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Volumn 34, Issue 11, 2013, Pages

Iron deficiency and heart failure: Diagnostic dilemmas and therapeutic perspectives

Author keywords

Exercise capacity; Heart failure; Hepcidin; Iron deficiency; Prognosis; Soluble transferrin receptor

Indexed keywords

HEPCIDIN; IRON; TRANSFERRIN RECEPTOR;

EID: 84875205478     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs224     Document Type: Review
Times cited : (311)

References (146)
  • 1
    • 65449120792 scopus 로고    scopus 로고
    • Iron behaving badly: Inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
    • Kell DB. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics 2009;8:2.
    • (2009) BMC Med Genomics , vol.8 , pp. 2
    • Kell, D.B.1
  • 2
    • 34547652466 scopus 로고    scopus 로고
    • Nutritional iron deficiency
    • Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007;370: 511-520.
    • (2007) Lancet , vol.370 , pp. 511-520
    • Zimmermann, M.B.1    Hurrell, R.F.2
  • 3
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC. Disorders of iron metabolism. N Engl J Med 1999;341:1986-1995.
    • (1999) N Engl J Med , vol.341 , pp. 1986-1995
    • Andrews, N.C.1
  • 4
    • 79955938334 scopus 로고    scopus 로고
    • Anemia-still a major health problem in many parts of the world!
    • Milman N. Anemia-still a major health problem in many parts of the world! Ann Hematol 2011;90:369-377.
    • (2011) Ann Hematol , vol.90 , pp. 369-377
    • Milman, N.1
  • 5
    • 38349061342 scopus 로고    scopus 로고
    • Maternal and child undernutrition: Global and regional exposures and health consequences
    • Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008;371:243-260.
    • (2008) Lancet , vol.371 , pp. 243-260
    • Black, R.E.1    Allen, L.H.2    Bhutta, Z.A.3    Caulfield, L.E.4    De Onis, M.5    Ezzati, M.6    Mathers, C.7    Rivera, J.8
  • 6
    • 0035150473 scopus 로고    scopus 로고
    • Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship
    • Haas JD, Brownlie T IV. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 2001;131: 676S-690S.
    • (2001) J Nutr , vol.131
    • Haas, J.D.1    Brownlie, T.2
  • 7
    • 73349113184 scopus 로고    scopus 로고
    • Iron homoeostasis in rheumatic disease
    • Baker JF, Ghio AJ. Iron homoeostasis in rheumatic disease. Rheumatology 2009; 48:1339-1344.
    • (2009) Rheumatology , vol.48 , pp. 1339-1344
    • Baker, J.F.1    Ghio, A.J.2
  • 10
    • 70349785234 scopus 로고    scopus 로고
    • Anemia and inflammatory bowel diseases
    • Gomollon F, Gisbert JP. Anemia and inflammatory bowel diseases. World J Gastroenterol 2009;15:4659-4665.
    • (2009) World J Gastroenterol , vol.15 , pp. 4659-4665
    • Gomollon, F.1    Gisbert, J.P.2
  • 11
    • 67349115201 scopus 로고    scopus 로고
    • Iron metabolism in the anemia of chronic disease
    • Weiss G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 2009;1790:682-693.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 682-693
    • Weiss, G.1
  • 12
    • 33746915548 scopus 로고
    • Acute reversible heart failure in severe iron-deficiency anemia associated with hookworm infestation in Uganda Africans
    • Somers K. Acute reversible heart failure in severe iron-deficiency anemia associated with hookworm infestation in Uganda Africans. Circulation 1959;19: 672-675.
    • (1959) Circulation , vol.19 , pp. 672-675
    • Somers, K.1
  • 13
    • 0014492988 scopus 로고
    • The hemodynamic response to chronic anemia
    • Duke M, Abelmann WH. The hemodynamic response to chronic anemia. Circulation 1969;39:503-515.
    • (1969) Circulation , vol.39 , pp. 503-515
    • Duke, M.1    Abelmann, W.H.2
  • 14
    • 0642336978 scopus 로고    scopus 로고
    • Adaptations to iron deficiency: Cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy
    • Turner LR, Premo DA, Gibbs BJ, Hearthway ML, Motsko M, Sappington A, Walker L, Mullendore ME, Chew HG Jr. Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. BMC Physiol 2002;2:1.
