Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status

Cell Biochemistry and Biophysics

Volumn 65, Issue 3, 2013, Pages 433-444

  Sun, Chao ^a,b,c   Zhang, Hong ^a,b   Ma, Xiao fei ^a,b,c   Zhou, Xin ^a,b,c   Gan, Lu ^a,b   Liu, Yuan yuan ^a,b   Wang, Zhen hua ^a,b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Isoliquiritigenin; Nrf 2; Radiosensitization; Radox status; ROS

Indexed keywords

EID: 84875221485     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-012-9447-x     Document Type: Article

References (59)

1. Droge, W. (2002). Free radicals in the physiological control of cell function. Physiological Reviews, 82, 47-95.
2. Reth, M. (2002). Hydrogen peroxide as second messenger in lymphocyte activation. Nature Immunology, 3, 1129-1134.
3. Mehdi, M. Z., Azar, Z. M., & Srivastava, A. K. (2007). Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling. Cell Biochemistry and Biophysics, 47, 1-10.
4. Trachootham, D., Lu, W., Ogasawara, M. A., Nilsa, R. D., & Huang, P. (2008). Redox regulation of cell survival. Antioxidants & Redox Signaling, 10, 1343-1374.
5. Holmgren, A., Johansson, C., Berndt, C., Lonn, M. E., Hudemann, C., & Lillig, C. H. (2005). Thiol redox control via thioredoxin and glutaredoxin systems. Biochemical Society Transactions, 33, 1375-1377.
6. Kirshner, J. R., He, S., Balasubramanyam, V., Kepros, J., Yang, C. Y., Zhang, M., et al. (2008). Elesclomol induces cancer cell apoptosis through oxidative stress. Molecular Cancer Therapeutics, 7, 2319-2327.
7. Liu, Z. Q., & Shan, H. Y. (2006). Cholesterol, not polyunsaturated fatty acids, is target molecule in oxidation induced by reactive oxygen species in membrane of human erythrocytes. Cell Biochemistry and Biophysics, 45, 185-193.
8. Chiu, L. Y., Ho, F. M., Shiah, S. G., Chang, Y., & Lin, W. W. (2011). Oxidative stress initiates DNA damager MNNG-induced poly (ADP-ribose) polymerase-1-dependent parthanatos cell death. Biochemical Pharmacology, 81, 459-470.
9. Halliwell, B. (2007). Oxidative stress and cancer: have we moved forward? Biochemical Journal, 401, 1-11.
10. Trachootham, D., Alexandre, J., & Huang, P. (2009). Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature Reviews Drug Discovery, 8, 579-591.
11. Acharya, A., Das, I., Chandhok, D., & Saha, T. (2010). Redox regulation in cancer: a double-edged sword with therapeutic potential. Oxidative Medicine and Cellular Longevity, 3, 23-34.
12. Wu, W. S. (2006). The signaling mechanism of ROS in tumor progression. Cancer and Metastasis Reviews, 25, 695-705.
13. Breimer, L. H. (1990). Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage. Molecular Carcinogenesis, 3, 188-197.
14. Meneghini, R. (1997). Iron homeostasis, oxidative stress, and DNA damage. Free Radical Biology & Medicine, 23, 783-792.
15. Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008). The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology, 246, 24-33.
16. Zhang, D. D. (2006). Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metabolism Reviews, 38, 769-789.
17. Hsieh, C. Y., Hsiao, H. Y., Wu, W. Y., Liu, C. A., Tsai, Y. C., Chao, Y. J., et al. (2009). Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells. Journal of Biomedical Science, 16, 12.
18. Surh, Y. J., Kundu, J. K., & Na, H. K. (2008). Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Medica, 74, 1526-1539.
19. Masutani, H., Otsuki, R., Yamaguchi, Y., Takenaka, M., Kanoh, N., Takatera, K., et al. (2009). Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress. Antioxidants & Redox Signaling, 11, 949-962.
20. Yu, S., Khor, T. O., Cheung, K. L., Li, W., Wu, T. Y., Huang, Y., et al. (2010). Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS ONE, 5, 8579.
21. Lee, J. S., & Surh, Y. J. (2005). Nrf2 as a novel molecular target for chemoprevention. Cancer Letters, 224, 171-184.
22. Akhdar, H., Loyer, P., Rauch, C., Corlu, A., Guillouzo, A., & Morel, F. (2009). Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells. European Journal of Cancer, 12, 2219-2227.
23. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry & Cell Biology, 39, 44-84.
24. Bouayed, J. (2010). Polyphenols: a potential new strategy for the prevention and treatment of anxiety and depression. Current Nutrition & Food Science, 6, 13-18.
25. Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N. (2006). Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective. Journal of Controlled Release, 113, 189-207.
26. Azam, S., Hadi, N., Khan, N. U., & Hadi, S. M. (2004). Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicology in Vitro, 18, 555-561.
27. Raza, H., & John, A. (2005). Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicology and Applied Pharmacology, 207, 212-220.
28. Wätjen, W., Michels, G., Steffan, B., Niering, P., Chovolou, Y., Kampkötter, A., et al. (2005). Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. Journal of Nutrition, 135, 525-531.
29. Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G. (2007). Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biology International, 31, 1245-1250.
30. Galati, G., & O'Brien, P. J. (2004). Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radical Biology & Medicine, 37, 287-303.
