Cholesterol, not polyunsaturated fatty acids, is target molecule in oxidation induced by reactive oxygen species in membrane of human erythrocytes

Cell Biochemistry and Biophysics

Volumn 45, Issue 2, 2006, Pages 185-193

  Liu, Zai Qun ^a   Shan, Hong Yan ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Cholesterol; Free radical; Human erythrocyte membrane; Oxidation; Polyunsaturated fatty acid; Reactive oxygen species

Indexed keywords

4,6 CHOLESTADIEN 3 ONE; 4,6-CHOLESTADIEN-3-ONE; 7 DEHYDROCHOLESTEROL; CHOLEST 4 EN 3 ONE; CHOLESTA 3,5 DIEN 7 ONE; CHOLESTA-3,5-DIEN-7-ONE; CHOLESTEROL; GLYCEROPHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; UNSATURATED FATTY ACID;

ARTICLE; CELL MEMBRANE; CHEMICAL MODEL; ERYTHROCYTE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

CELL MEMBRANE; CHOLESTADIENOLS; CHOLESTENONES; CHOLESTEROL; ERYTHROCYTES; FATTY ACIDS, UNSATURATED; GLYCEROPHOSPHOLIPIDS; HUMANS; MODELS, CHEMICAL; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

EID: 33745726023     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:45:2:185     Document Type: Article

References (22)

1. Bland, J. S. (1995) Oxidants and antioxidants in clinical medicine: past, present and future potential. J. Nutr. Environ. Med. 5, 255-280.
2. Kirkwood, T. B. L. and Austad, S. N. (2000) Why do we age? Nature 408, 233-238.
3. Finkel, T. and Holbrook, N, J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
4. Werner, E. (2004) GTPases and reactive oxygen species: switches for killing and signaling. J. Cell Sci. 117, 143-153.
5. Esterbauer, H. and Ramos, P. (1995) Chemistry and pathophysiology of oxidation of LDL. Rev. Physiol. Biochem. Pharmacol. 127, 31-64.
6. Spiteller, D. and Spiteller, G. (2000) Identification of toxic 2,4-decadienal in oxidized low-density lipoprotein by solid-phase microextraction. Angew. Chem. Int. Ed. 39, 583-585.
7. Spiteller, D. and Spiteller, G., (2000) Oxidation of linoleic acid in low-density lipoprotein: an important event in atherogenesis. Angew. Chem. Int. Ed. 39, 585-589.
8. Jira, W., Spiteller, G., and Richter, A. (1998) Increased levels of lipid oxidation products in rheumatically destructed bones of patients suffering from rheumatoid. Z. Naturforsch. C 53, 1061-1071.
9. Richards, D. M. C., Dean, R. T., and Jessup, W. (1988) Membrane proteins are critical targets in free radical mediated cytolysis. Biochim. Biophys. Acta 946, 281-288.
10. Niki, E., Komuro, E., Takahashi, M., Urano, S., Ito, E., and Terao, K. (1988) Oxidative hemolysis of erythrocytes and its inhibition by free radical scavengers. J. Biol. Chem. 263, 19,809-19,814.
11. Ingold, K. U., Bowry V. W., Stocker, R., and Walling, C. (1993) Autoxidation of lipids and antioxidation by α-tocopherol and ubiquinol in homogenous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc. Natl. Acad. Sci. USA 90, 45-49.
12. Sato, Y., Kamo, S., Takahashi, T., and Suzuki, Y. (1995) Mechanism of free radical-induced hemolysis of human erythrocytes: hemolysis by water-soluble radical initiator. Biochemistry 34, 8940-8949.
13. Davies, K. J. A. and Goldberg, A. L. (1987) Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cell. J. Biol. Chem. 262, 8227-8234.
14. May, J. M., Qu, Z.-C., and Mendiratta, S. (1998) Protection and recycling of α-tocopherol in human erythrocytes by intracellular ascorbic acid. Arch. Biochem. Biophys. 349, 281-289.
15. Burkitt, M. (2001) A critical overview? of the chemistry of copper-dependent low density lipoprotein oxidation: role of lipid hydroperoxides, α-tocopherol, thiols, and ceruloplasmin. Arch. Biochem. Biophys. 394, 117-135.
16. Rice-Evans, C. A. and Diplock, A. T. (1993) Current status of antioxidant therapy. Free Radic. Biol. Med., 15, 77-96.
17. Neumann, G. A., Krause, D. S., Carman, C. V., et al. (2003) Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumor suppression. Nature 424, 561-565.
18. Horrocks, L. A. and Sharma, M. In Phospholipids (Hawthorne, J. N. and Answell, G. B., eds.). Elsevier, North Holland, Amsterdam, 1982, p. 52.
19. Thomas, C. E., Ohlweiler, D. F., and Kalyanaraman, B. (1994) Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps. J. Biol. Chem. 269, 28,055-28,061.
20. Streitwieser, A. Jr. and Heathcock, C. H. In Introduction to Organic Chemistry, 3rd ed. Macmillan Inc., New York, 1985, p.. 518-521.
21. Hawkins, C. L., Brown, B. E., and Davies, M. J. (2001) Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis. Arch. Biochem. Biophys. 395, 137-145.
22. Freyaldenhoven, M. A., Lehman, P. A., Franz, T. J., Lloyd, R. V., and Samokyszyn, V. M. (1998) Retinoic acid-dependent stimulation of 2,2′-azobis(2-amidinopropane)-initiated autoxidation of linoleic acid in sodium dodecyl sulfate micelles: a novel prooxidant effect of retinoic acid. Chem. Res. Toxicol. 11, 102-110.