    • (2002) BMC Physiol , vol.2 , pp. 1
    • Turner, L.R.1    Premo, D.A.2    Gibbs, B.J.3    Hearthway, M.L.4    Motsko, M.5    Sappington, A.6    Walker, L.7    Mullendore, M.E.8    Chew Jr., H.G.9
  • 17
    • 25144483332 scopus 로고    scopus 로고
    • Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: Involvement of nitric oxide synthase and protein tyrosine nitration
    • Dong F, Zhang X, Culver B, Chew HG Jr, Kelley RO, Ren J. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clin Sci 2005;109:277-286.
    • (2005) Clin Sci , vol.109 , pp. 277-286
    • Dong, F.1    Zhang, X.2    Culver, B.3    Chew Jr., H.G.4    Kelley, R.O.5    Ren, J.6
  • 18
    • 51349145542 scopus 로고    scopus 로고
    • The role of correction of anaemia in patients with congestive heart failure: A short review
    • Silverberg DS,Wexler D, Iaina A, Schwartz D. The role of correction of anaemia in patients with congestive heart failure: a short review. Eur J Heart Fail 2008;10: 819-823.
    • (2008) Eur J Heart Fail , vol.10 , pp. 819-823
    • Silverberg, D.S.1    Wexler, D.2    Iaina, A.3    Schwartz, D.4
  • 23
    • 0037458095 scopus 로고    scopus 로고
    • Anemia is common in heart failure and is associated with poor outcomes: Insights from a cohort of 12,065 patients with new-onset heart failure
    • Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new-onset heart failure. Circulation 2003;107:223-225.
    • (2003) Circulation , vol.107 , pp. 223-225
    • Ezekowitz, J.A.1    McAlister, F.A.2    Armstrong, P.W.3
  • 26
    • 60149089000 scopus 로고    scopus 로고
    • Hyporesponsiveness to erythropoietin: Causes and management
    • Elliott J, Mishler D, Agarwal R. Hyporesponsiveness to erythropoietin: causes and management. Adv Chronic Kidney Dis 2009;16:94-100.
    • (2009) Adv Chronic Kidney Dis , vol.16 , pp. 94-100
    • Elliott, J.1    Mishler, D.2    Agarwal, R.3
  • 27
    • 37349055203 scopus 로고    scopus 로고
    • Mechanisms of Disease: Erythropoietin resistance in patients with both heart and kidney failure
    • van der Putten K, Braam B, Jie KE, Gaillard CA. Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure. Nat Clin Pract Nephrol 2008;4:47-57.
    • (2008) Nat Clin Pract Nephrol , vol.4 , pp. 47-57
    • Van Der Putten, K.1    Braam, B.2    Jie, K.E.3    Gaillard, C.A.4
  • 28
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008;15: 169-175.
    • (2008) Curr Opin Hematol , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 30
    • 34548798205 scopus 로고    scopus 로고
    • Randomized double blind placebo-controlled trial to evaluate the effect of two dosing regimens of darbepoetin alpha in patients with heart failure and anaemia
    • Van Veldhuisen DJ, Dickstein K, Cohen-Solal A, Lok DJ, Wasserman SM, Baker N, Rosser D, Cleland JG, Ponikowski P. Randomized double blind placebo-controlled trial to evaluate the effect of two dosing regimens of darbepoetin alpha in patients with heart failure and anaemia. Eur Heart J 2007;28: 2208-2216.
    • (2007) Eur Heart J , vol.28 , pp. 2208-2216
    • Van Veldhuisen, D.J.1    Dickstein, K.2    Cohen-Solal, A.3    Lok, D.J.4    Wasserman, S.M.5    Baker, N.6    Rosser, D.7    Cleland, J.G.8    Ponikowski, P.9
  • 33
    • 0008323265 scopus 로고    scopus 로고
    • Iron deficiency
    • Beutler E (ed.) 6th ed. New York: McGraw-Hill and p447-50.
    • Fairbanks V, Beutler E. Iron deficiency. In: Beutler E (ed.), Williams Hematology. 6th ed. New York: McGraw-Hill; 2001, p295-304 and p447-50.
    • (2001) Williams Hematology , pp. 295-304
    • Fairbanks, V.1    Beutler, E.2
  • 35
    • 34247112583 scopus 로고    scopus 로고
    • A precious metal: Iron, an essential nutrient for all cells
    • Cairo G, Bernuzzi F, Recalcati S. A precious metal: iron, an essential nutrient for all cells. Genes Nutr 2006;1:25-39.
