ^a   Verla Tebit, Emaculate ^a   Risch, Angela ^a   Jäger, Birgit ^a   Hoffmeister, Michael ^b   Brenner, Hermann ^b   Chang Claude, Jenny ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b GERMAN CENTRE FOR RESEARCH ON AGEING   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; GENE PRODUCT; HETEROCYCLIC AMINE; TOBACCO SMOKE; ISOENZYME; N ACETYLTRANSFERASE 1; N-ACETYLTRANSFERASE 1; NAT2 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER RISK; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; FLUORESCENCE; FOOD INTAKE; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAT; MULTIVARIATE ANALYSIS; NAT1 GENE; NAT2 GENE; ONCOGENE; PRIORITY JOURNAL; SMOKING; ACETYLATION; AGED; ANIMAL; CASE CONTROL STUDY; CATTLE; CLINICAL TRIAL; COLORECTAL TUMOR; GENETIC PREDISPOSITION; GENETICS; INDOOR AIR POLLUTION; MIDDLE AGED; MULTICENTER STUDY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

ACETYLATION; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CASE-CONTROL STUDIES; CATTLE; COLORECTAL NEOPLASMS; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HUMANS; ISOENZYMES; LOGISTIC MODELS; MALE; MEAT; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; SMOKING; TOBACCO SMOKE POLLUTION;

EID: 33645457048     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-05-0618     Document Type: Article

References (56)

