메뉴 건너뛰기




Volumn 411, Issue 21-22, 2010, Pages 1565-1569

Hepcidin and iron metabolism: From laboratory to clinical implications

Author keywords

Anemia; Hemochromatosis; Hepcidin; Iron

Indexed keywords

FERROPORTIN 1; HEPCIDIN;

EID: 77956470416     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.07.003     Document Type: Review
Times cited : (49)

References (57)
  • 3
    • 77956874149 scopus 로고    scopus 로고
    • Recent advances in iron metabolism and related disorders. Intern Emerg Med [epub ahead of print].
    • Camaschella C, Strati P. Recent advances in iron metabolism and related disorders. Intern Emerg Med 2010 [epub ahead of print].
    • (2010)
    • Camaschella, C.1    Strati, P.2
  • 4
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001, 276:7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 5
    • 63749113268 scopus 로고    scopus 로고
    • Hepcidin modulation in human diseases: from research to clinic
    • Piperno A., Mariani R., Trombini P., Girelli D. Hepcidin modulation in human diseases: from research to clinic. WJ Gastroenterol 2009, 15:538-551.
    • (2009) WJ Gastroenterol , vol.15 , pp. 538-551
    • Piperno, A.1    Mariani, R.2    Trombini, P.3    Girelli, D.4
  • 6
    • 0015833302 scopus 로고
    • Iron absorption
    • Forth W., Rummel W. Iron absorption. Physiol Rev 1973, 53:724-792.
    • (1973) Physiol Rev , vol.53 , pp. 724-792
    • Forth, W.1    Rummel, W.2
  • 7
    • 33746773041 scopus 로고    scopus 로고
    • Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases
    • Su D., Asard H. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J 2006, 273:3722-3734.
    • (2006) FEBS J , vol.273 , pp. 3722-3734
    • Su, D.1    Asard, H.2
  • 8
    • 44449108683 scopus 로고    scopus 로고
    • Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells
    • Latunde-Dada G.O., Simpson R.J., McKie A.T. Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. J Nutr 2008, 138:991-995.
    • (2008) J Nutr , vol.138 , pp. 991-995
    • Latunde-Dada, G.O.1    Simpson, R.J.2    McKie, A.T.3
  • 10
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388:482-488.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3    Gunshin, Y.4    Romero, M.F.5    Boron, W.F.6
  • 11
    • 0032909207 scopus 로고    scopus 로고
    • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    • Vulpe C.D., Kuo Y.M., Murphy T.L., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999, 21:195-199.
    • (1999) Nat Genet , vol.21 , pp. 195-199
    • Vulpe, C.D.1    Kuo, Y.M.2    Murphy, T.L.3
  • 13
    • 54049093319 scopus 로고    scopus 로고
    • Mechanisms of heme iron absorption: current questions and controversies
    • Oates P.S., West A.R. Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol 2008, 14:4101-4110.
    • (2008) World J Gastroenterol , vol.14 , pp. 4101-4110
    • Oates, P.S.1    West, A.R.2
  • 14
    • 24144459870 scopus 로고    scopus 로고
    • Identification of an intestinal heme transporter
    • Shayeghi M., Latunde-Dada G.O., Oakhill J.S., et al. Identification of an intestinal heme transporter. Cell 2005, 122:789-801.
    • (2005) Cell , vol.122 , pp. 789-801
    • Shayeghi, M.1    Latunde-Dada, G.O.2    Oakhill, J.S.3
  • 15
    • 4544264523 scopus 로고    scopus 로고
    • Identification of a human heme exporter that is essential for erythropoiesis
    • Quigley J.G., Yang Z., Worthington M.T., et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell 2004, 118:757-766.
    • (2004) Cell , vol.118 , pp. 757-766
    • Quigley, J.G.1    Yang, Z.2    Worthington, M.T.3
  • 16
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A., Nietz S., Magert H.J., et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000, 480:147-150.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Nietz, S.2    Magert, H.J.3
  • 17
    • 33644862202 scopus 로고    scopus 로고
    • Nemeth E iron imports. IV. Hepcidin and regulation of body iron metabolism
    • Ganz T. Nemeth E iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006, 290:G199-G203.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Ganz, T.1
  • 19
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C., Ilyin G., Courselaud B., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001, 276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 20
    • 4644301624 scopus 로고    scopus 로고
    • Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
    • Frazer D.M., Inglis H.R., Wilkins S.J., et al. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 2004, 53:1509-1515.
    • (2004) Gut , vol.53 , pp. 1509-1515
    • Frazer, D.M.1    Inglis, H.R.2    Wilkins, S.J.3
  • 21
    • 33644772206 scopus 로고    scopus 로고
    • Animal models with enhanced erythropoiesis and iron absorption