    • (2006) Genes Nutr , vol.1 , pp. 25-39
    • Cairo, G.1    Bernuzzi, F.2    Recalcati, S.3
  • 36
    • 0038219647 scopus 로고    scopus 로고
    • Ferritins, iron uptake and storage from the bacterioferritin viewpoint
    • Carrondo MA. Ferritins, iron uptake and storage from the bacterioferritin viewpoint. EMBO J 2003;22:1959-1968.
    • (2003) EMBO J , vol.22 , pp. 1959-1968
    • Carrondo, M.A.1
  • 37
    • 0035153971 scopus 로고    scopus 로고
    • Iron biology in immune function, muscle metabolism and neuronal functioning
    • Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001;131(Suppl 2):568S-579S.
    • (2001) J Nutr , vol.131 , Issue.SUPPL. 2
    • Beard, J.L.1
  • 38
    • 17144378216 scopus 로고    scopus 로고
    • Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis
    • Rouault TA, Tong WH. Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat Rev Mol Cell Biol 2005;6:345-351.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 345-351
    • Rouault, T.A.1    Tong, W.H.2
  • 39
    • 80155135813 scopus 로고    scopus 로고
    • Mitochondrial mayhem: The mitochondrion as a modulator of iron metabolism and its role in disease
    • Huang ML, Lane DJ, Richardson DR. Mitochondrial mayhem: the mitochondrion as a modulator of iron metabolism and its role in disease. Antioxid Redox Signal 2011;15:3003-3019.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 3003-3019
    • Huang, M.L.1    Lane, D.J.2    Richardson, D.R.3
  • 41
    • 78751580475 scopus 로고    scopus 로고
    • Iron and erythropoiesis: A dual relationship
    • Camaschella C, Pagani A. Iron and erythropoiesis: a dual relationship. Int J Hematol 2011;93:21-26.
    • (2011) Int J Hematol , vol.93 , pp. 21-26
    • Camaschella, C.1    Pagani, A.2
  • 42
    • 34047207831 scopus 로고    scopus 로고
    • Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1)
    • Alcantara O, Boldt DH. Iron deprivation blocks multilineage haematopoietic differentiation by inhibiting induction of p21(WAF1/CIP1). Br J Haematol 2007;137: 252-261.
    • (2007) Br J Haematol , vol.137 , pp. 252-261
    • Alcantara, O.1    Boldt, D.H.2
  • 43
    • 59449085388 scopus 로고    scopus 로고
    • Energy metabolism in heart failure and remodelling
    • Ingwall JS. Energy metabolism in heart failure and remodelling. Cardiovasc Res 2009;81:412-419.
    • (2009) Cardiovasc Res , vol.81 , pp. 412-419
    • Ingwall, J.S.1
  • 44
    • 67651237070 scopus 로고    scopus 로고
    • Exercise training, energy metabolism, and heart failure
    • Ventura-Clapier R. Exercise training, energy metabolism, and heart failure. Appl Physiol Nutr Metab 2009;34:336-339.
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 336-339
    • Ventura-Clapier, R.1
  • 46
    • 77956586695 scopus 로고    scopus 로고
    • Mitochondria in heart failure
    • Rosca MG, Hoppel CL. Mitochondria in heart failure. Cardiovasc Res 2010;88: 40-50.
    • (2010) Cardiovasc Res , vol.88 , pp. 40-50
    • Rosca, M.G.1    Hoppel, C.L.2
  • 48
    • 78649444888 scopus 로고    scopus 로고
    • Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples
    • Kell DB. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol 2010;84:825-889.
    • (2010) Arch Toxicol , vol.84 , pp. 825-889
    • Kell, D.B.1
  • 53
    • 77955508573 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Pathogenesis, diagnosis, and treatment
    • Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 2010;139:393-408.
    • (2010) Gastroenterology , vol.139 , pp. 393-408
    • Pietrangelo, A.1
  • 55
    • 79953078598 scopus 로고    scopus 로고
    • Disorders of iron metabolism Part 1: Molecular basis of iron homoeostasis
    • Munoz M, Garc?a-Erce JA, Remacha AF. Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis. J Clin Pathol 2011;64:281-286.
