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Volumn 40, Issue 12, 2008, Pages 1426-1435

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

(50)  Houlston, Richard S a   Webb, Emily a   Broderick, Peter a   Pittman, Alan M a   Di Bernardo, Maria Chiara a   Lubbe, Steven a   Chandler, Ian a   Vijayakrishnan, Jayaram a   Sullivan, Kate a   Penegar, Steven a   Carvajal Carmona, Luis b   Howarth, Kimberley b   Jaeger, Emma b   Spain, Sarah L b   Walther, Axel b   Barclay, Ella b   Martin, Lynn b   Gorman, Maggie b   Domingo, Enric b   Teixeira, Ana S b   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; COLORECTAL CANCER; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 56749176944     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.262     Document Type: Article
Times cited : (476)

References (44)
  • 1
    • 0034644185 scopus 로고    scopus 로고
    • Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland
    • Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 78-85
    • Lichtenstein, P.1
  • 2
    • 33846332027 scopus 로고    scopus 로고
    • Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors
    • Aaltonen, L., Johns, L., Jarvinen, H., Mecklin, J.P. & Houlston, R. Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin. Cancer Res. 13, 356-361 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 356-361
    • Aaltonen, L.1    Johns, L.2    Jarvinen, H.3    Mecklin, J.P.4    Houlston, R.5
  • 3
    • 34547498546 scopus 로고    scopus 로고
    • A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    • Tomlinson, I. et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat. Genet. 39, 984-988 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 984-988
    • Tomlinson, I.1
  • 4
    • 34547092701 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    • Zanke, B.W. et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat. Genet. 39, 989-994 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 989-994
    • Zanke, B.W.1
  • 5
    • 42649136554 scopus 로고    scopus 로고
    • A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
    • Tomlinson, I.P. et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat. Genet. 40, 623-630 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 623-630
    • Tomlinson, I.P.1
  • 6
    • 42649124305 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    • Tenesa, A. et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat. Genet. 40, 631-637 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 631-637
    • Tenesa, A.1
  • 7
    • 37549072226 scopus 로고    scopus 로고
    • Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
    • Jaeger, E. et al. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat. Genet. 40, 26-28 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 26-28
    • Jaeger, E.1
  • 8
    • 35648937584 scopus 로고    scopus 로고
    • A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
    • Broderick, P. et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat. Genet. 39, 1315-1317 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 1315-1317
    • Broderick, P.1
  • 9
    • 34247548755 scopus 로고    scopus 로고
    • Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    • Yeager, M. et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat. Genet. 39, 645-649 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 645-649
    • Yeager, M.1
  • 10
    • 0037093072 scopus 로고    scopus 로고
    • Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells
    • Kim, J.S. et al. Oncogenic β-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res. 62, 2744-2748 (2002).
    • (2002) Cancer Res , vol.62 , pp. 2744-2748
    • Kim, J.S.1
  • 11
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
    • He, X.C. et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nat. Genet. 36, 1117-1121 (2004).
    • (2004) Nat. Genet , vol.36 , pp. 1117-1121
    • He, X.C.1
  • 12
    • 0034972978 scopus 로고    scopus 로고
    • Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
    • Howe, J.R. et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat. Genet. 28, 184-187 (2001).
    • (2001) Nat. Genet , vol.28 , pp. 184-187
    • Howe, J.R.1
  • 13
    • 0034829630 scopus 로고    scopus 로고
    • Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes
    • Zhou, X.P. et al. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am. J. Hum. Genet. 69, 704-711 (2001).
    • (2001) Am. J. Hum. Genet , vol.69 , pp. 704-711
    • Zhou, X.P.1
  • 14
    • 0037113916 scopus 로고    scopus 로고
    • The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization
    • Peck, J.W., Oberst, M., Bouker, K.B., Bowden, E. & Burbelo, P.D. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. J. Biol. Chem. 277, 43924-43932 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 43924-43932
    • Peck, J.W.1    Oberst, M.2    Bouker, K.B.3    Bowden, E.4    Burbelo, P.D.5
  • 15
    • 33750594388 scopus 로고    scopus 로고
    • Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
    • Bellovin, D.I. et al. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 25, 6959-6967 (2006).
