-
1
-
-
0034644185
-
Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland
-
Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 78-85
-
-
Lichtenstein, P.1
-
2
-
-
33846332027
-
Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors
-
Aaltonen, L., Johns, L., Jarvinen, H., Mecklin, J.P. & Houlston, R. Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin. Cancer Res. 13, 356-361 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 356-361
-
-
Aaltonen, L.1
Johns, L.2
Jarvinen, H.3
Mecklin, J.P.4
Houlston, R.5
-
3
-
-
34547498546
-
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
-
Tomlinson, I. et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat. Genet. 39, 984-988 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 984-988
-
-
Tomlinson, I.1
-
4
-
-
34547092701
-
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
-
Zanke, B.W. et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat. Genet. 39, 989-994 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 989-994
-
-
Zanke, B.W.1
-
5
-
-
42649136554
-
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
-
Tomlinson, I.P. et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat. Genet. 40, 623-630 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 623-630
-
-
Tomlinson, I.P.1
-
6
-
-
42649124305
-
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
-
Tenesa, A. et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat. Genet. 40, 631-637 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 631-637
-
-
Tenesa, A.1
-
7
-
-
37549072226
-
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
-
Jaeger, E. et al. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat. Genet. 40, 26-28 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 26-28
-
-
Jaeger, E.1
-
8
-
-
35648937584
-
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
-
Broderick, P. et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat. Genet. 39, 1315-1317 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 1315-1317
-
-
Broderick, P.1
-
9
-
-
34247548755
-
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
-
Yeager, M. et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet. 39, 645-649 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 645-649
-
-
Yeager, M.1
-
10
-
-
0037093072
-
Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells
-
Kim, J.S. et al. Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res. 62, 2744-2748 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 2744-2748
-
-
Kim, J.S.1
-
11
-
-
6944224156
-
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
-
He, X.C. et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nat. Genet. 36, 1117-1121 (2004).
-
(2004)
Nat. Genet
, vol.36
, pp. 1117-1121
-
-
He, X.C.1
-
12
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
Howe, J.R. et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat. Genet. 28, 184-187 (2001).
-
(2001)
Nat. Genet
, vol.28
, pp. 184-187
-
-
Howe, J.R.1
-
13
-
-
0034829630
-
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes
-
Zhou, X.P. et al. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am. J. Hum. Genet. 69, 704-711 (2001).
-
(2001)
Am. J. Hum. Genet
, vol.69
, pp. 704-711
-
-
Zhou, X.P.1
-
14
-
-
0037113916
-
The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization
-
Peck, J.W., Oberst, M., Bouker, K.B., Bowden, E. & Burbelo, P.D. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. J. Biol. Chem. 277, 43924-43932 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 43924-43932
-
-
Peck, J.W.1
Oberst, M.2
Bouker, K.B.3
Bowden, E.4
Burbelo, P.D.5
-
15
-
-
33750594388
-
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
-
Bellovin, D.I. et al. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 25, 6959-6967 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 6959-6967
-
-
Bellovin, D.I.1
-
16
-
-
33846264945
-
RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility
-
Chang, Y.W., Marlin, J.W., Chance, T.W. & Jakobi, R. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. Cancer Res. 66, 11700-11708 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 11700-11708
-
-
Chang, Y.W.1
Marlin, J.W.2
Chance, T.W.3
Jakobi, R.4
-
17
-
-
23844507181
-
The role of the Wnt signalling pathway in colorectal tumorigenesis
-
Behrens, J. The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem. Soc. Trans. 33, 672-675 (2005).
-
(2005)
Biochem. Soc. Trans
, vol.33
, pp. 672-675
-
-
Behrens, J.1
-
18
-
-
0035058012
-
Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer
-
Wheeler, J.M. et al. Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut 48, 367-371 (2001).
-
(2001)
Gut
, vol.48
, pp. 367-371
-
-
Wheeler, J.M.1
-
19
-
-
0032568370
-
E-cadherin germline mutations in familial gastric cancer
-
Guilford, P. et al. E-cadherin germline mutations in familial gastric cancer. Nature 392, 402-405 (1998).
-
(1998)
Nature
, vol.392
, pp. 402-405
-
-
Guilford, P.1
-
20
-
-
0033029710
-
Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
-
Richards, F.M. et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum. Mol. Genet. 8, 607-610 (1999).
-
(1999)
Hum. Mol. Genet
, vol.8
, pp. 607-610
-
-
Richards, F.M.1
-
21
-
-
0035491309
-
A germline E-cadherin mutation in a family with gastric and colon cancer
-
Salahshor, S. et al. A germline E-cadherin mutation in a family with gastric and colon cancer. Int. J. Mol. Med. 8, 439-443 (2001).
-
(2001)
Int. J. Mol. Med
, vol.8
, pp. 439-443
-
-
Salahshor, S.1
-
22
-
-
0034652622
-
A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities
-
Li, L.C. et al. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res. 60, 873-876 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 873-876
-
-
Li, L.C.1
-
23
-
-
33846978695
-
Relative impact of nucleotide and copy number variation on gene expression phenotypes
-
Stranger, B.E. et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848-853 (2007).
-
(2007)
Science
, vol.315
, pp. 848-853
-
-
Stranger, B.E.1
-
24
-
-
55449112185
-
Genome-wide associations of gene expression variation in humans
-
Stranger, B.E. et al. Genome-wide associations of gene expression variation in humans. PLoS Genet. 1, e78 (2005).