    • (2011) J Clin Pathol , vol.64 , pp. 281-286
    • Munoz, M.1    Garca-Erce, J.A.2    Remacha, A.F.3
  • 60
    • 79952162002 scopus 로고    scopus 로고
    • Regulation of cellular iron metabolism
    • Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J 2011; 434:365-381.
    • (2011) Biochem J , vol.434 , pp. 365-381
    • Wang, J.1    Pantopoulos, K.2
  • 61
    • 34249686049 scopus 로고    scopus 로고
    • Ferritin and ferritin isoforms I: Structure-function relationships, synthesis, degradation and secretion
    • Koorts AM, Viljoen M. Ferritin and ferritin isoforms I: structure-function relationships, synthesis, degradation and secretion. Arch Physiol Biochem 2007;113: 30-54.
    • (2007) Arch Physiol Biochem , vol.113 , pp. 30-54
    • Koorts, A.M.1    Viljoen, M.2
  • 62
    • 77949774448 scopus 로고    scopus 로고
    • Molecular mechanisms of hepcidin regulation: Implications for the anemia of CKD
    • Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis 2010;55:726-741.
    • (2010) Am J Kidney Dis , vol.55 , pp. 726-741
    • Babitt, J.L.1    Lin, H.Y.2
  • 63
    • 69949088488 scopus 로고    scopus 로고
    • Hepcidin, the iron watcher
    • Viatte L, Vaulont S. Hepcidin, the iron watcher. Biochimie 2009;91:1223-1228.
    • (2009) Biochimie , vol.91 , pp. 1223-1228
    • Viatte, L.1    Vaulont, S.2
  • 64
    • 77956470416 scopus 로고    scopus 로고
    • Hepcidin and iron metabolism: From laboratory to clinical implications
    • Franchini M, Montagnana M, Lippi G. Hepcidin and iron metabolism: from laboratory to clinical implications. Clin Chim Acta 2010;411:1565-1569.
    • (2010) Clin Chim Acta , vol.411 , pp. 1565-1569
    • Franchini, M.1    Montagnana, M.2    Lippi, G.3
  • 65
    • 70450214396 scopus 로고    scopus 로고
    • The role of hepcidin in iron metabolism
    • Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009; 122:78-86.
    • (2009) Acta Haematol , vol.122 , pp. 78-86
    • Nemeth, E.1    Ganz, T.2
  • 66
    • 43749090222 scopus 로고    scopus 로고
    • Iron and anemia in human biology: A review of mechanisms
    • Handelman GJ, Levin NW. Iron and anemia in human biology: a review of mechanisms. Heart Fail Rev 2008;13:393-404.
    • (2008) Heart Fail Rev , vol.13 , pp. 393-404
    • Handelman, G.J.1    Levin, N.W.2
  • 69
    • 33846702712 scopus 로고    scopus 로고
    • Assessing iron status: Beyond serum ferritin and transferrin saturation
    • Wish JB. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006;1(Suppl 1):S4-S8.
    • (2006) Clin J Am Soc Nephrol , vol.1 , Issue.SUPPL. 1
    • Wish, J.B.1
  • 70
    • 78649753411 scopus 로고    scopus 로고
    • Detection, evaluation, and management of iron-restricted erythropoiesis
    • Goodnough LT, Nemeth E, Ganz T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 2010;116:4754-4761.
    • (2010) Blood , vol.116 , pp. 4754-4761
    • Goodnough, L.T.1    Nemeth, E.2    Ganz, T.3
  • 71
    • 74549149524 scopus 로고    scopus 로고
    • Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: Oral or intravenous?
    • Macdougall IC. Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: oral or intravenous? Curr Med Res Opin 2010;26:473-482.
    • (2010) Curr Med Res Opin , vol.26 , pp. 473-482
    • Macdougall, I.C.1
  • 75
    • 80052571546 scopus 로고    scopus 로고
    • Guidelines for the management of iron deficiency anaemia
    • Goddard AF, James MW, McIntyre AS, Scott BB; on behalf of the British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia. Gut 2011;60:1309-1316.
    • (2011) Gut , vol.60 , pp. 1309-1316
    • Goddard, A.F.1    James, M.W.2    McIntyre, A.S.3    Scott, B.B.4
  • 76
    • 72249092796 scopus 로고
    • The quantitative estimation of total iron stores in human bone marrow
    • Gale E, Torrance J, Bothwell T. The quantitative estimation of total iron stores in human bone marrow. J Clin Invest 1963;42:1076-1082.
