Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation

Acta Pharmacologica Sinica

Volumn 32, Issue 4, 2011, Pages 528-536

  Gao, Mai Cang ^a   Jia, Xiao Di ^a   Wu, Qi Fei ^a   Cheng, Yan ^a   Chen, Fen Rong ^a   Zhang, Jun ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

antioxidant enzymes; cell cycle distribution; esophageal cancer; ionizing radiation; peroxiredoxin; radiosensitivity; reactive oxygen species; RNA interference

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; ISOPROTEIN; MESSENGER RNA; PEROXIREDOXIN 1; PEROXIREDOXIN 5; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; ESOPHAGEAL NEOPLASMS; GENE SILENCING; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MICE, INBRED BALB C; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES;

EID: 79953801861     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.235     Document Type: Article

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