Iron supplementation improves endurance after training in iron-depleted, nonanemic women

Journal of Applied Physiology

Volumn 88, Issue 3, 2000, Pages 1103-1111

  Hinton, Pamela S ^a   Giordano, Christina ^a   Brownlie, Thomas ^a   Haas, Jere D ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Aerobic training; Endurance capacity; Iron deficiency; Serum transferrin receptors

Indexed keywords

FERRITIN; FERROUS SULFATE; HEMOGLOBIN; IRON; TRANSFERRIN RECEPTOR;

ADAPTATION; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDURANCE; ERGOMETRY; EXERCISE; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; IRON THERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRAINING;

EID: 0034093437     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.3.1103     Document Type: Article

References (34)

1. Aker, R., and E. Buskirk. An underwater weighing system utilizing "force cube" transducers. J. Appl. Physiol. 26: 642-649, 1969.
2. Assendelft, O. van, and J. England. Advances in Hematological Methods. Boca Raton, FL: CRC, 1990.
3. Belko, A., and E. Obarzanek. Effects of aerobic exercise and weight loss on riboflavin requirements of moderately obese marginally deficient young women. Am. J. Clin. Nutr. 40: 553-561, 1984.
4. Blum, S., and A. Sherman. The effects of fitness-type exercise on iron status in adult women. Am. J. Clin. Nutr. 43: 456-463, 1986.
5. Celsing, F., E. Blomstrand, B. Werner, P. Pihlstdet, and B. Ekblom. Effects of iron deficiency on endurance and muscle enzyme activity in man. Med. Sci. Sports Exerc. 18: 156-161, 1988.
6. Celsing, F., and B. Ekblom. Anemia causes a relative decrease in blood lactate concentration during exercise. Eur. J. Appl. Physiol. 55: 74-78, 1986.
7. Davies, K., M. Donovan, C. Refino, G. Brooks, L. Packer, and P. Dallman. Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rat. Am. J. Physiol. Endocrinol. Metab. 246: E535-E543, 1984.
8. Finch, C., L. Miller, A. Inamandar, R. Person, L. Packer, and P. Dallman. Iron deficiency in the rat. J. Clin. Invest. 58: 447-453, 1976.
9. Flowers, C., M. Cuizon, J. Beard, B. Skikne, A. Covell, and J. Cook. A serum ferritin assay for prevalence studies of iron deficiency. Am. J. Hematol. 23: 141-151, 1986.
10. Flowers, C., B. Skikne, A. Covell, and J. Cook. The clinical measurement of serum transferrin receptor. J. Lab. Clin. Med. 114: 368-377, 1989.
11. Gardner, G., V. Edgerton, B. Senewiratne, R. J. Barnard, and Y. Ohira. Physical work capacity and metabolic stress in subjects with iron-deficient anemia. Am. J. Clin. Nutr. 30: 910-917, 1977.
12. Holloszy, J., and E. Coyle. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 65: 256-263, 1984.
13. Hoppeler, H., and O. Hudlicka. Changes in the composition of muscle fibers and their ultrastructure in stimulated rat fast muscles with limited blood supply. Abstr. Birmingham Mtg. Physiol. Soc., December 1985, p. 373.
14. Jensen, C., and C. Weaver. Iron supplementation and iron status in exercising young women J. Nutr. Biochem. 2: 368-373, 1991.
15. Klingshirn, L., R. Pate, S. Bourque, J. Davis, and R. Sargent. Effects of iron supplementation on endurance capacity in iron-depleted female runners. Med. Sci. Sports Exerc. 24: 819-824, 1992.
16. 2max, endurance, and blood lactate in iron-depleted female runners. Med. Sci. Sports Exerc. 24: 819-824, 1993.
17. Lohman, T., A. Roche, and R. Martorell. Anthropometric Standardization Reference Manual (abridged ed.). Champaign, IL: Human Kinetics, 1988.
18. Looker, A., P. Dallman, M. Carroll, E. Gunter, and C. Johnson. Prevalence of iron deficiency in the United States. JAMA 277: 973-976, 1997.
19. Lyle, R., C. Weaver, D. Sedlock, S. Rajaram, B. Martin, and C. Melby. Iron status in exercising women: the effect of oral iron therapy vs. increased consumption of muscle foods. Am. J. Clin. Nutr. 56: 1049-1055, 1992.
20. Magazanik, A., Y. Weinstein, J. Abarbanel, U. Lewinski, Y. Shapiro, O. Inbar, and S. Epstein. Effect of an iron supplement on body iron status and aerobic capacity of young training women. Eur. J. Appl. Physiol. 62: 317-323, 1991.
21. McArdle, W., F. Katch, and V. Katch. Exercise Physiology. Philadelphia, PA: Lea & Febiger, 1991.
22. McArdle, W., and J. Magel. Physical work capacity and maximal oxygen uptake in treadmill and bicycle exercise. Med. Sci. Sports Exerc. 2: 118-123, 1970.
23. Newhouse, I., D. Clement, J. Taunton, and D. McKenzie. The effect of prelatent/latent iron deficiency on physical work capacity. Med. Sci. Sports Exerc. 21: 263-268, 1989.
24. Persijn, J., W. V. D. Slik, and A. Riethorst. Determination of serum iron and latent iron-binding capacity (LIBC). Clin. Chim. Acta 35: 91-93, 1971.
25. Rowland, T. W., M. B. Deisroth, G. M. Green, and J. F. Kelleher. The effect of iron therapy on the exercise capacity of non-anemic iron-deficient adolescent runners. Am. J. Dis. Child. 142: 165-168, 1988.
26. Saltin, B., and S. Strange. Maximal oxygen uptake: "old" and "new" arguments for cadiovascular limitation. Med. Sci. Sports Exerc. 24: 30-36, 1991.
27. SAS Institute. SAS/STAT Software: The GLM, REG, T-Test Procedures, version 6. Gary, NC: SAS Institute, 1991.
28. Tobin B. W., J. L. Beard, and W. L. Kenney. Exercise training alters feed efficiency and body composition in iron deficient rats. Med. Sci. Sports Exerc. 25: 52-59, 1993.
29. Tufts, D., J. D. Haas, J. L. Beard, and H. Spielvogel. Distribution of hemoglobin and functional consequences of anemia in adult males at high altitude. Am. J. Clin. Nutr. 42: 1-11, 1985.
30. Willis, W., G. Brooks, S. Henderson, and P. Dallman. Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle. J. Appl. Physiol. 62: 2442-2446, 1987.
31. Willis, W. T., P. R. Dallman, and G. A. Brooks. Physiological and biochemical correlates of increased work in iron-deficient rats. J. Appl. Physiol. 65: 256-263, 1988.
32. Zhu, Y. I., and J. D. Haas. Iron depletion without anemia and physical performance in young women. Am. J. Clin. Nutr. 66: 334-341, 1997.
33. Zhu, Y. I., and J. D. Haas. Response of serum transferrin receptor to iron supplementation in iron-depleted, nonanemic women. Am. J. Clin. Nutr. 67: 271-275, 1998.
34. Zhu, Y. I., and J. D. Haas. Altered metabolic response of iron-depleted non-anemic women during a 15-km time trial. J. Appl. Physiol. 84: 1768-1775, 1998.