    • Latunde-Dada G.O., McKie A.T., Simpson R.J. Animal models with enhanced erythropoiesis and iron absorption. Biochim Biophys Acta 2006, 1762:414-423.
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 414-423
    • Latunde-Dada, G.O.1    McKie, A.T.2    Simpson, R.J.3
  • 22
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G., Chauvet C., Viatte L., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002, 110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 23
    • 59449104943 scopus 로고    scopus 로고
    • Interacting signals in the control of hepcidin expression
    • Darshan D., Anderson G.J. Interacting signals in the control of hepcidin expression. Biometals 2009, 22:77-87.
    • (2009) Biometals , vol.22 , pp. 77-87
    • Darshan, D.1    Anderson, G.J.2
  • 24
    • 34447120059 scopus 로고    scopus 로고
    • Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
    • Peyssonnaux C., Zinkernagel A.S., Schuepbach R.A., et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007, 117:1926-1932.
    • (2007) J Clin Invest , vol.117 , pp. 1926-1932
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Schuepbach, R.A.3
  • 25
    • 14844299760 scopus 로고    scopus 로고
    • Hypoxia enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins
    • McMahon S., Grondin F., McDonald P.P., et al. Hypoxia enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins. J Biol Chem 2005, 280:6561-6569.
    • (2005) J Biol Chem , vol.280 , pp. 6561-6569
    • McMahon, S.1    Grondin, F.2    McDonald, P.P.3
  • 26
    • 0037174609 scopus 로고    scopus 로고
    • C/EBP alpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism cross-talk between C/EBP pathway and iron metabolism
    • Courselaud B., Pigeon C., Inoue Y., et al. C/EBP alpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002, 277:41163-41170.
    • (2002) J Biol Chem , vol.277 , pp. 41163-41170
    • Courselaud, B.1    Pigeon, C.2    Inoue, Y.3
  • 27
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101:2461-2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 28
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting D.M., Andrews N.C. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006, 108:3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 29
    • 33845985236 scopus 로고    scopus 로고
    • STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    • Verga Falzacappa M.V., Vujic Spasic M., Kessler R., et al. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007, 109:353-358.
    • (2007) Blood , vol.109 , pp. 353-358
    • Verga Falzacappa, M.V.1    Vujic Spasic, M.2    Kessler, R.3
  • 30
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 32
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah Y.M., Matsubara T., Ito S., Yim S.H., Gonzalez F.J. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab 2009, 9:152-164.
    • (2009) Cell Metab , vol.9 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.H.4    Gonzalez, F.J.5
  • 34
    • 69249220411 scopus 로고    scopus 로고
    • Hepcidin assays: ironing out some details
    • Malyszko J. Hepcidin assays: ironing out some details. Clin J Am Soc Nephrol 2009, 4:1015-1016.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1015-1016
    • Malyszko, J.1
  • 35
  • 37
    • 34147197662 scopus 로고    scopus 로고
    • Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    • Kemna E.H., Tjalsma H., Podust V.N., Swinkels D.W. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007, 53:620-628.
    • (2007) Clin Chem , vol.53 , pp. 620-628
    • Kemna, E.H.1    Tjalsma, H.2    Podust, V.N.3    Swinkels, D.W.4
  • 38
    • 77952502655 scopus 로고    scopus 로고
    • Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based on SELDI-TOF MS
    • Campostrini N., Castagna A., Zaninotto F., et al. Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based on SELDI-TOF MS. J Biomed Biotechnol 2010, 2010:329646.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 329646
    • Campostrini, N.1    Castagna, A.2    Zaninotto, F.3
  • 39
    • 67349229546 scopus 로고    scopus 로고
    • Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS
    • Li H., Rose M.J., Tran L., et al. Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS. J Pharmacol Toxicol Methods 2009, 59:171-180.
    • (2009) J Pharmacol Toxicol Methods , vol.59 , pp. 171-180
    • Li, H.1    Rose, M.J.2    Tran, L.3
  • 41
    • 84887212612 scopus 로고    scopus 로고
    • A novel immunological assay for hepcidin quantification in human serum
    • Koliaraki V., Marinou M., Vassilakopoulos T.P., et al. A novel immunological assay for hepcidin quantification in human serum. PLoS ONE 2009, 4:e4581.
    • (2009) PLoS ONE , vol.4
    • Koliaraki, V.1    Marinou, M.2    Vassilakopoulos, T.P.3
  • 42
    • 48149090865 scopus 로고    scopus 로고
    • The hepcidin-binding site on ferroportin is evolutionarily conserved