    • (1963) J Clin Invest , vol.42 , pp. 1076-1082
    • Gale, E.1    Torrance, J.2    Bothwell, T.3
  • 78
    • 65349101612 scopus 로고    scopus 로고
    • Quality counts: New parameters in blood cell counting
    • Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277-297.
    • (2009) Int J Lab Hematol , vol.31 , pp. 277-297
    • Briggs, C.1
  • 79
    • 0017854347 scopus 로고
    • Serum ferritin concentration and bone marrow iron stores: A prospective study
    • Ali MA, Luxton AW, Walker WH. Serum ferritin concentration and bone marrow iron stores: a prospective study. Can Med Assoc J 1978;118:945-946.
    • (1978) Can Med Assoc J , vol.118 , pp. 945-946
    • Ali, M.A.1    Luxton, A.W.2    Walker, W.H.3
  • 82
    • 77958184956 scopus 로고    scopus 로고
    • Automated reticulocyte counting: State of the art and clinical applications in the evaluation of erythropoiesis
    • Piva E, Brugnara C, Chiandetti L, Plebani M. Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis. Clin Chem Lab Med 2010;48:1369-1380.
    • (2010) Clin Chem Lab Med , vol.48 , pp. 1369-1380
    • Piva, E.1    Brugnara, C.2    Chiandetti, L.3    Plebani, M.4
  • 83
    • 48249141136 scopus 로고    scopus 로고
    • Automated blood cell counts: State of the art
    • Buttarello M, Plebani M. Automated blood cell counts: state of the art. Am J Clin Pathol 2008;130:104-116.
    • (2008) Am J Clin Pathol , vol.130 , pp. 104-116
    • Buttarello, M.1    Plebani, M.2
  • 84
    • 77949332615 scopus 로고    scopus 로고
    • Evaluation and treatment of iron deficiency anemia: A gastroenterological perspective
    • Zhu A, Kaneshiro M, Kaunitz JD. Evaluation and treatment of iron deficiency anemia: a gastroenterological perspective. Dig Dis Sci 2010;55:548-559.
    • (2010) Dig Dis Sci , vol.55 , pp. 548-559
    • Zhu, A.1    Kaneshiro, M.2    Kaunitz, J.D.3
  • 90
    • 55549127206 scopus 로고    scopus 로고
    • Serum transferrin receptor
    • Skikne BS. Serum transferrin receptor. Am J Hematol 2008;83:872-875.
    • (2008) Am J Hematol , vol.83 , pp. 872-875
    • Skikne, B.S.1
  • 91
    • 34250191778 scopus 로고    scopus 로고
    • Clinical utility of serum soluble transferrin receptor levels and comparison with bone marrow iron stores as an index for iron-deficient erythropoiesis in a heterogeneous group of patients
    • Chang J, Bird R, Clague A, Carter AC. Clinical utility of serum soluble transferrin receptor levels and comparison with bone marrow iron stores as an index for iron-deficient erythropoiesis in a heterogeneous group of patients. Pathology 2007;39:349-353.
    • (2007) Pathology , vol.39 , pp. 349-353
    • Chang, J.1    Bird, R.2    Clague, A.3    Carter, A.C.4
  • 92
    • 0032730905 scopus 로고    scopus 로고
    • Serum transferrin receptor assay in iron deficiency anaemia and anaemia of chronic disease in the elderly
    • Chua E, Clague JE, Sharma AK, Horan MA, Lombard M. Serum transferrin receptor assay in iron deficiency anaemia and anaemia of chronic disease in the elderly. QJM 1999;92:587-594.
    • (1999) QJM , vol.92 , pp. 587-594
    • Chua, E.1    Clague, J.E.2    Sharma, A.K.3    Horan, M.A.4    Lombard, M.5
  • 93
  • 98
    • 67849087296 scopus 로고    scopus 로고
    • Regulation of intestinal iron absorption: The mucosa takes control?
    • Simpson RJ, McKie AT. Regulation of intestinal iron absorption: the mucosa takes control? Cell Metab 2009;10:84-87.
    • (2009) Cell Metab , vol.10 , pp. 84-87
    • Simpson, R.J.1    McKie, A.T.2
  • 100
    • 58149130150 scopus 로고    scopus 로고
    • Immune modulation: Role of the inflammatory cytokine cascade in the failing human heart
    • Satoh M, Minami Y, Takahashi Y, Nakamura M. Immune modulation: role of the inflammatory cytokine cascade in the failing human heart. Curr Heart Fail Rep 2008;5:69-74.
