Ultraviolet B light-induced apoptosis in human keratinocytes enriched with epidermal stem cells and normal keratinocytes

Chinese Medical Journal

Volumn 124, Issue 4, 2011, Pages 591-598

  Mei, Xue Ling ^a,b   Lian, Shi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Skin; Skin cancer; Stem cell; Ultraviolet light

Indexed keywords

BETA1 INTEGRIN; COLLAGEN TYPE 4; PROTEIN P63;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL ISOLATION; CONTROLLED STUDY; EPIDERMAL STEM CELL; HUMAN; HUMAN CELL; KERATINOCYTE; PROTEIN EXPRESSION; RADIATION RESPONSE; STEM CELL; ULTRAVIOLET B RADIATION;

APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; KERATINOCYTES; STEM CELLS; ULTRAVIOLET RAYS;

EID: 79951795001     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.04.020     Document Type: Article

References (29)

1. Watt FM, Jensen KB. Epidermal stem cell diversity and quiescence. EMBO Mol Med 2009; 1: 260-267.
2. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks RA, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464-468.
3. Hahn WC, Weinberg RA. Rules for making human tumor cells. New Engl J Med 2002; 347: 1593-1603.
4. Zhang W, Remenyik E, Zelterman D, Brash DE, Wikonkal NM. Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc Natl Acad Sci U S A 2001; 98: 13948-13953.
5. Finlan LE, Hupp TR. Epidermal stem cells and cancer stem cells: insights into cancer and potential therapeutic strategies. Eur J Cancer 2006; 42: 1283-1292.
6. Brash DE, Pontén J. Skin precancer. Cancer Surv 1998; 32: 69-113.
7. Owens DM, Watt FM. Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer 2003; 3: 444-451.
8. Xu S, Wang X, Xu W, Xia Y, Zhang C. Evaluation of photodynamic therapy of skin cancers with partial differential alpha-aminolevulinic acid. Chin Med J 2002; 115: 1141-1145.
9. Gailani MR, Leffell DJ, Ziegler A, Gross EG, Brash DE, Bale AE. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst 1996; 88: 349-354.
10. Cleaver JE, Crowley E. UV damage, DNA repair and skin carcinogenesis. Front Biosci 2002; 7: 1024-1043.
11. Sarasin A. The molecular pathways of ultravioletinduced carcinogenesis. Mutat Res 1999; 428: 5-10.
12. Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993; 73: 713-724.
13. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398: 708-713.
14. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, et al. P63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A 2001; 98: 3156-3161.
15. Wittmann M, Purwar R, Hartmann C, Gutzmer R, Werfel T. Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases. J Invest Dermatol 2005; 124: 1225-1233.
16. Kim DS, Cho HJ, Choi HR, Kwon SB, Park KC. Isolation of human epidermal stem cells by adherence and the reconstruction of skin equivalents. Cell Mol Life Sci 2004; 6: 2774-2781.
17. Barrandon Y, Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A 1987; 84: 2302-2306.
18. Lyle S, Christofidou-Solomidou M, Liu Y, Elder DE, Albelda S, Cotsarelis G. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 1998; 111: 3179-3188.
19. Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, Meyer W, Faessler R, et al. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol 2008; 17: 592-609.
20. Michel M, Török N, Godbout MJ, Lussier M, Gaudreau P, Royal A, et al. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. J Cell Sci 1996; 109: 1017-1028.
21. Bowen AR, Hanks AN, Allen SM, Alexander A, Diedrich MJ, Grossman D. Apoptosis regulators and responses in human melanocytic and keratinocytic cells. J Invest Dermatol 2003; 120: 48-55.
22. Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994; 30: 774-778.
23. Urbach F. Incidence of nonmelanoma skin cancer. Dermatol Clin 1991; 9: 751-755.
24. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A 1991; 88: 10124-10128.
25. Takahashi H, Ishida-Yamamoto A, Iizuka H. Ultraviolet B irradiation induces apoptosis of keratinocytes by direct activation of Fas antigen. J Invest Dermatol Symp Proc 2001; 6: 64-68.
26. Chaturvedi V, Qin JZ, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Apoptosis in proliferating, senescent, and immortalized keratinocytes. J Biol Chem 1999; 274: 23358-23367.
27. Qin JZ, Chaturvedi V, Denning MF, Bacon P, Panella J, Choubey D, et al. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene 2002; 21: 2991-3002.
28. Chaturvedi V, Qin JZ, Stennett L, Choubey D, Nickoloff BJ. Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. J Cell Physiol 2004; 198: 100-109.
29. Bowden GT. Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer 2004; 4: 23-35.