-
(2005)
PLoS Genet
, vol.1
-
-
Stranger, B.E.1
-
25
-
-
46849098205
-
Multiple loci with different cancer specificities within the 8q24 gene desert
-
Ghoussaini, M. et al. Multiple loci with different cancer specificities within the 8q24 gene desert. J. Natl. Cancer Inst. 100, 962-966 (2008).
-
(2008)
J. Natl. Cancer Inst
, vol.100
, pp. 962-966
-
-
Ghoussaini, M.1
-
26
-
-
34547121725
-
A common genetic risk factor for colorectal and prostate cancer
-
Haiman, C.A. et al. A common genetic risk factor for colorectal and prostate cancer. Nat. Genet. 39, 954-956 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 954-956
-
-
Haiman, C.A.1
-
27
-
-
35648977025
-
National study of colorectal cancer genetics
-
Penegar, S. et al. National study of colorectal cancer genetics. Br. J. Cancer 97, 1305-1309 (2007).
-
(2007)
Br. J. Cancer
, vol.97
, pp. 1305-1309
-
-
Penegar, S.1
-
28
-
-
52049111037
-
-
Eisen, T., Matakidou, A., Consortium, G. & Houlston, R. Identification of low penetrance alleles for lung cancer: The GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8, 244 (2008).
-
Eisen, T., Matakidou, A., Consortium, G. & Houlston, R. Identification of low penetrance alleles for lung cancer: The GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8, 244 (2008).
-
-
-
-
29
-
-
33749620329
-
Generation Scotland: The Scottish Family Health Study; a new resource for researching genes and heritability
-
Smith, B.H. et al. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med. Genet. 7, 74 (2006).
-
(2006)
BMC Med. Genet
, vol.7
, pp. 74
-
-
Smith, B.H.1
-
30
-
-
32144461525
-
Cohort profile: 1958 British birth cohort (National Child Development Study)
-
Power, C. & Elliott, J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int. J. Epidemiol. 35, 34-41 (2006).
-
(2006)
Int. J. Epidemiol
, vol.35
, pp. 34-41
-
-
Power, C.1
Elliott, J.2
-
32
-
-
0031938045
-
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
-
Zhou, X.P. et al. Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites. Genes Chromosomes Cancer 21, 101-107 (1998).
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 101-107
-
-
Zhou, X.P.1
-
33
-
-
0032534069
-
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
-
Boland, C.R. et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 58, 5248-5257 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 5248-5257
-
-
Boland, C.R.1
-
35
-
-
0037098199
-
Quantifying heterogeneity in a meta-analysis
-
Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539-1558 (2002).
-
(2002)
Stat. Med
, vol.21
, pp. 1539-1558
-
-
Higgins, J.P.1
Thompson, S.G.2
-
36
-
-
0029859724
-
Genetics of coeliac disease
-
Houlston, R.S. & Ford, D. Genetics of coeliac disease. QJM 89, 737-743 (1996).
-
(1996)
QJM
, vol.89
, pp. 737-743
-
-
Houlston, R.S.1
Ford, D.2
-
37
-
-
33847337318
-
A common coding variant in CASP8 is associated with breast cancer risk
-
Cox, A. et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat. Genet. 39, 352-358 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 352-358
-
-
Cox, A.1
-
38
-
-
0034793635
-
A systematic review and meta-analysis of familial colorectal cancer risk
-
Johns, L.E. & Houlston, R.S. A systematic review and meta-analysis of familial colorectal cancer risk. Am. J. Gastroenterol. 96, 2992-3003 (2001).
-
(2001)
Am. J. Gastroenterol
, vol.96
, pp. 2992-3003
-
-
Johns, L.E.1
Houlston, R.S.2
-
39
-
-
52949139429
-
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
-
Di Bernardo, M.C. et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 40, 1204-1210 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 1204-1210
-
-
Di Bernardo, M.C.1
-
40
-
-
31744435871
-
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
-
Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 38, 209-213 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 209-213
-
-
Skol, A.D.1
Scott, L.J.2
Abecasis, G.R.3
Boehnke, M.4
-
41
-
-
0142063079
-
Polygenic inheritance of breast cancer: Implications for design of association studies
-
Antoniou, A.C. & Easton, D.F. Polygenic inheritance of breast cancer: Implications for design of association studies. Genet. Epidemiol. 25, 190-202 (2003).
-
(2003)
Genet. Epidemiol
, vol.25
, pp. 190-202
-
-
Antoniou, A.C.1
Easton, D.F.2
-
42
-
-
0345196595
-
Power and sample size calculations in case-control studies of gene-environment interactions: Comments on different approaches
-
Garcia-Closas, M. & Lubin, J.H. Power and sample size calculations in case-control studies of gene-environment interactions: comments on different approaches. Am. J. Epidemiol. 149, 689-692 (1999).
-
(1999)
Am. J. Epidemiol
, vol.149
, pp. 689-692
-
-
Garcia-Closas, M.1
Lubin, J.H.2
-
43
-
-
0025099777
-
On power and sample size for studying features of the relative odds of disease
-
Lubin, J.H. & Gail, M.H. On power and sample size for studying features of the relative odds of disease. Am. J. Epidemiol. 131, 552-566 (1990).
-
(1990)
Am. J. Epidemiol
, vol.131
, pp. 552-566
-
-
Lubin, J.H.1
Gail, M.H.2
-
44
-
-
0021993033
-
A Wilcoxon-type test for trend
-
Cuzick, J. A Wilcoxon-type test for trend. Stat. Med. 4, 87-90 (1985).
-
(1985)
Stat. Med
, vol.4
, pp. 87-90
-
-
Cuzick, J.1
|