    • (2008) Curr Heart Fail Rep , vol.5 , pp. 69-74
    • Satoh, M.1    Minami, Y.2    Takahashi, Y.3    Nakamura, M.4
  • 101
    • 38549102037 scopus 로고    scopus 로고
    • Cytokines and myocardial dysfunction: State of the art
    • El-Menyar AA. Cytokines and myocardial dysfunction: state of the art. J Card Fail 2008;14:61-74.
    • (2008) J Card Fail , vol.14 , pp. 61-74
    • El-Menyar, A.A.1
  • 102
    • 78650411136 scopus 로고    scopus 로고
    • Cachexia as a major underestimated and unmet medical need: Facts and numbers
    • von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle 2010;1:1-5.
    • (2010) J Cachexia Sarcopenia Muscle , vol.1 , pp. 1-5
    • Von Haehling, S.1    Anker, S.D.2
  • 103
    • 79955612531 scopus 로고    scopus 로고
    • An overview of sarcopenia: Facts and numbers on prevalence and clinical impact
    • von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle 2010; 1:129-133.
    • (2010) J Cachexia Sarcopenia Muscle , vol.1 , pp. 129-133
    • Von Haehling, S.1    Morley, J.E.2    Anker, S.D.3
  • 104
    • 0345737279 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha and the failing heart: Pathophysiology and therapeutic implications
    • von Haehling S, Jankowska EA, Anker SD. Tumour necrosis factor-alpha and the failing heart: pathophysiology and therapeutic implications. Basic Res Cardiol 2004;99:18-28.
    • (2004) Basic Res Cardiol , vol.99 , pp. 18-28
    • Von Haehling, S.1    Jankowska, E.A.2    Anker, S.D.3
  • 105
    • 77955656211 scopus 로고    scopus 로고
    • The iron-regulatory peptide hepcidin is upregulated in the ischemic and in the remote myocardium after myocardial infarction
    • Simonis G, Mueller K, Schwarz P, Wiedemann S, Adler G, Strasser RH, Kulaksiz H. The iron-regulatory peptide hepcidin is upregulated in the ischemic and in the remote myocardium after myocardial infarction. Peptides 2010;31: 1786-1790.
    • (2010) Peptides , vol.31 , pp. 1786-1790
    • Simonis, G.1    Mueller, K.2    Schwarz, P.3    Wiedemann, S.4    Adler, G.5    Strasser, R.H.6    Kulaksiz, H.7
  • 114
    • 35248870765 scopus 로고    scopus 로고
    • Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    • Toblli JE, Lombrana A, Duarte P, Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 2007;50:1657-1665.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1657-1665
    • Toblli, J.E.1    Lombrana, A.2    Duarte, P.3    Di Gennaro, F.4
  • 117
    • 77955496945 scopus 로고    scopus 로고
    • Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure
    • Middlekauff HR. Making the case for skeletal myopathy as the major limitation of exercise capacity in heart failure. Circ Heart Fail 2010;3:537-546.
    • (2010) Circ Heart Fail , vol.3 , pp. 537-546
    • Middlekauff, H.R.1
  • 118
    • 0030297870 scopus 로고    scopus 로고
    • Exercise limitation in chronic heart failure: Central role of the periphery
    • Clark AL, Poole-Wilson PA, Coats AJ. Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol 1996;28:1092-1102.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 1092-1102
    • Clark, A.L.1    Poole-Wilson, P.A.2    Coats, A.J.3
  • 119
    • 54049084164 scopus 로고    scopus 로고
    • Heart and iron deficiency anaemia in rats with renal insufficiency: The role of hepcidin
    • Toblli JE, Cao G, Rivas C, Kulaksiz H. Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin. Nephrology 2008;13:636-645.
    • (2008) Nephrology , vol.13 , pp. 636-645
    • Toblli, J.E.1    Cao, G.2    Rivas, C.3    Kulaksiz, H.4
  • 120
    • 34250850987 scopus 로고    scopus 로고
    • The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation
    • Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 2007;148:2663-2668.
