Anemia and inflammatory bowel diseases

World Journal of Gastroenterology

Volumn 15, Issue 37, 2009, Pages 4659-4665

  Gomollón, Fernando ^a   Gisbert, Javier P ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Anemia; Ferritin; Inflammatory bowel diseases; Iron

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; AZATHIOPRINE; ERYTHROPOIETIN; FERRIC HYDROXIDE SUCROSE; HEMOGLOBIN; IRON; IRON DEXTRAN; MERCAPTOPURINE; SALAZOSULFAPYRIDINE;

ABDOMINAL PAIN; ADVANCED CANCER; ANEMIA; CROHN DISEASE; DIARRHEA; DOSE RESPONSE; DRUG ABSORPTION; DRUG COST; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; DYSERYTHROPOIESIS; ENTERITIS; ERYTHROPOIESIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON THERAPY; LOW DRUG DOSE; NAUSEA; PATHOGENESIS; PATIENT COMPLIANCE; PREVALENCE; QUALITY OF LIFE; RECOMMENDED DRUG DOSE; REVIEW; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; METABOLISM; TREATMENT OUTCOME;

ANEMIA; ANEMIA, IRON-DEFICIENCY; DIETARY SUPPLEMENTS; ERYTHROPOIETIN; HUMANS; INFLAMMATORY BOWEL DISEASES; IRON; PREVALENCE; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 70349785234     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.4659     Document Type: Review

References (86)