    • (2006) Oncogene , vol.25 , pp. 6959-6967
    • Bellovin, D.I.1
  • 16
    • 33846264945 scopus 로고    scopus 로고
    • RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility
    • Chang, Y.W., Marlin, J.W., Chance, T.W. & Jakobi, R. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. Cancer Res. 66, 11700-11708 (2006).
    • (2006) Cancer Res , vol.66 , pp. 11700-11708
    • Chang, Y.W.1    Marlin, J.W.2    Chance, T.W.3    Jakobi, R.4
  • 17
    • 23844507181 scopus 로고    scopus 로고
    • The role of the Wnt signalling pathway in colorectal tumorigenesis
    • Behrens, J. The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem. Soc. Trans. 33, 672-675 (2005).
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 672-675
    • Behrens, J.1
  • 18
    • 0035058012 scopus 로고    scopus 로고
    • Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer
    • Wheeler, J.M. et al. Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut 48, 367-371 (2001).
    • (2001) Gut , vol.48 , pp. 367-371
    • Wheeler, J.M.1
  • 19
    • 0032568370 scopus 로고    scopus 로고
    • E-cadherin germline mutations in familial gastric cancer
    • Guilford, P. et al. E-cadherin germline mutations in familial gastric cancer. Nature 392, 402-405 (1998).
    • (1998) Nature , vol.392 , pp. 402-405
    • Guilford, P.1
  • 20
    • 0033029710 scopus 로고    scopus 로고
    • Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
    • Richards, F.M. et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum. Mol. Genet. 8, 607-610 (1999).
    • (1999) Hum. Mol. Genet , vol.8 , pp. 607-610
    • Richards, F.M.1
  • 21
    • 0035491309 scopus 로고    scopus 로고
    • A germline E-cadherin mutation in a family with gastric and colon cancer
    • Salahshor, S. et al. A germline E-cadherin mutation in a family with gastric and colon cancer. Int. J. Mol. Med. 8, 439-443 (2001).
    • (2001) Int. J. Mol. Med , vol.8 , pp. 439-443
    • Salahshor, S.1
  • 22
    • 0034652622 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities
    • Li, L.C. et al. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res. 60, 873-876 (2000).
    • (2000) Cancer Res , vol.60 , pp. 873-876
    • Li, L.C.1
  • 23
    • 33846978695 scopus 로고    scopus 로고
    • Relative impact of nucleotide and copy number variation on gene expression phenotypes
    • Stranger, B.E. et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848-853 (2007).
    • (2007) Science , vol.315 , pp. 848-853
    • Stranger, B.E.1
  • 24
    • 55449112185 scopus 로고    scopus 로고
    • Genome-wide associations of gene expression variation in humans
    • Stranger, B.E. et al. Genome-wide associations of gene expression variation in humans. PLoS Genet. 1, e78 (2005).
    • (2005) PLoS Genet , vol.1
    • Stranger, B.E.1
  • 25
    • 46849098205 scopus 로고    scopus 로고
    • Multiple loci with different cancer specificities within the 8q24 gene desert
    • Ghoussaini, M. et al. Multiple loci with different cancer specificities within the 8q24 gene desert. J. Natl. Cancer Inst. 100, 962-966 (2008).
    • (2008) J. Natl. Cancer Inst , vol.100 , pp. 962-966
    • Ghoussaini, M.1
  • 26
    • 34547121725 scopus 로고    scopus 로고
    • A common genetic risk factor for colorectal and prostate cancer
    • Haiman, C.A. et al. A common genetic risk factor for colorectal and prostate cancer. Nat. Genet. 39, 954-956 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 954-956
    • Haiman, C.A.1
  • 27
    • 35648977025 scopus 로고    scopus 로고
    • National study of colorectal cancer genetics
    • Penegar, S. et al. National study of colorectal cancer genetics. Br. J. Cancer 97, 1305-1309 (2007).
    • (2007) Br. J. Cancer , vol.97 , pp. 1305-1309
    • Penegar, S.1
  • 28
    • 52049111037 scopus 로고    scopus 로고
    • Eisen, T., Matakidou, A., Consortium, G. & Houlston, R. Identification of low penetrance alleles for lung cancer: The GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8, 244 (2008).
    • Eisen, T., Matakidou, A., Consortium, G. & Houlston, R. Identification of low penetrance alleles for lung cancer: The GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8, 244 (2008).