1. Norat T, Lukanova A, Ferrari P, Riboli E. Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies. Int J Cancer 2002;98:241-56.
2. Giovannucci E. An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2001;10:725-31.
3. Cross AJ, Sinha R. Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ Mol Mutagen 2004;44:44-55.
4. International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 83. Tobacco smoke and involuntary smoking. Lyon (France): IARC Press; 2004.
5. Ilett KF, Ingram DM, Carpenter DS, et al. Expression of monomorphic and polymorphic N-acetyltransferases in human colon. Biochem Pharmacol 1994;47:914-7.
6. Hickman D, Pope J, Patil SD, et al. Expression of arylamine N-acetyltransferase in human intestine. Gut 1998;42:402-9.
7. Hein DW, Doll MA, Rustan TD, et al. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Carcinogenesis 1993;14:1633-8.
8. Bell DA, Badawi AF, Lang NP, Ilett KF, Kadlubar FF, Hirvonen A. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res 1995;55:5226-9.
9. Hein DW, Doll MA, Fretland AJ, et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 2000;9:29-42.
10. Brockton N, Little J, Sharp L, Cotton SC. N-Acetyltransferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 2000; 151:846-61.
11. de Jong MM, Nolte IM, te Meerman GJ, et al. Low-penetrance genes and their involvement in colorectal cancer susceptibility. Cancer Epidemiol Biomarkers Prev 2002;11:1332-52.
12. Chan AT, Tranah GJ, Giovannucci EL, Willett WC, Hunter DJ, Fuchs CS. Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int J Cancer 2005;115:648-52.
13. Tiemersma EW, Kampman E, Bueno de Mesquita HB, et al. Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. Cancer Causes Control 2002;13:383-93.
14. Tiemersma EW, Bunschoten A, Kok FJ, Glatt H, de Boer SY, Kampman E. Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. Int J Cancer 2004; 108:97-103.
15. van der Hel OL, Bueno de Mesquita HB, Sandkuijl L, et al. Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands). Cancer Causes Control 2003; 14:293-8.
16. Barrett JH, Smith G, Waxman R, et al. Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer. Carcinogenesis 2003;24:275-82.
17. Slattery ML, Edwards S, Curtin K, Schaffer D, Neuhausen S. Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. Cancer Epidemiol Biomarkers Prev 2003;12:882-9.
18. Slattery ML, Potter JD, Samowitz W, Bigler J, Caan B, Leppert M. NAT2, GSTM-1, cigarette smoking, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 1998;7:1079-84.
19. Potter JD, Bigler J, Fosdick L, et al. Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms. Cancer Epidemiol Biomarkers Prev 1999;8:69-75.
20. Welfare MR, Cooper J, Bassendine MF, Daly AK. Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England. Carcinogenesis 1997;18:1351-4.
21. Probst-Hensch NM, Haile RW, Ingles SA, et al. Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res 1995;55:2017-20.
22. Bell DA, Stephens EA, Castranio T, et al. Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 1995;55:3537-42.
23. Hein DW, Rustan TD, Ferguson RJ, Doll MA, Gray K. Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch Toxicol 1994; 68:129-33.
24. King RS, Teitel CH, Kadlubar FF. In vitro bioactivation of N-hydroxy-2-amino-a-carboline. Carcinogenesis 2000;21:1347-54.
25. Murtaugh MA, Ma KN, Sweeney C, Caan BJ, Slattery ML. Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women. J Nutr 2004;134:776-84.
26. Kampman E, Slattery ML, Bigler J, et al. Meat consumption, genetic susceptibility, and colon cancer risk: a United States multicenter case-control study. Cancer Epidemiol Biomarkers Prev 1999;8:15-24.
27. Chen J, Stampfer MJ, Hough HL, et al. A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res 1998;58:3307-11.
28. Tiemersma EW, Voskuil DW, Bunschoten A, et al. Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a dutch population. Cancer Causes Control 2004;15:225-36.
29. Wikman H, Thiel S, Jäger B, et al. Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics 2001;11:157-68.
30. Chang-Claude J, Kropp S, Jäger B, Bartsch H, Risch A. Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11:698-704.
31. Yang M, Katoh T, Delongchamp R, Ozawa S, Kohshi K, Kawamoto T. Relationship between NAT1 genotype and phenotype in a Japanese population. Pharmacogenetics 2000;10:225-32.
32. Lo-Guidice JM, Allorge D, Chevalier D, et al. Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay. Pharmacogenetics 2000;10:293-300.
33. Kropp S, Chang-Claude J. Active and passive smoking and risk of breast cancer by age 50 years among German women. Am J Epidemiol 2002; 156:616-26.
34. Ahrens W, Bellach BM, Jöckel KH. Messung soziodemographischer merkmale in der epidemiologie. RKI-Schrift 1/98. Munich (Germany): MMV Medizin Verlag; 1998.
35. Moslehi R, Chen J, Hein DW, et al. Cigarette smoking, NAT1 and NAT2 susceptibility haplotypes, and the risk of advanced colorectal adenoma. Proc Am Assoc Cancer Res 2005;46:769.
36. Risch A, Wallace DM, Bathers S, Sim E. Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum Mol Genet 1995:4:231-6.
37. Vineis P, Bartsch H, Caporaso N, et al. Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens. Nature 1994;369:154-6.
38. Yu MC, Skipper PL, Taghizadeh K, et al. Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California. J Natl Cancer Inst 1994;86:712-6.
39. Vineis P, Caporaso N, Tannenbaum SR, et al. Acetylation phenotype, carcinogen-hemoglobin adducts, and cigarette smoking. Cancer Res 1990; 50:3002-4.
40. Gerhardsson de Verdier M, Plato N, Steineck G, Peters JM. Occupational exposures and cancer of the colon and rectum. Am J Ind Med 1992;22: 291-303.
41. Nishino Y, Tsubono Y, Tsuji I, et al. Passive smoking at home and cancer risk: a population-based prospective study in Japanese nonsmoking women. Cancer Causes Control 2001;12:797-802.
42. Sandler RS, Sandler DP, Comstock GW, Helsing KJ, Shore DL. Cigarette smoking and the risk of colorectal cancer in women. J Natl Cancer Inst 1988; 80:1329-33.
43. Morabia A, Bernstein MS, Bouchardy I, Kurtz J, Morris MA. Breast cancer and active and passive smoking: the role of the N-acetyltransferase 2 genotype. Am J Epidemiol 2000;152:226-32.
44. Kune GA, Kune S, Vitetta L, Watson LF. Smoking and colorectal cancer risk: data from the Melbourne Colorectal Cancer Study and brief review of literature. Int J Cancer 1992;50:369-72.
45. International Agency for Research on Cancer. IARC monograph on the evaluation of the carcinogenic risk of chemicals to humans. Vol. 38. Tobacco Smoking. Lyon (France): IARC Press; 1986.
46. Johnson KC. Accumulating evidence on passive and active smoking and breast cancer risk. Int J Cancer 2005;117:619-28.
47. Ishibe N, Sinha R, Hein DW, et al. Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas. Pharmacogenetics 2002; 12:145-50.
48. Smelt VA, Mardon HJ, Sim E. Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2. Pharmacol Toxicol 1998;83:149-57.
49. Felton JS, Jägerstad M, Knize MG, Skog K, Wakabayashi K. Contents in foods, berverages and tobacco. In: Nagao M, Sugimura T, editors. Food borne carcinogens, heterocyclic amines. Chichester (United Kingdom): John Wiley & Sons, Ltd; 2000. p. 31-71.
50. Purewal M, Velasco M, Fretland AJ, Hein DW, Wargovich MJ. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats. Cancer Epidemiol Biomarkers Prev 2000;9: 529-32.
51. Purewal M, Fretland AJ, Schut HA, Hein DW, Wargovich MJ. Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats. Cancer Lett 2000;149:53-60.
52. Cascorbi I, Brockmöller J, Mrozikiewicz PM, Muller A, Roots I. Arylamine N-acetyltransferase activity in man. Drug Metab Rev 1999;31:489-502.
53. Jensen OM, Wahrendorf J, Rosenqvist A, Geser A. The reliability of questionnaire-derived historical dietary information and temporal stability of food habits in individuals. Am J Epidemiol 1984;120:281-90.
54. Goldbohm RA, van't Veer P, van den Brandt PA, et al. Reproducibility of a food frequency questionnaire and stability of dietary habits determined from five annually repeated measurements. Eur J Clin Nutr 1995;49:420-9.
55. Brenner H. A birth cohort analysis of the smoking epidemic in West Germany. J Epidemiol Community Health 1993;47:54-8.
56. Wacholder S, Rothman N, Caporaso N. Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 2000;92:1151-8.