1. Kulnigg S, Gasche C. Systematic review: managing anaemia in Crohn's disease. Aliment Pharmacol Ther 2006; 24: 1507-1523 (Pubitemid 44915199)
2. de la Morena F, Gisbert JP. [Anemia and inflammatory bowel disease] Rev Esp Enferm Dig 2008; 100: 285-293
3. Gasche C. Anemia in IBD: the overlooked villain. Inflamm Bowel Dis 2000; 6: 142-150; discussion 151
4. Gasche C, Lomer MC, Cavill I, Weiss G. Iron, anaemia, and inflammatory bowel diseases. Gut 2004; 53: 1190-1197 (Pubitemid 38961976)
5. Pizzi LT, Weston CM, Goldfarb NI, Moretti D, Cobb N, Howell JB, Infantolino A, Dimarino AJ, Cohen S. Impact of chronic conditions on quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis 2006; 12: 47-52 (Pubitemid 43032451)
6. Wells CW, Lewis S, Barton JR, Corbett S. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis 2006; 12: 123-130
7. Cucino C, Sonnenberg A. Cause of death in patients with inflammatory bowel disease. Inflamm Bowel Dis 2001; 7: 250-255 (Pubitemid 32776519)
8. Wilson A, Reyes E, Ofman J. Prevalence and outcomes of anemia in inflammatory bowel disease: a systematic review of the literature. Am J Med 2004; 116 Suppl 7A: 44S-49S
9. Bambach CP, Hill GL. Long term nutritional effects of extensive resection of the small intestine. Aust N Z J Surg 1982; 52: 500-506
10. Beeken WL. Absorptive defects in young people with regional enteritis. Pediatrics 1973; 52: 69-74
11. Beeken WL. Remediable defects in Crohn disease: a prospective study of 63 patients. Arch Intern Med 1975; 135: 686-690
12. Burbige EJ, Huang SH, Bayless TM. Clinical manifestations of Crohn's disease in children and adolescents. Pediatrics 1975; 55: 866-871
13. Dyer NH, Child JA, Mollin DL, Dawson AM. Anaemia in Crohn's disease. Q J Med 1972; 41: 419-436
14. Ebinger M, Leidl R, Thomas S, Von Tirpitz C, Reinshagen M, Adler G, Konig HH. Cost of outpatient care in patients with inflammatory bowel disease in a German University Hospital. J Gastroenterol Hepatol 2004; 19: 192-199 (Pubitemid 38253360)
15. Ershler WB, Chen K, Reyes EB, Dubois R. Economic burden of patients with anemia in selected diseases. Value Health 2005; 8: 629-638 (Pubitemid 43110277)
16. Gasché C, Reinisch W, Lochs H, Parsaei B, Bakos S, Wyatt J, Fueger GF, Gangl A. Anemia in Crohn's disease. Importance of inadequate erythropoietin production and iron deficiency. Dig Dis Sci 1994; 39: 1930-1934 (Pubitemid 24306074)
17. Greenstein AJ, Kark AE, Dreiling DA. Crohn's disease of the colon. II. Controversial aspects of hemorrhage, anemia and rectal involvement in granulomatous disease involving the colon. Am J Gastroenterol 1975; 63: 40-48
18. Harries AD, Fitzsimons E, Dew MJ, Heatley RV, Rhodes J. Association between iron deficiency anaemia and mid-arm circumference in Crohn's disease. Hum Nutr Clin Nutr 1984; 38: 47-53
19. Hoffbrand AV, Stewart JS, Booth CC, Mollin DL. Folate deficiency in Crohn's disease: incidence, pathogenesis, and treatment. Br Med J 1968; 2: 71-75
20. Horina JH, Petritsch W, Schmid CR, Reicht G, Wenzl H, Silly H, Krejs GJ. Treatment of anemia in inflammatory bowel disease with recombinant human erythropoietin: results in three patients. Gastroenterology 1993; 104: 1828-1831 (Pubitemid 23235479)
21. Lakatos L, Pandur T, David G, Balogh Z, Kuronya P, Tollas A, Lakatos PL. Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study. World J Gastroenterol 2003; 9: 2300-2307 (Pubitemid 37321464)
22. Niv Y, Abukasis G. Prevalence of ulcerative colitis in the Israeli kibbutz population. J Clin Gastroenterol 1991; 13: 98-101
23. Niv Y, Torten D, Tamir A, Epstein L. Incidence and prevalence of ulcerative colitis in the upper Galilee, Northern Israel, 1967-1986. Am J Gastroenterol 1990; 85: 1580-1583
24. Oldenburg B, Koningsberger JC, Van Berge Henegouwen GP, Van Asbeck BS, Marx JJ. Iron and inflammatory bowel disease. Aliment Pharmacol Ther 2001; 15: 429-438
25. Reilly J, Ryan JA, Strole W, Fischer JE. Hyperalimentation in inflammatory bowel disease. Am J Surg 1976; 131: 192-200
26. Revel-Vilk S, Tamary H, Broide E, Zoldan M, Dinari G, Zahavi I, Yaniv I, Shamir R. Serum transferrin receptor in children and adolescents with inflammatory bowel disease. Eur J Pediatr 2000; 159: 585-589 (Pubitemid 30469445)
27. Schreiber S, Howaldt S, Schnoor M, Nikolaus S, Bauditz J, Gasché C, Lochs H, Raedler A. Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. N Engl J Med 1996; 334: 619-623 (Pubitemid 26076567)
28. Vijverman A, Piront P, Belaiche J, Louis E. Evolution of the prevalence and characteristics of anemia in inflammatory bowel diseases between 1993 and 2003. Acta Gastroenterol Belg 2006; 69: 1-4
29. Walker AM, Szneke P, Bianchi LA, Field LG, Sutherland LR, Dreyer NA. 5-Aminosalicylates, sulfasalazine, steroid use, and complications in patients with ulcerative colitis. Am J Gastroenterol 1997; 92: 816-820 (Pubitemid 27200797)
30. Werlin SL, Grand RJ. Severe colitis in children and adolescents: diagnosis. Course, and treatment. Gastroenterology 1977; 73: 828-832