31. Galati, G., Lin, A., Sultan, A. M., & O'Brien, P. J. (2006). Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radical Biology & Medicine, 40, 570-580.
32. Sergediene, E., Jonsson, K., Szymusiak, H., Tyrakowska, B., Rietjens, I. M., & Cenas, N. (1999). Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Letters, 462, 392-396.
33. Chen, G., Zhu, L., Liu, Y., Zhou, Q., Chen, H., & Yang, J. (2009). Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo. Phytotherapy Research, 23, 498-506.
34. Park, I., Park, K. K., Park, J. H., & Chung, W. Y. (2009). Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. Cancer Letters, 277, 174-181.
35. Zhang, X., Yeung, E. D., Wang, J., Panzhinskiy, E. E., Tong, C., Li, W., et al. (2010). Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Clinical and Experimental Pharmacology and Physiology, 37, 841-847.
36. Li, D., Wang, Z., Chen, H., Wang, J., Zheng, Q., Shang, J., et al. (2009). Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free Radical Biology & Medicine, 46, 731-736.
37. Liu, Q., He, X., Liu, Y., Du, B., Wang, X., Zhang, W., et al. (2008). NADPH oxidase-mediated generation of reactive oxygen species: a new mechanism for X-ray-induced HeLa cell death. Biochemical and Biophysical Research Communications, 377, 775-779.
38. Martinez, V. G., Williams, K. J., Stratford, I. J., Clynes, M., & O'Connor, R. (2008). Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved. Toxicology, 22, 582-588.
39. Solly, K., Wang, X., Xu, X., Strulovici, B., & Zheng, W. (2004). Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay and Drug Development Technologies, 4, 363-372.
40. Yang, X. H., Zheng, X., Cao, J. G., Xiang, H. L., Liu, F., & Lv, Y. (2010). 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. World Journal of Gastroenterology, 16, 3385-3393.
41. Mei, X. L., & Lian, S. (2011). Ultraviolet B light-induced apoptosis in human keratinocytes enriched with epidermal stem cells and normal keratinocytes. Chinese Medical Journal (English Edition), 124, 591-598.
42. Yallapu, M. M., Maher, D. M., Sundram, V., Bell, M. C., Jaggi, M., & Chauhan, S. C. (2010). Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. Journal of Ovarian Research, 3, 11.
43. Berberat, P. O., Dambrauskas, Z., Gulbinas, A., Giese, T., Giese, N., Künzli, B., et al. (2005). Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clinical Cancer Research, 11, 3790-3798.
44. Nowis, D., Legat, M., Grzela, T., Niderla, J., Wilczek, E., Wilczynski, G. M., et al. (2006). Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity. Oncogene, 25, 3365-3374.
45. Ebadi, M., & Sharma, S. K. (2003). Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Antioxidants & Redox Signaling, 5, 319-335.
46. Sharma, S. K., & Ebadi, M. (2003). Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxidants & Redox Signaling, 5, 251-264.
47. Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., et al. (2009). Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature, 458, 780-783.
48. Leach, J. K., van Tuyle, G., Lin, P. S., Schmidt-Ullrich, R., & Mikkelsen, R. B. (2001). Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Research, 61, 3894-3901.
49. Gao, M. C., Jia, X. D., Wu, Q. F., Cheng, Y., Chen, F. R., & Zhang, J. (2011). Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation. Acta Pharmacologica Sinica, 32, 528-536.
50. Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y., & Kinoshita, T. (1998). Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorganic & Medicinal Chemistry, 6, 339-347.
51. Yu, X. L., Wang, W., & Yang, M. (2007). Antioxidant activities of compounds isolated from Dalbergia odorifera T. Chen and their inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Food Chemistry, 104, 715-720.
52. Halliwell, B., & Gutteridge, J. M. (1990). Role of free radicals and catalytic metal ions in human disease: an overview. Methods in Enzymology, 186, 1-85.
53. Halliwell, B., & Aruoma, O. I. (1991). DNA damage by oxygenderived species. Its mechanism and measurement in mammalian systems. FEBS Letters, 281, 9-19.
54. Gaspar, J., Rodrigues, A., Laires, A., Silva, F., Costa, S., Monteiro, M. J., et al. (1994). On the mechanisms of genotoxicity and metabolism of quercetin. Mutagenesis, 9, 445-449.
55. Metodiewa, D., Jaiswal, A. K., Cenas, N., Dickancaite, E., & Segura-Aguilar, J. (1999). Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radical Biology & Medicine, 26, 107-116.
56. Hodnick, W. F., Kung, F. S., Roettger, W. J., Bohmont, C. W., & Pardini, R. S. (1986). Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study. Biochemical Pharmacology, 35, 2345-2357.
57. Ochiai, M., Nagao, M., Wakabayashi, K., & Sugimura, T. (1984). Superoxide dismutase acts as an enhancing factor for quercetin mutagenesis in rat-liver cytosol by preventing its decomposition. Mutation Research, 129, 19-24.
58. Kitano, H. (2004). Cancer as a robust system: implications for anticancer therapy. Nature Reviews Cancer, 4, 227-235.
59. McDonald, J. T., Kim, K., Norris, A. J., Vlashi, E., Phillips, T. M., Lagadec, C., et al. (2010). Ionizing radiation activates the Nrf2 antioxidant response. Cancer Research, 70, 8886-8895.