  • 29
    • 33749620329 scopus 로고    scopus 로고
    • Generation Scotland: The Scottish Family Health Study; a new resource for researching genes and heritability
    • Smith, B.H. et al. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med. Genet. 7, 74 (2006).
    • (2006) BMC Med. Genet , vol.7 , pp. 74
    • Smith, B.H.1
  • 30
    • 32144461525 scopus 로고    scopus 로고
    • Cohort profile: 1958 British birth cohort (National Child Development Study)
    • Power, C. & Elliott, J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int. J. Epidemiol. 35, 34-41 (2006).
    • (2006) Int. J. Epidemiol , vol.35 , pp. 34-41
    • Power, C.1    Elliott, J.2
  • 32
    • 0031938045 scopus 로고    scopus 로고
    • Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
    • Zhou, X.P. et al. Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites. Genes Chromosomes Cancer 21, 101-107 (1998).
    • (1998) Genes Chromosomes Cancer , vol.21 , pp. 101-107
    • Zhou, X.P.1
  • 33
    • 0032534069 scopus 로고    scopus 로고
    • A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
    • Boland, C.R. et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 58, 5248-5257 (1998).
    • (1998) Cancer Res , vol.58 , pp. 5248-5257
    • Boland, C.R.1
  • 35
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539-1558 (2002).
    • (2002) Stat. Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 36
    • 0029859724 scopus 로고    scopus 로고
    • Genetics of coeliac disease
    • Houlston, R.S. & Ford, D. Genetics of coeliac disease. QJM 89, 737-743 (1996).
    • (1996) QJM , vol.89 , pp. 737-743
    • Houlston, R.S.1    Ford, D.2
  • 37
    • 33847337318 scopus 로고    scopus 로고
    • A common coding variant in CASP8 is associated with breast cancer risk
    • Cox, A. et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat. Genet. 39, 352-358 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 352-358
    • Cox, A.1
  • 38
    • 0034793635 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of familial colorectal cancer risk
    • Johns, L.E. & Houlston, R.S. A systematic review and meta-analysis of familial colorectal cancer risk. Am. J. Gastroenterol. 96, 2992-3003 (2001).
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 2992-3003
    • Johns, L.E.1    Houlston, R.S.2
  • 39
    • 52949139429 scopus 로고    scopus 로고
    • A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
    • Di Bernardo, M.C. et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat. Genet. 40, 1204-1210 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 1204-1210
    • Di Bernardo, M.C.1
  • 40
    • 31744435871 scopus 로고    scopus 로고
    • Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
    • Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 38, 209-213 (2006).
    • (2006) Nat. Genet , vol.38 , pp. 209-213
    • Skol, A.D.1    Scott, L.J.2    Abecasis, G.R.3    Boehnke, M.4
  • 41
    • 0142063079 scopus 로고    scopus 로고
    • Polygenic inheritance of breast cancer: Implications for design of association studies
    • Antoniou, A.C. & Easton, D.F. Polygenic inheritance of breast cancer: Implications for design of association studies. Genet. Epidemiol. 25, 190-202 (2003).
    • (2003) Genet. Epidemiol , vol.25 , pp. 190-202
    • Antoniou, A.C.1    Easton, D.F.2
  • 42
    • 0345196595 scopus 로고    scopus 로고
    • Power and sample size calculations in case-control studies of gene-environment interactions: Comments on different approaches
    • Garcia-Closas, M. & Lubin, J.H. Power and sample size calculations in case-control studies of gene-environment interactions: comments on different approaches. Am. J. Epidemiol. 149, 689-692 (1999).
    • (1999) Am. J. Epidemiol , vol.149 , pp. 689-692
    • Garcia-Closas, M.1    Lubin, J.H.2
  • 43
    • 0025099777 scopus 로고
    • On power and sample size for studying features of the relative odds of disease
    • Lubin, J.H. & Gail, M.H. On power and sample size for studying features of the relative odds of disease. Am. J. Epidemiol. 131, 552-566 (1990).
    • (1990) Am. J. Epidemiol , vol.131 , pp. 552-566
    • Lubin, J.H.1    Gail, M.H.2
  • 44
    • 0021993033 scopus 로고
    • A Wilcoxon-type test for trend
    • Cuzick, J. A Wilcoxon-type test for trend. Stat. Med. 4, 87-90 (1985).
    • (1985) Stat. Med , vol.4 , pp. 87-90
    • Cuzick, J.1


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