31. de Vizia B, Poggi V, Conenna R, Fiorillo A, Scippa L. Iron absorption and iron deficiency in infants and children with gastrointestinal diseases. J Pediatr Gastroenterol Nutr 1992; 14: 21-26
32. Ormerod TP. Observations on the incidence and cause of anaemia in ulcerative colitis. Gut 1967; 8: 107-114
33. Ormerod TP. Anaemia in ulcerative colitis. Proc R Soc Med 1968; 61: 931
34. Semrin G, Fishman DS, Bousvaros A, Zholudev A, Saunders AC, Correia CE, Nemeth E, Grand RJ, Weinstein DA. Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation. Inflamm Bowel Dis 2006; 12: 1101-1106 (Pubitemid 44847466)
35. de Silva AD, Mylonaki M, Rampton DS. Oral iron therapy in inflammatory bowel disease: usage, tolerance, and efficacy. Inflamm Bowel Dis 2003; 9: 316-320 (Pubitemid 37161751)
36. Dubois RW, Goodnough LT, Ershler WB, Van Winkle L, Nissenson AR. Identification, diagnosis, and management of anemia in adult ambulatory patients treated by primary care physicians: evidence-based and consensus recommendations. Curr Med Res Opin 2006; 22: 385-395 (Pubitemid 44296763)
37. Tsiolakidou G, Koutroubakis IE. Stimulating erythropoiesis in inflammatory bowel disease associated anemia. World J Gastroenterol 2007; 13: 4798-4806 (Pubitemid 47496743)
38. Cronin CC, Shanahan F. Anemia in patients with chronic inflammatory bowel disease. Am J Gastroenterol 2001; 96: 2296-2298 (Pubitemid 32769186)
39. Goddard AF, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. British Society of Gastroenterology. Gut 2000; 46 Suppl 3-4: IV1-IV5
40. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992; 119: 385-390
41. Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood 2000; 96: 823-833
42. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-1023
43. Gasche C, Berstad A, Befrits R, Beglinger C, Dignass A, Erichsen K, Gomollon F, Hjortswang H, Koutroubakis I, Kulnigg S, Oldenburg B, Rampton D, Schroeder O, Stein J, Travis S, Van Assche G. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm Bowel Dis 2007; 13: 1545-1553
44. Gisbert JP, Gomollón F. Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. Am J Gastroenterol 2008; 103: 1299-1307 (Pubitemid 351678000)
45. Taffet SL, Das KM. Sulfasalazine. Adverse effects and desensitization. Dig Dis Sci 1983; 28: 833-842
46. Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 2001; 131: 676S-688S; discussion 688S-690S
47. Goodnough LT, Nissenson AR. Anemia and its clinical consequences in patients with chronic diseases. Am J Med 2004; 116 Suppl 7A: 1S-2S
48. Kulnigg S, Teischinger L, Dejaco C, Waldhör T, Gasche C. Rapid recurrence of IBD-associated anemia and iron deficiency after intravenous iron sucrose and erythropoietin treatment. Am J Gastroenterol 2009; 104: 1460-1467
49. Leitgeb C, Pecherstorfer M, Fritz E, Ludwig H. Quality of life in chronic anemia of cancer during treatment with recombinant human erythropoietin. Cancer 1994; 73: 2535-2542 (Pubitemid 24155530)
50. Gasché C, Dejaco C, Waldhoer T, Tillinger W, Reinisch W, Fueger GF, Gangl A, Lochs H. Intravenous iron and erythropoietin for anemia associated with Crohn disease. A randomized, controlled trial. Ann Intern Med 1997; 126: 782-787 (Pubitemid 27209644)
51. Bodemar G, Kechagias S, Almer S, Danielson BG. Treatment of anaemia in inflammatory bowel disease with iron sucrose. Scand J Gastroenterol 2004; 39: 454-458 (Pubitemid 38626625)
52. WHO/UNICEF/UNU. Iron Deficiency Anemia: Assessment, Prevention and Control. Report of a joint WHO/UNICEF/UNU consultation. Geneva: World Health Organization, 1998
53. Hunt JM. Reversing productivity losses from iron deficiency: the economic case. J Nutr 2002; 132: 794S-801S
54. Crawford J, Cella D, Cleeland CS, Cremieux PY, Demetri GD, Sarokhan BJ, Slavin MB, Glaspy JA. Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy. Cancer 2002; 95: 888-895 (Pubitemid 34839682)
55. Mei Z, Cogswell ME, Parvanta I, Lynch S, Beard JL, Stoltzfus RJ, Grummer-Strawn LM. Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr 2005; 135: 1974-1980 (Pubitemid 41099758)
56. Rockey DC. Treatment of iron deficiency. Gastroenterology 2006; 130: 1367-1368
57. Rimon E, Kagansky N, Kagansky M, Mechnick L, Mashiah T, Namir M, Levy S. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med 2005; 118: 1142-1147 (Pubitemid 41363767)
58. Zlotkin S, Arthur P, Antwi KY, Yeung G. Randomized, controlled trial of single versus 3-times-daily ferrous sulfate drops for treatment of anemia. Pediatrics 2001; 108: 613-616 (Pubitemid 32786588)
59. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM. Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr 2003; 78: 145-153 (Pubitemid 39662686)
60. Kawai M, Sumimoto S, Kasajima Y, Hamamoto T. A case of ulcerative colitis induced by oral ferrous sulfate. Acta Paediatr Jpn 1992; 34: 476-478
61. Reifen R, Matas Z, Zeidel L, Berkovitch Z, Bujanover Y. Iron supplementation may aggravate inflammatory status of colitis in a rat model. Dig Dis Sci 2000; 45: 394-397 (Pubitemid 30133904)