    • (2007) Endocrinology , vol.148 , pp. 2663-2668
    • Merle, U.1    Fein, E.2    Gehrke, S.G.3    Stremmel, W.4    Kulaksiz, H.5
  • 121
    • 71749089888 scopus 로고    scopus 로고
    • The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes
    • Ge XH,Wang Q, Qian ZM, Zhu L, Du F, Yung WH, Yang L, Ke Y. The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. J Nutr Biochem 2009;20:860-865.
    • (2009) J Nutr Biochem , vol.20 , pp. 860-865
    • Ge Xhwang, Q.1    Qian, Z.M.2    Zhu, L.3    Du, F.4    Yung, W.H.5    Yang, L.6    Ke, Y.7
  • 124
    • 0020592119 scopus 로고
    • Electron microscopic study on the cardiac hypertrophy induced by iron deficiency anaemia in the rat
    • Rossi MA, Carillo SV. Electron microscopic study on the cardiac hypertrophy induced by iron deficiency anaemia in the rat. Br J Exp Pathol 1983;64:373-387.
    • (1983) Br J Exp Pathol , vol.64 , pp. 373-387
    • Rossi, M.A.1    Carillo, S.V.2
  • 126
    • 0026769833 scopus 로고
    • Myocyte cellular hypertrophy and hyperplasia contribute to ventricular wall remodeling in anemia-induced cardiac hypertrophy in rats
    • Olivetti G, Quaini F, Lagrasta C, Ricci R, Tiberti G, Capasso JM, Anversa P. Myocyte cellular hypertrophy and hyperplasia contribute to ventricular wall remodeling in anemia-induced cardiac hypertrophy in rats. Am J Pathol 1992;141: 227-239.
    • (1992) Am J Pathol , vol.141 , pp. 227-239
    • Olivetti, G.1    Quaini, F.2    Lagrasta, C.3    Ricci, R.4    Tiberti, G.5    Capasso, J.M.6    Anversa, P.7
  • 127
    • 0031827830 scopus 로고    scopus 로고
    • Dietary iron deficiency results in cardiac eccentric hypertrophy in rats
    • Medeiros DM, Beard JL. Dietary iron deficiency results in cardiac eccentric hypertrophy in rats. Proc Soc Exp Biol Med 1998;218:370-375.
    • (1998) Proc Soc Exp Biol Med , vol.218 , pp. 370-375
    • Medeiros, D.M.1    Beard, J.L.2
  • 128
    • 0014369406 scopus 로고
    • The effect of iron deficiency on the synthesis of collagenous and non-collagenous proteins in wound granulation tissue and in the heart of rats
    • Chvapil M, Hurych J, Ehrlichova E. The effect of iron deficiency on the synthesis of collagenous and non-collagenous proteins in wound granulation tissue and in the heart of rats. Exp Med Surg 1968;26:52-60.
    • (1968) Exp Med Surg , vol.26 , pp. 52-60
    • Chvapil, M.1    Hurych, J.2    Ehrlichova, E.3
  • 129
    • 79960601913 scopus 로고    scopus 로고
    • Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure
    • Maeder MT, Khammy O, dos Remedios C, Kaye DM. Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. J Am Coll Cardiol 2011;58:474-480.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 474-480
    • Maeder, M.T.1    Khammy, O.2    Dos Remedios, C.3    Kaye, D.M.4
  • 130
    • 0015651975 scopus 로고
    • The myoglobin content of human skeletal muscle
    • Boulton FE. The myoglobin content of human skeletal muscle. Br J Haematol 1973;25:281.
    • (1973) Br J Haematol , vol.25 , pp. 281
    • Boulton, F.E.1
  • 133
    • 0022464750 scopus 로고
    • Biochemical basis for the manifestations of iron deficiency
    • Dallman PR. Biochemical basis for the manifestations of iron deficiency. Annu Rev Nutr 1986;6:13-40.
    • (1986) Annu Rev Nutr , vol.6 , pp. 13-40
    • Dallman, P.R.1
  • 134
    • 0020035215 scopus 로고
    • Perspectives in iron metabolism
    • Finch CA, Huebers H. Perspectives in iron metabolism. N Engl J Med 1982;306: 1520-1528.
    • (1982) N Engl J Med , vol.306 , pp. 1520-1528
    • Finch, C.A.1    Huebers, H.2
  • 135
    • 1642393242 scopus 로고    scopus 로고
    • Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women
    • Brownlie T IV, Utermohlen V, Hinton PS, Haas JD. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr 2004;79:437-443.
