Myocardial and systemic iron depletion in heart failure: Implications for anemia accompanying heart failure

Journal of the American College of Cardiology

Volumn 58, Issue 5, 2011, Pages 474-480

  Maeder, Micha T ^a,b,c   Khammy, Ouda ^a   Dos Remedios, Cris ^d   Kaye, David M ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c Cardiology Division   (Switzerland)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

anemia; heart failure; iron

Indexed keywords

ALDOSTERONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOLAMINE; CD71 ANTIGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; IRON; MESSENGER RNA; SPIRONOLACTONE;

ANEMIA; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL ISOLATION; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEFIBRILLATION; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HEART MUSCLE CELL; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN TISSUE; IRON DEFICIENCY; IRON DEPLETION; IRON TRANSPORT; MALE; MEDICAL ASSESSMENT; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RAT; TRANSFERRIN BLOOD LEVEL;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-AGONISTS; ALDOSTERONE; ANEMIA, IRON-DEFICIENCY; ANIMALS; ANTIGENS, CD; CASE-CONTROL STUDIES; CELLS, CULTURED; DOWN-REGULATION; FEMALE; HEART FAILURE; HEMOGLOBINS; HUMANS; IRON; ISOPROTERENOL; MALE; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; NOREPINEPHRINE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

EID: 79960601913     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.01.059     Document Type: Article

References (28)

1. I.S. Anand Anemia and chronic heart failure implications and treatment options J Am Coll Cardiol 52 2008 501 511
2. Y.D. Tang, and S.D. Katz Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options Circulation 113 2006 2454 2461 (Pubitemid 43948053)
3. I. Anand, J.J. McMurray, and J. Whitmore Anemia and its relationship to clinical outcome in heart failure Circulation 110 2004 149 154 (Pubitemid 38924582)
4. J. Szachniewicz, J. Petruk-Kowalczyk, and J. Majda Anaemia is an independent predictor of poor outcome in patients with chronic heart failure Int J Cardiol 90 2003 303 308 (Pubitemid 37087891)
5. T.B. Horwich, G.C. Fonarow, M.A. Hamilton, W.R. MacLellan, and J. Borenstein Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure J Am Coll Cardiol 39 2002 1780 1786 (Pubitemid 34595288)
6. R. Sharma, D.P. Francis, B. Pitt, P.A. Poole-Wilson, A.J. Coats, and S.D. Anker Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial Eur Heart J 25 2004 1021 1028 (Pubitemid 38869420)
7. M. Kosiborod, G.L. Smith, M.J. Radford, J.M. Foody, and H.M. Krumholz The prognostic importance of anemia in patients with heart failure Am J Med 114 2003 112 119 (Pubitemid 36183592)
8. E.A. Jankowska, P. Rozentryt, and A. Witkowska Iron deficiency: an ominous sign in patients with systolic chronic heart failure Eur Heart J 31 2010 1872 1880
9. D.J. van Veldhuisen, K. Dickstein, and A. Cohen-Solal Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia Eur Heart J 28 2007 2208 2216 (Pubitemid 47428946)
10. J.N. Nanas, C. Matsouka, and D. Karageorgopoulos Etiology of anemia in patients with advanced heart failure J Am Coll Cardiol 48 2006 2485 2489 (Pubitemid 44881220)
11. B.D. Westenbrink, A.A. Voors, and D.J. van Veldhuisen Is anemia in chronic heart failure caused by iron deficiency? J Am Coll Cardiol 49 2007 2301 2302, author reply 2302 (Pubitemid 46856817)
12. G. Weiss, and L.T. Goodnough Anemia of chronic disease N Engl J Med 352 2005 1011 1023
13. S.D. Anker, J. Comin Colet, and G. Filippatos Ferric carboxymaltose in patients with heart failure and iron deficiency N Engl J Med 361 2009 2436 2448
14. Y. Naito, T. Tsujino, M. Matsumoto, T. Sakoda, M. Ohyanagi, and T. Masuyama Adaptive response of the heart to long-term anemia induced by iron deficiency Am J Physiol Heart Circ Physiol 296 2009 H585 H593
15. C. Thomas, and L. Thomas Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency Clin Chem 48 2002 1066 1076 (Pubitemid 34680903)
16. E. O'Meara, T. Clayton, and M.B. McEntegart Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program Circulation 113 2006 986 994 (Pubitemid 43879474)
17. M. Volpe, C. Tritto, and U. Testa Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles Am J Cardiol 74 1994 468 473 (Pubitemid 24269966)
18. J.K. Ghali, I.S. Anand, and W.T. Abraham Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia Circulation 117 2008 526 535
19. K. Hadley, L. Johnson, and J. Hunt Iron absorption in healthy women is not associated with eitherserum or urinary prohepcidin Am J Clin Nutr 84 2006 150 155 (Pubitemid 44699179)
20. L. Blayney, R. Bailey-Wood, A. Jacobs, A. Henderson, and J. Muir The effects of iron deficiency on the respiratory function and cytochrome content of rat heart mitochondria Circ Res 39 1976 744 748
21. Z. Tanne, R. Coleman, M. Nahir, D. Shomrat, J.P. Finberg, and M.B. Youdim Ultrastructural and cytochemical changes in the heart of iron-deficient rats Biochem Pharmacol 47 1994 1759 1766 (Pubitemid 24172843)
22. F. Dong, X. Zhang, B. Culver, H.G. Chew Jr., R.O. Kelley, and J. Ren Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration Clin Sci (Lond) 109 2005 277 286 (Pubitemid 41337132)
23. L.R. Turner, D.A. Premo, and B.J. Gibbs Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy BMC Physiol 2 2002 1
24. N.C. Andrews Forging a field: the golden age of iron biology Blood 112 2008 219 230
25. Okazaki F, Matsunaga N, Okazaki H, et al. Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice. Cancer Res;70:6238-46.
26. A.C. Chua, C.E. Herbison, S.F. Drake, R.M. Graham, J.K. Olynyk, and D. Trinder The role of Hfe in transferrin-bound iron uptake by hepatocytes Hepatology 47 2008 1737 1744 (Pubitemid 351702755)
27. M.W. Hentze, M.U. Muckenthaler, and N.C. Andrews Balancing acts: molecular control of mammalian iron metabolism Cell 117 2004 285 297 (Pubitemid 38534536)
28. L. Tacchini, E. Gammella, C. De Ponti, S. Recalcati, and G. Cairo Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals J Biol Chem 283 2008 20674 20686