    • De Domenico I., Nemeth E., Nelson J.M., et al. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab 2008, 8:146-156.
    • (2008) Cell Metab , vol.8 , pp. 146-156
    • De Domenico, I.1    Nemeth, E.2    Nelson, J.M.3
  • 43
    • 73149122764 scopus 로고    scopus 로고
    • Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization
    • Kroot J.J., Kemna E.H., Bansal S.S., et al. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica 2009, 94:1748-1752.
    • (2009) Haematologica , vol.94 , pp. 1748-1752
    • Kroot, J.J.1    Kemna, E.H.2    Bansal, S.S.3
  • 44
    • 33144456592 scopus 로고    scopus 로고
    • Hemochromatosis: genetics and pathophysiology
    • Beutler E. Hemochromatosis: genetics and pathophysiology. Annu Rev Med 2006, 57:331-347.
    • (2006) Annu Rev Med , vol.57 , pp. 331-347
    • Beutler, E.1
  • 45
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis - a new look at an old disease
    • Pietrangelo A. Hereditary hemochromatosis - a new look at an old disease. N Engl J Med 2004, 350:2383-2397.
    • (2004) N Engl J Med , vol.350 , pp. 2383-2397
    • Pietrangelo, A.1
  • 46
    • 0742272103 scopus 로고    scopus 로고
    • The ferroportin disease
    • Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis 2004, 32:131-138.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 131-138
    • Pietrangelo, A.1
  • 47
    • 33644504859 scopus 로고    scopus 로고
    • Hereditary iron overload: update on pathophysiology, diagnosis, and treatment
    • Franchini M. Hereditary iron overload: update on pathophysiology, diagnosis, and treatment. Am J Hematol 2006, 81:202-209.
    • (2006) Am J Hematol , vol.81 , pp. 202-209
    • Franchini, M.1
  • 48
    • 37549059612 scopus 로고    scopus 로고
    • Regulation of iron acquisition and storage: consequences for iron-linked disorders
    • De Domenico I., McVey Ward D., Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 2008, 9:72-81.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 72-81
    • De Domenico, I.1    McVey Ward, D.2    Kaplan, J.3
  • 49
    • 33745755350 scopus 로고    scopus 로고
    • The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major
    • Kattamis A., Papassotiriou I., Palaiologou D., et al. The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 2006, 91:809-812.
    • (2006) Haematologica , vol.91 , pp. 809-812
    • Kattamis, A.1    Papassotiriou, I.2    Palaiologou, D.3
  • 50
    • 34447306076 scopus 로고    scopus 로고
    • Liver iron concentrations and urinary hepcidin in beta-thalassemia
    • Origa R., Galanello R., Ganz T., et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007, 92:583-588.
    • (2007) Haematologica , vol.92 , pp. 583-588
    • Origa, R.1    Galanello, R.2    Ganz, T.3
  • 51
    • 33745743014 scopus 로고    scopus 로고
    • Hepcidin and iron-loading anemias
    • Nemeth E., Ganz T. Hepcidin and iron-loading anemias. Haematologica 2006, 91:727-732.
    • (2006) Haematologica , vol.91 , pp. 727-732
    • Nemeth, E.1    Ganz, T.2
  • 52
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K., Taura K., Kodama Y., Schnabl B., Brenner D.A. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008, 48:1420-1429.
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5
  • 53
    • 45549096257 scopus 로고    scopus 로고
    • Fine tuning of hepcidin expression by positive and negative regulators
    • Muckenthaler M.U. Fine tuning of hepcidin expression by positive and negative regulators. Cell Metab 2008, 8:1-3.
    • (2008) Cell Metab , vol.8 , pp. 1-3
    • Muckenthaler, M.U.1
  • 54
    • 54349094273 scopus 로고    scopus 로고
    • A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
    • Melis M.A., Cau M., Congiu R., et al. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica 2008, 93:1473-1479.
    • (2008) Haematologica , vol.93 , pp. 1473-1479
    • Melis, M.A.1    Cau, M.2    Congiu, R.3
  • 55
    • 42649118442 scopus 로고    scopus 로고
    • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
    • Finberg K.E., Heeney M.M., Campagna D.R., et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 2008, 40:569-571.
    • (2008) Nat Genet , vol.40 , pp. 569-571
    • Finberg, K.E.1    Heeney, M.M.2    Campagna, D.R.3
  • 56
    • 70450212841 scopus 로고    scopus 로고
    • Anemia of chronic disease (anemia of inflammation)
    • Agarwal N., Prchal J.T. Anemia of chronic disease (anemia of inflammation). Acta Haematol 2009, 122:103-108.
    • (2009) Acta Haematol , vol.122 , pp. 103-108
    • Agarwal, N.1    Prchal, J.T.2
  • 57
    • 70450214396 scopus 로고    scopus 로고
    • The role of hepcidin in iron metabolism
    • Nemeth E., Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009, 12:78-86.
    • (2009) Acta Haematol , vol.12 , pp. 78-86
    • Nemeth, E.1    Ganz, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.