    • (2004) Am J Clin Nutr , vol.79 , pp. 437-443
    • Brownlie, T.I.V.1    Utermohlen, V.2    Hinton, P.S.3    Haas, J.D.4
  • 136
    • 0036201255 scopus 로고    scopus 로고
    • Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women
    • Brownlie T IV, Utermohlen V, Hinton PS, Giordano C, Haas JD. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr 2002;75:734-742.
    • (2002) Am J Clin Nutr , vol.75 , pp. 734-742
    • Brownlie, T.I.V.1    Utermohlen, V.2    Hinton, P.S.3    Giordano, C.4    Haas, J.D.5
  • 137
    • 0034093437 scopus 로고    scopus 로고
    • Iron supplementation improves endurance after training in iron-depleted, nonanemic women
    • Hinton PS, Giordano C, Brownlie T, Haas JD. Iron supplementation improves endurance after training in iron-depleted, nonanemic women. J Appl Physiol 2000;88:1103-1111.
    • (2000) J Appl Physiol , vol.88 , pp. 1103-1111
    • Hinton, P.S.1    Giordano, C.2    Brownlie, T.3    Haas, J.D.4
  • 138
    • 0037304555 scopus 로고    scopus 로고
    • Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women
    • Brutsaert TD, Hernandez-Cordero S, Rivera J, Viola T, Hughes G, Haas JD. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. Am J Clin Nutr 2003; 77:441-448.
    • (2003) Am J Clin Nutr , vol.77 , pp. 441-448
    • Brutsaert, T.D.1    Hernandez-Cordero, S.2    Rivera, J.3    Viola, T.4    Hughes, G.5    Haas, J.D.6
  • 140
    • 0023212889 scopus 로고
    • Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle
    • Willis WT, Brooks GA, Henderson SA, Dallman PR. Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle. J Appl Physiol 1987; 62:2442-2446.
    • (1987) J Appl Physiol , vol.62 , pp. 2442-2446
    • Willis, W.T.1    Brooks, G.A.2    Henderson, S.A.3    Dallman, P.R.4
  • 141
    • 0242691880 scopus 로고
    • Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion
    • Davies KJ, Maguire JJ, Brooks GA, Dallman PR, Packer L. Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol 1982;242:E418-E427.
    • (1982) Am J Physiol , vol.242
    • Davies, K.J.1    Maguire, J.J.2    Brooks, G.A.3    Dallman, P.R.4    Packer, L.5
  • 143
    • 33845514377 scopus 로고    scopus 로고
    • Iron supplementation maintains ventilatory threshold and improves energetic efficiency in iron-deficient nonanemic athletes
    • Hinton PS, Sinclair LM. Iron supplementation maintains ventilatory threshold and improves energetic efficiency in iron-deficient nonanemic athletes. Eur J Clin Nutr 2007;61:30-39.
    • (2007) Eur J Clin Nutr , vol.61 , pp. 30-39
    • Hinton, P.S.1    Sinclair, L.M.2
  • 144
    • 70350567772 scopus 로고    scopus 로고
    • A pilot evaluation of the long-term effect of combined therapy with intravenous iron sucrose and erythropoietin in elderly patients with advanced chronic heart failure and cardio-renal anemia syndrome: Influence on neurohormonal activation and clinical outcomes
    • Com?n-Colet J, Ruiz S, Cladellas M, Rizzo M, Torres A, Bruguera J. A pilot evaluation of the long-term effect of combined therapy with intravenous iron sucrose and erythropoietin in elderly patients with advanced chronic heart failure and cardio-renal anemia syndrome: influence on neurohormonal activation and clinical outcomes. J Card Fail 2009;15:727-735.
    • (2009) J Card Fail , vol.15 , pp. 727-735
    • Comn-Colet, J.1    Ruiz, S.2    Cladellas, M.3    Rizzo, M.4    Torres, A.5    Bruguera, J.6
  • 146
    • 50049102529 scopus 로고    scopus 로고
    • Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency
    • Usmanov RI, Zueva EB, Silverberg DS, Shaked M. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. J Nephrol 2008;21:236-242.
    • (2008) J Nephrol , vol.21 , pp. 236-242
    • Usmanov, R.I.1    Zueva, E.B.2    Silverberg, D.S.3    Shaked, M.4


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