62. Carrier J, Aghdassi E, Platt I, Cullen J, Allard JP. Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther 2001; 15: 1989-1999 (Pubitemid 34014356)
63. Aghdassi E, Carrier J, Cullen J, Tischler M, Allard JP. Effect of iron supplementation on oxidative stress and intestinal inflammation in rats with acute colitis. Dig Dis Sci 2001; 46: 1088-1094 (Pubitemid 32375042)
64. Carrier J, Aghdassi E, Cullen J, Allard JP. Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr 2002; 132: 3146-3150
65. Erichsen K, Hausken T, Ulvik RJ, Svardal A, Berstad A, Berge RK. Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn disease. Scand J Gastroenterol 2003; 38: 543-548 (Pubitemid 36609862)
66. Erichsen K, Ulvik RJ, Nysaeter G, Johansen J, Ostborg J, Berstad A, Berge RK, Hausken T. Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease. Scand J Gastroenterol 2005; 40: 1058-1065 (Pubitemid 41291355)
67. Erichsen K, Ulvik RJ, Grimstad T, Berstad A, Berge RK, Hausken T. Effects of ferrous sulphate and non-ionic ironpolymaltose complex on markers of oxidative tissue damage in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2005; 22: 831-838 (Pubitemid 41564363)
68. de Silva AD, Tsironi E, Feakins RM, Rampton DS. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial. Aliment Pharmacol Ther 2005; 22: 1097-1105 (Pubitemid 41779517)
69. Harvey RS, Reffitt DM, Doig LA, Meenan J, Ellis RD, Thompson RP, Powell JJ. Ferric trimaltol corrects iron deficiency anaemia in patients intolerant of iron. Aliment Pharmacol Ther 1998; 12: 845-848 (Pubitemid 28428948)
70. Schröder O, Mickisch O, Seidler U, de Weerth A, Dignass AU, Herfarth H, Reinshagen M, Schreiber S, Junge U, Schrott M, Stein J. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease - a randomized, controlled, open-label, multicenter study. Am J Gastroenterol 2005; 100: 2503-2509 (Pubitemid 43919683)
71. Kalantar-Zadeh K, Streja E, Miller JE, Nissenson AR. Intravenous iron versus erythropoiesis-stimulating agents: friends or foes in treating chronic kidney disease anemia? Adv Chronic Kidney Dis 2009; 16: 143-151
72. Allen LH. Iron supplements: scientific issues concerning efficacy and implications for research and programs. J Nutr 2002; 132: 813S-819S
73. Silverstein SB, Rodgers GM. Parenteral iron therapy options. Am J Hematol 2004; 76: 74-78
74. Bartels U, Pedersen NS, Jarnum S. Iron absorption and serum ferritin in chronic inflammatory bowel disease. Scand J Gastroenterol 1978; 13: 649-656 (Pubitemid 9003793)
75. Gasche C, Dejaco C, Reinisch W, Tillinger W, Waldhoer T, Fueger GF, Lochs H, Gangl A. Sequential treatment of anemia in ulcerative colitis with intravenous iron and erythropoietin. Digestion 1999; 60: 262-267 (Pubitemid 29221893)
76. Gasche C, Waldhoer T, Feichtenschlager T, Male C, Mayer A, Mittermaier C, Petritsch W. Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia. Am J Gastroenterol 2001; 96: 2382-2387 (Pubitemid 32769199)
77. Mamula P, Piccoli DA, Peck SN, Markowitz JE, Baldassano RN. Total dose intravenous infusion of iron dextran for iron-deficiency anemia in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2002; 34: 286-290 (Pubitemid 34437521)
78. Schröder O, Schrott M, Blumenstein I, Jahnel J, Dignass AU, Stein J. A study for the evaluation of safety and tolerability of intravenous high-dose iron sucrose in patients with iron deficiency anemia due to gastrointestinal bleeding. Z Gastroenterol 2004; 42: 663-667 (Pubitemid 39166150)
79. Auerbach M, Ballard H, Glaspy J. Clinical update: intravenous iron for anaemia. Lancet 2007; 369: 1502-1504 (Pubitemid 46670290)
80. Chertow GM, Mason PD, Vaage-Nilsen O, Ahlmén J. Update on adverse drug events associated with parenteral iron. Nephrol Dial Transplant 2006; 21: 378-382 (Pubitemid 43159991)
81. Kulnigg S, Stoinov S, Simanenkov V, Dudar LV, Karnafel W, Garcia LC, Sambuelli AM, D'Haens G, Gasche C. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial. Am J Gastroenterol 2008; 103: 1182-1192 (Pubitemid 351677967)
82. Demirtürk L, Hülagü S, Yaylaci M, Altin M, Ozel M. Serum erythropoietin levels in patients with severe anemia secondary to inflammatory bowel disease and the use of recombinant human erythropoietin in patients with anemia refractory to treatment. Dis Colon Rectum 1995; 38: 896-897
83. Koutroubakis IE, Karmiris K, Makreas S, Xidakis C, Niniraki M, Kouroumalis EA. Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anaemia: a pilot study. Eur J Gastroenterol Hepatol 2006; 18: 421-425
84. Dohil R, Hassall E, Wadsworth LD, Israel DM. Recombinant human erythropoietin for treatment of anemia of chronic disease in children with Crohn's disease. J Pediatr 1998; 132: 155-159 (Pubitemid 28082550)
85. Sandborn W. Erythropoietin for inflammatory bowel disease anemia. Gastroenterology 1997; 112: 660-661 (Pubitemid 27078854)
86. Christodoulou DK, Tsianos EV. Anemia in inflammatory bowel disease - the role of recombinant human erythropoietin. Eur J Intern Med 2000; 11: 222-227 (Pubitemid 30680179)