Adaptive response of the heart to long-term anemia induced by iron deficiency

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 3, 2009, Pages

  Naito, Yoshiro ^a   Tsujino, Takeshi ^a   Matsumoto, Mika ^a   Sakoda, Tsuyoshi ^a   Ohyanagi, Mitsumasa ^a   Masuyama, Tohru ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Cardiac remodeling; Erythropoietin; Hypertrophy

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; STAT3 PROTEIN; VASCULOTROPIN; ERYTHROPOIETIN RECEPTOR; HIF1A PROTEIN, RAT; IRON; STAT3 PROTEIN, RAT; TUMOR NECROSIS FACTOR ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART DILATATION; HEART FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; IRON DEFICIENCY ANEMIA; IRON RESTRICTION; LUNG CONGESTION; MALE; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SYSTOLE; UPREGULATION; ADAPTATION; ANIMAL; BLOOD; BLOOD PRESSURE; BODY WEIGHT; HEART; HEART CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART RATE; HEART VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; KIDNEY; LUNG EDEMA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; TIME;

ADAPTATION, PHYSIOLOGICAL; ANEMIA, IRON-DEFICIENCY; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HEART; HEART FAILURE; HEART RATE; HYPERTROPHY, LEFT VENTRICULAR; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; KIDNEY; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ERYTHROPOIETIN; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

EID: 64049118990     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00463.2008     Document Type: Article

References (31)

1. Anand IS, Chandrashekhar Y, Ferrari R, Poole-Wilson PA, Harris PC. Pathogenesis of oedema in chronic severe anaemia: studies of body water and sodium, renal function, haemodynamic variables, and plasma hormones. Br Heart J 70: 357-362, 1993.
2. Anand I, McMurray JJ, Whitmore J, Warren M, Pham A, McCamish MA, Burton PB. Anemia and its relationship to clinical outcome in heart failure. Circulation 110: 149-154, 2004.
3. Annoni G, Luvara G, Arosio B, Gagliano N, Fiordaliso F, Santam- brogio D, Jeremic G, Mircoli L, Latini R, Vergani C, Masson S. Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium. Mech Ageing Dev 101: 57-72, 1998.
4. Asaumi Y, Kagaya Y, Takeda M, Yamaguchi N, Tada H, Ito K, Ohta J, Shiroto T, Shirato K, Minegishi N, Shimokawa H. Protective role of endogenous erythropoietin system in nonhematopoietic cells against pressure overload-induced left ventricular dysfunction in mice. Circulation 115: 2022-2032, 2007.
5. Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood 104: 2073-2080, 2004.
6. Berry C, Hogg K, Norrie J, Stevenson K, Brett M, McMurray J. Heart failure with preserved left ventricular systolic function: a hospital cohort study. Heart 91: 907-913, 2005.
7. Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6: 484 -494, 2005.
8. Brucks S, Little WC, Chao T, Rideman RL, Upadhya B, Wesley- Farrington D, Sane DC. Relation of anemia to diastolic heart failure and the effect on outcome. Am J Cardiol 93: 1055-1057, 2004.
9. Deten A, Marx G, Briest W, Christian Volz H, Zimmer HG. Heart function and molecular biological parameters are comparable in young adult and aged rats after chronic myocardial infarction. Cardiovasc Res 66: 364-373, 2005.
10. Faquin WC, Schneider TJ, Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79: 1987-1994, 1992.
11. Horiguchi H, Oguma E, Kayama F. The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia. Blood 106: 67-74, 2005.
12. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Boren-stein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 39: 1780-1786, 2002.
13. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation 106: 2125-2131, 2002.
14. Mancini DM, Katz SD, Lang CC, LaManca J, Hudaihed A, Androne AS. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure. Circulation 107: 294-299, 2003.
15. Masuyama T, Yamamoto K, Sakata Y, Doi R, Nishikawa N, Kondo H, Ono K, Kuzuya T, Sugawara M, Hori M. Evolving changes in Doppler mitral flow velocity pattern in rats with hypertensive hypertrophy. JAm Coll Cardiol 36: 2333-2338, 2000.
16. Medeiros DM, Beard JL. Dietary iron deficiency results in cardiac eccentric hypertrophy in rats. Proc Soc Exp Biol Med 218: 370-375, 1998.
17. Naito Y, Tsujino T, Fujioka Y, Ohyanagi M, Iwasaki T. Augmented diurnal variations of the cardiac renin-angiotensin system in hypertensive rats. Hypertension 40: 827-833, 2002.
18. Nanas JN, Matsouka C, Karageorgopoulos D, Leonti A, Tsolakis E, Drakos SG, Tsagalou EP, Maroulidis GD, Alexopoulos GP, Ka- nakakis JE, Anastasiou-Nana MI. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 48: 2485-2489, 2006.
19. Okonko DO, Anker SD. Anemia in chronic heart failure: pathogenetic mechanisms. J Cadiac Fail 10 Suppl 1: S5-S9, 2004.
20. Okonko DO, Grzeslo A, Witkowski T, Mandal AK, Slater RM, Roughton M, Foldes G, Thum T, Majda J, Banasiak W, Missouris CG, Poole-Wilson PA, Anker SD, Ponikowski P. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol 51: 103-112, 2008.
21. Olivetti G, Lagrasta C, Quaini F, Ricci R, Moccia G, Caprasso JM, Anversa P. Capillary growth in anemia-induced ventricular wall remodeling in the rat heart. Circ Res 65: 1182-1192, 1989.
22. Olivetti G, Quaini F, Lagrasta C, Ricci R, Tiberti G, Capasso JM, Anversa P. Myocyte cellular hypertrophy and hyperplasia contribute to ventricular wall remodeling in anemia-induced cardiac hypertrophy in rats. Am J Pathol 141: 227-239, 1992.
23. Parsa CJ, Matsumoto A, Kim J, Riel RU, Pascal LS, Walton GB, Thompson RB, Petrofski JA, Annex BH, Stamler JS, Koch WJ. A novel protective effect of erythropoietin in the infarcted heart. J Clin Invest 112: 999-1007, 2003.
24. Prunier F, Pfister O, Hadri L, Liang L, Del Monte F, Liao R, Hajjar RJ. Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. Am J Physiol Heart Circ Physiol 292: H522-H529, 2007.
25. Ribatti D, Presta M, Vacca A, Ria R, Giuliani R, Dell'Era P, Nico B, Roncali L, Dammacco F. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood 93: 2627-2636, 1999.
26. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
27. Tanne Z, Coleman R, Nahir M, Shomrat D, Finberg JPM, Youdim MBH. Ultrastructural and cytochemical changes in the heart of iron- deficient rats. Biochem Pharmacol 47: 1759-1766, 1994.
28. Toblli JE, Lombrana A, Duarte P, Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 50: 1657-1665, 2007.
29. Varma S, Cohen HJ. Developmental stage-specific expression of the α-and β-subunits of the HIF-1 protein in the mouse and human fetus. Mol Genet Metab 75: 244-249, 2002.
30. Wright GL, Hanlon P, Amin K, Steenbergen C, Murphy E, Arcasoy MO. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythro- poietin during ischemia-reperfusion injury. FASEB J 18: 1031-1033, 2004.
31. Zipes DP, Libby P, Bonow RO, Braunwald E. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine (7th ed.). Philadelphia: Saunders, 2004, p. 560-561.